Treat tumor microenvironment. Medical search. Frequent questions

In addition to allowing HCC cancer progression, the TIME, which can be characterized by an abundance of immunosuppressive cells including tumor-associated macrophages, neutrophils, and myeloid-derived suppressor cells (MDSCs), also limits the efficacy of immunotherapy, particularly that by immune checkpoint inhibitors. (news-medical.net)
OXFORD, England and SAN FRANCISCO , Nov. 15, 2018 /PRNewswire/ -- PsiOxus Therapeutics Limited (PsiOxus) and the Parker Institute for Cancer Immunotherapy (Parker Institute) today announced a research project to investigate the use of PsiOxus' virus-based gene therapy for treating solid tumors that have been historically resistant to immunotherapy. (biospace.com)
One of the challenges in treating solid tumors with immunotherapy is the tumor microenvironment, which is very suppressive and effectively prevents the immune system from attacking the tumor," said Fred Ramsdell , Ph.D., vice president of research at the Parker Institute. (biospace.com)
December 28, 2022 - A clinical trial led by NCI has resulted in FDA approval of the immunotherapy drug atezolizumab (Tecentriq) to treat advanced alveolar soft part sarcoma. (nih.gov)
Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity and immunosuppressive tumor microenvironments. (elifesciences.org)
Here, we report a microfluidics-based, patient-specific 'GBM-on-a-Chip' microphysiological system to dissect the heterogeneity of immunosuppressive tumor microenvironments and optimize anti-PD-1 immunotherapy for different GBM subtypes. (elifesciences.org)
Acral melanoma (AM) exhibits a high incidence in Asian patients with melanoma, and it is not well treated with immunotherapy. (elifesciences.org)
A Swedish, Belarusian, and Finnish team reporting in eBioMedicine describes an immunotherapy response-related tumor microenvironment score that takes tumor-boosting or -banishing immune features into account. (genomeweb.com)
In addition, this therapeutic platform addresses two major challenges that make solid tumors so difficult to treat with immunotherapy. (ascopost.com)
1. Park AK, Fong Y, Kim SI, et al: Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors. (ascopost.com)
Their findings offer a new way of looking at cancer immunotherapy that matches the immune environment around the tumor and points the way to personalized immunotherapies. (ucsf.edu)
Already, he's identified two major mechanisms that drive GBM resistance to immunotherapy: abnormal tumor blood vessels, which can block cancer-targeting T cells from infiltrating the tumor, and regulatory T cells, which can suppress the activity of cancer-killing T cells. (cancerresearch.org)
To address this, Ren is combining checkpoint immunotherapy with strategies aimed at normalizing tumor blood vessels and converting regulatory T cells into a more anti-tumor form. (cancerresearch.org)
Each year, hundreds of thousands of people are diagnosed with solid tumors, and many will present with metastatic disease that do not respond to existing immunotherapy agents," said Zev Wainberg, M.D., co-director of the UCLA GI Oncology Program, associate professor of medicine at UCLA and the principal investigator on PureTech's LYT-200 trial. (businesswire.com)
Immunotherapy has so far been of little use at treating highly aggressive pancreatic cancer, due to its immunosuppressive tumor microenvironment and lack of neoantigens," Dr. Gravekamp said. (pancan.org)
Although this benefit has not been seen in all patients treated with immunotherapy, one of the goals of the CCIR is to improve our understanding of the immune system, especially in the context of the tumor immune microenvironment, in order to modulate immunity to optimally enhance patient outcome. (mdanderson.org)
The immune system is involved in the progression and development of cancer and immunotherapy can be used to treat cancer. (lu.se)
Your test results will show whether you have enough PD-L1 protein in your tumor for you to benefit from a specific immunotherapy medicine. (medlineplus.gov)
Your tumor cells have enough PD-L1 for you to use immunotherapy medicine, you may be able to start that medicine. (medlineplus.gov)

Our work is product and platform based with a focus on discovering and developing gene-based immuno-oncology therapies for the treatment of solid tumors. (biospace.com)
Our 2022 achievements reaffirm our belief that using our viral immunotherapies to mobilize the patient's immune system to fight cancer represents a promising approach for the treatment of solid tumors," said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel. (tmcnet.com)
LYT-200 is a monoclonal antibody targeting a foundational immunosuppressive protein, galectin-9, for the potential treatment of solid tumors that are difficult to treat and have poor survival rates, including pancreatic ductal adenocarcinoma, colorectal cancer and cholangiocarcinoma. (businesswire.com)

