• 19. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. (nih.gov)
  • Noncanonical mechanisms to regulate nuclear receptor signaling. (omeka.net)
  • Nuclear receptor (NR)-targeted therapies comprise a large class of clinically employed drugs. (omeka.net)
  • Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. (cusabio.com)
  • Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model. (research.com)
  • Extracellular acidification activates ovarian cancer G-protein-coupled receptor 1 and GPR4 homologs of zebra fish. (research.com)
  • The AKT nomenclature of PI3K, receptor, forms called to small post-translational RTK reactions either not or thereby, through the interferons, involving to a related paper in the PI3K system liver that promotes ha34 of the actual nuclear receptor. (familie-vos.de)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse G Protein Coupled Estrogen Receptor 1 (GPER) in serum, plasma, tissue homogenates and other biological fluids. (isogem.org)
  • These factors have a role in the tissue-specific regulation of gene expression in a number of tissues, including liver, kidney, intestine, and pancreatic islets [ 5 ] . (medscape.com)
  • Hepatocyte nuclear factor-1β (HNF-1β) is an essential transcription factor that regulates the development and function of epithelia in the kidney, liver, pancreas, and genitourinary tract. (nih.gov)
  • 3. Growth hormone regulates the expression of hepatocyte nuclear factor-3 gamma and other liver-enriched transcription factors in the bovine liver. (nih.gov)
  • 4. Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver. (nih.gov)
  • 8. Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver. (nih.gov)
  • 15. Rapid modulation of liver-specific transcription factors after injury. (nih.gov)
  • 17. Activation of albumin and other liver-specific gene expression in fibroblast-pancreatic cell hybrids: different roles of transcription factors. (nih.gov)
  • Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury. (omeka.net)
  • We have previously shown that mouse and human hepatocytes can be converted to expandable liver progenitor-like cells in vitro (HepLPCs). (thno.org)
  • Furthermore, under three-dimensional culture conditions, the formed hepatic spheroids showed multiple liver functions and toxicity profiles close to those of primary human hepatocytes. (thno.org)
  • Reticuloendothelial cells (macrophages in the bone marrow and spleen, Kupffer cells in the liver) and hepatocytes are two major areas of iron storage in humans. (ashpublications.org)
  • Type 2 diabetes is also associated with a profound alteration in lipid metabolism, such as increased levels of plasma very-low-density lipoprotein triglycerides (VLDL-TG) and free fatty acids, whose oxidation is increased in the liver and skeletal muscles ( 1 ). (diabetesjournals.org)
  • The etiology of liver cancer is diverse, including viral infection, alcoholic and non-alcoholic fatty liver disease, aflatoxins, genetic and metabolic factors and infection, among which viral infection [via hepatitis B virus (HBV) and hepatitis C virus (HCV)] is the most important factor ( 2 , 3 ). (spandidos-publications.com)
  • Prior research suggests that sex hormones and metabolic changes, such as obesity and hyperglycemia, can alter renal transporter expression in rodents. (nih.gov)
  • Taken together, these results suggest that renal drug efflux transporters and regulatory signaling pathways are altered by endocrine and metabolic changes that occur during pregnancy and Type I diabetes. (nih.gov)
  • Ukkola O, Sun G, Bouchard C. Insulin-like growth factor 2 (IGF2 ) and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes. (medscape.com)
  • The effects of benfluorex and two of its metabolites (S 422-1 and S 1475-1) on fatty acid and glucose metabolic fluxes and specific gene expression were studied in hepatocytes isolated from 24-h fasted rats. (diabetesjournals.org)
  • In conclusion, this work suggests that benfluorex mainly via S 422-1 reduces gluconeogenesis by affecting gene expression and metabolic status of hepatocytes. (diabetesjournals.org)
  • Induction of phase I metabolic enzymes in SC rat hepatocytes to levels representative of in vivo expression and function may extend the utility of this in vitro model to facilitate the prediction of hepatobiliary disposition of metabolically labile substrates. (aspetjournals.org)
  • In this review, we summarize and discuss principal metabolic changes following administration of particular kinase inhibitors on different levels of cellular metabolism (key metabolites and molecules affected by TKIs in cancer are summarized in Table 1 ). (biomedcentral.com)
  • In recent years, with the prevalence of obesity, diabetes and various metabolic syndromes increasing, the incidence of HCC has also been shown to be on a clear upward trajectory ( 1 , 4 , 5 ). (spandidos-publications.com)
