Multiple myelomaAllogeneicUmbilical cordHematopoieticPeripheral bloodLymphoidHSCTSurvivalMalignantDonorDiseasesTherapyCellularTreatmentProcessMarrow TransplantationAllogenicHaematopoieticBone marrowTumorsFetalTransplantMesenchymal stromal cellsProgenitorNeuralPhenotypesMalignancyDisordersMultipleRegenerativeInfectionsCurrentPatientsIndividualDivideDiseaseMainDependsFoundNumbersHumanBrainWhiteSmallBody
Multiple myeloma2
- [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
- Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
Allogeneic3
- Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
- Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (medscape.com)
- A speciality of our clinic is allogeneic and autologous stem cell Transplantation. (uniklinikum-dresden.de)
Umbilical cord1
- and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Hematopoietic4
- Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
- Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
- To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
- HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
Peripheral blood1
- The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Lymphoid3
- Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
- Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
- White blood cells formed in the body's lymphoid tissue. (lookformedical.com)
HSCT2
- This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
- Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
Survival1
- Intercellular mitochondrial transfer can be regarded as an extension of intracellular mitochondrial movement or intercellular communication, which undoubtedly increases the mtDNA content of the recipient cells and restores the respiration and survival of the recipient cells. (biomedcentral.com)
Malignant1
- The Internal Medicine Dept. I provides complete diagnostics and therapy of non-malignant and malignant diseases: a wide spectrum of cancers, blood disorders including coagulating disturbances, diseases of the gastro-intestinal and respiratory tract and infectious diseases including HIV and AIDS. (uniklinikum-dresden.de)
Donor1
- However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
Diseases3
- Organ transplantation is the ultimate treatment option for patients suffering from refractory diseases. (frontiersin.org)
- Collectively, although scientists are increasingly aware of mitochondria's dynamic and transferable capabilities of mitochondria, the unclear mechanism and effectiveness of mitochondrial transfer/transplantation therapy limit its widespread application in diseases. (biomedcentral.com)
- In addition, we also discuss the existing methods of artificial mitochondrial transfer/transplantation (AMT/T) and their therapeutic effects on diseases to explore the potential applications of mitochondrial transfer and transplantation in the treatment of mitochondrial-related diseases, mitochondrial diseases, and cancer. (biomedcentral.com)
Therapy1
- Depending on the patient's medical condition, a refractory disease patient also requires an on-time selective option, such as less invasive cellular therapy options or curative organ transplantation that can function immediately after transplantation. (frontiersin.org)
Cellular1
- Multiple research groups have developed artificial mitochondrial transfer/transplantation (AMT/T) methods that transfer healthy mitochondria into damaged cells and recover cellular function. (biomedcentral.com)
Treatment1
- The ideal treatment option for terminally ill patients is organ transplantation. (frontiersin.org)
Process1
- Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
Marrow Transplantation8
- Bone marrow transplantation is considered the specific protocol in medical science. (zenonco.io)
- The patients undergoing bone marrow transplantation are recommended for regular follow-ups under the observation of qualified management by a multidisciplinary team. (zenonco.io)
- Integrating bone marrow transplantation involves the action mechanism of stem cell transplant against malignancy. (zenonco.io)
- Bone marrow transplantation is considered an effective procedure for treating different cancer types. (zenonco.io)
- The expansion in the integration of bone marrow transplantation for different diseases across the globe while evolving modern techniques. (zenonco.io)
- Bone marrow transplantation is employed for novel indications in treating autoimmune and inherited metabolic disorders (Daikeler et al. (zenonco.io)
- 2012). The allogenic bone marrow transplantation involves the process of stem cell transplantation where a stem cell donor is matched with their related siblings or any other family member who is closely related (haploidentical). (zenonco.io)
- This Worldwide Network for Blood and Marrow Transplantation (WBMT) article is part one of two papers aiming to provide guidance to transplantation centres around the globe regarding infection prevention and treatment, and considerations for transplantation based on current evidence and expert opinion. (bvsalud.org)
Allogenic1
- Reconstruction of such defects has conventionally been approached using autologous, allogenic, or xenogeneic grafts to restore the missing tissue with the hope for long-term functional rehabilitation. (tissueandcells.com)
Haematopoietic1
- Haematopoietic stem cells (HSCs) are adult stem cells that represent almost 0.05 to 0.5% of the cellular density of the normal bone marrow. (zenonco.io)
Bone marrow5
- Some involve leukaemias, bone marrow failures, hemoglobinopathies (thalassemia, sickle cell disease), immunodeficiencies, and other HSC transplant-based treatments for solid tumors and other genetic disorders such as lysosomal storage disease along with autoimmunity. (zenonco.io)
- It helps increase the bone marrow function that depends upon the treatment of the disease in eliminating the tumor cells with malignancy or generating the functional cells that replace the dysfunctional cells in certain disorders such as immune deficiency syndromes, hemoglobinopathies, and other diseases. (zenonco.io)