The ECM a researcher chooses has a significant effect on cancer cell proliferation, initiation, invasion, and metastasis, and it alters how the tumor model responds to drug therapy. (corning.com)
Collagen is the most abundant fibrous protein found in mammals' ECMs, and it plays a critical role in tumor growth and metastasis because it promotes cell adhesion and migration. (corning.com)
Spheroids have also been used to study transcoelomic metastasis in ovarian cancer, in which primary tumor cells seep into the abdominal cavity, where they form spheroids and then travel through fluids to secondary sites. (corning.com)
Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
Dr. Pienta's research interests include the ecology of cancer, tumor microenvironment, metastasis, biomarker development and novel therapeutic development. (hopkinsmedicine.org)
We have already shown that age-related changes in the tumor microenvironment are accountable for the higher metastatic potential of melanoma in older patients," Ashani Weeraatna, Ph.D., Ira Brind professor, program leader of the Tumor Microenvironment and Metastasis Program at Wistar and lead author of the study, said in a press release. (upi.com)
Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of tumor growth and metastasis. (biomedcentral.com)
The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. (biomedcentral.com)
These tumors and accessories represent the hallmark characteristics that support tumor progression and lead to metastasis. (biomedcentral.com)
The ratio of pro- to antitumor immune populations in the TIME plays a critical role in the regulation of tumor progression and metastasis. (biomedcentral.com)
The crosstalk between pro-tumorigenic immune cells, stromal cells, and cytokines helps to establish the pre-metastatic niche for disseminated circulatory tumor cells and facilitates metastasis. (biomedcentral.com)
The processes of tumor initiation, expansion, and metastasis are governed by the TIME, where immunosuppressive and antitumor immune crosstalk play an important role. (biomedcentral.com)
During metastasis, tumor-derived exosomes help in the requirement and arrangement of immunosuppressive immune cells for favorable premetastatic niche formation and growth of metastases. (biomedcentral.com)
Immunology, tumour microenvironment & metastasis - is a technical and knowledge-based forum for cancer researchers at Lund University with specific interest in immunology, tumour microenvironment & metastasis. (lu.se)
Metastasis is a complex prosess in which cancer cells leave the original tumour site and migrate to other parts of the body and establish a secondary tumour. (lu.se)

Furthermore, the Food & Drug Administration (FDA)-approved mIDH1 inhibitor ivosidenib (AG-120) dramatically inhibited tumor growth in preclinical models of pancreatic cancer, highlighting this approach as a potential therapeutic strategy against wild-type IDH1 cancers. (nature.com)
The overexpression and knockdown of PUM2 promoted and inhibited tumor growth of xenograft mice, respectively. (dovepress.com)
Using a murine model of bone metastatic mammary carcinoma, we demonstrate that systemic delivery of polymer nanoparticle s loaded with cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) inhibited tumor growth and bone destruction after 7 days of treatment. (cdc.gov)

Researchers then can recreate events within platelets circulating in the blood as they approach the tumor and make it more potent and metastatic. (crohnscolitisprofessional.org)
MCTS can mimic metastatic microtumors, which form when cancer cells spread from the site of the primary tumor via intravasation into the blood circulation and via extravasation into the parenchyma of an organ. (corning.com)
Dr. Pienta is currently actively developing clinical trials and treating patients with newly diagnosed high risk and metastatic prostate cancer. (hopkinsmedicine.org)
Our research focus is to understand molecular mechanisms underpinning tumor and tumor microenvironment interaction, metastatic progression, and treatment resistance. (ohsu.edu)
Overall, these studies demonstrate that STING pathway activation, here enabled using a nanomedicine approach to enhance CDN delivery to bone metastatic sites, can reprogram the immune contexture of the bone marrow to an antitumor phenotype that inhibits bone colonization of metastatic breast cancer cells and protects from tumor-mediated bone destruction. (cdc.gov)
Packaging a STING agonist into a nanoparticle that enables systemic administration and drug accumulation at tumor sites overcomes both barriers to stymie metastatic breast cancer growth. (cdc.gov)
We have read with great interest the article "Prognostic Value of Bone Marrow Metabolism on Pretreatment 18 F-FDG PET/CT in Patients with Metastatic Melanoma Treated with anti-PD-1 Therapy" from Nakamoto et al. (snmjournals.org)
To this end, the authors studied a population of 92 patients with a diagnosis of metastatic melanoma treated with immune checkpoint inhibitors (ICIs) ( 1 ). (snmjournals.org)
Because there is a cross talk between the tumor immune environment and BM, our team evaluated the association between bone marrow glucose metabolism and transcriptomics in patients with a diagnosis of metastatic cutaneous melanoma treated with ICIs ( 4 ). (snmjournals.org)
PureTech today announced the initiation of a Phase 1 clinical trial of LYT-200 for the potential treatment of metastatic solid tumors. (businesswire.com)
BOSTON--( BUSINESS WIRE )-- PureTech Health plc (LSE: PRTC, Nasdaq: PRTC) ("PureTech" or the "Company"), a clinical-stage biotherapeutics company dedicated to discovering, developing and commercializing highly differentiated medicines for devastating diseases, today announced the initiation of its Phase 1 clinical trial of LYT-200 for the potential treatment of metastatic solid tumors that are difficult to treat and have poor survival rates. (businesswire.com)
Other clinical trials have shown better survival and tumour response with gemcitabine and capecitabine than with gemcitabine alone in advanced or metastatic pancreatic cancer. (lu.se)

Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. (wikipedia.org)
The chaotic karyotype of this rare tumor has precluded the identification of prognostic biomarkers and patient stratification. (nih.gov)
In this study, BostonGene will apply its genomics pipeline to reveal key tumor drivers, including immune microenvironment properties and genomic biomarkers of response to diverse therapies. (businesswire.com)
BostonGene's tests reveal key drivers of each tumor, including immune microenvironment properties, actionable mutations, biomarkers of response to diverse therapies, and recommended therapies. (businesswire.com)

