Treatment chemotherapeutic drug screening assays antitumor. Medical search. Frequent questions

The search for targeted drugs for cancer treatment includes consideration of natural products, which may provide new opportunities for antitumor cytotoxicity as single agents or in combination therapy. (cancer.gov)
Based on this method, we performed cytotoxicity assays on 42 AsPCs grown both as monolayers and spheroids. (biomedcentral.com)
The current investigation aimed to demonstrate how interpretation of results from several standard cytotoxicity and proliferation assays vary in dependence on contributions from the pentose phosphate pathway (PPP). (cdc.gov)
Non-tumorigenic Beas-2B cells were treated with graded concentrations of benzo[a]pyrene (B[a]P) for 24 and 48h prior to cytotoxicity and proliferation assessment with commonly used MTT, MTS, WST1, and Alamar Blue assays. (cdc.gov)
The ethanolic extracts of the plant were examined for the presence of bioactive components and their total flavonoid content, with focusing on quercetin detection using thin layer bioautography (TLB) and brine shrimp lethality assay (BSLA) for cytotoxicity. (who.int)

The identification, optimization and synthesis of antineoplastic drugs from PnV molecules may lead to a new multitarget chemotherapy. (nature.com)
The concept has now been extended to embrace synthetic lethal drug sensitivity, such as that observed with PARP inhibitors in combination with DNA-damaging chemotherapy in a variety of BRCA defective tumors 10 . (nature.com)
Although localized disease can be treated by surgery alone, the standard therapy for patients with metastatic disease usually comprises intensive induction chemotherapy, local surgery and myeloablative chemotherapy followed by autologous stem cell transplant, external radiotherapy and retinoic acid treatment. (biomedcentral.com)
Though chemotherapy drugs show initial positive response, tumor acquires resistance gradually and patients experience continued tumor growth and metastatic disease. (springernature.com)
These finding are particularly beneficial in the treatment of recurrent cancer when maintaining a good quality of life during chemotherapy is a priority and allows patients to have a natural, nutritional approach to preventing and managing chemotherapy adverse effects. (researchgate.net)
To reduce the number of patients suffering from side effects without a clear benefit of the therapy regimen, there is a great need for novel predictive tests to identify a group of patients that can be safely treated with conventional chemotherapy and a subgroup that has a significant benefit of taxane-based treatment. (justia.com)
The most challenging treatment decision in this context concerns ER+/HER2-breast cancer patients, for which classical clinical factors like grading, tumor size or lymph node involvement do not provide a clear answer to the question whether to use chemotherapy or not and what type of treatment therapy is appropriate for the individual patient. (justia.com)
The standard treatment for EOC is debulking surgery followed by chemotherapy, usually platinum/taxane based. (biomedcentral.com)
A statically significant gain in overall survival was seen in patients who received the combined treatment of trastuzumab and chemotherapy. (wjgnet.com)
Our finding supports PDL-1 in CAFs as a chemotherapy response biomarker and as a drug delivery and therapeutic target for chemoresistant NSCLC. (cdc.gov)
This insidious disease requires surgery, chemotherapy or radiotherapy all of which wreak havoc on the patient during and often long after treatment. (scientificamerican.com)
The major concern of chemotherapy is the side effects of existing drugs ( Baldo and Pham, 2013 ). (japsonline.com)
In addition, a growing number of clinical cases have found that pancreatic cancer exhibits significant resistance to traditional treatment options, including chemotherapy, radiation, and immunotherapy [ 6 , 7 ]. (hindawi.com)
The current standard treatment for gliomas is surgical resection supplemented by postoperative chemotherapy. (eurekaselect.com)
Chemotherapy with platinum drugs such as cisplatin, carboplatin, oxaliplatin, or a combination thereof is used to treat a variety of tumors. (eurekaselect.com)
However, the results of gliomas chemotherapy are unsatisfactory, and resistance to platinum drugs is one of the important reasons. (eurekaselect.com)
Standard treatment for women with ovarian cancer involves aggressive debulking surgery and chemotherapy. (medscape.com)

Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)
Currently available cytotoxic treatment options produce low rates of patient response and have modest survival impact. (biomedcentral.com)
Triticum aestivum L. root growth inhibition test and Allium cepa L. assay were used to assess the cytotoxic potential of phosphonates. (japsonline.com)

Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
Major Findings: The in vitro growth inhibition assays demonstrated additive activity when AHCC is co-administered with PLD. (researchgate.net)

A recent in vitro screening of the Phoneutria nigriventer spider venom (PnV) antitumor effects by our group has shown that the venom significantly affected glioblastoma cell lines. (nature.com)
Integration of a machine learning-derived signature of response with in vitro assessment of LP-184 efficacy facilitated the derivation of manageable yet robust biomarkers which can be used to predict drug sensitivity with high accuracy and clinical value. (biomedcentral.com)
Tetrazolium reduction and resazurin assays are the mainstay of routine in vitro toxicity batteries. (cdc.gov)

The discovery of vitamin-mediated drug targeting in plants led to the hypothesis that folate-targeted therapies could be of clinical use. (wikipedia.org)
A typical workflow for conventional bioprospecting and drug discovery. (microbialtec.com)
Further more, one of the most recent approaches in drug discovery from microorganisms is cocultivation. (microbialtec.com)
If you are interested in microbial drug discovery services, please contact us for more details. (microbialtec.com)
The Molecular Targets Program (MTP) provides the focus and infrastructure that enables CCR investigators to pursue molecularly targeted drug discovery research by promoting an interdisciplinary, collaborative, team-oriented approach to identifying and validating potential cancer-pertinent targets. (cancer.gov)
EFMC would like to remind his efforts, joint with Henk Timmerman and Han van de Waterbeemd, to launch the successful series of EFMC Short Course in Medicinal Chemistry in 2009 with a very successful course on "Improving Compound Quality: Physical Chemistry and DMPK Properties in Drug Discovery. (efmc.info)
Cancer research has been conducted using cultured cells as part of drug discovery testing, but conventional two-dimensional culture methods are unable to reflect the complex tumor microenvironment. (medsci.org)
In particular, the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed. (anti-agingfirewalls.com)
Mechanism-based target identification and drug discovery in cancer research. (jscimedcentral.com)
Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors. (jscimedcentral.com)
Organic chemistry in drug discovery. (jscimedcentral.com)
The role of the medicinal chemist in drug discovery--then and now. (jscimedcentral.com)
Dr. Cochran's translational interests span protein-based drug discovery and development for applications in oncology and regenerative medicine, and the development of new technologies for high-throughput protein analysis and engineering. (stanford.edu)

Ki67-a well-known cell proliferation marker-has been described to predict the benefit from adjuvant taxane-based treatment in the PACS01 trial (Penault-Llorca, J C O, 2008). (justia.com)
Adjuvant treatment with a modified FOLFIRINOX regimen has recently demonstrated an extended median overall survival of 4.53 years and a 3-year survival rate of 63.4% in patients after surgical operation [ 9 ]. (hindawi.com)

