• They originate from the retina, so they are not likely to have a surrounding or overlying retinal detachment. (eyecancer.com)
  • Retinal pigment epithelial (RPE) tear is an infrequent complication of pigment epithelial detachment in the elderly, and occurs either spontaneously or after laser photocoagulation. (ijo.in)
  • In essence, an early stage of retinal microvascular degeneration is followed by neovascularization that has the potential for the development of retinal detachment and permanent loss of vision. (medscape.com)
  • As the tumor enlarges, it may cause distortion of the pupil (iris melanoma), blurred vision (ciliary body melanoma), or markedly decreased visual acuity caused by secondary retinal detachment (choroidal melanoma). (cigna.com)
  • Ocular disorders: BALVERSA can cause central serous retinopathy/retinal pigment epithelial detachment (CSR/RPED). (nih.gov)
  • Results At presentation, four eyes of two patients who presented soon after the initial ocular symptoms showed mild and uniform hyperautofluorescence in the macula mixed with hypoautofluorescence in the areas of serous retinal detachment. (bmj.com)
  • The other six eyes of three patients, who presented weeks after the symptoms, initially demonstrated diffuse and mottled hyperautofluorescence over the posterior pole, mixed with hypoautofluorescence induced by serous retinal detachment in four eyes. (bmj.com)
  • Among the baseline characteristics, serous pigment epithelial detachment (B = - 2.580, P = 0.032) and thick-choroid (B = 1.980, P = 0.019) were significantly associated with recurrence. (plos.org)
  • Thinner choroid and serous pigment epithelial detachment appear protective for recurrences. (plos.org)
  • Central serous chorioretinopathy (CSC) is characterized by serous neurosensory retinal detachment at the posterior pole due to leakage from the retinal pigment epithelium (RPE) [ 1 - 5 ]. (plos.org)
  • Persistent serous retinal detachment in a patient with chronic CSC can lead to permanent visual impairment due to RPE decompensation and disruption of the photoreceptor ellipsoid zone [ 1 , 2 , 12 , 13 ]. (plos.org)
  • This meta-analysis was performed to determine the effectiveness of steroids as an adjunct following rhegmatogenous retinal detachment (RRD) surgery. (dovepress.com)
  • Rhegmatogenous retinal detachment (RRD) is the most common form of retinal detachment (RD). Proliferative vitreoretinopathy (PVR) is primarily a result of failure to correct RRD after initial retinal reattachment surgery, occurs in 5%-10% of patients, and may lead to recurrent RD. 1 Further surgery is the only proven therapy for recurrent RD with PVR. (dovepress.com)
  • CONCLUSION: Retention and migration of PFO to the anterior chamber following retinal detachment repair can lead to formation of nodules on the surface of the iris. (bvsalud.org)
  • Retinal detachment is separation of the neurosensory retina from the underlying retinal pigment epithelium. (msdmanuals.com)
  • The most common cause is a retinal break (a tear or, less commonly, a hole-rhegmatogenous detachment). (msdmanuals.com)
  • ultrasonography may help determine the presence and type of retinal detachment if it cannot be seen with funduscopy. (msdmanuals.com)
  • Immediate treatment is imperative if rhegmatogenous retinal detachment is acute and threatens central vision. (msdmanuals.com)
  • Treatment of rhegmatogenous detachment may include sealing retinal breaks (by laser or cryotherapy), supporting the breaks with scleral buckling, pneumatic retinopexy, and/or vitrectomy. (msdmanuals.com)
  • There are 3 types of detachment: rhegmatogenous (which involves a retinal break), traction, and serous (exudative) detachment. (msdmanuals.com)
  • Traction retinal detachment can be caused by vitreoretinal traction due to preretinal fibrous membranes as may occur in proliferative diabetic or sickle cell retinopathy. (msdmanuals.com)
  • Retinal detachment is painless. (msdmanuals.com)
  • Indirect ophthalmoscopy shows the retinal detachment and can differentiate the subtypes of retinal detachment in nearly all cases. (msdmanuals.com)
  • During atrophic AMD the waste/exchange pathway between the blood supply (choroid) and the retinal pigment epithelium (RPE) is compromised. (frontiersin.org)