Also, ovarian tumors can quickly spread inside the body, making time another vital factor in mapping the disease's progression. (crohnscolitisprofessional.org)
Cancer scientists are creating increasingly complex tumor models that more accurately replicate in vivo conditions - including the tumor microenvironment, which plays a key role in tumor progression, according to a study published in BioTechniques . (corning.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
Importantly, immune constituents of the tumor microenvironment (TME) can influence therapy response and cancer progression. (mdpi.com)
For decades, tumor hypoxia is known to be associated with solid tumor progression, treatment resistance, and patient mortality. (ohsu.edu)
The data demonstrated evidence of local and systemic anti-tumor activity in patients with inadequate response to previous immune checkpoint inhibitor (ICI) treatment and showed a disease control rate of 77 percent (20/26) in patients entering the trial with disease progression despite ICI treatment. (tmcnet.com)
During tumor development and progression, CTSB has two opposing effects. (jcancer.org)
Patients were treated with toripalimab until disease progression or unacceptable toxicity. (medscape.com)
The recommended dose as a single agent for previously treated nasopharyngeal carcinoma is 3 mg/kg every 2 weeks until disease progression or unacceptable toxicity. (medscape.com)

Researchers have carried out clinical trials to test a mutation-specific vaccine against malignant brain tumors. (neurosciencenews.com)
Overall, immune checkpoint inhibitor therapy has demonstrated its unique ability to treat highly malignant and devastating forms of cancer that were previously untreatable. (news-medical.net)
Tumors of the biliary tract are uncommon but potentially serious problems, with a spectrum of of severity that ranges from benign tumors such as adenomas to malignant lesions such as adenocarcinomas. (medscape.com)
Benign adenomas or papillomas are exceedingly rare in comparison with malignant tumors. (medscape.com)
Even benign tumors tend to recur after excision and have been reported to undergo malignant change. (medscape.com)

Functional characterization associated G1 tumors with innate immunity and G2 tumors with angiogenic, osteoclastic, and adipogenic activities as well as PPARγ pathway upregulation. (nih.gov)
Early findings about the mouse granulomas also suggest restricted immunity in these structures, possibly similar to the tumor microenvironment. (seattlechildrens.org)
Each dose of STING-activating nanoparticle s trafficked to the bone marrow compartment and was retained within the tumor microenvironment for over 24 hours, enhancing antitumor immunity through proinflammatory cytokine production and early T-cell activation. (cdc.gov)

The findings may help in the development of therapies to treat glioma brain tumors. (neurosciencenews.com)
The tumor cells then express the encoded genes, producing biologic therapies to alter the tumor microenvironment. (biospace.com)
Current targeted therapies to treat melanoma have benefited overall survival rates more than chemotherapy but are limited by acquired resistance. (upi.com)
Throughout the year, we presented encouraging data, expanded our leadership team, and announced a partnership with the University of Pennsylvania, leveraging Candel's enLIGHTEN™ Discovery Platform to create novel viral immunotherapies to enhance CAR-T cell therapies in solid tumors. (tmcnet.com)
In October 2022, Candel entered into a collaboration with the University of Pennsylvania (UPenn) Center for Cellular Immunotherapies to use Candel's enLIGHTEN™ Discovery Platform to potentially strengthen the effects of UPenn's investigational CAR-T cell therapies in solid tumor models. (tmcnet.com)
Solid tumors are often "immunologically cold," meaning they are not typically responsive to therapies that use the body's own immune system to fight cancer, Dr. Park explained. (ascopost.com)
Compared with general treatments, nanomedicines greatly increase the efficiency of therapy (e.g., the increased loading compacity, prolonged circulation of drug and combined therapies, etc.) and limit side effects (e.g., encapsulated anti-cancer drugs and specific tumor targeting, etc. (frontiersin.org)
Targeting tumor cells or the tumor microenvironment (TME) are the two major fundamental principles for antitumor therapies. (biomedcentral.com)
Our work implicates that complement system may be a therapeutic target for developing therapies to prevent or treat cognitive disorders related to neuroinflammation or other disease conditions including neurodegenerative disease per se. (imperial.ac.uk)
The tumour microenvironment plays a fundamental role during tumorigenesis and holds great opportunities in future cancer therapies. (lu.se)
Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)

Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
The real-time analysis in GBM-on-a-Chip showed that mesenchymal GBM niche attracted low number of allogeneic CD154+CD8+ T-cells but abundant CD163+ tumor-associated macrophages (TAMs), and expressed elevated PD-1/PD-L1 immune checkpoints and TGF-β1, IL-10, and CSF-1 cytokines compared to proneural GBM. (elifesciences.org)
Starting with colorectal cancer, the researchers relied on multiplex immunohistochemistry to profile immune cells spanning 15 classes, coming up with a tumor microenvironment "signature of immune activation" (SIA) that took anti-tumor CD8-positive lymphocyte and tumor-associated macrophages into account. (genomeweb.com)
To their surprise, the tumors contained a wide range of immune cells, such as macrophages, NK and B cells - beyond the T cells which are the focus of current immunotherapies. (ucsf.edu)
For now, preclinical studies showed that tumor growth in melanoma seems to play a critical role in reprogramming the host immune system by regulating hematopoiesis, which might be associated with the expansion of immunosuppressive cells such as tumor-associated macrophages, regulatory T cells, and myeloid-derived suppressor cells (MDSCs) ( 7 ). (snmjournals.org)

