• His filters have been installed in government schools in parts of Bengal and Assam where the ground water contains unsafe levels of arsenic. (governancenow.com)
  • Overexposure may result from relatively high levels of arsenic in drinking water and foods. (cdc.gov)
  • Common sources of exposure to higher-than-average levels of arsenic include working near or in hazardous waste sites or in areas with high levels naturally occurring arsenic in soil, rocks, and water. (vivianlawry.com)
  • Exposure to high levels of arsenic can cause death. (vivianlawry.com)
  • There was a positive correlation between the levels of Th17 cells and IL-17A and the levels of arsenic in hair. (ijbs.com)
  • TGen had recently identified arsenic trioxide among a library of 650 compounds that could potentially be used against different subtypes of glioblastoma. (tgen.org)
  • We sought to identify compounds that specifically disrupt the growth of different GBM molecular subtypes," said Dr. Leonidas Platanias, Director of the Robert H. Lurie Comprehensive Cancer Center at Northwestern's Feinberg School of Medicine, and the study's senior author. (tgen.org)
  • These applications are declining with the increasing recognition of the toxicity of arsenic and its compounds. (wikipedia.org)
  • A few species of bacteria are able to use arsenic compounds as respiratory metabolites. (wikipedia.org)
  • It burns in oxygen to form arsenic trioxide and arsenic pentoxide, which have the same structure as the more well-known phosphorus compounds, and in fluorine to give arsenic pentafluoride. (wikipedia.org)
  • NIOSH skin notation profile: Arsenic and inorganic arsenic containing compounds. (cdc.gov)
  • This Skin Notation Profile provides the SK assignments and supportive data for arsenic and inorganic arsenic containing compounds. (cdc.gov)
  • Himalayan rock contains arsenic as iron and aluminium compounds. (governancenow.com)
  • When weathered rock dust is carried by water to the plains, arsenic compounds mix in the alluvial soil and gradually poison ground water. (governancenow.com)
  • Today, the use of arsenic compounds in pesticides is highly restricted in most countries. (sbistudy.com)
  • In the field of medicine, arsenic compounds have been used in the treatment of certain medical conditions, most notably in the past for the treatment of syphilis. (sbistudy.com)
  • Therefore, the handling and disposal of arsenic and its compounds require strict safety measures and adherence to regulations. (sbistudy.com)
  • Arsenic compounds exist in a number of inorganic and organic forms. (cdc.gov)
  • Other inorganic arsenic compounds may vary somewhat in relative toxicity, and organic arsenic compounds appear to be essentially nontoxic. (cdc.gov)
  • Physical and chemical properties vary among the various arsenic compounds of toxicological concern. (cdc.gov)
  • the guidelines for decontamination and medical treatment are applicable for exposure to arsenic and inorganic arsenic compounds, including arsenic trioxide. (cdc.gov)
  • Inorganic arsenic compounds have been used as pesticides, but can no longer be used in agriculture. (cdc.gov)
  • Some organic arsenic compounds may be used as pesticides or as additives in animal feed. (cdc.gov)
  • Arsenic compounds began to be used in agriculture as ingredients in insecticides, rat poisons, herbicides and wood preservatives, as well as pigments in paints, wallpaper and ceramics. (ventolaphotography.com)
  • Although arsenic compounds were mined by the early Chinese, Greek and Egyptian civilizations, it is believed that arsenic itself was first identified by Albertus Magnus, a German alchemist, in 1250. (ventolaphotography.com)
  • Whorton In ancient times, there were other versions of arsenic, primarily sulfide compounds. (ventolaphotography.com)
  • acceptedAnswer": {"@type": "Answer", "text": "Inorganic arsenic compounds are found in soils, sediments, and groundwater. (kahveciogluinsaat.com.tr)
  • Cadmium and its compounds are Group 1 carcinogens as classified by the International Agency for Research on Cancer . (vivianlawry.com)
  • Due to its high atomic number and ease of attachment to organic compounds , it has also found favour as a non-toxic radiocontrast material. (wikipedia.org)
  • Arsenic trioxide (As2O3) is sometimes added to glass formulations to modify its optical properties. (sbistudy.com)