In the end, to have a potential therapeutic approach, we looked for an efficient inhibitor against the target kinase in the international union of basic and clinical pharmacology (IUPHAR) database, where a screen of 72 inhibitors against 456 human kinases binding activity is provided. (springernature.com)
A clinical study to evaluate of the combination of AHCC plus PLD in the treatment of ovarian cancer is being pursued. (researchgate.net)
Finally, several clinical trials are currently ongoing using MEK inhibitors in combination with chemotherapeutic drugs (including dacarbazine or paclitaxel). (biomedcentral.com)
The Part 2 post in this series is concerned with mainline anti-cancer drug interventions that simultaneously address multiple growth pathways, ones that are entering clinical practice. (anti-agingfirewalls.com)
The principle of preferentially selecting patients most likely to benefit from therapy according to their genetic profile has led to substantial clinical benefit in some tumour types, and has potential to considerably refine treatment in advanced nonsmall cell lung cancer (NSCLC). (ersjournals.com)
From one such study, it appeared that mutational testing should become standard at diagnosis, at least for adenocarcinoma patients with a never or low smoking history, as clinical predictors are insufficient to optimise treatment. (ersjournals.com)
Therapies tailored to specific genetic lesions and diagnostic tests that assay for their respective molecular targets are now an established part of clinical practice across various tumour types, including chronic myeloid leukaemia 1 , gastrointestinal stromal tumours and epithelial tumours, such as breast and colon cancer 2 . (ersjournals.com)
However, the use of molecular biomarkers to optimise clinical outcomes requires careful assessment of their role in terms of both prognosis and treatment decision-making. (ersjournals.com)
Today, anthracycline and taxane-based treatment strategies are commonly used in clinical routine, since these regimens have been shown to be superior compared to other standard chemotherapies. (justia.com)
Several large clinical trials demonstrated that the addition of taxanes to anthracycline-based treatment strategies results in an improved clinical outcome (Martin et al. (justia.com)
The application of this assay and the potential biomarkers with possible predictive significance to PARPis therapy of EOC patients now need testing in the setting of a clinical trial. (biomedcentral.com)
Thus, the molecular pathogenesis of EOC is heterogeneous, and is reflected in the variability of clinical characteristics such as histological type, differentiation, potential for invasion and metastasis, and response to therapy and outcome, as there is an unmet need to improve treatment strategies for this deadly disease [ 5 ]. (biomedcentral.com)
The ToGA trial must be characterized as a landmark in the treatment of gastric cancer and it has paved the way for a number of new HER2 targeted compounds such as pertuzumab, ado-trastuzumab emtansine, lapatinib, afatinib, and dacomitinib, which are currently undergoing phase II and III clinical testing. (wjgnet.com)
The active compound curcumin is believed to have a wide range of biological effects including anti-inflammatory, antioxidant, antitumor, antibacterial, and antiviral activities, which have shown a lot of potential for use in clinical medicine. (blogspot.com)
Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component of turmeric (a curry spice) showing strong anti-oxidant and anti-inflammatory activities, might be a potential candidate for the prevention and/or treatment of cancer and other chronic diseases. (blogspot.com)
BACKGROUND: Hypercortisolism has emerged as a prominent clinical condition worldwide caused by biochemical cortisol excess in patients, and optimization treatment is needed urgently in the clinic. (bvsalud.org)
Platinum drugs are a class of chemotherapeutic drugs that affect the cell cycle, and the main site of action is the DNA of cells, which are common chemotherapeutic drugs in clinical practice. (eurekaselect.com)

Emerging evidence suggests that they provide a cellular mechanism for induction and emergence of drug resistance and contribute to increased invasive and metastatic potential. (frontiersin.org)
MINK1 drives 5FU resistance via AKT/MDM2/p53 axis : Reveals a high throughput kinome knockout screening in OSCC. (springernature.com)
Here using high-throughput screening, we identified MINK1 as a driver of 5FU resistance through AKT/MDM2/p53 axis. (springernature.com)
Reprogramming resistant cells to undergo drug induced cell death is a feasible approach to overcome drug resistance. (springernature.com)
To understand the role of potential kinase signaling in 5FU resistance in OSCC, a CRISPR based kinome-wide high throughput screening was performed using a lentiviral sgRNA library knocking out 840 kinases individually with a total number of 3214 sgRNA constructs, followed by treatment with a sub lethal dose of 5FU for 48h after which cell death was measured in high content analyzer using a fluorescent cell viability dye. (springernature.com)
Chemotherapeutic drugs result in not only strong resistance but also more side effects [ 4 ]. (hindawi.com)
Among the many regulatory factors, overexpression of pro-survival Bcl-2 family members may promote resistance to chemotherapeutic drugs in many tumors. (oncotarget.com)
Title: Different ability of multidrug-resistant and-sensitive counterpart cells to release and capture extracellular vesicles Abstract: Cancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. (up.pt)
Dissemination of tumour cells and metastatic spread as well as cancer resistance to standard treatment are still the common cause of treatment failure and eventually death in prostate cancer patients. (uni-hamburg.de)
This resistance makes surgery the best option for pancreatic adenocarcinoma (PAAD) treatment, and for 10-20% of patients who undergo surgery, the 5-year survival rate is still only 15-25% [ 8 ]. (hindawi.com)
The resistance of gliomas to platinum drugs is the result of a combination of influencing factors. (eurekaselect.com)
miRNAs and lncRNAs control drug sensitivity and the development of tumor resistance towards platinum drugs. (eurekaselect.com)
This mini-review summarizes the resistance mechanisms of gliomas to platinum drugs, as well as molecules and therapies that can improve the sensitivity of gliomas to platinum drugs. (eurekaselect.com)