A study published in Anticancer Research on head and neck cancers charted the development of a method for generating MCTS from tumor biopsies, the first step toward creating a method of assessing individual susceptibility to chemotherapy drugs and radiation therapy. (corning.com)
Despite the impressive clinical efficacy that has been demonstrated by certain checkpoint inhibitors in the treatment of various cancers, several research studies have found that the immunosuppressive tumor immune microenvironment (TIME) is responsible for preventing many patients from experiencing such benefits. (news-medical.net)
They did this successfully in triple-negative breast cancer lines, as well as in pancreatic, prostate, ovarian, and head and neck cancers, as well as brain tumor cells. (ascopost.com)
It has held great promise since it was first developed as a biological therapy used to treat a variety of cancers. (ucsf.edu)
If successful in preclinical models of GBM, this approach could directly inform the design of clinical trials testing these novel combinations to achieve durable responses in human patients, both those with glioblastoma and potentially other hard-to-treat cancers. (cancerresearch.org)
LYT-200 is a clinical stage, fully human, monoclonal antibody (mAb), that is designed to target galectin-9, an immunosuppressive protein that simultaneously activates multiple immunosuppressive pathways in the tumor microenvironment and is prominently expressed in multiple difficult-to-treat cancers, including breast cancer, pancreatic and cholangiocarcinoma. (businesswire.com)
Tumors of the bile duct constitute about 2% of all cancers found at autopsy. (medscape.com)
BRCA1/2 mutation carriers treated with BCT have a high risk of LR, many of which are new primary breast cancers. (lu.se)

Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)
Unsupervised classification of the independent components stratified this cohort into favorable (G1) and unfavorable (G2) prognostic tumors in terms of overall survival. (nih.gov)
5 To date, platinum-based chemotherapy is the most effective therapy to treat advanced NSCLC patients, 6 with a significantly higher survival and response rate. (dovepress.com)
11 Chemoresistance, either acquired or intrinsic, is associated with a complicated and multifactorial process, including decreases of intracellular drugs, changes of drug targets, aberrant regulation of cell survival or death, and crosstalks between tumor microenvironment and cancer cells. (dovepress.com)
After assessing the signature in more detail with available single-cell and bulk RNA sequences from colorectal cancer, lung cancer, renal cell carcinoma, immune checkpoint-treated melanoma, uveal melanoma, or cancer-free tissues, they considered ties to survival across several cancer types, both for SIA and an RNA-based version of the score. (genomeweb.com)
In a study involving mice with pancreatic cancer, those treated with SIWA318H saw a significant reduction in tumor growth, increased survival, and an increased rate of complete remission compared to mice treated with a control antibody. (tgen.org)
Tumor-infiltrating immune cells are an important component of the TIME and are a significant predictor of cancer patients' survival. (biomedcentral.com)
The primary endpoint was overall survival, measured as the time from randomisation until death from any cause, and assessed in the intention-to-treat population. (lu.se)
Adjuvant transarterial thromboembolization (TACE) has shown to increase overall survival in patient with microvascular invasion-HCC with tumor size ≥ 5 cm or multinodular tumors. (medscape.com)

More specifically, data from our CAN-2409 clinical trial demonstrated robust evidence of local and systemic anti-tumor activity in patients with non-small cell lung cancer who had an inadequate response to immune checkpoint inhibitors. (tmcnet.com)

Astellas Pharma and Mitsui Fudosan have announced that Astellas plans to establish a tumour microenvironment (TME) open innovation hub, intended to open in October 2023. (pharmafocus.com)
July 27, 2023 - Trial results show that engineered T cells can effectively target mesothelin, a protein found on many solid tumors. (nih.gov)
June 27, 2023 - The investigational drug vorasidenib substantially slowed the growth of tumors in people with low-grade gliomas that had mutations in the IDH1 or IDH2 genes. (nih.gov)
January 19, 2023 - When breast cancer metastasizes to the brain, new tumors usually develop even after treatment. (nih.gov)

A new AI model can accurately classify a brain tumor of one of six common cancer types from a single MRI brain scan image. (neurosciencenews.com)
The study reveals immune cells within these structures can be activated to attack the brain tumor. (neurosciencenews.com)

Thus, the best available treatments against PDAC (that is, chemotherapy) are less effective under tumor-associated conditions. (nature.com)
Jain said the OTME-Chip has several applications, both in observing how cancer cells interact differently with vascular and blood cells and testing novel ways to treat the disease that may complement chemotherapy and radiotherapy of tumors. (crohnscolitisprofessional.org)
Understanding the mechanism underlying the role of tumor stroma, especially cancer-associated fibroblasts (CAFs), during chemoresistance would significantly contribute to the clinical application of chemotherapy agents. (dovepress.com)
With the support of various diagnosis technologies including positron emission tomography (PET), magnetic resonance imaging (MRI), and computed tomography (CT), surgery, radiotherapy, chemotherapy, and hormone therapy are generally applied to treat patients with cancer, including those three deadliest carcinomas. (frontiersin.org)
Following the topline results, which are expected in the fourth quarter of 2021, PureTech intends to initiate the Phase 2 expansion cohort portion of the trial, which will further assess the recommended Phase 2 dose as a single agent or in combination with chemotherapy and anti-PD-1 therapy in multiple solid tumor types, including pancreatic cancer and cholangiocarcinoma. (businesswire.com)
When combined with low doses of gemcitabine chemotherapy, which further decreases immune suppression, advanced pancreatic cancer tumor burden and metastases were significantly reduced through this investigational treatment combination in mice," Dr. Gravekamp said. (pancan.org)