  • 13. Octamer transcription factor-1 enhances hepatic nuclear factor-1alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter. (nih.gov)
  • In conclusion, Nrf2 markedly alters hepatic mRNA of a large number of drug metabolizing enzymes and xenobiotic transporters, and thus Nrf2 plays a central role in xenobiotic metabolism and detoxification. (nih.gov)
  • Human type 2 diabetes or animal models are characterized by hyperglycemia as a result of increased hepatic glucose production and peripheral insulin resistance ( 1 ). (diabetesjournals.org)
  • For instance, overnight treatment of patients with type 2 diabetes with acipimox markedly improved glucose metabolism ( 6 , 7 ), whereas long-term treatment (1 month) was without effect on hepatic glucose production ( 8 ). (diabetesjournals.org)
  • Although this may be caused to some extent by decreased D1 expression or cofactor levels, a diminished activity of transporter(s) mediating hepatic uptake of T4 and rT3 appears to be another important mechanism. (phoenixrising.me)
  • Treatment of SC rat hepatocytes with DEX resulted in alterations in the expression of CYP3A1/2 and some hepatic transport proteins. (aspetjournals.org)
  • Huss and Kasper, 2000 ) and a common medium supplement, on hepatic transport protein expression and function have not been investigated in SC rat hepatocytes. (aspetjournals.org)
  • Transporter mRNA and protein expression were quantified in kidneys from vehicle- and STZ-treated non-pregnant and pregnant mice on gestation day 14. (nih.gov)
  • The purpose of this study was to investigate the role of Nrf2 in regulating the mRNA of genes encoding drug metabolizing enzymes and xenobiotic transporters. (nih.gov)
  • However, Nrf2 increased mRNA of many other phase-I enzymes, such as aldo-keto reductases, carbonyl reductases, and aldehyde dehydrogenase 1. (nih.gov)
  • One-way ANOVA test showed higher mRNA transcription of SPs in groups 3 and 4 than groups 1 and 2. (medsci.org)
  • Significantly lower Foxm1 mRNA transcription and protein expression were observed in group 3 or 4 compared with group 1 or 2. (medsci.org)
  • Renal efflux transporter expression in pregnant mice with Type I diabetes. (nih.gov)
  • The purpose of this study was to characterize the expression of kidney efflux transporters and regulatory transcription factors in response to Type I diabetes and pregnancy. (nih.gov)
  • Pregnancy had little effect on STZ-mediated changes in renal efflux transporter expression. (nih.gov)
  • Transcriptional profiles of Hnf1α, PXR, AhR, and Nrf2 were altered in patterns similar to some efflux transporters suggesting potential involvement in their regulation. (nih.gov)
  • Efflux transporters, such as multidrug resistance-associated proteins, breast cancer resistant protein, as well as ATP-binding cassette g5 and g8 were induced by Nrf2. (nih.gov)
  • 2) The interaction between the main constituents and efflux pumps or intestinal transporters. (frontiersin.org)
  • Description: A sandwich ELISA kit for detection of ATP Binding Cassette Transporter C9 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
  • Description: Quantitativesandwich ELISA kit for measuring Human Claudin-1 (CLDN1) in samples from serum, plasma, tissue homogenates, cell lysates. (operatiebrp.nl)
  • Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic stress. (nih.gov)
  • Kelch-like ECH associating protein 1 (Keap1) sequesters Nrf2 in the cytosol. (nih.gov)
  • Microarray analysis was performed in livers of Nrf2-null, wild-type, Keap1-knockdown mice with increased Nrf2 activation, and Keap1-hepatocyte knockout mice with maximum Nrf2 activation. (nih.gov)
  • In general, Nrf2 did not have a marked effect on uptake transporters, but the mRNAs of organic anion transporting polypeptide 1a1, sodium taurocholate cotransporting polypeptide, and organic anion transporter 2 were decreased with Nrf2 activation. (nih.gov)
  • In the pancreas these genes influence expression of, among others, the genes for insulin, the principal glucose transporter (GLUT2), and several proteins involved in glucose and mitochondrial metabolism. (wikipedia.org)
  • Many patients with MODY 1 are treated with sulfonylureas for years before insulin is required. (wikipedia.org)
  • We searched for biologically plausible candidate genes in these regions and prioritized seven genes for exhaustive genetic investigation: adiponectin (3q27), AMP kinase gamma 2 subunit and nuclear respiratory factor-1 (7q36), stearoyl CoA desaturase (10q23), sterol regulatory element binding protein (17p11), insulin sensitive glucose transporter (17p13), and hepatocyte nuclear factor 4 alpha (20q12). (nih.gov)
  • Pramlintide is indicated for the treatment of type 1 or type 2 diabetes in combination with insulin. (medscape.com)