20423 bioactive compound berberine was determined by MTT assay, and the oxidative stress was determined by lipid peroxidation method along with assessment of changes in the enzymatic and non enzymatic antioxidant status. (pdfplayer.org)

Our researchers are now extracting bacterial DNA from soil and marine habitats, cloning large fragments into, for example, bacterial artificial chromosomes, expressing in a host bacterium and screening the library for new compounds. (microbialtec.com)
Compounds of interest include not only classical "drug-like" organic small molecules, but also peptides, proteins, and other bioactive chemical classes. (cancer.gov)
This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
Antineoplastons are drugs composed of chemical compounds that are naturally present in the urine and blood . (cancer.gov)

These findings establish a mechanism for co-targeting DNA damage-induced cell cycle checkpoints in combination with repair of cisplatin-DNA lesions in vivo using RNAi nanocarriers, and motivate further exploration of ASL as a generalized strategy to improve cancer treatment. (nature.com)
The chemotherapeutic regimen used for OSCC are cisplatin, 5FU and Docetaxel (TPF)(3). (springernature.com)
Cisplatin showed concentration-dependent antitumor effects due to loss of cell adhesion and spheroid disruption in each cell line, while cetuximab exhibited antitumor effects that correlated with EGFR expression in each cell line. (medsci.org)

We have developed a 3D (spheroid) functional assay to assess the sensitivity of two PARPis (niraparib and olaparib) in ascites-derived primary cell cultures (AsPCs) from HGSOC patients. (biomedcentral.com)
The response to PARPis treatment in monolayer AsPCs, was significantly higher, compared to 3D AsPCs, as 88% and 52% of the monolayer AsPCs displayed sensitivity to niraparib and olaparib respectively, while 66% of the 3D AsPCs were sensitive to niraparib and 38% to olaparib, the latter being more consistent with previous estimates of HRD (40%-60%) in EOC. (biomedcentral.com)
Global gene expression comparison of 6 PARPi-resistant and 6 PARPi-sensitive 3D AsPCs was indicative for the predominant downregulation of numerous genes and networks with previously demonstrated roles in EOC chemoresistance, suggesting that the PARPis-sensitive AsPCs could display enhanced sensitivity to other chemotherapeutic drugs, commonly applied in cancer management. (biomedcentral.com)

Microtubule binding drugs are of special interest as they have important roles in the modulation of cellular functions and many of them act as anticancer agents. (rgcb.res.in)
With greater control over where exogenous agents are delivered, diagnostic and treatment therapies are more effective and cause fewer side effects. (wikipedia.org)
While some drugs and radioimaging agents are delivered to cells as folate conjugates in a one-to-one folate-to-conjugate ratio, folate-targeted liposomes allow for the delivery of larger amounts of chemotherapeutic agents. (wikipedia.org)
Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. (mdpi.com)
Microbial metabolites are among the most important of the cancer chemotherapeutic agents. (microbialtec.com)
This can be achieved by identifying the causative factors for acquired chemoresistance and discovering novel agents to target critical causative factors, which will restore drug-induced cell death in chemoresistant OSCC. (springernature.com)
Importantly, each of these pathways is known to respond effectively to different therapeutic agents, thus personalized diagnosis equates to personalized treatment. (nih.gov)
To date, many different chemotherapeutic agents have been widely used as common treatments for oral cancers. (oncotarget.com)
On the basis of this information, we established a screening system using N18-RE-105 cells to identify therapeutic agents that can protect cells from glutamate toxicity. (researchgate.net)
Although, taxanes are among the most active agents, the absolute benefit of taxane-based treatment is modest (3-5%) and has to be balanced according to serious side-effects. (justia.com)