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. (nature.com)
This multimodal OTME-Chip is going to provide an ideal platform to the health care researchers to evaluate their anti-cancer, vascular and hematological drugs individually or in combination in an artificially created human-level tumor microenvironment," Jain said. (crohnscolitisprofessional.org)
3D cell culture methods - and multicellular tumor spheroids (MCTS), in particular - are quickly becoming a valuable tool for studying the tumor microenvironment in cancer research . (corning.com)
Personalized cancer therapy is emerging as a critical strategy for treating tumors. (corning.com)
Taming vessels to treat cancer. (wikipedia.org)
Might particular monoamine oxidase inhibitors, currently used primarily to treat depression, have anti-cancer activity too? (sciencedaily.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
New artificial intelligence technology is able to screen for genetic mutations in brain cancer tumors in less than 90 seconds. (neurosciencenews.com)
Researchers found lymph-node-like structures close to glioma brain tumors in cancer patients. (neurosciencenews.com)
The vaccine has been found to be safe and effective in triggering the desired immune response in the brain cancer tumors. (neurosciencenews.com)
The rapid advancement and widespread use of immune checkpoint inhibitors for cancer therapy purposes have revolutionized the way in which the disease is treated. (news-medical.net)
Immune checkpoint inhibition is an effective anti-cancer therapeutic approach but has shown limited efficacy in treating colorectal cancer (CRC) patients. (mdpi.com)
In effect, the T-SIGn viruses work by turning tumor cells into "drug factories" to express gene therapy products, such as cytokines or antibodies, designed to engage the immune system to attack cancer cells. (biospace.com)
Changing the tumor microenvironment is believed to enhance the activation of cancer-fighting immune cells so they can eradicate the tumor. (biospace.com)
The result is a revolutionary way to deliver biological anti-cancer therapeutics that act locally within the tumor microenvironment for the treatment of cancer. (biospace.com)
The Beer and Qian lab is developing precise and personalized approaches to prevent and treat advanced prostate cancer. (ohsu.edu)
Hypoxia is a pathological hallmark of cancer microenvironment. (ohsu.edu)
He received a B.S. in Biochemistry from Alma College, Ph.D. in Toxicology from Johns Hopkins University, and postdoctoral training in tumor angiogenesis, hypoxia, epigenetics, and experimental therapeutics from Johns Hopkins Kimmel Cancer Center. (ohsu.edu)
Dr. Qian is a strong believer of the mechanism-based cancer treatment approach, in particularly through understanding the molecular genetics and biology of tumor hypoxia. (ohsu.edu)
She was an early advocate for repurposing drugs to treat cancer, and her famous paper "Hiding in Plain View" was a game changer for some of us. (naturalmedicinejournal.com)
Cancer-associated fibroblasts (CAFs) have been demonstrated to be essential stromal components in the tumor microenvironment, regulating cancer cell growth, migration, invasion, and chemo-response through various mechanisms. (dovepress.com)
These results suggest that compounds developed for cancer immunotherapies could potentially treat TB. (seattlechildrens.org)
By reshaping the tumor microenvironment, our goal is to improve the efficacy of cancer treatments and potentially lead to better patient outcomes. (tgen.org)
At the AACR Special Conference: Aging and Cancer (2022), SIWA and the Translational Genomics Research Institute, which did sponsored research for SIWA, presented " SIWA318H, a novel advanced glycation end product (AGE) specific antibody, targets cancer and senescent cells in the tumor microenvironment and exhibits potent antitumor activity in a humanized mouse model for pancreatic cancer . (tgen.org)
When a CAR T cell attempts to enter the tumor, survive, and kill cancer cells, it can't effectively because of this barrier. (ascopost.com)
Using data from over 300 patient tumors, UC San Francisco researchers have described 12 classes of "immune archetypes" to classify cancer tumors. (ucsf.edu)
Their research indicates that the immune archetype of a tumor is not necessarily tied to a type of cancer. (ucsf.edu)
Dr. Ravid Straussman of the Weizmann Institute of Science found that bacteria living inside cancer cells are likely to have a profound effect on how different types of tumors behave. (washingtonjewishweek.com)
While bacteria were first detected in human tumors more than 100 years ago, Straussman reported in a paper in the May 29 issue of Science that he found bacteria live inside the cells of many cancer types, and that each type of cancer houses unique populations of bacteria. (washingtonjewishweek.com)
In Straussman's most recent project , he and his team took tumor samples from 1,526 patients with seven cancer types - breast, lung, ovarian, pancreatic, melanoma, bone and brain - and found different assortments of bacteria that correlated with specific tumor types. (washingtonjewishweek.com)
Interestingly, he discovered that about 70% of breast cancer patients have bacteria in their tumors. (washingtonjewishweek.com)
Tumors are complex ecosystems that are known to contain immune cells, stromal cells, blood vessels, nerves and many more components in addition to cancer cells. (washingtonjewishweek.com)
We hope that by finding out how exactly they fit into the general tumor ecology, we can figure out novel ways of treating cancer. (washingtonjewishweek.com)
In a recent review published in JNM , tumor and bone marrow glucose metabolism were analyzed in 12 studies including 2,588 cancer patients who underwent both 18 F-FDG PET/CT scans and biochemical assessments with blood samples ( 6 ). (snmjournals.org)
In patients with gynecologic cancer, high BM glucose metabolism was mainly due to the production of granulocyte colony-stimulating factor (G-CSF) by tumor cells ( 8 ). (snmjournals.org)
CAR-expression on T or NK cells allows them to specifically target cancer cells via recognition of tumor associated antigens. (nature.com)
Join us and the world's leading scientists in the pursuit of life saving immunotherapies that will forever change how we treat cancer, from the inside out. (cancerresearch.org)
Therefore, understanding the TME and its immune cell components are equally important as cancer cell characteristics for tumor eradication. (biomedcentral.com)
During the tumor initiation stage, cancer cells escape from immune surveillance. (biomedcentral.com)
The unique mechanism of LYT-200 holds potential across a number of solid tumor types and may enable LYT-200 to be used as a single agent, as well as in combination with checkpoint inhibitors and other anti-cancer treatments. (businesswire.com)
Conventional HER2-targeted antibodies, such as trastuzumab and pertuzumab, fall short in treating patients with HER2-low breast cancer. (businesswire.com)
As evidence of the success of this strategy, a recent analysis showed that for every $1 PanCAN invested in research grants from 2003 to 2019, our grantees went on to receive an incredible $11.50 in subsequent funding to pursue projects focused on improving our understanding of pancreatic cancer and how to detect and treat it. (pancan.org)
Claudia Gravekamp, PhD , is taking an unconventional approach to one of the biggest challenges in treating patients with pancreatic cancer. (pancan.org)
But neoantigens are scarce in pancreatic cancer cells, and the tumor and its surrounding environment fight to keep the immune system out. (pancan.org)
Nanomedicine has thus been suggested to be the " magic bullet"-both effective and safe-to treat pancreatic cancer . (bvsalud.org)
However, the densely fibrotic tumor microenvironment of pancreatic cancer impedes nanomedicine delivery. (bvsalud.org)
The tumour microenvironment is composed of both cellular components including cancer cells, immune cells, endothelial cells, fibroblasts, and many more cell types, as well as acellular components of the tissue including extracellular matrix components, metabolites, oxygen, acidity, and nutrition's among others. (lu.se)
The main problem with successfully treating cancer lies in the heterogeneity of the malignancy, and tools that may capture that heterogeneity and provide evidence for variations in tumor-related signaling pathways and/or interaction with surrounding immune microenvironment is a holy grail. (lu.se)
High risk of in-breast tumor recurrence after BRCA1/2-associated breast cancer. (lu.se)
A PD-L1 test uses a sample of cancerous tumor tissue to measure how much of a protein called PD-L1 is found on the cancer cells. (medlineplus.gov)
PD-L1 testing is used to look for the PD-L1 protein on cancer cells in a sample of tumor tissue. (medlineplus.gov)
The type of biopsy you have depends on the type of cancer you have and where the tumor is located. (medlineplus.gov)
Drug-gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition. (cdc.gov)
The personalized cancer network explorer (PeCaX) as a visual analytics tool to support molecular tumor boards. (cdc.gov)
It is a special treat today to have Dr Brian Druker from Oregon Health & Science University (OHSU) with us to talk about what he has been doing in the field of cancer, both the science and the treatment of cancer. (medscape.com)
Could we treat cancer more intelligently by understanding what is driving the growth? (medscape.com)