- A stem cell transplant, also called a bone marrow transplant, can be used to treat certain types of cancer. (cancer.org)
- Stem cells mostly live in the bone marrow (the spongy center of certain bones). (cancer.org)
- Once blood cells mature, they leave the bone marrow and enter the bloodstream. (cancer.org)
Tumors1
- Relapsed or refractory tumors, although rare, established the need for second-line therapies, including high-dose chemotherapy with autologous stem cell transplantation (HDCT/ASCT). (bvsalud.org)
Fetal4
- Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. (edu.au)
- Tissue-specific stem cells (also known as Somatic Stem Cells) that appear during fetal development and remain in the body throughout life. (edu.au)
- Implanted human fetal glial progenitor cells myelinated extensive regions of a shiverer mouse forebrain. (jamanetwork.com)
- High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain. (jamanetwork.com)
Transplant3
- This procedure might be called peripheral stem cell transplant or cord blood transplant, depending on where the stem cells come from. (cancer.org)
- Here we'll explain stem cells and stem cell transplant, cover some of the issues that come with transplants, and describe what it's like to donate stem cells. (cancer.org)
- G, Kaplan-Meier plot showing the survival curves of shiverer mice who were untreated, were treated with a saline control, or underwent human glial progenitor cell transplant. (jamanetwork.com)
Mesenchymal stromal cells1
- A possible therapy is the administration of mesenchymal stromal cells (MSCs). (bvsalud.org)
Progenitor5
- Progenitor cells from which all blood cells derived. (edu.au)
- Myelination of a leukodystrophic brain by engrafted human glial progenitor cells. (jamanetwork.com)
- These images are taken from either 1-year-old (A and B), 12-week-old (C and D), or 35-week-old (E and F) immunodeficient and myelin-deficient shiverer mice (shi/shi x rag2 −/− ), implanted at birth with A2B5 + /PSA-NCAM − -sorted human glial progenitor cells. (jamanetwork.com)
- B, Higher-magnification view of the engrafted shiverer cerebellum, illustrating the high-efficiency myelination of the cerebellar white matter (MBP, green) by human glial progenitor cells (red) (4',6-diamidino-2-phenylindole counterstain of mouse cells, blue). (jamanetwork.com)
- Stem and progenitor cell-based therapy of the human central nervous system. (jamanetwork.com)
Neural2
- Koch P, Kokaia Z, Lindvall O, Brüstle O. Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling. (jamanetwork.com)
- Using human neural stem cells to model neurological disease. (jamanetwork.com)
Phenotypes1
- Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. (edu.au)
Malignancy1
- The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Disorders1
- Lindvall O, Kokaia Z. Stem cells in human neurodegenerative disorders: time for clinical translation? (jamanetwork.com)
Multiple3
- Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
- Martino G, Franklin RJ, Van Evercooren AB, Kerr DA.Stem Cells in Multiple Sclerosis (STEMS) Consensus Group. (jamanetwork.com)
- Stem cell transplantation in multiple sclerosis: current status and future prospects. (jamanetwork.com)
Regenerative2
- With continually evolving tissue engineering and stem cell technologies, the application of regenerative strategies has gained momentum among many research groups worldwide. (tissueandcells.com)
- Cell transplantation is often used when the defect is challenging to repair using only the natural regenerative process. (tissueandcells.com)
Infections1
- White blood cells help fight infections caused by bacteria, viruses, and fungi. (cancer.org)
Current1
- The current "gold standard" for craniofacial bone tissue replacement is the use of autologous bone grafts from the rib, cranium, or iliac crest. (tissueandcells.com)
Patients1
- METHODS: In this retrospective study, 52 patients with severe SR-aGVHD were treated with MSCs from umbilical cord (UC-MSCs) in nine institutions. (bvsalud.org)
Individual1
- The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). (edu.au)
Divide1
- This is where they divide to make new blood cells. (cancer.org)
Disease1
- Goldman SA, Windrem MS. Cell replacement therapy in neurological disease. (jamanetwork.com)
Main1
- It has a rich supply of stem cells, and its main job is to make blood cells that circulate in your body. (cancer.org)
Depends1
- The body depends on lymphocytes to recognize its own cells and reject cells that don't belong in the body, such as invading germs or cells that are transplanted from someone else. (cancer.org)
Found1
- Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
Numbers1
- You can get more information on blood counts and what the numbers mean in Understanding Your Lab Test Results 3. (cancer.org)
Human1
- Direct isolation of human central nervous system stem cells. (jamanetwork.com)
Brain2
- This can be dangerous if bleeding occurs in the brain, or if blood begins to leak into the intestines or stomach. (cancer.org)
- Using animal models, scientists recently discovered that a change to the gut microbiota brought about by chronic stress can lead to depressive-like behaviors, in particular by causing a reduction in lipid metabolites (small molecules resulting from metabolism) in the blood and the brain. (regenerativemedicine.net)
White1
- Stem cells make red blood cells , white blood cells , andplatelets. (cancer.org)
Small1
- A small number of the immature stem cells also get into the bloodstream. (cancer.org)
Body3
- Even though they start out the same, these stem cells can mature into any type of blood cell, depending on what the body needs when each stem cell is developing. (cancer.org)
- Red blood cells carry oxygen away from the lungs to all of the cells in the body. (cancer.org)
- They are the first cells to respond to an injury or when germs enter the body. (cancer.org)