Considerable efforts have been made to identify biomarkers that allow a prediction of a specific treatment while minimizing the risk of unnecessary side effects. (justia.com)
Abstract Circulating tumor cells (CTCs) are essential biomarkers for liquid biopsies, which are important in the early screening, prognosis, and real-time monitoring of cancer. (techscience.com)

Derivatives of diaminoketothiazoleare for inhibitors of cyclin-dependent kinases and glycogen synthase kinase-3 and thus could be useful for the treatment of malignancies and diabetes. (rgcb.res.in)
The concept of synthetic lethality (SL) holds great promise for the treatment of human cancers, best exemplified by the now widespread use of PARP inhibitors in BRCA mutant cancers. (nature.com)
Some Mek inhibitors showed promising antitumor activity, although schedules and doses associated with low systemic toxicity need to be defined. (biomedcentral.com)

Finally, the efficacy of certain potential drugs was predicted using the pRRophetic algorithm, and the results in the high- and low-risk groups were compared. (hindawi.com)

What conclusions about treatment can we draw from EGFR copy number or KRAS mutation status? (ersjournals.com)
What role should anti-EGFR antibodies play in NSCLC treatment, and in which patients? (ersjournals.com)

Both ikarugamycin and astemizole improved the anticancer activity of the immunogenic chemotherapeutic agent oxaliplatin in a T cell-dependent fashion. (bmj.com)

Therefore, there is an urgent need for development of more effective therapies that may rely on molecularly targeted individualized treatments. (biomedcentral.com)

His achievements in understanding the role of physiochemical properties in drug activity, more precisely in the disposition of medicines ought to be particularly recognised. (efmc.info)
Unfortunately, some targets with potent oncogenic activity fall into this category, and currently little is known about how to solve this problem, which largely hampered drug research on human cancers. (techscience.com)

Based on the natural high affinity of folate for the folate receptor protein (FR), which is commonly expressed on the surface of many human cancers, folate-drug conjugates also bind tightly to the FR and trigger cellular uptake via endocytosis. (wikipedia.org)
This is the third post in a three-part series concerned with new, emerging and potential future treatments for cancers. (anti-agingfirewalls.com)
To the best of our knowledge, this is the first demonstration of the antitumor effects of ABT-737 on human oral cancers. (oncotarget.com)

The treatment modalities for advanced OSCC include surgical removal of tumor followed by concomitant chemo-radiotherapy. (springernature.com)

In the current work, we screened a small library of fifty-five FDA and foreign-approved anti-neoplastic drugs in order to identify candidates that sensitized resistant prostate and pancreatic cancer cells to TRAIL-induced apoptosis. (biomedcentral.com)
Drugs demonstrating the highest synergy were selected as leads and tested in different prostate and pancreatic cancer cell lines, and one immortalized human pancreatic epithelial cell line. (biomedcentral.com)
Fourteen drugs were identified as having synergy with TRAIL, including those whose TRAIL sensitization activities were previously unknown in either prostate or pancreatic cancer cells or both. (biomedcentral.com)
The identification of a number of FDA-approved drugs as TRAIL sensitizers can expand chemotherapeutic options for combination treatments in prostate and pancreatic cancer diseases. (biomedcentral.com)

In this review of the literature on curcumin, I am looking at the anti-inflammatory effects, diabetes prevention, anti-cancer effects, with a section devoted to prostate cancer, treatment and prevention of neurodegenerative disorders, and finally, its use of psychological disorders. (blogspot.com)
Antineoplastons were first proposed as a possible cancer treatment in 1976. (cancer.gov)
Many current cancer treatment methods are expensive and not readily accessible. (who.int)

Therefore, there is substantial interest in developing chemotherapeutic drugs that directly target pro-survival Bcl-2 proteins by mimicking the BH3 domain and unleashing pro-apoptotic molecules in tumor cells. (oncotarget.com)
MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. (up.pt)