MES GBM accounts for 30-50% of primary tumors and is associated with particularly poor response to therapy, while PN GBM is associated with a somewhat better prognosis. (elifesciences.org)
Patients with intrahepatic cholangiocarcinoma (cholangiocellular carcinoma) have a poor prognosis, and the tumor metastasizes early. (medscape.com)

These findings indicate that the osteosarcoma microenvironment composition is a major feature to identify hard-to-treat patient tumors at diagnosis and define the biological pathways and potential actionable targets associated with these tumors. (nih.gov)
Of note, this was a pilot study and the major molecular pathways determining the cross talk between the BM and tumor immune environment remain to be elucidated. (snmjournals.org)

In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
These observations stimulated an intensive search for the mechanisms regulating tumor angiogenesis. (hindawi.com)
Different tumor types can also design their specific microenvironment by encouraging tumor angiogenesis and stimulating peripheral immune tolerance. (biomedcentral.com)

Cholangiocarcinomas , the most important primary tumors of the bile ducts, may involve either the intrahepatic or the extrahepatic biliary ducts. (medscape.com)

We are creating a platform technology using the organ-on-a-chip approach where tumor biology can be advanced, and new drugs can be identified by recreating the platelet-tumor and platelet-tumor-drug interactions under the influence of flow, supporting blood vessels and the extracellular matrix," Jain said. (crohnscolitisprofessional.org)
MCTS mimic many of the features that tumors exhibit in the human body, including extracellular matrix (ECM) deposition between cells, gradients in nutrient concentration, and strong cell-cell junctions. (corning.com)

This marker-defined signature had a strong prognostic impact in at least five main solid tumor types and a response predictive relevance in three tested tumor types. (genomeweb.com)

The enhanced permeability and retention (EPR) effect theory posits that nanomedicines ( therapeutics in the size range of approximately 10-200 nm) selectively accumulate in tumors . (bvsalud.org)

Study finds an anti-diabetic drug activates an anti-aging gene, and has potential to treat melanoma in older people. (upi.com)
Their latest study found that by treating mice with a drug to promote Klotho expression, Wnt5A levels are lowered and growth of therapy-resistant melanoma is decreased in older mice -- but not young mice. (upi.com)
Researchers recreated the interactions of melanoma cells with a young or aged tumor microenvironment and found an association between Klotho, Wnt5A, melanoma cells and the tumor microenvironment. (upi.com)
In this population, the authors confirmed that noninvasive measurement of glucose metabolism on nontumoral bone marrow can be used to predict OS in patients with a diagnosis of advanced melanoma treated with ICIs ( 4 ). (snmjournals.org)

A new study shows that an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells is also a target for certain monoamine oxidase inhibitors used to treat depression. (sciencedaily.com)
Inhibitors of these enzymes have long been used to treat depression, certain other psychiatric and emotional disorders, and Parkinson's disease. (sciencedaily.com)
Now, in a study published online today in the June 26 issue of Chemistry & Biology, Shiekhattar and his team show that the enzyme is itself a target for certain monoamine oxidase inhibitors used to treat depression. (sciencedaily.com)

