• South Africa
  • Their perspective and the original article by Schaaf and colleagues from South Africa, which describes the pharmacokinetics of isoniazid based upon age and specific genotype for acetylation, suggest the future - a time when virtually every drug that we prescribe for children will be based upon age, weight, gender, and genotype. (bmj.com)
  • doses
  • The aim of the trial is to assess the safety, tolerability and immunogenicity of two doses of RUTI® vaccine administered four weeks apart after one month pre-treatment with INH. (clinicaltrials.gov)
  • hepatitis
  • Isoniazid has a boxed warning for severe and sometimes fatal hepatitis, which is age-dependent at a rate of 0.3% in people 21 to 35 years old and over 2% in those over age 50. (wikipedia.org)
  • adults
  • The reason nurse A gave for declining treatment was that most adults from the Philippines, where TB is endemic, have positive TST results and generally do not take treatment for LTBI. (cdc.gov)
  • Participants
  • Participants who were tuberculin skin test positive (ie, ≥5 mm induration) at enrolment received a substantial benefit from continued isoniazid treatment (0·26, 0·09-0·80, p=0·02), whereas participants who were tuberculin skin test-negative received no significant benefit (0·75, 0·38-1·46, p=0·40). (www.gov.uk)
  • prevention
  • Prevention of TB involves screening those at high risk, early detection and treatment of cases, and vaccination with the bacillus Calmette-Guérin vaccine. (wikipedia.org)
  • diagnosis
  • Again, prognosis is variable and dependent upon the affected individual, treatment compliance, and degree of vision loss at diagnosis. (wikipedia.org)
  • ELISPOT testing is not useful for the diagnosis of acute TB meningitis and is often false negative, but may paradoxically become positive after treatment has started, which helps to confirm the diagnosis. (wikipedia.org)
  • people
  • The identification and treatment of people with latent TB is an important part of controlling this disease. (wikipedia.org)
  • Steroids can be used in the first six weeks of treatment, A few people may require immunomodulatory agents such as thalidomide. (wikipedia.org)
  • Asymptomatic elevation of serum liver enzyme concentrations occurs in 10% to 20% of people taking INH, and liver enzyme concentrations usually return to normal even when treatment is continued. (wikipedia.org)
  • People taking isoniazid and acetaminophen are at risk of acetaminophen toxicity. (wikipedia.org)
  • patients
  • If no objective antitumor responses are observed among the first 14 patients at a given dose, no further patients are entered on that treatment arm. (clinicaltrials.gov)
  • If one or more antitumor responses are seen at a given dose, up to 45 patients may be entered on that treatment arm. (clinicaltrials.gov)
  • known
  • It is the mesylate (methanesulfonate) ester of isoniazid, which is also an antituberculosis drug but has comparatively been far more widely known and used. (wikipedia.org)
  • Drugs
  • Drugs are not used singly (except in latent TB or chemoprophylaxis), and regimens that use only single drugs result in the rapid development of resistance and treatment failure. (wikipedia.org)
  • liver
  • Isoniazid is thought to induce a liver enzyme which causes a larger amount of acetaminophen to be metabolized to a toxic form. (wikipedia.org)
  • effective
  • The findings emphasize the difficulty of conducting contact investigations in certain settings and the importance of effective LTBI testing and treatment programs for health-care workers (HCWs) to prevent TB disease and subsequent health-care--associated transmission. (cdc.gov)
  • Subjects
  • A reduction and/or clearance of the latent viral reservoir (i.e.: virus that remains dormant in HIV-infected subjects receiving suppressive treatment ) is considered essential for HIV eradication. (nih.gov)
  • 50 c/ml or b) 16 weeks of treatment, and subjects will be observed for the remaining 4 weeks (total of 20 weeks on treatment). (nih.gov)
  • levels
  • The aim of this study is to determine whether a 20-week treatment course with 1μg/kg/week of pegylated interferon alpha 2 b (peg-IFN-α2b) will reduce the levels of HIV-1 proviral DNA levels in circulating PBMC and mucosa-associated lymphoid tissue (MALT) in HIV-infected individuals receiving long-term ART. (nih.gov)
  • It is possible that isoniazid may decrease the serum levels of ketoconazole after long term treatment. (wikipedia.org)