  • This Medical Management Guideline focuses on arsenic trioxide (As2O3), one of the most toxic and prevalent forms. (cdc.gov)
  • Arsenic trioxide (As2O3) has been shown to induce apoptosis and differentiation in NPC xenografts. (scielo.br)
  • iii) The reduction of MMP-9 was found in As2O3-treated groups, more evident in HNE1-LMP1 cells. (scielo.br)
  • Chronic toxicity from ingestion or inhalation of arsenic may be occupational or environmental. (medscape.com)
  • [ 6 ] Accidental ingestion, ingestion with suicidal intent, and intentional poisoning most commonly are associated with acute toxicity. (medscape.com)
  • At one time, people in southern Austria reportedly found that eating arsenic had a "tonic" effect and were able to ingest without toxicity what would usually be a fatal dose. (medscape.com)
  • Clinical effects of arsenic toxicity depend on the chronicity of exposure (eg, acute, chronic) and the chemical form involved, which may be inorganic arsenic (pentavalent arsenic and trivalent arsenic), organic arsenicals, or arsine gas. (medscape.com)
  • Treatment of acute arsenic toxicity is supportive. (medscape.com)
  • Arsenic trioxide dust is readily absorbed from the lungs, but inhaled quantities are usually insufficient to cause acute systemic toxicity. (cdc.gov)
  • Contaminated soil may also be a source of significant arsenic exposure in children, although it is not likely that children would ingest sufficient arsenic- contaminated soil to cause significant acute toxicity. (cdc.gov)
  • Notable human health toxicity effects identified from human and/or animal studies include respiratory cancer, non-cancer toxicity effects following inhalation, dermatitis, and reproductive effects. (mdpi.com)
  • The United States' Environmental Protection Agency states that all forms of arsenic are a serious risk to human health. (wikipedia.org)
  • nonflammable solid) is one of the most toxic and prevalent forms of arsenic. (cdc.gov)
  • Arsenic trioxide (an odorless, tasteless, white or transparent, nonflammable solid) is one of the most toxic and prevalent forms of arsenic. (cdc.gov)
  • Some forms of arsenic (inorganic arsenic) can have serious side effects. (kahveciogluinsaat.com.tr)
  • Trace quantities of arsenic are an essential dietary element in rats, hamsters, goats, chickens, and presumably other species. (wikipedia.org)
  • It was only from the 20th century on that scientists understood the ill effects of consuming water or food contaminated with microscopic quantities of arsenic. (governancenow.com)
  • Small quantities of arsenic metal are used in alloys in products such as lead-acid batteries. (cdc.gov)
  • Though stable in dry air, arsenic forms a golden-bronze tarnish upon exposure to humidity which eventually becomes a black surface layer. (wikipedia.org)
  • Chronic exposure, as in well water, has been associated with bladder cancer and risk of diabetes with neuropathy. (medscape.com)
  • Chronic exposure to arsenic can lead to serious health problems, including various cancers, cardiovascular diseases, skin disorders, and neurological effects. (sbistudy.com)
  • The primary focus regarding arsenic is on its potential health and environmental risks, and measures are taken to minimize exposure and ensure safe handling practices. (sbistudy.com)
  • A resurgence of interest in arsenic as a medicinal agent for the treatment of acute promyelocytic leukemias, multiple myeloma, myelodysplastic syndromes, and assorted resistant solid tumors may potentially contribute to increases in arsenic exposure. (medscape.com)
  • Ingestion is the most important route of acute exposure of arsenic trioxide. (cdc.gov)
  • In 2016, the Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS) reported 670 cases of hydrogen sulfide exposure and 198 cases of cyanide exposure . (medscape.com)
  • OSHA PEL (permissible exposure limit) = 10 µg/m 3 as an 8-hour TWA concentration (as As) for inorganic arsenic (OSHA 2006). (cdc.gov)
  • Our group previously reported that arsenic (As) exposure induced apoptosis in hippocampus neurons. (springer.com)
  • Arsenic released by human activities is triple the exposure from natural sources. (vivianlawry.com)
  • Symptoms of lower arsenic exposure include nausea and vomiting, reduced production of erythrocytes and leucocytes, abnormal heart beat, pricking sensation in hand and feet, damage to blood vessels. (vivianlawry.com)