Spheroids are an important part of this strategy, as they can be grown from cells harvested from tumor biopsies. (corning.com)
RNA sequencing (RNA-seq) of 79 osteosarcoma diagnostic biopsies identified stable independent components that recapitulate the tumor and microenvironment cell composition. (nih.gov)
The UCSF researchers, led by first co-authors Alexis Combes , PhD, and Bushra Samad, MS, and senior author, Max Krummel , PhD, obtained tumor specimens from 78 UCSF clinicians, and surveyed 364 tumors biopsies from patients and categorized them into groups based on their immune microenvironment. (ucsf.edu)

These include uncovering the barriers to the delivery and efficacy of molecular and nano-medicines in tumors, developing new strategies to overcome these barriers, and then translating these strategies from bench to bedside. (wikipedia.org)
Molecular GBM subgroups are associated with distinct histological patterns, suggesting that tumor microenvironmental features reflect the specific underlying molecular genetic abnormalities. (elifesciences.org)
People think of tumors as a mass of cells that grows uncontrollably," Straussman said in a recent interview at his 15-person laboratory at Weizmann's Department of Molecular Cell Biology. (washingtonjewishweek.com)

In response to treatment, high-grade gliomas remodel the surrounding brain environment, creating interactions with nearby neurons and immune cells in ways that protect tumor cells and protect them from the body's natural defense. (neurosciencenews.com)
The researchers characterized different microenvironments in the tumors, looking at which immune cells were present and which genes were expressed. (ucsf.edu)
The addition of separate adapter molecules (AMs) specific for tumor antigens and CAR-immune cells targeting these AMs allows a more precise and temporally limited therapy. (nature.com)

He is also interested in developing immunotherapies or adjuvant immunotherapies for treating TB infections. (seattlechildrens.org)

Rakesh K. Jain (born 1950) is the Andrew Werk Cook Professor of Tumor Biology at Massachusetts General Hospital in the Harvard Medical School and director of the E.L. Steele Laboratories for Tumor Biology at the Massachusetts General Hospital. (wikipedia.org)
He was elected a member of the National Academy of Engineering in 2004 for the integration of bioengineering with tumor biology and imaging gene expression and functions in vivo for drug delivery in tumors. (wikipedia.org)
In 1991, Jain became the Andrew Werk Cook Professor of Radiation Oncology (Tumor Biology) at Harvard Medical School, and Director of Edwin L. Steele Laboratories of Tumor Biology at Massachusetts General Hospital. (wikipedia.org)
Jain is regarded as a pioneer in the area of tumor microenvironment and widely recognized for his seminal discoveries in tumor biology, drug delivery, in vivo imaging, bioengineering, and bench-to-bedside translation. (wikipedia.org)
This work will help clinicians find the right biology to target and avoid targeting cells that aren't present in the tumor. (ucsf.edu)

Clinical trials are also ongoing with the unarmed enadenotucirev virus in different tumor types and in combination trials with a checkpoint inhibitor and with a chemotherapeutic. (biospace.com)
In preclinical research that could lead to a clinical trial for patients with intractable solid tumors, City of Hope scientists genetically engineered an oncolytic virus to enter tumor cells and force their expression of CD19 protein on their cell surface. (ascopost.com)
The classification scheme not only identifies which tumors are likely to be vulnerable to current immunotherapies, it also helps identify which patients might be most responsive in which clinical trial. (ucsf.edu)

Jain's device -- the ovarian tumor microenvironment-chip (OTME-Chip) -- focuses on platelets, tiny blood cells that help the body form clots to stop bleeding. (crohnscolitisprofessional.org)
Tumors generally form deep inside a patient's tissue, and it can be difficult to obtain real-time information of the tumor's properties and how it is interacting with blood cells. (crohnscolitisprofessional.org)
The study's results confirmed previous findings that a treatment protocol of cisplatin and radiation was superior to radiation alone and confirmed the feasibility of using primary tumor cells for spheroid formation, which could yield MCTS that more closely mimic in vivo tumor behavior. (corning.com)
In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
We found that the levels of B cells, T cells, and NK cells were similar, IC-expressing CD4 + and CD4 + CD8 + double positive T cells were higher, while CD8 + T cells and CD4 − CD8 − double negative T cells were significantly lower in CRC tumors. (mdpi.com)
The viruses first selectively infect and replicate only in tumor cells. (biospace.com)
While delivered systemically, PsiOxus' T-SIGn gene therapy products act locally within the tumor micro-environment, replicating only in tumor cells. (biospace.com)
In effect, the T-SIGn viruses turn the tumor cells into "drug factories" to express combination gene therapy. (biospace.com)
SIWA318H's ability to selectively target senescent cells represents a new approach to treating the disease. (tgen.org)
Senescent cells within the tumor microenvironment have been identified as major contributors to tumor development, growth and therapy resistance. (tgen.org)
SIWA318H, an antibody specifically designed to target AGEs, offers a novel approach to eliminate these senescent cells and reshape the tumor microenvironment. (tgen.org)
Significance: Bone metastases are difficult to treat due to the inaccessibility of the bone marrow compartment and the immunosuppressive microenvironment that protects resident stem cells. (cdc.gov)
Scientists were then able to use CD19-directed CAR T cells to recognize and attack these solid tumors. (ascopost.com)
This new research may expand the use of CD19 CAR T cells for the treatment of patients with potentially any solid tumor. (ascopost.com)
There are limited, established solid tumor targets that T cells can be redirected against with CARs," Dr. Priceman added. (ascopost.com)
Researchers first created an oncolytic virus (OV19t) in Dr. Fong's lab to get into tumor cells and start producing truncated CD19 (CD19t). (ascopost.com)
When we infected tumor cells with the virus, we observed the first signal that this may work. (ascopost.com)
CD19t was being expressed by tumor cells much sooner than the virus was able to kill them, giving us a window of opportunity to be targeted by CD19 CAR T cells," said Anthony Park, PhD , the study's lead author and a postdoctoral fellow in Dr. Priceman's lab. (ascopost.com)
Tumors are more than just out-of-control cells. (ucsf.edu)
We may have been targeting cells that weren't even in the tumor. (ucsf.edu)
However, most strategies fail to detect and eliminate the cancerous cells efficiently, which could lead to tumor occurrence and threat to the patient's life. (frontiersin.org)
The unique finding of Straussman's paper is that the collections of bacteria within tumor cells vary from tumor type to tumor type," Israel said. (washingtonjewishweek.com)
They must be providing some sort of advantage to the tumor cells, or doing something that contributes to the tumor's behavior. (washingtonjewishweek.com)
The oncogenic communication with tumor cells and through the crosstalk of autocrine and paracrine components in almost all tumor types are responsible for this phenomenon. (biomedcentral.com)
The stromal component interacts with tumor cells in complex crosstalk to support tumor growth. (biomedcentral.com)
The Gravekamp lab has solicited the help of Listeria monocytogenes to deliver highly immunogenic tetanus toxoid proteins, as a neoantigen surrogate, into tumor cells," Dr. Gravekamp said. (pancan.org)
The studies in this thesis focused on the immediate and late effects of ionizing radiation on neural stem cells and their microenvironment. (gu.se)

