Transporting protein transport. Medical search. Frequent questions

Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS , which move molecules across membranes, by the mode in which the molecules are transported. (online-medical-dictionary.org)
Vesicular Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "Vesicular Transport Proteins" by people in this website by year, and whether "Vesicular Transport Proteins" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Vesicular Transport Proteins" by people in Profiles. (uchicago.edu)

In that case, Myo1c could be an attractive therapeutic target, as inhibiting it would prevent these proteins from leaving the cell membrane, an event that triggers the injury response. (sciencedaily.com)

Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23. (bvsalud.org)
The ATP -binding cassette (ABC) transporter multidrug resistance protein 1 (MRP1/ABCC1) is responsible for the cellular export of a chemically diverse array of xenobiotics and endogenous compounds. (bvsalud.org)

Superprotein candidates are apparent among the rapidly transported proteins of many neurons from the CNS and PNS, including cranial, sympathetic, sensory, and motor neurons from mammals, fish, and amphibians. (jneurosci.org)
RNA transport and regulated local translation play critically important roles in spatially restricting gene expression in neurons. (frontiersin.org)
To address these issues, we monitored how siRNA mediated loss of JIP1 influenced transport of enhanced green fluorescent protein (EGFP)-tagged APP through axons and production of endogenous Aβ in living neurons. (kcl.ac.uk)
Peripherin is a neural intermediate filament protein that is expressed in peripheral and enteric neurons, as well as in PC12 cells. (northwestern.edu)

They play a role in the intracellular transport of molecules contained within membrane vesicles. (online-medical-dictionary.org)
This manuscript reports data consistent with a new and unanticipated phenomenon: that Cre or its mRNA may be transmitted between tissues in the mouse and that the male reproductive tract (epididymis) appears to be the most common target of such transported molecules. (elifesciences.org)
Guwahati: Indian Institute of Technology Guwahati researchers have shown how some specialised protein molecules found on the cell membranes of all biological cells carry carbohydrate molecules into cells from outside. (indiaeducationdiary.in)
They have studied specific protein molecules called ABC transporters, present in bacterial cell membranes and have shown that these transporters are selective about the type of carbohydrates they transport into cells. (indiaeducationdiary.in)
These carbohydrates are large molecules that cannot penetrate the membranes that surround the cell by themselves and depend on some special helpers or transporting molecules to carry them across. (indiaeducationdiary.in)
One of the largest classes of transporting molecules is the ATP-Binding Cassette (ABC) transporter, which is widespread in all forms of life", says Dr. Kanaujia. (indiaeducationdiary.in)

These results serve to unite the observations on the synthesis, distribution, metabolism, and axonal transport of Superprotein with observations of SNAP-25 and its mRNA. (jneurosci.org)
Degeneration of these cells was completely prevented by inhibiting protein synthesis during lidocaine application. (nih.gov)
These abnormalities are due to impaired DNA synthesis and, to a lesser extent, RNA and protein synthesis. (medscape.com)
For heme synthesis, transferrin transports iron to the erythroblast mitochondria, which insert the iron into protoporphyrin IX for it to become heme. (msdmanuals.com)

Disruption to axonal transport is an early pathological feature in Alzheimer's disease. (kcl.ac.uk)
The amyloid precursor protein (APP) is a key axonal transport cargo in Alzheimer's disease since perturbation of its transport increases APP processing and production of amyloid-β peptide (Aβ) that is deposited in the brains of Alzheimer's disease patients. (kcl.ac.uk)
To distinguish between these two possibilities, we induced a reversible axonal transport blockade in the developing optic nerve by topical application of a local anesthetic (lidocaine). (nih.gov)
We found that axonal transport blockade induced only a limited number of pyknotic RGCs. (nih.gov)

Through this interaction, mRNAs and their associative proteins form messenger ribonucleoprotein particles (mRNPs) that are actively transported along the cytoskeleton to intracellular destinations. (frontiersin.org)
More recently, the concept of lysosomal storage disease has been expanded to include deficiencies or defects in proteins necessary for the normal post-translational modification of lysosomal enzymes (which themselves are often glycoproteins), activator proteins, or proteins important for proper intracellular trafficking between the lysosome and other intracellular compartments. (medscape.com)

