AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceNamed GroupsHealth CareGeographicals
Bronchopulmonary DysplasiaAspergillosis, Allergic BronchopulmonaryInfant, PrematureInfant, NewbornInfant, Very Low Birth WeightHyperoxiaInfant, Premature, DiseasesRespiratory Distress Syndrome, NewbornInfant, Extremely Low Birth WeightGestational AgeBronchopulmonary SequestrationLungUreaplasma InfectionsRespiration, ArtificialOxygen Inhalation TherapyIntensive Care Units, NeonatalFibrous Dysplasia of BoneInfant, Extremely PrematureUreaplasma urealyticumChorioamnionitisPulmonary SurfactantsRespiratory AspirationPulmonary AlveoliIntensive Care, NeonatalEctodermal DysplasiaPapioAnimals, NewbornLung InjuryBone Diseases, DevelopmentalUreaplasmaLung DiseasesLeukomalacia, PeriventricularClinical Trials as TopicInfant, Low Birth WeightDevelopmental DisabilitiesAmbroxolRetinopathy of PrematurityTracheaAspergillus fumigatusSucking BehaviorApneaConsensus Development Conferences, NIH as TopicDuctus Arteriosus, PatentPremature BirthApgar ScoreHyaline Membrane DiseaseBirth WeightPregnancyTransducers, PressureMaximal Expiratory Flow RateDexamethasoneFunctional Residual CapacityUterine Cervical DysplasiaBronchial DiseasesFibromuscular DysplasiaPneumocytesGastrointestinal ContentsAdministration, InhalationContinuous Positive Airway PressureSuctionIntermittent Positive-Pressure VentilationPsychomotor DisordersProspective StudiesVentilator WeaningTreatment OutcomeRetrospective StudiesBronchoalveolar Lavage FluidOsteochondrodysplasiasFollow-Up StudiesPortugalDisease Models, AnimalFibrous Dysplasia, MonostoticFatty AlcoholsRespiratory Function TestsFibrous Dysplasia, PolyostoticRisk FactorsOxygenFetusLung Diseases, FungalEnterocolitis, NecrotizingHip Dysplasia, CanineBronchiectasisCleidocranial DysplasiaInfant, Newborn, DiseasesCerebral PalsyAdrenal Cortex HormonesTime FactorsRetinal DysplasiaBronchial NeoplasmsHip Dislocation, CongenitalStatistics, NonparametricAnti-Inflammatory Agents
Moderate or severe bronchopulmonary dysplasiaInfantsPretermPulmonary artery hyperSepsisNeonatalSevereClinical TrialLung diseaseMortalityMulticenterOutcomes20212022Premature BabiesCell TherapyCohortPediatricsMulticentreStem cellPaediatricAdultsAcuteStudyTreatmentPreclinicalChildEffectsPhasePlaceboResultsPatientsStudies
Moderate or severe bronchopulmonary dysplasia2
  • The primary endpoint is the composite outcome of death by 36 weeks' postmenstrual age or moderate or severe bronchopulmonary dysplasia (BPD) at 36 weeks postmenstrual age. (ox.ac.uk)
  • Of the hydrocortisone-treated infants, 16.6% survived to 36 weeks without moderate or severe bronchopulmonary dysplasia, which did not differ significantly from 13.2% in the placebo group. (unchealthcare.org)
Infants20
  • 05-23-2006 Prevention of bronchopulmonary dysplasia in premature infants 10-21-2005 Treatment of bronchopulmonary dysplasia in premature infants. (wikipedia.org)
  • Further randomized trials are needed to provide definite conclusions and to assess whether reducing oxygen saturation has an impact on mortality among very and extremely low birth weight infants. (nih.gov)
  • The Brain Oxygenation-II study (BOx-II) is a phase-II, multicenter, single-arm clinical trial evaluating interventions based on near-infrared spectroscopy (NIRS) monitoring of cerebral oxygen saturation in extremely premature infants. (stanford.edu)
  • Matthew Laughon, MD, MPH, professor of pediatrics at the UNC School of Medicine, led UNC's site for a national clinical trial that compared the use of hydrocortisone versus placebo for preventing damage that can result from oxygen and ventilator therapy necessary to keep preterm infants alive. (unchealthcare.org)
  • Bronchopulmonary dysplasia is the most common lung problem in premature infants," said Laughon. (unchealthcare.org)
  • Premature infants with bronchopulmonary dysplasia have longer hospitalizations and more problems when they go home compared to infants without bronchopulmonary dysplasia. (unchealthcare.org)
  • The trial enrolled 800 infants born before the 30th week of pregnancy who had been on a ventilator for at least seven days. (unchealthcare.org)
  • Background Preterm infants are susceptible to the damaging effects of hyperoxia which may lead to bronchopulmonary dysplasia (BPD) and intestinal damage. (ui.ac.id)
  • Methods We conducted an unblinded, randomized controlled clinical trial in premature infants requiring supplemental oxygen in the first minutes of life. (ui.ac.id)
  • BACKGROUND: Free oxygen radicals have been implicated in the pathogenesis of bronchopulmonary dysplasia (BPD) in preterm infants. (bvsalud.org)
  • Providing supplementary SOD has been tested in clinical trials to prevent BPD in preterm infants. (bvsalud.org)