  • Exposure to arsenic may be associated with immune-related problems. (ijbs.com)
  • These results indicated that exposure to arsenic is associated with immune-related problems. (ijbs.com)
  • In the Guizhou province of China, arsenic poisoning caused by the burning of coal in unventilated indoor stoves is a common means of exposure, and more than 200,000 villagers are at risk for such exposures [ 2 ]. (ijbs.com)
  • Occupational exposure limits with proteins such as topoisomerase inhibitors, and mitotic and meiotic spindle poisons. (cdc.gov)
  • However, arsenic exposure induces cardiovascular diseases, logical malignancies and the discovery strategies. (med-abstracts.com)
  • In two clinical studies they examined, the therapeutic effects of arsenic trioxide were initially dismissed. (tgen.org)
  • Arsenic trioxide is produced during the smelting of ores that contain arsenic. (cdc.gov)
  • For patients who cannot tolerate an anthracycline drug, another possibility would be to give ATRA plus another differentiating drug called arsenic trioxide (Trisenox). (xediton.com)
  • water solubility of arsenic salts varies depending on the salt. (cdc.gov)
  • In the 19th century, arsenides and arsenic salts were used in the form of external pastes to treat ulcers and cancer. (ventolaphotography.com)
  • Acute oliguric renal failure occurs because concentration of arsenic in the proximal tubules and binding to proteins of tubular epithelium damages the tubules. (medscape.com)
  • In many wells on both sides of the border, the concentration of arsenic is 20 to 50 times the limit. (governancenow.com)
  • The United States' Agency for Toxic Substances and Disease Registry ranked arsenic as number 1 in its 2001 Priority List of Hazardous Substances at Superfund sites. (wikipedia.org)
  • Inorganic arsenicals, such as the trioxide, a by-product of smelting of ore containing copper, lead, and zinc, are more toxic than the organic. (medscape.com)
  • While arsenic is highly toxic and poses significant health risks, it also has some important applications and uses. (sbistudy.com)
  • However, due to the toxic nature of arsenic, its medical use is highly controlled and limited to specific cases under strict medical supervision. (sbistudy.com)
  • It's important to note that the toxic nature of arsenic poses significant health and environmental risks. (sbistudy.com)
  • Most modern brands of flypaper contain no poison, but only a non-toxic adhesive such as rosin. (kahveciogluinsaat.com.tr)
  • Liver damage constitutes an important part of the pathology of exogenic poisons since the liver is the prime organ in metabolizing toxic agents and acts with the kidneys in detoxication processes. (cloudaccess.net)
  • Cadmium is an extremely toxic metal commonly found in industrial workplaces, particularly where any ore is being processed or smelted. (vivianlawry.com)
  • Arsenic is used as a doping agent in the production of certain types of semiconductors, such as gallium arsenide (GaAs) and indium arsenide (InAs). (sbistudy.com)
  • In extreme & Chronic arsenic poisoning the victim can experience burring in the hands and feet, a numbing sensation through the whole body, hair loss, skin irritation nausea, vomiting cramps, weight loss, visual disturbance and finally cardiac failure. (murderuk.com)
  • Chronic inorganic arsenic poisoning is also associated with a number of chronic medical conditions (hypertension, diabetes mellitus, and peripheral vascular disease) as well as lung, bladder, and hepatic malignancies. (medscape.com)
  • Sometimes, patients exposed to arsenic have a garlic odor to their breath and tissue fluids. (medscape.com)
  • Arsenic trioxide has no odor and thus provides no warning of hazardous airborne concentrations. (cdc.gov)
  • It exists in various kinds of forms and compound such as sulfide and sulfate minerals which can be found everywhere around the universe and earth. (blansacar.cn)
  • Arsenic: a beneficial therapeutic poison - a historical overview Arsenicals have been used since ancient Greek and Roman civilizations and in the Far East as part of traditional Chinese medicine. (ventolaphotography.com)
  • Arsenic poisoning can occur through ingestion, inhalation, or contact with contaminated substances. (sbistudy.com)
  • Arsenic trioxide was found to be the most potent compound in non-MES GBM cells. (tgen.org)