  • The acute uveitic stage is heralded by the onset of sequential blurring of vision in both eyes, 1-2 days after the onset of CNS signs, and is marked by bilateral granulomatous anterior uveitis, a variable degree of vitritis, thickening of the posterior choroid, edema of the optic nerve, and multiple serous retinal detachments (Fig 9-52). (aao.org)
  • Retinal Pigment Epithelium and Choroid Translocation in Massive Submacular Hemorrhage. (stanford.edu)
  • The highly vascular choroid, located between the retinal pigment epithelium and the sclera, supplies oxygen and nutrients to the outer retina and plays an essential role in vision-guided eye growth. (bmj.com)
  • The focal serous retinal detachments are often shallow, exhibiting a cloverleaf pattern around the posterior pole, but they may coalesce and evolve into large, bullous, exudative detachments. (aao.org)
  • Traction and serous retinal detachments (not involving retinal breaks) cause central or peripheral vision loss. (msdmanuals.com)
  • Traction and serous retinal detachments do not involve a break and are called nonrhegmatogenous. (msdmanuals.com)
  • Traction and serous (exudative) retinal detachments can cause blurriness of vision, but they may not cause any symptoms in the early stages. (msdmanuals.com)
  • Direct funduscopy using a handheld ophthalmoscope can miss some retinal detachments, which may be peripheral. (msdmanuals.com)
  • In the rare instance of retinal adenocarcinoma, most patients have been enucleated with a presumed diagnosis of choroidal melanoma. (eyecancer.com)
  • The study eye had not yet received treatment for active choroidal neovascularization, and patients received either ranibizumab ( Lucentis , Genentech) or bevacizumab ( Avastin , Genentech) in one of three dosing regimens. (medscape.com)
  • 0001), larger choroidal neovascularization area ( P = .002), and the presence of retinal pigment epithelium elevation ( P = .001). (medscape.com)
  • The number of choroidal melanocytes decreases with loss of melanin pigment, which corresponds with the characteristic clinical feature known as sunset-glow fundus . (aao.org)
  • 6-9 On OCT imaging, consistent features of CHRRPEs include varying amount of thickened retinal and pre-retinal tissue, retinal disorganization, epiretinal membranes with secondary retinal folds and striae, normal adjacent retina and no evidence of choroidal involvement. (reviewofoptometry.com)
  • Nitric oxide synthase and arginase contribute to ischemia/reperfusion-induced neurovascular degeneration, mediators of the hypoxia-inducible factor pathway (eg, vascular endothelial growth factor [VEGF], metabolic factors such as succinate) drive destructive neovascularization, and the extracellular matrix is involved in hypoxia-induced retinal revascularization. (medscape.com)
  • In many forms of human retinal disease, including age-related macular degeneration (AMD), the underlying pathogenesis resides within the support cells of the retina, the retinal pigment epithelium (RPE). (ca.gov)
  • Patients with neovascular age-related macular degeneration (AMD) who have a poor initial response to an antivascular endothelial growth factor (anti-VEGF) agent may still respond to treatment with the same drug over time, without being switched to an alternative agent, the Comparison of Age-Related Macular Degeneration Treatment Trials (CATT) study suggests. (medscape.com)
  • Background The human retinal pigment epithelium (RPE) plays an important role in the pathogenesis of age related macular degeneration (AMD). (vu.nl)
  • Senescence of retinal pigment epithelial (RPE) cells is a crucial event in the pathogenesis of age-related macular degeneration (AMD). (nist.gov)
  • It showed that normal recommended doses of simple dietary supplements prevents the most common form of blindness, the age related degeneration of the retina otherwise known as "retinal calcification. (vitalraadet.dk)
  • Current treatments are effective in slowing down AMD, but they do not reverse the degeneration that has already occurred. (brightfocus.org)
  • The trial will evaluate the therapy for the treatment of patients suffering from age-related macular degeneration, the major cause of loss of vision in people aged 65 and older, as part of an ongoing collaboration with The London Project at the Institute of Ophthalmology, UCL. (genengnews.com)
  • Ask your doctor about new age-related macular degeneration treatments. (rxwiki.com)
  • Age-related macular degeneration (AMD) is a leading cause of blindness with no treatment available for early stages. (mdfoundation.com.au)