From a mechanistic perspective, the FR functions to concentrate exogenous ligands (e.g. folates and folate-drug conjugates) into the cell cytosol by endocytosis. (wikipedia.org)
In order to confirm the effect of the extract on motility of human endothelial cells, cell migration assay was conducted. (emanresearch.org)
To confirm the finding from the kinome screening, cell viability and cell death assays were performed which suggest that knocking out MINK1 (MINK1 KO) significantly resenitized chemoresistant cells to 5FU (Fig. 2A&B). (springernature.com)
FDA-approved drugs were screened for their ability to sensitize TRAIL resistant prostate cancer cells to TRAIL using an MTT assay for cell viability. (biomedcentral.com)
N- trans -Feruloyloctopamine (FO), a natural compound, was reported in our previous study to inhibit a tumor cell malignant phenotype by AKT- and EMT-related signals and might be used as a promising drug for HCC treatment. (hindawi.com)
Open data on the gene expression of the NCI-60 cell lines, provides a unique opportunity to add another dimension to the preclinical development of such drugs by interrogating correlations with gene expression patterns. (biomedcentral.com)
In this sense, the lack of technologies that would allow for molecular screening of individual stromal cell types poses a major challenge for the development of therapies targeting the tumor microenvironment. (biomedcentral.com)
Method For immunopharmacological screening campaigns, we built an artificial miniature immune system in which dendritic cells (DCs) derived from immature precursors present MHC (major histocompatibility complex) class I-restricted antigen to a T-cell hybridoma that then secretes interleukin-2 (IL-2). (bmj.com)
Sunitinib (marketed as Sutent by Pfizer, and previously known as SU11248) is an oral, small-molecule, multi-targeted receptor tyrosine kinase inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor. (ncats.io)
Role of PDL-1 in NSCLC chemoresistance was assessed using CRISPR/Cas9 knockdown and various functional assays including MTT, cell invasion, sphere formation, and cell apoptosis. (cdc.gov)
Decreased intracellular drug concentration, enhanced function of cell processing active products, enhanced repair ability of cellular DNA damage, and blockage of related apoptosis pathways play an important role in it. (eurekaselect.com)

Potential molecular mechanism supporting this synergistic effect was assessed with emphasis on determining whether the combination treatment enhanced inhibition of the anti-apoptotic signal transducers Akt and NF-kB leading to increased activation of caspase mediated apoptosis. (rgcb.res.in)
Library has been assembled using in house structural biology insight, molecular stimulation-modeling, virtual screening of ChemDiv's novel chemistries and medicinal chemistry filtering/ranking of the resulting hits. (chemdiv.com)
Guidebook on molecular modeling in drug design: Academic Press. (jscimedcentral.com)
Ooms F. Molecular modeling and computer aided drug design. (jscimedcentral.com)

In order to establish which patients will benefit most from a treatment, and by how much, the predictive value of a biomarker must be separated from its prognostic value. (ersjournals.com)
However, neither the association between Ki67 index and treatment effect nor any other clinicopathological parameter or biomarker predictive for the efficiency of taxanes has been validated so far. (justia.com)

50 years of preclinical anticancer drug screening:empirical to target-driven approaches. (jscimedcentral.com)
The contribution of synthetic organic chemistry to anticancer drug development. (jscimedcentral.com)

It is being evaluated by FDA for the treatment of metastatic melanoma with BRAF V600 mutation. (biomedcentral.com)

Since in classic chemotherapies it is observed a decrease in immune response, methotrexate (MTX) was used only to compare the PnV effects on innate immune cells with a highly immunosuppressive antineoplastic drug. (nature.com)
Previously, Kinases are known to play important role in regulating several phenotypes of carcinogenesis including growth, proliferation, angiogenesis, metastasis and evasion of antitumor immune responses [5]. (springernature.com)

SUTENT is a kinase inhibitor indicated for the treatment of: Gastrointestinal stromal tumor (GIST) after disease progression on or intolerance to imatinib mesylate. (ncats.io)

There is considerable effort dedicated to finding a way to make curcumin/turmeric more bioavailable, including lipid delivery systems, self-microemulsifying drug delivery system (SMEDDS) , nanoparticulate delivery systems. (blogspot.com)