  • SELECTION CRITERIA: Randomized, quasi-randomized and cluster-randomized controlled trials (RCTs) where the participants were preterm infants who had developed, or were at risk of developing BPD, and who were randomly allocated to receive either SOD (in any form, by any route, any dose, anytime) or placebo, or no treatment. (bvsalud.org)
  • The effects of SOD in preterm infants has not been reported in any trial in the last few decades, considering that the most recent trial on SOD in preterm infants was conducted in 1997/1998, and no new studies are ongoing. (bvsalud.org)
  • 104 In clinical trials, intubated infants receiving erythromycin did not have reduced risk of BPD. (99nicu.org)
  • Neonatal drug development comes out of the Dark Ages Left out of clinical trials for years, preterm infants have very few drugs developed just for them. (airwaytherapeutics.com)
  • Permissive hypercapnia in extremely low birthweight infants (PHELBI): a randomised controlled multicentre trial. (ebneo.org)
  • In mechanically ventilated, extremely low-birthweight infants (ELBW) with birthweight between 400 g and 1000 g and gestational age 23-28 weeks plus 6 days, does the use of higher target ranges for PaCo2 in the first 14 days of life versus lower target ranges for PaCO₂, was compared regarding the primary outcome of death or bronchopulmonarydysplasia (BPD) at 36 weeks of gestational age. (ebneo.org)
  • Infants may recover completely or develop chronic lung damage, resulting in bronchopulmonary dysplasia (BPD). (medscape.com)
  • Objective-- To investigate the relationship between postnatal CMV infection and bronchopulmonary dysplasia (BPD) and mortality in a large, multicenter cohort of VLBW infants. (cdc.gov)
  • Despite the improvements in pre- vention of acute respiratory disease in preterm infants, the incidence of bronchopulmonary dysplasia (BPD) remains largely unchanged. (who.int)
Preterm4
  • Bronchopulmonary dysplasia (BPD) is the most critical complication in preterm neonates and is an independent risk factor affecting long-term cognitive development ( 1 - 6 ). (spandidos-publications.com)
  • In the APOSTEL III trial we aimed to compare the effectiveness and safety of the calcium-channel blocker nifedipine and the oxytocin inhibitor atosiban in women with threatened preterm birth. (monash.edu)
  • Study protocol: baby-OSCAR trial: Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial. (ox.ac.uk)
  • METHODS: This is a multicentre, masked, randomised, placebo-controlled parallel group trial to determine if early-targeted treatment of a large PDA with parenteral ibuprofen in extremely preterm babies (23+ 0-28+ 6 weeks' gestation) improves short and long-term health and economic outcomes. (ox.ac.uk)
Pulmonary artery hyper1
Sepsis2
  • MAIN OUTCOMES: Antenatal and postnatal mortality, bronchopulmonary dysplasia (BPD), sepsis, surgically treated necrotising enterocolitis (NEC), treated retinopathy of prematurity (ROP). (lu.se)
  • The discouraging results of these first clinical trials were a consequence of technical complications, sepsis , and the inability of conventional immunosuppression to control rejection, which was attributed to the large quantity of lymphoid tissue and bacterial load of the intestine. (medscape.com)
Neonatal4
  • NICHD expects the NRN to be its primary and first-line infrastructure involved in implementing multi-site neonatal clinical trials. (nih.gov)
  • Perinatal exposure of the neonatal lung to inflammation leads to decreased lung angiogenesis and the development of bronchopulmonary dysplasia (BPD). (spandidos-publications.com)
  • Neonatal chronic lung disease, also known as bronchopulmonary dysplasia (BPD), is defined as the need for respiratory support with oxygen and/or mechanical ventilation in the first 28 days of life 1-4 . (bvsalud.org)
  • Working closely with Professor Euan Wallace, we are keenly focused on translational outcomes and our preclinical studies on adult and neonatal respiratory disease have been translated into ongoing clinical trials. (hudson.org.au)
Severe3
  • Ten studies were identified, of which 8 had severe retinopathy of prematurity (n = 3811) and 8 had bronchopulmonary dysplasia/lung problems (n = 4612) as outcomes. (nih.gov)
  • The relative risk (RR) in favor of low SpO2 was 0.42 (95% CI 0.34-0.51) for severe retinopathy of prematurity, 0.73 (95% CI 0.63-0.86) for bronchopulmonary dysplasia/lung problems, and 1.12 (95% CI 0.86-1.45) for mortality. (nih.gov)
  • When analyzing the randomized trial separately, the RR (95% CI) for severe retinopathy of prematurity was 0.48 (0.34-0.68), for bronchopulmonary dyslasia/lung problems it was 0.79 (0.64-0.97), and for mortality it was 1.27 (1.01-1.60). (nih.gov)
Clinical Trial4
