• South Africa
  • Their perspective and the original article by Schaaf and colleagues from South Africa, which describes the pharmacokinetics of isoniazid based upon age and specific genotype for acetylation, suggest the future - a time when virtually every drug that we prescribe for children will be based upon age, weight, gender, and genotype. (bmj.com)
  • doses
  • The aim of the trial is to assess the safety, tolerability and immunogenicity of two doses of RUTI® vaccine administered four weeks apart after one month pre-treatment with INH. (clinicaltrials.gov)
  • regimens
  • Drugs are not used singly (except in latent TB or chemoprophylaxis), and regimens that use only single drugs result in the rapid development of resistance and treatment failure. (wikipedia.org)
  • diagnosis
  • Again, prognosis is variable and dependent upon the affected individual, treatment compliance, and degree of vision loss at diagnosis. (wikipedia.org)
  • ELISPOT testing is not useful for the diagnosis of acute TB meningitis and is often false negative, but may paradoxically become positive after treatment has started, which helps to confirm the diagnosis. (wikipedia.org)
  • people
  • The identification and treatment of people with latent TB is an important part of controlling this disease. (wikipedia.org)
  • Steroids can be used in the first six weeks of treatment, A few people may require immunomodulatory agents such as thalidomide. (wikipedia.org)
  • Asymptomatic elevation of serum liver enzyme concentrations occurs in 10% to 20% of people taking INH, and liver enzyme concentrations usually return to normal even when treatment is continued. (wikipedia.org)
  • People taking isoniazid and acetaminophen are at risk of acetaminophen toxicity. (wikipedia.org)
  • known
  • It is the mesylate (methanesulfonate) ester of isoniazid, which is also an antituberculosis drug but has comparatively been far more widely known and used. (wikipedia.org)
  • prevention
  • Prevention of TB involves screening those at high risk, early detection and treatment of cases, and vaccination with the bacillus Calmette-Guérin vaccine. (wikipedia.org)
  • liver
  • Isoniazid is thought to induce a liver enzyme which causes a larger amount of acetaminophen to be metabolized to a toxic form. (wikipedia.org)
  • test
  • Participants who were tuberculin skin test positive (ie, ≥5 mm induration) at enrolment received a substantial benefit from continued isoniazid treatment (0·26, 0·09-0·80, p=0·02), whereas participants who were tuberculin skin test-negative received no significant benefit (0·75, 0·38-1·46, p=0·40). (www.gov.uk)