These results suggest that MEK inhibition might represent a valid treatment option for patients with both mutated- or wild type-BRAF melanomas, affecting tumor growth through multiple targets. (biomedcentral.com)
The obstacle effect of FO can provide new targets and new credibility for the treatment of liver cancer. (hindawi.com)
However, the drug targets and the detailed mechanisms have been masked. (hindawi.com)
Billingsley ML. Druggable targets and targeted drugs: enhancing the development of new therapeutics. (jscimedcentral.com)
Progress in microenvironment genetic studies represents a formidable opportunity for the development of new selective drugs because stromal cells have lower mutation rates than malignant cells, and should prove to be good targets for therapy. (biomedcentral.com)
However, there are still limitations in the treatment and diagnosis of PAAD, and further research to explore new mechanisms and discover new potential targets is still warranted. (hindawi.com)

The harmful effects of chemicals and the side effects of chemical drugs on human health have a widely focused global attention on herbal drugs and medicinal plants. (researchgate.net)
Early detection through widely applied screening programs is the most important factor in the recent decline of colorectal cancer in developed countries (see Overview/Epidemiology ). (medscape.com)

In the future, it may become possible to produce tumor spheroids from tissue samples of oral cancer patients, and then apply them to drug screening and to develop individualized diagnostic and treatment methods. (medsci.org)

Sequential and simultaneous dosing modalities were investigated and the annexin V/propidium iodide assay, in concert with fluorescence microscopy, was employed to visualize cells undergoing apoptosis. (biomedcentral.com)
After treatment with β-iminophosphonate (E,Z)(3-Methyl-2-(pyridin2-ylimino)butyl)diphenylphosphine oxide (4e) proliferation/viability of cancer cells was strongly inhibited and in 65.61% of the cells signs of early apoptosis were observed. (japsonline.com)

Colon cancer is now often detected during screening procedures. (medscape.com)

No difference in toxicity was observed in the control or treatment groups. (researchgate.net)
PD0325901 treatment, dramatically inhibited growth of melanosphere-generated xenografts and determined impaired tumor vascularization of both mutated- and wild type-BRAF tumors, in the absence of mice toxicity. (biomedcentral.com)

The FR is an emerging therapeutic target for diagnosis and treatment of cancer and chronic inflammatory diseases. (wikipedia.org)
2011). Considerable progress has been made in terms of breast cancer diagnosis and treatment in the last years. (justia.com)
Fine-needle aspiration (FNA) or percutaneous biopsy of an adnexal mass is not routinely recommended, as it may delay diagnosis and treatment of ovarian cancer. (medscape.com)

However, despite of having all these treatment modalities, chemoresistance remains as one of the major causes of treatment failure in OSCC(4). (springernature.com)

Amongst all the marine invertebrates, sponges represent the most described group with potential application in medicinal chemistry, representing a valid starting point for new drug leads due to their chemical defense mechanisms. (microbialtec.com)
Sawa M, Masai H. Drug design with Cdc7 kinase: a potential novel cancer therapy target. (jscimedcentral.com)
Therefore, an experiment was run in the form of completely random blocks in 3 iterations to study the effects of the 1000 grain weight on the sprouting rate and seed potential of Salvia L. Ten different 1000 seed weight treatments were used in a standard sprouting test and accelerated aging test inside a germinating machine. (researchgate.net)
Conclusions These findings underscore the potential utility of this screening system for the identification of immunostimulatory drugs with anticancer effects. (bmj.com)
This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application of curcumin for the prevention and/or treatment of cancer. (blogspot.com)
We observed intracellular reactive oxygen species(ROS) level by DCFH-DA method, mitochondrial membrane potential alteration by rhodamine 123 staining and apoptotic morphological changes by acridine orang/ethidium bromine dual staining method and Hoest staining assay and comet assay. (pdfplayer.org)

Therefore, there have been recent attempts to develop effective anticancer strategies targeting apoptotic signaling pathways [ 2 ], such as through inhibiting anti-apoptotic survival factors, which are likely overexpressed in many tumors and may confer drug-resistant phenotypes [ 2 , 3 ]. (oncotarget.com)
However, outstanding questions remain: what are the treatment options for patients with tumours resistant to erlotinib/gefitinib? (ersjournals.com)