  • The study is registered at the Dutch Clinical Trial Registry, number NTR2947. (monash.edu)
  • The clinical trial studied the use of hydrocortisone as a potential treatment for the condition known as bronchopulmonary dysplasia (BPD), a serious condition that can develop in newborns as a complication of another breathing condition or from lung injuries caused by treatments like mechanical ventilation. (unchealthcare.org)
  • doi: 10.1056/NEJMoa2116045.PMID: 37467497 Clinical Trial. (the-incubator.org)
  • A clinical trial assessed fever in 142 children aged 6-47 months randomized to receive acetaminophen, oral placebo, or ibuprofen immediately following IIV and for 24 hours after vaccination. (cdc.gov)
Lung disease1
  • Bronchopulmonary dysplasia (BPD) is a multifactorial chronic lung disease that contributes to disruption of pulmonary development. (bvsalud.org)
Mortality1
Multicenter1
Outcomes2
  • Future clinical research should focus on large placebo-controlled trials, powered for perinatal outcomes. (monash.edu)
  • The outcomes from these studies will inform the design of clinical trials and allow us to develop target approaches for the clinical use of amnion cells. (hudson.org.au)
20211
20222
  • At the 2022 AAP National Conference & Exhibition, one session reviews pediatric considerations for dosing, safety, and regulatory approval for medications and vaccines for SARS-CoV-2, and a look at the Pediatric Trials Network. (contemporarypediatrics.com)
  • SEARCH METHODS: We searched CENTRAL, PubMed, Embase, and three trials registers on 22 September 2022 together with reference checking, citation searching and contact with study authors to identify additional studies. (bvsalud.org)
Premature Babies1
Cell Therapy1
  • In this review, we discuss the rationale for MSC-based cell therapy in COPD, the main findings from in vitro and in vivo preclinical COPD model studies, clinical trials in patients with COPD and directions for further research. (bmj.com)
Cohort1
Pediatrics2
  • Institutions across the country were involved in the trial, including a team at UNC led by Matthew Laughon, MD, MPH , professor of pediatrics at the UNC School of Medicine. (unchealthcare.org)
  • On the basis of successful clinical trials, the American Academy of Pediatrics (AAP) issued recommendations14 for ribavirin use in 1993. (rtmagazine.com)
Multicentre1
  • Methods We did this multicentre, randomised controlled trial in ten tertiary and nine teaching hospitals in the Netherlands and Belgium. (monash.edu)
Stem cell1
  • The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (nih.gov)
Paediatric1
  • The register also displays information on 18700 older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006). (clinicaltrialsregister.eu)
Adults1
  • Endoscopic ear surgeon and pioneer, Alejandro Rivas, MD, discusses the latest advances in cochlear implant surgery and his clinical trials aimed to prevent hearing loss in children and adults. (uhhospitals.org)
Acute1
  • A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial. (cdc.gov)
Study4
Treatment2
  • However, although clinical trials have demonstrated the safety of MSC treatment, thus far they have not provided evidence for MSC efficacy in the treatment of COPD. (bmj.com)
  • Nevertheless, as a result of concerns about the validity of initial trials and the high cost associated with treatment, a 1996 revision of the AAP recommendations 19 was released. (rtmagazine.com)
Preclinical1
  • Preclinical testing will be necessary before clinical trials can begin. (eurekalert.org)
Child1
  • She further discussed the importance of the PTN, aimed at creating an infrastructure for investigators to conduct trials to improve pediatric labeling and child health. (contemporarypediatrics.com)
Effects1
Phase1
Placebo1
  • Folic acid as placebo in controlled clinical trials of hydroxychloroquine prophylaxis in COVID-19: Is it scientifically justifiable? (cdc.gov)
Results1
  • Purulent pericarditis results from depression of myocardial ischemia angina pectoris empiric trial regardless of the eating disorder, examining instead the impact of longitudinal deficiency affecting the cervical vertebrae, are common. (albionfoundation.org)
Patients1
  • Stanford is currently not accepting patients for this trial. (stanford.edu)
Studies2
  • Among their successes: in trials with more than 11,000 participants, 26 products were submitted to the FDA, 18 therapeutic areas studied, with studies covered in nearly 100 publications. (contemporarypediatrics.com)
  • Er zijn meerdere studies verricht naar het effect van antibiotische profylaxe bij dreigende vroeggeboorte, met en zonder prematuur gebroken vliezen, op uitstel van de vroeggeboorte en mortaliteit, en morbiditeit bij de pasgeborene. (richtlijnendatabase.nl)