• tryptophan
  • Based on a study of ribosomal protein genes, it had been concluded that UGA does not code for tryptophan in plant-pathogenic mycoplasma-like organisms (MLO) and the Acholeplasmataceae (Lim and Sears, 1992) and there seems to be only a single tRNA-CCA for tryptophan in Acholeplasma laidlawii (Tanaka et al. (wikipedia.org)
  • anticodon
  • Despite the common belief that most bacteria are similar to E. coli , the tRNA gene organization and anticodon complement in B. subtilis , and probably in most gram-positive bacteria, are remarkably different from those in E. coli i. (asmscience.org)
  • While preQ1 was first discovered as an anticodon sequence of tRNAs from E.coli in 1972, preQ1 riboswitch was not first found until 2004 and recognized even later. (wikipedia.org)
  • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon . (wikipedia.org)
  • amino-acyl tRNA
  • To ensure fidelity of the genetic code, physiologically misacylated tRNAs (Glu-tRNAGln and Asp-tRNAAsn) are recognised by the heterotrimeric enzyme GatCAB, and through a transamidation reaction, synthesise the cognate amino-acyl tRNA. (openwetware.org)
  • PMID
  • Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric [ PMID: 10673435 ]. (ebi.ac.uk)
  • Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [ PMID: 8364025 ], and are mostly dimeric or multimeric, containing at least three conserved regions [ PMID: 8274143 , PMID: 2053131 , PMID: 1852601 ]. (ebi.ac.uk)
  • Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c [ PMID: 10447505 ]. (ebi.ac.uk)
  • aspartyl-tRNA
  • In enzymology, an asparaginyl-tRNA synthase (glutamine-hydrolysing) (EC 6.3.5.6) is an enzyme that catalyzes the chemical reaction ATP + aspartyl-tRNAAsn + L-glutamine ⇌ {\displaystyle \rightleftharpoons } ADP + phosphate + asparaginyl-tRNAAsn + L-glutamate The 3 substrates of this enzyme are ATP, aspartyl-tRNA(Asn), and L-glutamine, whereas its 4 products are ADP, phosphate, asparaginyl-tRNA(Asn), and L-glutamate. (wikipedia.org)
  • synthetases
  • This explains how RNase P can recognize all of its tRNA precursor substrates and contrasts with the aminoacyl-tRNA synthetases that recognize many different nucleotide positions scattered throughout the tRNA. (asmscience.org)
  • As aminoacyl-tRNA synthetases are so critical to the cell's metabolism, understanding their genetic regulation is especially important. (asmscience.org)
  • Aminoacyl-tRNA synthetases have been divided into two classes on the basis of the presence of several different stretches of amino acid sequences. (asmscience.org)
  • The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. (ebi.ac.uk)
  • However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. (ebi.ac.uk)
  • In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. (ebi.ac.uk)
  • Aminoacyl-tRNA synthetases, the genetic code, and the evolutionary process. (ebi.ac.uk)
  • Aminoacyl-tRNA synthetases: versatile players in the changing theater of translation. (ebi.ac.uk)
  • Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs. (ebi.ac.uk)
  • Classes of aminoacyl-tRNA synthetases and the establishment of the genetic code. (ebi.ac.uk)
  • Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases. (ebi.ac.uk)
  • Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. (ebi.ac.uk)
  • The aminoacyl-tRNA synthetases (EC 6.1.1. (wikipedia.org)
  • citation needed] However, beyond an incremental change in size, the Megavirus genome exhibits 7 aminoacyl tRNA synthetases (Table 2), the archetypes of enzymes previously thought only to be encoded by cellular organisms. (wikipedia.org)
  • gene
  • The majority of the tRNA genes are in two large groups, one containing 21 and the other containing 16 tRNA genes, immediately following the 3′ ends of ribosomal gene operons. (asmscience.org)
  • Numbers of genes in each tRNA gene cluster are indicated by arrows. (asmscience.org)
  • Nucleic
  • Two examples of this type of reaction occur during the formation of nucleic acids and the charging of tRNA prior to translation. (wikipedia.org)