Protein-specific energy requirements for protein transport across or into thylakoid membranes. (wikipedia.org)
So-called solute carriers (SLC), proteins that can transport such substances across the boundaries of cellular membranes, play a central role in metabolism. (prohealth.com)
These special form of proteins present in the cell membranes of almost all living cells, capture the carbohydrates from outside the cell and deliver them into the cells. (indiaeducationdiary.in)

Scientists in Giulio Superti-Furga's research group at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences have now discovered that the previously uncharacterised protein SLC25A51 acts as a transporter into the mitochondria for the coenzyme NAD. (prohealth.com)
Many of these transporter proteins are still relatively poorly studied and the question of how some nutrients enter and leave cells often remains unanswered. (prohealth.com)
Our previous studies on the structure and function of the transition-metal ion transporter from Staphylococcus capitis (ScaDMT) have revealed the general architecture of the SLC11/NRAMP family and they provided initial insight into the structural basis of selective transition-metal ion transport 16 . (nature.com)
The most important open questions concern the structure of the transporter in an outward-facing conformation and whether, similar to their eukaryotic counterparts, transport in the prokaryotic transporters would be coupled to H + . To resolve these questions we have investigated the structural and functional properties of the SLC11 transporter from the bacterium Eremococcus coleocola (EcoDMT). (nature.com)
They said that PPTs have the potential to "readily affect glucose absorption in the small intestine," noting that many polyphenols, phenolic acids and tannins can interact with certain sugar transporters - for example, inhibition of sodium-dependent glucose transporter 1 (SGLT1 - an active transport mechanism in which glucose is co-transported with sodium ion) or by inhibition of GLUT2. (nutraingredients.com)

Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. (uchicago.edu)

Their findings suggest that Myo1c uses the actin cytoskeleton as a 'track' for Neph1 transport -- a finding with translational relevance for glomerular diseases such as diabetic nephropathy, as movement of Neph1 to and from the surface membrane triggers the injury/recovery response. (sciencedaily.com)
These findings suggest that Myo1c uses the actin cytoskeleton as a "track" for cellular transport of its Neph1 cargo (bound to its C tail). (sciencedaily.com)

When injury occurs, Neph1 and other surface proteins are dislodged into the cytoplasm and must find their way back to the surface of the cell membrane to trigger the events needed for recovery. (sciencedaily.com)
Highly homologous prokaryotic SLC11 family members transport Mn 2+ into the cytoplasm 11 . (nature.com)

The results reveal that non-filamentous, non-membrane bound peripherin particles and short peripherin intermediate filaments, termed 'squiggles', are transported at high speed throughout PC12 cell bodies, neurites and growth cones. (northwestern.edu)
Our data demonstrate that peripherin particles and squiggles can move as components of a rapid transport system capable of delivering cytoskeletal subunits to the most distal regions of neurites over relatively short time periods. (northwestern.edu)

The apparent permeability value for rosuvastatin across MDR1-Madin-Darby canine kidney cells was low (∼8 nm/s), and no directional transport was observed. (aspetjournals.org)
An Eadie-Hofstee analysis suggested that there were two transport sites in BCRP, with an apparent K m of 10.8 μM for the high affinity site and 307 μM for the low affinity site. (aspetjournals.org)

Solute carriers (SLC) are proteins that act as transporters and enable the entry and exit of nutrients and waste products into and from the cell and its organelles. (prohealth.com)

Superprotein is a rapidly axonally transported protein that is conspicuously labeled with 35S-methionine supplied to the cell bodies of retinal ganglion cells. (jneurosci.org)
Labeled Superprotein disappeared from the superior colliculus more rapidly than another protein (synapsin I-like protein) that is concentrated in synaptic terminals. (jneurosci.org)
Injected intravenously into adult Xenopus females, the protein-DNA complex is rapidly transported through the bloodstream and, within the ovary, the vitellogenin ligand present in the protein binds to the receptors at the surface of the oocytes. (biologists.com)

