• Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol. (wikipedia.org)
  • Anthelminthic agents include the macrocyclic lactone derivatives ivermectin and moxidectin, piperazine derivatives, and benzimidazole derivatives. (medscape.com)
  • It treats psychotic disorders and shares a distinct chemical and pharmacological resemblance with piperazine derivatives of the phenothiazine series. (daicelpharmastandards.com)
  • In fact, a large number of piperazine compounds have an anthelmintic action. (wikipedia.org)
  • Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. (pharmaoffer.com)
  • Piperazine works through anthelmintic action (used to expel or destroy parasitic worms in the gastro-intestinal tract). (americanaquariumproducts.com)
  • Another class is the avermectins, which includes ivermectin and moxidectin. (pharmaoffer.com)
  • The piperazine is separated from the product stream, which contains ethylenediamine, diethylenetriamine, aminoethylpiperazine and other related linear and cyclic chemicals of this type. (wikipedia.org)
  • Antihistamines are arranged into different classes based on chemical structure: the ethanolamine class, the ethylenediamine class, the piperazine class, the piperidine class, and the propylamine class. (vin.com)
  • Diethylcarbamazine, a derivative of piperazine, is used to treat some types of filariasis. (wikipedia.org)
  • Patients with asymptomatic microfilaremia in lymphatic filariasis can be treated on an outpatient basis. (medscape.com)
  • The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. (wikipedia.org)
  • Piperazine (/paɪˈpɛrəziːn/) is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. (wikipedia.org)
  • These drugs are often referred to simply as "piperazine" which may cause confusion between the specific anthelmintic drugs, the entire class of piperazine-containing compounds, and the compound itself. (wikipedia.org)
  • In organic chemistry, Phenylpiperazines are organic compounds in the piperazine subclass in the diazines class in the organoheterocyclic compound superclass , containing a phenylpiperazine skeleton, consisting of a piperazine bound to a phenyl group . (wellnessadvantage.com)
  • Oral regimens of the compound 1-maleinyl-4-(3′-chloro-4′-methyl-phenyl)-piperazine (Hoechst S 688) were found to have a strong chemotherapeutic effect on mature infections of Schistosoma mansoni (Puerto Rican) in white mice and monkeys. (ajtmh.org)
  • Further medicinal chemistry efforts focused on the piperidine-piperazine urea moiety may result in the identification of a selective antibacterial lead compound. (tbdrugaccelerator.org)
  • In the reactions illustrated above, the compound of formula II is made by hydrogenating the known compound N-(2-furoyl) piperazine to give N(tetrahydro-2-furoyl) piperazine. (justia.com)
  • This compound converted to the acid chloride with oxalyl chloride and is then treated with N-benzyl piperazine. (justia.com)
  • Study of this effect indicated that AK301-treated cells showed high levels of ATM signaling during mitotic arrest and exit from mitosis, following compound withdrawal, resulted in a p53-dependent apoptosis. (uconn.edu)
  • Piperazine is an organic compound used as an anti-parasitic in veterinary medicine, primarily for worms. (americanaquariumproducts.com)
  • The plant leaves were used for the extraction, and the identified compound was S-benzo[d]oxazol-2-yl 2-(piperazine-1-yl)ethanethioate, confirmed by spectral analysis. (ijper.org)
  • Our study concluded that DM could be treated using an isolated compound after further in-vivo and in-vitro studies. (ijper.org)
  • A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. (wikipedia.org)
  • 194 g. (1Mole) piperazine hexahydrate was dissolved in 250 ml. (justia.com)
  • Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. (blansacar.cn)
  • Gastroenteritis (diarrhea, nausea, vomiting) can occur with the ethanolamine class of antihistamines. (medscape.com)
  • Thiothixene is an antipsychotic for treating schizophrenia, a psychiatric disorder characterized by disrupted or atypical thinking, diminished interest in life, and intense or inappropriate emotions. (daicelpharmastandards.com)
  • Stelazine treats anxiety and schizophrenia. (rxwiki.com)
  • Stelazine is a prescription medication used to treat schizophrenia or anxiety. (rxwiki.com)
  • For more than a decade, phenothiazine drugs have been used to treat a variety of disorders and have proved particularly effective in the treatment of schizophrenia. (blansacar.cn)
  • Among them, mGlu2/3 receptor agonists have been proven to be effective for treating schizophrenia and anxiety disorders in clinical studies, which may prove utilities of mGlu receptor ligands for the treatment of psychiatric disorders. (openmedicinalchemistryjournal.com)
  • Piperazine hydrate, piperazine adipate and piperazine citrate (used to treat ascariasis and enterobiasis) are the most common anthelmintic piperazine compounds. (wikipedia.org)
  • The benzimidazoles class includes compounds like albendazole and mebendazole, which disrupt the energy metabolism of the worms, leading to their paralysis and eventual death. (pharmaoffer.com)