  • Some people with age-related macular degeneration lose their sight because cells in the retina of the eye called retinal pigment epithelium (RPE) cells stop working. (yourgenome.org)
  • An illustration showing how stem cells can be used to produce retinal pigment epithelium (RPE) cells that can be used to treat patients with age-related macular degeneration (AMD). (yourgenome.org)
  • NEW ORLEANS - Retinal pigment epithelial (RPE) cells derived from human embryonic stem cells can be safely transplanted into the eyes of patients with retinal degeneration, with early signs of vision gain, according to pioneers in the field. (medscape.com)
  • But this is just a first step in the long road towards making regenerative cell therapy a reality in macular and retinal degeneration. (medscape.com)
  • In both studies presented here, human embryonic stem cells were turned into RPE cells and injected into the subretinal space of patients with retinal degeneration at a dose of 50,000 to 200,000 cells. (medscape.com)
  • On the other hand, if a patient does not respond well by week 12, they should still be given an opportunity to continue with treatment, as they have a reasonably good opportunity to gain visual acuity by year 2 with continued treatment, using the same drug. (medscape.com)
  • SCORE2 Report 20: Relationship of Treatment Discontinuation with Visual Acuity and Central Subfield Thickness Outcomes. (mdfoundation.com.au)
  • After six months the decrease in retinal fluid was sustained and mean visual acuity improved enabling patients in the first and second group to read an additional line on the eye chart. (elsevier.com)
  • PVR odds ratio, visual acuity, retinal reattachment rate, and complications were evaluated in three trials. (dovepress.com)
  • 3 , 4 Several recent studies have indicated that postoperative treatment with oral 13- cis -retinoic acid decreases the risk of PVR and improves the operative rate of RD and visual acuity (VA). 5 , 6 Curcumin effectively causes human fetal retinal pigment epithelium cell accumulation at the G2/M phase in vitro 7 and also inhibits proliferation by causing cell death. (dovepress.com)
  • Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat. (ca.gov)
  • Induced pluripotent stem cells (iPSCs) generated from patient fibroblasts could potentially be used as a source of autologous cells for transplantation in retinal disease. (nature.com)
  • This important proof-of-concept finding supports the development of personalized iPSC-based transplantation therapies for retinal disease. (nature.com)
  • Stem cell-derived cell transplantation in the eye is one therapy being explored for inherited retinal degenerations such as retinitis pigmentosa (RP). (nature.com)
  • Now that we have established the lack of immune response in monkeys and in human cells in vitro," explains Sugita, "using the iPS cell bank appears to be a viable solution, at least in the case of retinal pigment epithelial cell transplantation. (neurosciencenews.com)
  • Retinal pigment epithelial cell. (nih.gov)
  • Figure 1: (A) Fundus photograph of the left eye showing the presence of a juxtafoveal retinal pigment epithelial (RPE) tear. (ijo.in)
  • 1-5 On fundus examination, these lesions often appear elevated, pigmented (usually grey, white or brown, but may be orange, yellow or green) and are frequently associated with overlying glial tissue that may produce retinal distortion, wrinkling and/or striae. (reviewofoptometry.com)
  • Among other extracolonic manifestations, odontomas, pigmented lesions of the fundus, congenital hypertrophy of the retinal pigment epithelium and dental anomalies, such as supernumerary and impacted teeth, are present. (bvsalud.org)
  • Recent clinical trials evaluating allogeneic retinal grafts derived from human embryonic stem cells (hESCs) show the procedure to be safe and potentially effective 1 . (nature.com)
  • Retinal pigment epithelial (RPE) tear has been described to occur spontaneously, after laser photocoagulation and in recent times, after intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents. (ijo.in)
  • Premature birth results in a disruption of normal retinal vascular maturation. (medscape.com)
  • Blood vessels constrict and can become obliterated, resulting in delays of normal retinal vascular development. (medscape.com)