  • knockout mouse is caused by a significant reduction in expression of the high-capacity/low-affinity sodium-glucose transporter-2 (SGLT-2) [ 9 ] . (medscape.com)
  • In hepatocytes cultured in the presence of benfluorex or S 422-1 (10 or 100 μmol/l), the expression of genes encoding enzymes of fatty acid oxidation (carnitine palmitoyltransferase [CPT] I), ketogenesis (hydroxymethylglutaryl-CoA synthase), and gluconeogenesis (glucose-6-phosphatase, PEPCK) was decreased, whereas mRNAs encoding glucokinase and pyruvate kinase were increased. (diabetesjournals.org)
  • These genes and their encoded proteins are regulated by polyunsaturated fatty acids (PUFAs) and physical activity, and several code for transcription factors involved in adiponectin expression. (nih.gov)
  • The intrinsic defense against toxic chemicals largely depends on a set of genes and proteins collectively known as the chemical defensome 1 . (springer.com)
  • Only 1-2% of the mammalian genome is translated into proteins. (frontiersin.org)
  • Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. (cusabio.com)
  • The tubules modulate reabsorption and secretion of fluid and solutes by passive or active mechanisms [ 1 - 3 ]. (chikd.org)
  • Before secretion by hepatocytes, primary BAs are conjugated with either taurine or glycine, which increases their polarity and water solubility. (pancreapedia.org)
  • Renal tubules are responsible for homeostasis of body fluid, electrolyte, and acid-base conditions [ 1 , 2 ]. (chikd.org)
  • demonstrated that renal tubule-derived FGF23 can activate myofibroblasts and induce fibrosis via transforming growth factor β- related pathways in a model of acute interstitial nephritis. (renalfellow.org)
  • 16. Synergistic activation of the Atlantic salmon hepatocyte nuclear factor (HNF) 1 promoter by the orphan nuclear receptors HNF4 and chicken ovalbumin upstream promoter transcription factor I (COUP-TFI). (nih.gov)
  • This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome . (springer.com)
  • Tachykinin peptide-induced activation and desensitization of neurokinin 1 receptors. (omeka.net)
  • The term "chemical defensome" refers to a wide range of transcription factors, enzymes, transporters, and antioxidant enzymes that together function to detoxify and eliminate harmful compounds, including xenobiotic and endobiotic chemicals. (springer.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human ATP Binding Cassette Transporter C9 (ABCC9) in samples from tissue homogenates, cell lysates or other biological fluids. (myelisakit.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human ATP Binding Cassette Transporter C9 (ABCC9) in Tissue homogenates, cell lysates and other biological fluids. (myelisakit.com)
  • 현재까지 선천성 고인슐린혈증의 원인으로 ATP-binding cassette transporter (ABCC8), potassium inwardly-rectifying channel (KCNJ11), glucokinase (GCK), glutamate dehydrogenase 1 (GLUD1) 유전자의 이상이 알려져 있다[ 2 - 5 ]. (sch.ac.kr)
  • Here, we reported the generation of a novel hepatocyte model not only to provide unlimited cell sources for human hepatocytes but also to establish a tool for studying iDILI in vitro . (thno.org)
  • They could easily differentiate back into metabolically functional hepatocytes in vitro within 10 days. (thno.org)
  • We aimed to test this hypothesis and to study whether aminoaciduria is a more generalized feature of type 1 and type 2 diabetes. (medscape.com)
  • New drug development based on gene-specific treatments, such as apical sodium-dependent bile acid transporter (ASBT) inhibitor, for BSEP defects are underway. (biomedcentral.com)
  • sodium-dependent transporter [Ocean. (nig.ac.jp)
  • Mutations exclusively in equilibrative nucleoside transporter 3 (ENT3), the only intracellular nucleoside transporter within the solute carrier 29 ( SLC29 ) gene family, cause an expanding spectrum of human genetic disorders (e.g. (nature.com)
  • Genetic and environmental factors are known to be important in the development of obesity, yet the interactions between polymorphic variants within genes and environmental risk factors are poorly understood despite their fundamental importance. (nih.gov)
  • In the embryonic kidney, HNF-1β is required for ureteric bud branching, initiation of nephrogenesis, and nephron segmentation. (nih.gov)
  • Solute carrier family 22 member 8, or organic anion transporter 3 (OAT3), is a protein that in humans is encoded by the SLC22A8 gene. (wikipedia.org)
  • This gene codes for hepatocyte nuclear factor 4-alpha (HNF4-α) protein also known as transcription factor 14 (TCF14). (wikipedia.org)
  • These studies have demonstrated that the central intra-acinar events in pancreatitis are elevation of intra-acinar Ca 2+ concentration, premature activation of trypsinogen and the activation of the proinflammatory transcription factor, nuclear factor-κB (NF-κB) which leads to pancreatic injury (6, 16-18, 36, 44). (pancreapedia.org)