  • One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. (nootropic.com)
  • This invention relates to compounds selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquinazol ine, and pharmaceutically acceptable acid addition salts thereof, represented by the following formulas, respectively. (justia.com)
  • Towards this goal, we identified a series of mitotically acting piperazine-based compounds that sensitized colon cancer cells to TNF-dependent apoptosis. (uconn.edu)
  • The most potent of these compounds, 1-(3-chlorophenyl)-4-(2-ethoxybenzoyl)piperazine or AK301, arrested cells in a mitotic state (EC 50 ≈ 115 nM) in which the TNF receptor was efficiently coupled to caspase-8 activation. (uconn.edu)
  • This work details the identification and structure-activity relationship studies of a new class of small molecule compounds and explores their anti-mitotic activity and provides a paradigm for exploiting molecular alterations in mutated cells. (uconn.edu)
  • Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue. (justia.com)
  • Piperazine is freely soluble in water and ethylene glycol, but insoluble in diethyl ether. (wikipedia.org)
  • Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. (pharmaoffer.com)
  • Wormer gel is a water-soluble worming treatment that can treat several kinds of worm infestations, and can either be mixed in with your pigeon's drinking water or mixed in with their food. (nepigeonsupplies.com)
  • Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). (wikipedia.org)
  • The -az- infix added to "piperazine" refers to the extra nitrogen atom, compared to piperidine. (wikipedia.org)
  • The 2.3-Å crystal structure of Mtb PheRS in complex with PF-3845 revealed its novel binding mode, in which a trifluoromethyl-pyridinylphenyl group occupies the phenylalanine pocket, whereas a piperidine-piperazine urea group binds into the ATP pocket through an interaction network enforced by a sulfate ion. (tbdrugaccelerator.org)
  • Loratadine, a member of the piperidine class of antihistamines, has gotten relatively positive reviews in particular for treating feline itchy skin, but actual published studies are few. (vin.com)
  • This product doesn't just get rid of worms, but can treat other pests and is applied to your pigeon's neck to treat roundworms, once a week for three weeks. (nepigeonsupplies.com)
  • Treat again in 14 days to kill new hatchings of Anchor worms. (americanaquariumproducts.com)
  • Also be careful with the use of Dylox/Clout to treat Detritus Worms (who many confuse are Planaria), as the combination of the die off, high bio-load, and ammonia spike can often then take out the fish in the aquarium too that otherwise would not be affected by the treatment. (americanaquariumproducts.com)
  • Piperazines aquatic uses are restricted to internal parasite control, especially intestinal worms. (americanaquariumproducts.com)
  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (rxwiki.com)
  • Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. (rxwiki.com)
  • 6H2O, which melts at 44 °C and boils at 125-130 °C. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid). (wikipedia.org)
  • In addition, students are generally only provided the best specimens during practical classes in which they are taught to identify parasites. (cdc.gov)
  • nonetheless, the CO2 absorption rate, heat of absorption, and solvent capacity are increased through the addition of piperazine to amine gas treating solvents, the most common of which is MDEA due to its unmatched high rate and capacity efficiency. (wikipedia.org)
  • First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 195. (pharmaoffer.com)
  • After uptake of H.sub.2 ceased, the catalyst was filtered, the solvent concentrated, and the residue crystallized from isopropyl alcohol to give 35.2 g. tetrahydrofuroyl piperazine HBr, m.p. 152.degree. (justia.com)
  • Treats worm infections such as pinworms and roundworms. (limamemorial.org)
  • Piperazine, (Wazine) levamisole, fenbendazole (Safe-guard) and hygromycin are all effective anthelminthics (anti-worm drugs….NEVER play scrabble against a vet! (1atlanticfunding.com)
  • Finely diced garlic, cayenne pepper, and raw, grated carrot are all-natural vermifuges (worm expellers) that can be used to naturally treat infested birds. (1atlanticfunding.com)
  • In such trials, several antihistamines of different classes are used sequentially in hopes of finding one that was especially effective. (vin.com)
  • When treating allergic skin disease, antihistamines are felt to synergize with omega-3 fatty acid supplements , and, as a general rule for this condition, can be used medications together. (vin.com)
  • This product should not be used to treat fungal infections of the scalp or nails. (medicatione.com)
  • This medication treats only bacterial eye infections. (medicatione.com)
  • A recently introduced drug, 2-[4-(2-furoyl)-1-piperazine-1-yl]-4-amino-6,7-dimethoxyquinazoline, commonly identified by the generic name prazosin, is a hypotensive drug producing peripheral arterial dilation. (justia.com)