  • The retina continues to grow in thickness and eventually outgrows this vascular supply, and the inner retina must receive oxygen and nutrients from the retinal vessels. (medscape.com)
  • Treatment modalities for CSC include focal laser photocoagulation, photodynamic therapy (PDT), and intravitreal anti-vascular endothelial growth factor (VEGF) injections [ 14 ]. (plos.org)
  • Also, total retinal thickness decreased between week 24 and year 1 by a mean of 26 μm ( P = .04), and by year 2, the mean decrease was 36 μm ( P = .02). (medscape.com)
  • Collectively, all macular segmentation lines revealed a 92 percent total retinal fluid decrease at 3 months (Credit: The American Journal of Medicine). (elsevier.com)
  • To investigate the relationship of anti-VEGF treatment discontinuation with baseline factors and outcomes in eyes treated initially with aflibercept or bevacizumab for macular edema from central or hemiretinal vein occlusion. (mdfoundation.com.au)
  • Results support the need for continued monitoring and individualized treatment for patients treated with anti-VEGF for macular edema from central or hemiretinal vein occlusion. (mdfoundation.com.au)
  • In the next clinical trial," continues Sugita, "we plan to use allogeneic iPS-retinal pigment epithelial cells from HLA homozygote donors. (neurosciencenews.com)
  • A phase I/II trial by allogeneic mesenchymal stem cells for patients with systemic lupus erythematosus with kidney damage resistant to traditional treatments is underway. (afm-telethon.fr)
  • Chemoradiation is the most effective treatment, but its use is associated with significant ocular and cerebral morbidity. (medscape.com)
  • The prognosis for ocular lymphoma depends on the tumor's histologic type and stage and the treatment employed. (medscape.com)
  • Induced pluripotent stem (iPS) cells have the potential to differentiate into any cell type, making them a potential source from which to produce cells as a therapeutic platform for the treatment of a wide range of diseases. (ca.gov)
  • Summary: Researchers report they have successfully transplanted retinal pigment cells derived from stem cells without rejection or the need of immunosuppressant drugs. (neurosciencenews.com)
  • Researchers at the RIKEN Center for Developmental Biology (CDB) have successfully transplanted retinal pigment cells derived from stem cells of one monkey into the eyes of other monkeys without rejection and without the need for immunosuppressant drugs. (neurosciencenews.com)
  • Published in Stem Cell Reports , the study shows that this procedure is possible as long as a set of cells called the MHC are genetically matched between the host monkey and the new retinal cells. (neurosciencenews.com)
  • The team grew retinal pigment cells from induced pluripotent stem cells (iPSCs) and transplanted them into the damaged retina of a human participant. (neurosciencenews.com)
  • In a separate study published in the same issue of Stem Cell Reports , the researchers saw similar results when they repeated this last experiment with human T cells and HLA-matched or unmatched retinal pigment cells grown from IPSCs. (neurosciencenews.com)
  • Therapeutic Candidate or Device The therapeutic candidate is a patient specific (autologous) induced pluripotent stem cell derived retinal pigment epithelium (AiPSC-RPE) product. (ca.gov)
  • In this study, the researchers will isolate mouse adult retinal stem cells and enrich them for cone photoreceptors by manipulating specific cellular pathways as through a cell sorting technique. (brightfocus.org)
  • They will also test the ability of transplanted adult retinal stem cells to restore vision in mice that lack functioning cone photoreceptors. (brightfocus.org)
  • Stem cell therapy offers the promise of an inexhaustible supply of retinal cells that can be used for transplant into eyes affected by AMD. (brightfocus.org)
  • These researchers have shown that isolated retinal stem cells can generate cone photoreceptors and retinal pigment epithelial cells. (brightfocus.org)
  • When these retinal stem cells are transplanted into mouse eyes, they are able to integrate into the host retina and develop correctly. (brightfocus.org)
  • Blood stem cells are used to provide a source of healthy blood cells for people with some blood conditions, such as thalassaemia, and cancer patients who have lost their own blood stem cells during treatment. (yourgenome.org)