  • 2. Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation. (nih.gov)
  • 9. Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation. (nih.gov)
  • His Endocrinology study combines topics in areas such as Epidermal growth factor, Regulation of gene expression and Proband. (research.com)
  • Individual heterogeneity is considered to be an essential factor of iDILI. (thno.org)
  • Mutant variants encoding transporters in any tubular segments can cause inherited tubulopathies and determine their distinguishing clinical features [ 2 ]. (chikd.org)
  • ENT3 is unique as the only intracellular nucleoside transporter in the family with putative localization in late endosomes, lysosomes, and mitochondria (other human ENTs (hENTs) primarily function at the cell surface) 19 , 20 . (nature.com)
  • The sulfated form of TLC (TLCS) causes Ca 2+ signalling in pancreatic acinar cells via an inositol 1,4,5-trisphosphate (IP 3 )-dependent mobilization of sequestered intracellular Ca 2+ (49). (pancreapedia.org)
  • We search literatures in scientific databases with key words of "each main SHXXT constituent," in combination with "each main inflammatory pathway target molecule" or each main intestinal transporter, respectively. (frontiersin.org)
  • Treatment with the tiny molecule bryostatin-1 or hepatocyte development aspect (HGF), which activate S727-STAT3 indirectly, conserved mitochondrial function during FAK inhibition, but failed in the current presence of the STAT3 inhibitor. (roma2024.com)
  • We conclude, (1) The synergistic effect of constituents at both levels confirm the mutual reinforcement theory of TCM as it is proven in this work. (frontiersin.org)
  • Up to 90% of EOCs do not have an identified genetic component, and the development of specific and sensitive screening tools has proven elusive [ 1 ]. (hindawi.com)
  • 1 More than 500 million persons throughout the world have iron deficiency, 2 while hereditary hemochromatosis is the most common genetic disorder among Caucasians. (ashpublications.org)
  • We report the effect of five main constituents on target molecules which lies in three main inflammatory signaling pathways, we as well investigate the interaction between constituents and intestinal transporter. (frontiersin.org)
  • These studies examined the influence of DEX treatment on transport protein expression and function in sandwich-cultured (SC) rat hepatocytes. (aspetjournals.org)
  • The human dependent gene exhibit apparatus has the yield of H+ transporters into the transcription, which induces pathway coreceptors, affecting in the complex of RNP C1 of the s few caution differentiation. (familie-vos.de)
  • Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan (CPT-11), its metabolite SN-38, and its glucuronide: role of canalicular multispecific organic anion transporter and P-glycoprotein. (kanazawa-u.ac.jp)
  • The switch from normal tissue to malignancy is a result of oncogenes-driven biochemical processes aimed at sustaining an accelerated rate of proliferation and growth [ 1 ]. (biomedcentral.com)
  • analyses encode to a tumor of isoelectric semaphorin( IF) factors that are mitochondrial proprotein Proteoglycans, which play subsequently and translocation to form respectively 10 family mechanism companies. (familie-vos.de)
  • MODY 1 is due to a loss-of-function mutation in the HNF4A (MODY1) gene on chromosome 12. (wikipedia.org)
  • Onset of Diabetes in Young 1 (MODY1) and hyperinsulinemic hypoglycemia (HH)8-11. (gasyblog.com)
  • However by proteolytically probing its DNA-assembled complex we identified an extended segment corresponding to the DBD-hinge-LBD portions corresponding to residues 46-368 (Supplementary Physique 1). (gasyblog.com)
  • (+)-Longifolene Based on phosphorylation of residues S727 or Y705, STAT3 can inhibit or promote nuclear gene appearance [23]. (roma2024.com)
  • The two-dimensional gradient Hepsin marrow repeats nuclear and can be to the nucleoplasmic type. (familie-vos.de)
  • Major Depressive Disorder: Risk Factors, Characteristics and Treatment Options. (irb.hr)
  • A la I Conferència i Taller Internacional sobre diferenciació dels antígens leucocitaris humans , celebrada a París el 1982, fou aprovada la terminologia CD (cúmul o grup de diferenciació [18] o cluster of differentiation en anglès). (wikipedia.org)
  • Table 1 Summary of key metabolites and molecules affected by TKIs in cancer. (biomedcentral.com)
  • MODY 1 or HNF4A-MODY is a form of maturity onset diabetes of the young. (wikipedia.org)
  • FGF23 can induce the expression of cytokines such as C-reactive protein and interleukin-6 in cultured hepatocytes . (renalfellow.org)
  • Bile is synthesized and secreted by polarized hepatocytes into bile-canaliculi, flows through bile ducts, stored in the gall bladder and is finally drained into the duodenum. (biomedcentral.com)