• organs
  • One of the earliest mentions about the real possibility of a kidney transplant was by American medical researcher Simon Flexner, who declared in a reading of his paper on "Tendencies in Pathology" in the University of Chicago in 1907 that it would be possible in the then-future for diseased human organs substitution for healthy ones by surgery, including arteries, stomach, kidneys and heart. (wikipedia.org)
  • Kidneys are paired vital organs located behind the abdominal cavity at the bottom of the ribcage corresponding to the levels T12-L3 of the spine vertebrae. (wikipedia.org)
  • This, as well as scarcity of donor organs for kidney transplantation has prompted research in developing alternative therapies, including the development of a wearable or implantable device. (wikipedia.org)
  • congestive heart f
  • Additionally low calcium concentrations in the blood, overactive muscle reflexes, muscle spasms, QT interval prolongation, and congestive heart failure may occur. (wikipedia.org)
  • immunosuppressive
  • Although the donated kidney was rejected ten months later because no immunosuppressive therapy was available at the time-the development of effective antirejection drugs was years away-the intervening time gave Tucker's remaining kidney time to recover and she lived another five years. (wikipedia.org)
  • proteinuria
  • Laboratory tests may also reveal low levels of platelets (cells in the blood that aid in clotting), elevated lactate dehydrogenase (LDH, a chemical released from damaged cells, and which is therefore a marker of cellular damage), decreased haptoglobin (indicative of the breakdown of red blood cells), anemia (low red blood cell count)/schistocytes (damaged red blood cells), elevated creatinine (indicative of kidney dysfunction), and proteinuria (indicative of kidney injury). (wikipedia.org)
  • Complications
  • Causes of intestinal failure may be clinically complex, and may result from a combination of nutritional, infectious, traumatic, and metabolic complications that affect ordinary anatomy and physiology. (wikipedia.org)
  • glomerular
  • In 1995, a group led by Mendley studied two siblings and determined that renal histopathologic (features that can be identified in the laboratory) and clinical features of a primarily glomerular disorder (a kidney disorder involving the glomeruli, or clusters of blood vessels that act as filters in the kidney) were features of the syndrome. (wikipedia.org)
  • pediatric
  • The purpose of this study is to generate information which will help to change the current practice of pediatric transplantation into one that is more individualized and preventative. (clinicaltrials.gov)
  • Nephrologists may provide care to people without kidney problems and may work in general/internal medicine, transplant medicine, immunosuppression management, intensive care medicine, clinical pharmacology, perioperative medicine, or pediatric nephrology. (wikipedia.org)
  • uncommon
  • Gastric antral vascular ectasia (GAVE) is an uncommon cause of chronic gastrointestinal bleeding or iron deficiency anemia. (wikipedia.org)
  • urine
  • Other symptoms include acute tubular necrosis, red blood cells in the urine, excess proteins in the urine, lower back pain, decreased or absent production of urine, elevated blood concentration of potassium, and acute kidney failure. (wikipedia.org)
  • collagen
  • Although much is known about the molecular background and mediators that prompt fibroblasts or transdifferentiated kidney cells to release collagen and matrix ( 4 - 6 ), the search for a unique event that initiates the process remains inconclusive. (diabetesjournals.org)