• topical
  • Based on the American Academy of Dermatology guidelines of care for the management of acne vulgaris , trimethoprim, in combination with topical therapy, may be considered as an alternative therapeutic option for the management of moderate and severe acne. (drugs.com)
  • combination
  • Based on the US Department of Health and Human Services (HHS) Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents , trimethoprim (in combination with dapsone) is an effective and recommended alternative agent for the treatment of mild to moderate Pneumocystis pneumonia (PCP) in adolescent and adult HIV-infected patients. (drugs.com)
  • Based on the US Department of Health and Human Services (HHS) Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV-exposed and HIV-infected Children , trimethoprim (in combination with dapsone) is an effective and recommended alternative agent for the treatment of mild to moderate PCP in HIV-exposed or -infected children. (drugs.com)
  • different
  • Trimethoprim is metabolized in vitro to 11 different metabolites, of which, five are glutathione adducts and six are oxidative metabolites, including the major metabolites, 1- and 3-oxides and the 3- and 4-hydroxy derivatives. (nih.gov)