Molecules from animal venoms are promising candidates for the development of new drugs. (nature.com)
The plant can be used as promising candidate for anti-neoplasic drug development. (emanresearch.org)
Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)

RGCB scientists developed a combination treatment synergism of great effectiveness by combining Curcumin and Taxol. (rgcb.res.in)

Studies in progress are selecting the venom molecules with antitumor and immunomodulatory effects and trying to better understand their mechanisms. (nature.com)

The US Preventive Services Task Force (USPSTF) recommends against screening (with serum CA125 level or transvaginal ultrasonography) for ovarian cancer in the general population. (medscape.com)

Results The screening of three drug libraries relevant to known signaling pathways, FDA (Food and Drug Administration)-approved drugs and neuroendocrine factors yielded two major hits, astemizole and ikarugamycin. (bmj.com)

Their inclusion should not be viewed as an endorsement of the content of the websites, or of any treatment or product, by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board or the National Cancer Institute . (cancer.gov)
The current limitations with traditional treatments are reasonable well known and this stems largely from the nature if these therapies. (scientificamerican.com)
This knowledge is slowly making its way into the clinic and being employed to better stratify individual risks of developing colorectal cancer, discover better screening methodologies, allow for better prognostication, and improve the ability to predict benefit from new anticancer therapies. (medscape.com)

Despite the success of these treatments, most patients eventually progress. (biomedcentral.com)
Thus, cancer not only afflicts individuals, but it has become a social problem that burdens the public health systems which provide treatment and support to patients. (biomedcentral.com)
Patients with a strong overexpression of the HER2 protein (IHC3+) specifically benefited from the treatment, with a median overall survival of 17.9 mo. (wjgnet.com)
Our findings will benefit the prognostication and treatment of PAAD patients. (hindawi.com)

Surgery currently is the definitive treatment modality. (medscape.com)

Finally, the antitumor effect of the leaves ethanolic extract was evaluated using in vivo human tumor xenograft model. (emanresearch.org)
Hexane extract of the stem bark and ethanolic leaves extract profoundly inhibited the sprouting of microvessels (by 89.56% and 87.12% respectively) in rat aortic ring assay. (emanresearch.org)

Chemotherapeutic drugs target cancer-specific characteristics, such as alterations in DNA repair, which has complicated roles in oncogenesis and tumor progression. (biomedcentral.com)
This makes them very interesting target locations for therapeutics even though direct treatment of the necrosis itself has not been shown to aid recovery. (scientificamerican.com)

Go to Oncology Decision Point Colorectal Cancer for expert commentary on treatment decisions and related guidelines. (medscape.com)

But recently novel research looking at using certain bacteria as a therapy is gaining traction that may result in new treatment options that are cheap, easy to produce, noninvasive and if the current research is any indication capable of complete remission in some cases. (scientificamerican.com)

Anatomy18

Organisms6

Diseases39

Chemicals and Drugs113

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes45

Disciplines and Occupations2

Technology, Industry, Agriculture4

Information Science2

Health Care2

Cytotoxicity5

Chemotherapy17

Cytotoxic3

Growth inhibition2

Vitro3

Discovery13

Adjuvant2

Clinical17

Resistance13

Antioxidant1

Compounds4

Cisplatin3

Sensitivity3

Agents10

Biomarkers2

Inhibitors3

Efficacy1

EGFR2

Oxaliplatin1

Molecularly targeted1

Activity2

Cancers3

Radiotherapy1

Pancreatic cancer4

Cancer treatment3

Tumor Cells2

Cell11

Molecular4

Predictive2

Anticancer drug2

Metastatic1

Immune2

Gastrointestinal1

Lipid1

Targets6

Widely2

Methods1

Apoptosis2

Colon1

Toxicity2

Diagnosis and treatment3

Modalities1

Potential6

Resistant2

Development3

Combination1

Molecules1

Ovarian cancer1

Pathways1

Therapies3

Patients4

Surgery1

Extract2

Target2

Oncology1

Options1