  • Commenting on the trial in a statement, Dr Carmel Toomes, associate professor at the Leeds Institutes of Molecular Medicine, says: "These results give the many patients out there who suffer from AMD and other retinal degenerations real hope that stem cells replacement therapy may be a reality in the near future. (medscape.com)
  • Indication AiPSC-RPE cell product will be indicated for the treatment of maculopathies related to RPE atrophy. (ca.gov)
  • AMD has two types: dry AMD with the presence of drusen and atrophy and wet AMD with the features of edema and hemorrhage within or below the retina or retinal pigment epithelium besides drusen and atrophy [ 3 ]. (hindawi.com)
  • Zolgensma® (onasemnogene abeparvovec: first gene therapy treatment derived partly from research conducted at Genethon ) for spinal muscular atrophy linked to SMN1. (afm-telethon.fr)
  • Several studies presented at ARVO demonstrate the short- and long-term safety and efficacy of MicroPulse laser treatment for multiple types of glaucoma, including open-angle glaucoma and neovascular glaucoma, and for retinal conditions. (iridex.com)
  • Fekri F, Delos Santos RC, Karshafian R, Antonescu CN (2016) Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms. (plos.org)
  • Normal vision relies on the function of cells called cone photoreceptors and retinal pigment epithelial cells. (brightfocus.org)
  • Light-induced damage is a particularly serious threat for vertebrate photoreceptors, which absorb light photons using the photopigments in their outer segments (OS) and transduce electrochemical signals to inner retinal neurons. (molcells.org)
  • These findings have identified an alternative source of replacement tissue for use in human retinal cellular therapies, and provide a new in vitro cellular model system in which to study RPE diseases affecting human patients. (ca.gov)
  • Defective retinoid metabolism has also been reported in other retinal degenerative diseases. (molcells.org)
  • used as a diagnostic agent in suspected thyroid disease and in the treatment of selected thyroid diseases. (theodora.com)
  • The use of hESC-derived cells is an attractive treatment approach, in fact, for many different diseases because transplanted cells may be able to react to changing conditions in the microenvironment, which is an important biological process, Dr Banin pointed out. (medscape.com)
  • The clinical success of anti-CD19 CAR T-cell therapies has not only provided efficacious treatment alternatives for cancer patients but also aided the developmental and regulatory precedent for the translation of cell-based therapies for other disease areas. (scienceboard.net)
  • Although pharmacologic manipulation of intrinsically photosensitive retinal ganglion cells and the neural pathways that mediate photophobia may be possible in the future, current therapies are directed at the underlying cause of the photophobia and optical modulation of these cells and pathways. (researchgate.net)
  • Retinal nerve fiber layer thickness measurement may elucidate the risk of structural and functional sequelae. (researchgate.net)
  • Diagnosis and treatment of infertility. (cdc.gov)
  • To investigate long-term treatment response after intravitreal bevacizumab injections (IVBIs) for central serous chorioretinopathy (CSC). (plos.org)
  • Kang HM, Choi JH, Koh HJ, Lee SC (2020) Long-term treatment response after intravitreal bevacizumab injections for patients with central serous chorioretinopathy. (plos.org)
  • Drug : Intravitreal administration of 2.0 mg Aflibercept was administered to single-group subjects as the first treatment at Visit 2, and 2.0 mg Aflibercept was released twice at 4-week intervals during Visits 4 and 6. (who.int)
  • After three treatments, a total of 5 intravitreal Aflibercept injections were performed at the same dose at 8-week intervals over visits 8, 10, 12, 14, and 16. (who.int)
  • I think one of the key findings from this study is that if a patient responds to anti-VEGF treatment after the first three injections - in other words, by week 12 - they will most likely continue to respond with further treatment, and treatment should continue," Dr Ying told Medscape Medical News . (medscape.com)
  • Western immunoblots with patient serum samples from the 7-month and 41-month follow-up visits against human donor retinal extract (lanes A and B) revealed similar bands (a prominent approximately 21-kDa band was weaker in the older [7-month] serum, likely due to successive use of this serum sample). (jamanetwork.com)
