Transplantation human bone regeneration. Medical search. Frequent questions

Transplantation of ALDHhl mixed progenitor cells or culture- expanded multipotent stromal cells (MSC) into streptozotocin-treated NOD/SCID mice revealed endogenous islet regeneration occurred via distinct mechanisms. (uwo.ca)
Contrary to mixed-progenitor cells, transplantation of cultured MSC stably reduced hyperglycemia via an increase in islet number directly associated with the ductal epithelium without evidence of NGN3+ endocrine precursor activation. (uwo.ca)

These include molecular and cellular materials that tissue engineer the bone. (allenpress.com)
2 , 3 Bone engineering involves the delivery of cells or biologic molecules such as growth factors to a defect site for tissue regeneration. (allenpress.com)
It is often necessary to use a scaffold for transplanting these cells to enhance the regeneration of the affected tissue or organ. (allenpress.com)
This allows the regeneration of fat tissue in other parts of the body, using a patient's own extra fat tissue. (plasticsurgery.org)
Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. (mdpi.com)
Stem cells are regarded as the ideal resource for tissue regeneration, outside of formal organ transplantation. (empowher.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
In this work we report on therapeutic efficacy of CS from mouse ADSC transduced to express human vascular endothelial growth factor 165 a/a isoform (VEGF165), which showed potency to restore perfusion and protect tissue in a model of limb ischemia. (biomedcentral.com)
Delivery of ADSC by subcutaneous transplantation of CS is effective for stimulation of angiogenesis and tissue protection in limb ischemia with a potential for efficacy improvement by BV transduction to express VEGF165. (biomedcentral.com)
We have shown that when the chronically damaged liver is undergoing repair and regeneration the macropahges are important for reducing the scar tissue in the liver, stimulating the livers own stem cells to expand and multiply and finally help those stem cells turn into hepatocytes through the secretion of several factors. (ukri.org)
Critical to the hypothesis is the experimental fact that human endometrial-derived stem cells (hEnSCs) as multipotent accessible source of cells are known as useful cell candidates in the field of nerve tissue engineering. (scirp.org)
The human endometrial is a dynamic tissue, which undergoes cycles of growth and regression with each menstrual cycle. (scirp.org)
The gold standard for the treatment of bone defects is the use of autografts (patient's own tissue). (bartleby.com)
Therefore, an alternative method to autograft bone treatment is the use of allografts (tissue from another patient). (bartleby.com)
Specifically when developing a device to fix a medical bone issue, tissue engineering plays a crucial role. (bartleby.com)
We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)
We developed techniques to isolate mouse OMSCs derived from mandibles and verified their MSC characteristics by single colony formation, multi-lineage differentiation, and in vivo tissue regeneration. (ca.gov)
Many experts have investigated to apply MSCs as progenitors of osteoblasts for bone tissue executive. (bio-cavagnou.info)
SHED also express a unique tissue regeneration capability of forming dentin/pulp and bone/bone marrow constructions when subcutaneously transplanted into immunocompromised mice [10]. (bio-cavagnou.info)
Exfoliated deciduous teeth possess advantages of minimal invasiveness and easily accessible tissue source in comparison with other human cells such as bone marrow and adipose cells [10]. (bio-cavagnou.info)
Here we demonstrate that a branched poly[Lys(Ser(i)-DL-Ala(m))] polymer functionalized with cyclic arginyl-glycyl-aspartate, when immobilized by simple adsorption to tissue culture plastic, surgical titanium alloy (Ti6Al4V), or Bio-Oss(®) bovine bone substitute, significantly accelerates serum-free adhesion and enhances seeding efficiency of human adipose tissue-derived MSCs. (nih.gov)
Daley's research aims to identify mechanisms that underlie blood disorders and cancer, including how stem cells contribute to tissue regeneration and repair, and to improve drug therapies and transplantation for patients with malignant and genetic bone marrow disease. (northwestern.edu)
Clinical human comparison of expanded polytetrafluoroethylene barrier membrane and freeze-dried dura mater allografts for guided tissue regeneration of lost periodontal support. (thejcdp.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
Darcy's lab is focused on engineering lung tissue outside the body for the purpose of regeneration. (lu.se)
There, she focused on bone tissue engineering - specifically on how to physiological mineral deposition with manufacturing processes outside the body. (lu.se)
Creating artificial human lung scaffolds from computer models (left), to 3D bioprinting (center), Darcy's team created tubes and branches out of decellularized tissue. (lu.se)
Although some current treatment approaches offer high success rate in Endodontics, pulp regeneration may be an alternative to replace necrosed by healthy pulp tissue aiming at tooth revitalization 12 . (bvsalud.org)
Stem cell biology is an important study field to understand tissue regeneration and the implementation of regenerative medicine 11 . (bvsalud.org)