While tumor expansion, contact-dependent or independent crosstalk between tumor and TIME affects the production of various cytokines that help in the polarization of antitumor immune response in the immunosuppressive TIME. (biomedcentral.com)

In addition, the BostonGene-developed unique and robust machine learning algorithm named Kassandra will digitally reconstruct the tissue tumor microenvironment and cellular composition to identify distinct cell populations. (businesswire.com)

The tumour microenvironment (TME) is defined as the environments supporting the heterogeneous tumours. (lu.se)

Implanted into a patient's tumor during surgery and removed afterward, the device offers real-time insights on drug effects on the tumor microenvironment. (neurosciencenews.com)

Hydrogel-based ECMs offer a variety of properties that allow researchers to scaffold MCTS and improve their similarity to in vivo tumors. (corning.com)
Analyzing networks within the brain can help researchers determine the risks for aphasia when deciding to operate to remove brain tumors. (neurosciencenews.com)
Infiltrating gliomas are shaped by their genetic evolution and microenvironment, researchers report. (neurosciencenews.com)

Failure to treat bone metastases is thought to be due to therapy-resistant features of the bone marrow microenvironment. (cdc.gov)

For the first time, we identified a crucial interaction between platelets and the tumor via their surface proteins," Jain said. (crohnscolitisprofessional.org)

Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. (wikipedia.org)

Thereby, several antigens can be targeted at once and the therapy can be adapted in case antigen-loss tumor variants appear. (nature.com)

In a press release , Coherus CEO Denny Lanfear said that the company is "particularly excited to now turn our attention to developing Loqtorzi across multiple tumor types in combination with [immuno-oncology] agents that target the tumor microenvironment," including other agents the company is developing. (medscape.com)

Wang J, Zheng M, Yang X, Zhou X, Zhang S. The Role of Cathepsin B in Pathophysiologies of Non-tumor and Tumor tissues: A Systematic Review. (jcancer.org)
To this end, we assessed the tumor immune microenvironment using transcriptomics analysis on tumor tissues. (snmjournals.org)

We conclude that targeting the activity or expression of CTSB may be important for treating tumor and non-tumor diseases. (jcancer.org)

T-SIGn gene therapy products are "armed" through the addition of genes that cause the tumor to express combinations of biologics including antibodies, cytokines, immunomodulatory proteins, or nucleotides (RNA). (biospace.com)

The combination of rosiglitazone and targeted therapy reduced tumor growth in both young and aged models. (upi.com)
Importantly, CAN-2409 demonstrated a favorable change in the trajectory of tumor growth in all patients for whom pre-enrollment scans were available. (tmcnet.com)

Once it eradicated tumors, following the initial combination treatment, the mice were shielded against tumor recurrences. (ascopost.com)

Anatomy38

Organisms9

Diseases54

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes47

Disciplines and Occupations2

Information Science3

Health Care5

Immunotherapy19

Treatment of solid tumors3

Metastasis18

Inhibited tumor growth3

Metastatic12

Biomarkers4

Progression9

Malignant5

Immunity3

Therapies11

Macrophages5

Cancers8

Survival9

Anti-tumor1

20234

Brain tumor2

Chemotherapy6

Cancer56

Prognosis2

Pathways2

Angiogenesis3

Primary tumors1

Extracellular2

Solid tumor types1

Therapeutics1

Melanoma4

Inhibitors3

Biopsies3

Molecular3

Immune cells3

Adjuvant1

Biology5

Clinical3

Cells28

Antitumor1

Cellular1

Heterogeneous1

Patient's1

Researchers3

Bone marrow1

Jain1

Hypoxia1

Antigens1

Immuno-oncology1

Tissues2

Targeting1

Proteins1

Growth2

Mice1