  • According to Dr. Snyder, although this limited proof-of-concept study included a small sample size and limited patient diversity, its findings suggest efficacy and support the targeting of the GPR13 receptor with levodopa for the treatment of nAMD in future studies. (elsevier.com)
  • While the patient awaited surgical treatment, recurrent anterior uveitis prompted doctors to prescribe a tapering course of topical corticosteroids. (cdc.gov)
  • However, there is currently no consensus regarding the ideal treatment for macular hemorrhage. (stanford.edu)
  • Patients with adenomas of the retinal pigment epithelium typically have no symptoms. (eyecancer.com)
  • I've spent my career specializing in the care of patients with metastatic urothelial carcinoma and understand the need for new treatments for this disease," said Arlene O. Siefker-Radtke, M.D., professor of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, and lead study investigator. (jnj.com)
  • BALVERSA is an important new therapy for this small subset of patients with urothelial carcinoma who, up until now, had limited treatment options. (jnj.com)
  • Methods FAF photography with blue light (BL-FAF) and near-infrared light (NIR-FAF) was performed on 10 eyes of five patients using a confocal scanning laser ophthalmoscope before and after treatment. (bmj.com)
  • The main outcome measure was long-term treatment outcome after IVBIs in patients with CSC. (plos.org)
  • Understanding the cause will be the first step in the development of novel treatments which may prevent or cure this potentially blinding condition for millions of patients. (rxwiki.com)
  • MicroPulse technology gives physicians the control and results they need when managing some of their patients' most serious glaucoma and retinal conditions. (iridex.com)
  • In the first study, 20 patients newly diagnosed with nAMD who had never had VEGF treatment were given a small daily dose of levodopa for one month and were evaluated weekly by their referring retina specialist, who determined whether anti-VEGF treatment was needed. (elsevier.com)
  • In the second part of the study, the patients who completed the first study and a second group of 14 patients who had received anti-VEGF treatment for at least three months before the study received escalating doses of levodopa to test the tolerance and efficacy of the drug. (elsevier.com)
  • The investigators noted that levodopa may be unlikely as a standalone treatment in patients with newly diagnosed nAMD since 11 of the patients did require anti-VEGF injections. (elsevier.com)
  • The treatment group included patients in whom steroids were used as an adjunct and a control group in which placebo was used. (dovepress.com)
  • Six patients demonstrated preretinal pigmented cells near the site of injection. (medscape.com)
  • Randomized clinical trials with larger numbers of patients are needed to establish the efficacy, treatment protocol, and safety of IVM injection. (bvsalud.org)
  • HA565 trade name] is indicated as a pharmacokinetic enhancer for protease inhibitors when these are used in combination therapy with other antiretroviral agents for the treatment of HIV-1 infected patients. (who.int)
  • Saquinavir 1000 mg twice daily with ritonavir 100 mg twice daily in antiretroviral treatment (ART)- experienced patients. (who.int)
  • Initiate treatment with saquinavir 500 mg twice daily with ritonavir 100 mg twice daily for the first 7 days, then saquinavir 1000 mg twice daily with ritonavir 100 mg twice daily in ART- naïve patients. (who.int)
  • Tipranavir with ritonavir should not be used in treatment-naïve patients. (who.int)
  • Results showed that in cultured human-derived retinal pigment epithelial ARPE-19 cells , the extract of Chlorella zofingiensis and its nutritional ingredient astaxanthin exhibited significant inhibitory effects on the formation of endogenous N ε -carboxymethyllysine (CML), a key AGE representative, through the suppression of intracellular oxidative stress. (rsc.org)
  • However, hESC-based treatments involve the controversial use of human embryos and pose a risk of immune-mediated rejection. (nature.com)
  • Premature senescence of human ARPE-19 cells was induced by repeated treatments with 6 mM tert-butylhydroperoxide (tert-BHP). (nist.gov)