The research, published in Molecular Nutrition & Food Research , suggests that some polyphenols, phenolic acids and tannins extracted from apples and strawberries may block the transport of glucose across intestinal tissues, potentially blunting post-meal glucose spikes. (nutraingredients.com)
In the human body, iron is present in all cells and has several vital functions -- as a carrier of oxygen to the tissues from the lungs in the form of hemoglobin (Hb), as a facilitator of oxygen use and storage in the muscles as myoglobin, as a transport medium for electrons within the cells in the form of cytochromes, and as an integral part of enzyme reactions in various tissues. (cdc.gov)

Lead author Enrico Girardi and the research group of CeMM Scientific Director Giulio Superti-Furga, in cooperation with scientists from the University of Bari (Italy), have now identified the protein responsible for the important transport of NAD into mitochondria: SLC25A51. (prohealth.com)

The motor protein Myo1c binds to Neph1, a protein crucial for ensuring effective filtration by the kidney, and serves as one mode of its cellular transport, according to findings by investigators at the Medical University of South Carolina (MUSC) and their collaborators reported in the May 16, 2016 issue of Molecular and Cellular Biology . (sciencedaily.com)
The newly developed oocyte shuttle protein contains a streptavidin moiety that tightly binds biotinylated DNA. (biologists.com)

They added that their study is the first to show an inhibition of glucose transport across intestinal tissue by phenolic fruit extracts, and further characterize the contribution of individual phenolic components for their role in the inhibition of glucose transport. (nutraingredients.com)
Therefore, the consumption of strawberry and apple juices could affect glucose absorption via the inhibition of glucose transport," said the researchers. (nutraingredients.com)

MDR1/ABCB1, MRP2/ABCC2, and breast cancer resistance protein (BCRP)/ABCG2 are expressed in the liver and intestine and contribute to the disposition of many drugs. (aspetjournals.org)

The crystallographic structure of two of Myo1c's three segments had previously been determined but never that of the entire protein or the complex it forms with another protein. (sciencedaily.com)

Here we report a class of mRNA granules in human neuronal processes that are enriched in the nuclear cap-binding protein complex (CBC) and exon junction complex (EJC) core components, Y14 and eIF4AIII. (frontiersin.org)
The existence of mRNAs retaining both nuclear cap binding protein and EJC in the distal sites of neuronal processes suggests that some localized mRNAs have not yet undergone the "very first translation," which contribute to the spatio-temporal regulation of gene expression. (frontiersin.org)
Lysosomal storage diseases are generally classified by the accumulated substrate and include the sphingolipidoses, oligosaccharidoses, mucolipidoses, mucopolysaccharidoses (MPSs), lipoprotein storage disorders, lysosomal transport defects, neuronal ceroid lipofuscinoses and others. (medscape.com)

The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. (nih.gov)

A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES . (online-medical-dictionary.org)
In this study, marked differences in As(GS)3 transport kinetics were observed between MRP1-enriched membrane vesicles prepared from human embryonic kidney 293 (HEK) (Km 3.8 µM and Vmax 307 pmol/mg per minute) and HeLa (Km 0.32 µM and Vmax 42 pmol/mg per minute) cells . (bvsalud.org)

APP is transported anterogradely through axons on kinesin-1 motors. (kcl.ac.uk)

Polyphenols and phenolic acids from strawberry and apple may decrease glucose uptake by blocking transport through human intestinal cells, according to a new study. (nutraingredients.com)
transferrin can transport iron from cells (intestinal, macrophages) to specific receptors on erythroblasts, placental cells, and liver cells. (msdmanuals.com)

Researchers used small-angle X-ray scattering to determine the full structure of the motor protein Myo1c and its complex with Neph1, a protein crucial for kidney filtration. (sciencedaily.com)

As a means of transport for Neph1, Myo1c likely plays an important role in the injury/recovery response as well. (sciencedaily.com)
Despite the advance in the understanding of ion selectivity, important properties of the transport mechanism remained elusive. (nature.com)

Defective transport of carbohydrates into cells is associated with a range of disorders, including cystic fibrosis, hypercholesterolaemia and diabetes. (indiaeducationdiary.in)
"The results obtained demonstrate that polyphenols, phenolic acids and tannin-rich extracts from strawberry and apple were able to influence glucose uptake into the cells and transport … by inhibiting activities of the glucose transporters," said the authors. (nutraingredients.com)