  • of a particular arsenic compound depends in part on its solubility. (cdc.gov)
  • The most widely used antimony compound is antimony trioxide which is used as a flame retardant. (experttoxicologist.com)
  • Up to 25 supplements of this type were found to contain varying amounts of sildenafil citrate, a chemical compound that is a member of the Secure Medical family of online pharmacies. (governmentgrantsaustralia.org)
  • In that sense, the first modern chemotherapeutic agent was Paul Ehrlich 's arsphenamine , an arsenic compound discovered in 1909 and used to treat syphilis . (wikidoc.org)
  • One of the primary uses of arsenic historically was in the production of certain pesticides and herbicides. (sbistudy.com)
  • Arsenic-based pesticides were used in agriculture to control pests and protect crops. (sbistudy.com)
  • Arsenic is also used in the hide tanning process and, to a limited extent, in pesticides, feed additives and pharmaceuticals. (ventolaphotography.com)
  • Some animal feeding operations, pesticides, and fertilizers also release arsenic to the environment. (vivianlawry.com)
  • Arsenic occurs in many minerals, usually in combination with sulfur and metals, but also as a pure elemental crystal. (wikipedia.org)
  • It forms readily when elemental metallic arsenic is heated to high temperatures or burned. (cdc.gov)
  • The first mention of the therapeutic potentialities of Vitamin C in leukaemia, can be found in the book "The healing Factor: Vitamin C against disease", written by the biochemist Irwin Stone, in 1974 [ 3 ]. (scholars.direct)
  • Reaction time, Normally within half an hour of the ingestion, death will occur in as little as a few hours, or, in the case of slow poisoning over a prolonged period, can take several weeks. (murderuk.com)
  • Documented cases of arsenic poisoning have been associated with ingestion of traditional Chinese herbal balls, Korean herbal preparations used to treat hemorrhoids, and kelp supplements. (medscape.com)
  • Antimony is also found in Ant-paste, which is where many Victorians found their poison. (murderuk.com)
  • Antimony (element 51) is found primarily in natural ore deposits. (experttoxicologist.com)
  • The primary use of arsenic is in alloys of lead (for example, in car batteries and ammunition). (wikipedia.org)
  • Arsenic has also found limited use in the production of certain alloys. (sbistudy.com)
  • For instance, it can be added to lead to create lead-arsenic alloys, which have improved strength and resistance to corrosion. (sbistudy.com)
  • Furthermore, small amounts of arsenic are present in some metal alloys, such as copper and lead alloys. (sbistudy.com)
  • Arsenic was used to strengthen lead and, in the glassmaking industry, to reduce discoloration caused by trace amounts of iron. (medscape.com)
  • However, arsenic poisoning occurs in multicellular life if quantities are larger than needed. (wikipedia.org)
  • As arsenic's triple point is at 3.628 MPa (35.81 atm), it does not have a melting point at standard pressure but instead sublimes from solid to vapor at 887 K (615 °C or 1137 °F). Arsenic occurs in nature as one stable isotope, 75As, a monoisotopic element. (wikipedia.org)
  • Arsenic occurs naturally in soil and many kinds of rock (especially minerals and ores that contain copper and lead) as inorganic arsenic. (cdc.gov)
  • Das J, Ghosh J, Manna P, Sil PC (2010) Protective role of Tau against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. (springer.com)
  • We further found that ADV significantly promoted APL cell differentiation and apoptosis, thereby restraining the progression of APL. (biomedcentral.com)
  • But as Drs. Dhruv and Bell drilled down into the studies, they discovered that a specific subtype of GBM cells were more responsive to the arsenic trioxide treatment. (tgen.org)
  • Dr Chander Kumar Singh, a professor at TERI SAS's energy and environment department, who led the study on the Indian side, says villagers in Punjab were very concerned about arsenic poisoning and responsive to the team's efforts. (governancenow.com)
  • Effects, Not completely agreed upon in the scientific community, but, it is believed that arsenic interferes with certain enzymes and chemicals in the body. (murderuk.com)
  • It is also found in three deiodinase enzymes, which convert one thyroid hormone to another. (w3we.com)