  • LCN2 was increased by SOX9 and SIRT1 deacetylated SOX9 to promote its nuclear translocation, which further inhibited the viability of human retinal pigment epithelial cells and promoted cell apoptosis and angiogenesis as well as CNV-induced AMD formation. (hindawi.com)
  • 8 , 9 Daunomycin inhibits formation of PVR in pigmented rabbits 10 and proliferation of human retinal cells. (dovepress.com)
  • To test whether MHC matching is a viable method, the team used retinal pigment cells that were grown from monkey iPSCs in the iPS cell bank at the Center for iPS Cell Research and Application, Kyoto University. (neurosciencenews.com)
  • Conclusion FAF photography non-invasively visualised sequential metabolic and functional changes in the retinal pigment epithelium (RPE) in acute VKH disease. (bmj.com)
  • Long-term visual function is maintained in this model of retinal disease even though the xenografted cells are eventually lost, suggesting a secondary protective host cellular response. (ca.gov)
  • At these annual meetings, there will be 20 scientific presentations on MicroPulse laser therapy that utilize IRIDEX's Cyclo G6® Glaucoma Laser and MicroPulse P3® Delivery Device for treating multiple types of glaucoma, and IRIDEX's IQ family of laser consoles for treating a variety of retinal disorders. (iridex.com)
  • Elucidating the function of the mutated gene, ALMS1 , is critical for the development of specific treatments and may uncover pathways relevant to a range of other disorders including common forms of obesity and type 2 diabetes. (springer.com)
  • This group of rare disorders involves a primary pathologic process occurring at or near the level of the retinal pigment epithelium (RPE) with or without photoreceptor outer segment and choriocapillaris involvement. (medscape.com)
  • PURPOSE: To describe a case of PFO retention, migration into the anterior chamber, and the subsequent formation of iris nodules following the repair of a giant retinal tear. (bvsalud.org)
  • This could allow this novel bioactive substrate to be a potential treatment for atrophic AMD that would function two-fold: deliver the required monolayer of healthy RPE cells to the macula on a synthetic BM and remove diseased structures within the retina, restoring the waste/exchange pathway and preventing vision loss. (frontiersin.org)
  • There is currently no treatment or cure for atrophic AMD. (frontiersin.org)
  • Objective Incorporating an enhancer such as nano-titanium dioxide into antimicrobial photodynamic therapy can improve treatment outcome. (thieme-connect.de)
  • In addition, the rate of fluid-phase endocytosis was enhanced, but with delayed onset upon USMB treatment relative to the enhancement of CME, suggesting that the two processes are distinctly regulated by USMB. (plos.org)
  • Indeed, vacuolin-1 or desipramine treatment prevented the enhancement of CME but not of fluid phase endocytosis upon USMB, suggesting that lysosome exocytosis and acid sphingomyelinase, respectively, are required for the regulation of CME but not fluid phase endocytosis upon USMB treatment. (plos.org)
  • These results indicate that USMB enhances both CME and fluid phase endocytosis through distinct signaling mechanisms, and suggest that strategies for potentiating the enhancement of endocytosis upon USMB treatment may improve targeted drug delivery. (plos.org)
  • In the first month, retinal fluid decreased by 29 percent. (elsevier.com)
  • retinal fluid completely resolved at the same macular segmentation line at month 2, and fluid remained stable up to month 3 without anti-VEGF injections. (elsevier.com)
  • An attractive method to enhance the safety and efficiency of drug treatment in cancer is to supplement conventional administration methods with targeted drug delivery strategies in order to enhance drug uptake within tumour tissues while limiting their action within healthy cells [ 3 , 4 ]. (plos.org)
  • METHODS: Analysis included 150 SCORE2 Month 60 completers classified into three groups: discontinued treatment early, treated intermittently, and treated continuously. (mdfoundation.com.au)
  • Alström syndrome (AS) is characterised by metabolic deficits, retinal dystrophy, sensorineural hearing loss, dilated cardiomyopathy and multi-organ fibrosis. (springer.com)
  • This receptor can be supportive of retinal health and survival, which led to the development of our hypothesis that it may prevent or treat AMD. (elsevier.com)