  • Dr. It is used to treat the symptoms of allergic skin conditions such as rash, redness, itching, swelling, etc. (borreliosidilyme.it)
  • Carvedilol indications This medication is used primarily in treating hypertension or high blood pressure. (medicatione.com)
  • Hydroxyzine pamoate (Vistaril) is an antihistamine that's sometimes prescribed to treat anxiety or insomnia. (borreliosidilyme.it)
  • Researchers don't know exactly how hydroxyzine works in the human body and mind to treat anxiety, but most healthcare providers agree that it affects 2 chemicals in our bodies. (borreliosidilyme.it)
  • The drug is not recommended for children younger than 10 years, in totally blind persons (unless they require relief from intensely itchy lesions), in lightly to moderately infected people with no symptoms and whose eyes are not at risk, or in pregnant women (who should be treated after delivery). (medscape.com)
  • Several inhibitors were developed and successfully introduced to the market as a novel drug class to treat type-2 diabetes. (ommegaonline.org)
  • Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. (rxwiki.com)
  • X-ray crystal structure of Sitagliptin bound to DPP-IV, (Figure-2), illustrates that the triazolo-piperazine fragment of the drug is oriented towards the Phe357 residue in the catalytic site, and the trifluromethyl group towards the Ser209 residue. (ommegaonline.org)
  • Piperazines, especially BZP and TFMPP were extremely common adulterants in the club and rave scene, often being passed off as MDMA, although they do not share many similarities in their effects. (wikipedia.org)
  • Gastrointestinal There is no conclusive evidence effects in the first several months as (piperazine estrone sulfate), which has omic-toledo.org taken inadvertently during early pregnancy. (omic-toledo.org)
  • Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. (wikipedia.org)
  • These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including this drug. (nih.gov)
  • Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. (nih.gov)
  • Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyquinazo line, and pharmaceutically acceptable acid addition salts thereof. (justia.com)
  • Field comparison of impingers and treated filters for sampling of total aliphatic isocyanate s with the MAP reagent. (cdc.gov)
  • Cardiol - Carvedilol information Carvedilol is a blood pressure medication and belongs to the class of drugs known as beta-blockers. (medicatione.com)
  • There was a suggestion that the chemical had prophylactic activity in preventing some of the S. japonicum infection from developing in dogs treated for the three days after the exposure day. (ajtmh.org)
  • The search for new antibiotics to treat drug-sensitive as well as drug-resistant tuberculosis has become a priority. (tbdrugaccelerator.org)
  • X-ray structure of Sitagliptin with DPP-IV indicated hydrophobic interaction of the triazolo-piperazine ring system with the S2 pocket through the amino acid Phe357. (ommegaonline.org)
  • The current research aimed to design molecules maintaining the β-amino amide pharmacophore of Sitagliptin, but with the triazolo-piperazine ring system replaced by more lipophilic entities for better hydrophobic interactions with Phe 357 in the S2 pocket. (ommegaonline.org)
  • For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). (nih.gov)
  • CYMIT QUÍMICA, S.L. as responsible for the treatment will treat your data in order to respond to your queries or requests. (cymitquimica.com)
  • There are various treatment methods including oxidation processes, biological degradation, membrane filtration and coagulation/flocculation have been studied to treat dyeing wastewater. (intechopen.com)
  • Piperazine exists as small alkaline deliquescent crystals with a saline taste. (wikipedia.org)
  • It is used to treat endocrine (hormonal) disorders when the body does not produce enough of its own steroids. (medicatione.com)
  • The WHO has recommended that suramin not be used to treat onchocerciasis in individuals who are elderly or infirm or in patients with severe liver or renal disease. (medscape.com)
  • Education best site to buy xanax on opioid use and opioid disorders is important to keep children best site to buy xanax away from these drugs. (wynardtage.de)
  • The development and regular implementation of standardized hookah prevalence questions into our national and state surveillance systems, as well as targeted, state-specific youth education and prevention activities are essential to thwart this growing public health concern. (who.int)
  • Caution is needed in patients who have a known predisposing factor to cardiac arrhythmia, including electrolyte imbalance (hypokalaemia, hypomagnesaemia), who have pre-existing heart disease, or who are concomitantly treated with a potentially arrhythmogenic drug. (dvago.pk)
  • Natural Products as Tools for Neuroscience: Discovery and Development of Novel Agents to Treat Drug Abuse. (acs.org)
  • Again, be sure to read the instructions for each specific wormer to apply it safely. (1atlanticfunding.com)
  • Here you will find a list of producers, manufacturers and traders of Piperazine. (pharmaoffer.com)