  • Kadeyala PK, Sannadi S, Gottipolu RR (2013) Alterations in apoptotic caspases and antioxidant enzymes in arsenic exposed rat brain regions: reversal effect of essential metals and a chelating agent. (springer.com)
  • [9] [10] This is distinct from the fully oxidized Mo(VI) found complexed with molybdopterin in all other molybdenum-bearing enzymes, which perform a variety of crucial functions. (knowpia.com)
  • The incidence of carbon monoxide poisoning may increase during natural disasters owing to the improper use of portable electrical power generators. (medscape.com)
  • An increase in the incidence of lung cancer has been observed among workers in industries that produce chromate and manufacture pigments containing chromate. (vivianlawry.com)
  • But in ultra-low dosage, and in the right form, this naturally occurring chemical element can be a potent force against cancer. (tgen.org)
  • Clinically poisoning is similar to arsenic poisoning, typically diagnosis was that of gastric fever as the symptoms include fever, nausea, vomiting, dehydration and bad diarrhoea often containing blood. (murderuk.com)
  • The most common effect of arsenic poisoning is extreme stomach pain and cramp, in fact in Victorian England doctors would often diagnose arsenic poisoning as gastric fever, normally it was to late for the victim by the time they established the true cause. (murderuk.com)
  • Preliminary symptoms in people who drink arsenic-contaminated water are headaches, dizziness, diarrhoea, and changes in skin colour. (governancenow.com)
  • Symptoms of this blood and bone marrow cancer include excessive bleeding, easy bruising, low red blood cell count, fever, and fatigue. (themedicaldispatch.com)
  • The first drug used for cancer chemotherapy, however, dates back to the early 20th century, though it was not originally intended for that purpose. (wikidoc.org)
  • Northwestern was involved in one of the clinical trials, which tested the efficacy of arsenic trioxide in combination with temozolomide (TMZ) and radiation in treatment of GBM. (tgen.org)
  • The next step will be to validate the findings published in Molecular Cancer Research by initiating a new clinical trial specifically designed to match arsenic trioxide with glioblastoma patients that have a specific genomic signature, according to Dr. Michael Berens, a TGen Deputy Director and Professor in TGen's Cancer and Cell Biology Division, and one of the study's authors. (tgen.org)
  • A clinical trial has found that the combination of all-trans retinoic acid, which is a metabolite of vitamin A, and arsenic trioxide is highly effective in children with standard- and high-risk acute promyelocytic leukemia, or APL. (themedicaldispatch.com)
  • In this review, we countries, arsenic derivatives were once used for syphilis treatment discussed latest advancement in repositioning old drugs for hemato- [14]. (med-abstracts.com)
  • Black arsenic can also be formed by cooling vapor at around 100-220 °C and by crystallization of amorphous arsenic in the presence of mercury vapors. (wikipedia.org)
  • Severe gastro-intestinal syndromes, such as those due to phosphorus, mercury or arsenic are manifested by vomiting, colic, and bloody mucus and stools and may be accompanied by liver damage (hepatomegalia, jaundice). (cloudaccess.net)
  • Air pollution threatens the health of humans and other living beings and creates smog and acid rain, causes cancer and respiratory diseases, reduces the ozone layer atmosphere and contributes to global warming. (ispatguru.com)
  • Black arsenic is similar in structure to black phosphorus. (wikipedia.org)
  • Arsenic has a similar electronegativity and ionization energies to its lighter congener phosphorus and accordingly readily forms covalent molecules with most of the nonmetals. (wikipedia.org)
  • Milk is often given to penitents as it acts a a binder in the stomach for arsenic and other metal derivatives. (murderuk.com)
  • Treatment, Similar to arsenic poisoning, the stomach needs to be pumped, and a formula called dimercaprol is given , this needs to be done within 1 - 2 hours so as to neutralize the poison. (murderuk.com)
  • Treatment , The first course of action, if the doctor knows that it is arsenic poisoning, is to pump the stomach. (murderuk.com)
  • The combination of all-trans retinoic acid and arsenic trioxide is currently the preferred initial treatment for adults with standard-risk APL. (themedicaldispatch.com)