The IIT Guwahati team studied the ABC Transport system of a bacterium called Thermus thermophilus, that are present in hot springs. (indiaeducationdiary.in)
Is the ABC transport system in this bacterium inherently selective to specific carbohydrates or does it have no such preference? (indiaeducationdiary.in)

These proteins are highly conserved across all kingdoms of life and thus likely share a common transport mechanism. (nature.com)
By determining the structure of EcoDMT in an outward-facing conformation, we provide a framework that defines the conformational changes underlying transport by the alternate access mechanism 19 . (nature.com)

Its crystal structure reveals a previously unknown outward-facing state of the protein family. (nature.com)

We did a solution-based structure where we could actually get the structure of the entire protein and study that structure in complex with a cargo protein (Neph1). (sciencedaily.com)

However, direct experimental evidence to support a role of JIP1 in APP transport is lacking. (kcl.ac.uk)

Together, our findings should motivate caution when interpreting conditional alleles, and suggest the exciting possibility of inter-tissue RNA or protein trafficking in modulation of reproductive biology. (elifesciences.org)

These are early findings, but they show that Myo1c is critical to the transport of Neph1. (sciencedaily.com)
We have optimized our transport assays to show that EcoDMT transports Mn 2+ with a K M in the low μM range and that metal ion transport is coupled to the cotransport of protons. (nature.com)

The present study was designed to determine whether rosuvastatin is transported by MDR1, MRP2, and BCRP. (aspetjournals.org)
To validate this hypothesis, the team used X-ray crystallography techniques to determine the three-dimensional crystal structure of the ABC transport system connected to various types of carbohydrates having different kinds of glycosidic bonds. (indiaeducationdiary.in)

They also hope to study whether Myo1c forms complexes with other proteins key for the maintenance of healthy renal function. (sciencedaily.com)
Combined with previous results, our study defines the conformational changes underlying transition-metal ion transport in the SLC11 family and it provides molecular insight to its coupling to protons. (nature.com)

These data demonstrate that rosuvastatin is transported efficiently by BCRP and suggest that BCRP plays a significant role in the disposition of rosuvastatin. (aspetjournals.org)

Heterogeneous population of RNA granules serve as motile units to translocate, store, translate, and degrade mRNAs in the dendrites contain cis -elements and trans -acting factors such as RNA-binding proteins and microRNAs to convey stimulus-, transcript-specific local translation. (frontiersin.org)

Together, these results suggest that Asn19/Asn23 glycosylation and Tyr920/Ser921 phosphorylation are responsible for altering the kinetics of MRP1-mediated As(GS)3 transport. (bvsalud.org)

We conclude that the rapid degeneration of RGCs after axotomy can be ascribed only partly to the loss of retrogradely transported trophic factors. (nih.gov)

Surprisingly, we found that knockdown of JIP1 did not affect either APP transport or Aβ production. (kcl.ac.uk)

Having a 3D crystal structure is more like a snapshot of the protein in three-dimensional space but of more physiological relevance is understanding how the proteins behave in solution," says senior author Deepak Nihalani, Ph.D., an Associate Professor in the College of Medicine, Division of Nephrology, at MUSC. (sciencedaily.com)

Anatomy37

Organisms18

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes56

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science3

Health Care1

Vesicular Transpor4

Leaving the cell1

Multidrug resistance protein2

Neurons4

Molecules6

Synthesis4

Axonal transport4

Intracellular2

Membranes3

Transporter5

Triggered by phosphorylation1

Cytoskeleton2

Cytoplasm2

Particles2

Apparent2

Solute1

Rapidly3

Tissues2

Mitochondria1

Binds2

Glucose transport2

Expressed in the liver1

Another protein1

Neuronal3

Gene1

VESICLES2

Axons1

Intestinal2

Researchers1

Important2

Cells2

Bacterium2

Mechanism2

Reveals1

Cargo1

Evidence1

Tissue1

Show2

Determine2

Study2

Data1

Specific1

Suggest1

Loss1

Found1

Crystal structure1