  • Clofarabine is a substance that is being studied in the treatment of cancer . (bionity.com)
  • Chemotherapy , in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer . (wikidoc.org)
  • In popular usage, it usually refers to antineoplastic drugs used to treat cancer or the combination of these drugs into a standardized treatment regimen . (wikidoc.org)
  • Actually some old drugs have been developed for new indications, such as aspirin for Arsenic trioxide has been used for the treatment of cancers and stroke, sildenafil (Viagra) for erection dysfunction and other disorders for more than 500 years in China [14]. (med-abstracts.com)
  • Contaminated water used for drinking, food preparation and irrigation of food crops poses the greatest threat to public health from arsenic. (kahveciogluinsaat.com.tr)
  • Arsenic is sometimes found in homeopathic preparations containing sulphur. (medscape.com)
  • Because of weak bonding between the layers, grey arsenic is brittle and has a relatively low Mohs hardness of 3.5. (wikipedia.org)
  • Nitrogen oxides cause lung tissues to become leathery and brittle and may cause lung cancer and emphysema. (environmentalpollution.in)
  • Selenium is found in , where it partially replaces the sulfur. (w3we.com)
  • There is considerable controversy regarding the role of estrogen metabolites in breast cancer risk, fueled in part by the development of a rapid ELISA that is suitable for large scale investigations. (lookformedical.com)
  • This is not uncommon as chemotherapy can affect healthy cells as well as cancer cells. (chemocare.com)
  • An earlier Children's Oncology Group trial showed that children with APL who were treated with arsenic trioxide and all-trans retinoic acid, along with chemotherapy drugs that included anthracyclines, had high rates of two-year event-free survival and low risk of relapse. (themedicaldispatch.com)
  • Arsenic is considered a transitional element intermediate between metals and nonmetals, but it classically is considered a heavy metal. (medscape.com)
  • Odorless and colorless, it went into food as food coloring, and it was used in beauty products, such as arsenic complexion wafers that promised women pure white skin, until as late as the 1920s. (ventolaphotography.com)
  • The doctor will also need to treat the side effects of the arsenic, such as any shock, cardiac and blood related problems. (murderuk.com)
  • Arsenic is a common n-type dopant in semiconductor electronic devices. (wikipedia.org)
  • Grey arsenic is a semimetal, but becomes a semiconductor with a bandgap of 1.2-1.4 eV if amorphized. (wikipedia.org)
  • In recent years, arsenic has gained attention in the field of semiconductor technology. (sbistudy.com)
  • Isotopes lighter than the stable isotopes primarily undergo beta plus decay to isotopes of arsenic, and isotopes heavier than the stable isotopes undergo beta minus decay to isotopes of bromine, with some minor neutron emission branches in the heaviest known isotopes. (w3we.com)
  • Sulfur has been known since ancient times primarily because it is a rather common substance.It is the 15th most common element in the universe, and though it is not found in allregions of the Earth, there are significant deposits in south Texas and Louisiana, as well in allvolcanoes. (blansacar.cn)
  • Effects, Typically this poison is a skin irritant. (murderuk.com)
  • Arsenic is believes to be a carcinogenic, thus possibly causing skin cancer. (murderuk.com)
  • In cases of slow poisoning the signs are jaundiced skin, weakness and restlessness, headache and dizzy spells, with occasional spells of paralysis. (murderuk.com)
  • Arsenic may be inhaled in particulate form, ingested, or absorbed through skin and mucous membranes. (medscape.com)
  • See Clues on the Skin: Acute Poisonings , a Critical Images slideshow, to help diagnose patients based on their dermatologic presentations. (medscape.com)
  • Direct contact with arsenic trioxide dust can cause localized skin irritation, but systemic absorption through the skin is negligible. (cdc.gov)
  • Arsenic was used even in medications to treat everything from asthma and cancer to reduced libido and skin problems. (ventolaphotography.com)
  • Arsenic trioxide is readily absorbed if ingested or inhaled, but only slowly absorbed through the skin. (cdc.gov)
  • Skin cancers during nursing baby. (myjuicecup.com)