The limitations of these two approaches for the treatment of bone defects can be overcome by the use of synthetic bone scaffolds. (bartleby.com)
In this review, biomaterial scaffolds and cell-based therapies for IVD regeneration are briefly discussed. (bjbms.org)
Lidgren L., Tägil M., Kumar A. Biocomposite macroporous cryogels as potential carrier scaffolds for bone active agents augmenting bone regeneration. (lu.se)

The current study aimed to investigate the effect of mesenchymal stem cells (MSCs) transplantation as a new strategy for treatment of diabetes in Streptozotacin (STZ) induced diabetic male albino rats. (alliedacademies.org)
After six weeks of MSCs transplantation, the treated group showed a significant amelioration in these biochemical parameters. (alliedacademies.org)
In this study, we aimed to clarify whether combination therapy of intracerebral transplantation of human modified bone marrow-derived MSCs, SB623 cells, and voluntary exercise with running wheel (RW) could exert synergistic therapeutic effects on a rat model of ischemic stroke. (biomedcentral.com)
SB623 cells are human modified bone marrow-derived MSCs transiently transfected with the human Notch-1 intracellular domain. (biomedcentral.com)
Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
Activated T-lymphocytes impaired OMSCs via the Fas/Fas ligand pathway, as occur in long bone MSCs. (ca.gov)
Furthermore, we found that OMSCs are distinct from long bone MSCs with respect to regulating T-lymphocyte survival and proliferation. (ca.gov)
Seeding of bone implants with mesenchymal stem cells (MSCs) may promote osseointegration and bone regeneration. (nih.gov)
However, implant material surfaces, such as titanium or bovine bone mineral, fail to support rapid and efficient attachment of MSCs, especially under serum-free conditions that may be desirable when human applications or tightly controlled experiments are envisioned. (nih.gov)

The technology has entered the world of medicine through 3D printed devices like prosthetics and surgical instruments, and researchers are now testing out bio-ink as a way of printing vital organs, bones and cartilage. (medicaldevice-network.com)
Autologous chondrocytes implantation and osteochondral autograft transplantation are limited by scarce cartilage production, low proliferative capacity of chondrocytes, chondrocyte de-differentiation and complications due to donor site morbidity 5 . (nature.com)
Embryologic development and amalgamations of the complex array of bones and cartilage in the craniofacial region have revealed that the molecular mechanisms controlling skeletogenesis in the orofacial bones are quietly unique and different from in the axial and appendicular bones. (ca.gov)
GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)

Pilot studies suggest that intracoronary transplantation of progenitor cells derived from bone marrow (BMC) or circulating blood (CPC) may improve left ventricular function after acute myocardial infarction. (pharmaceuticalintelligence.com)

2010) Expansion of human bone marrow-derived mesenchymal stromal cells: serum-reduced medium is better than conventional medium. (ukaachen.de)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)

Several procedures have been proposed, including refixation of the detached fragment bone marrow stimulation, osteochondral autograft implantation, fresh osteochondral allograft transplantation, and cell-based or cell-free regenerative techniques. (unimi.it)
Nerve allograft transplantation for functional restoration of the upper extremity: case series. (medscape.com)

However, this technique comes with its limitations, as these structures can often have inappropriate mechanical integrity and don't allow the formation of new bone tissues. (medicaldevice-network.com)
Regenerative medicine is the science of using adipose-derived stem cells harvested from fat to regenerate cells and tissues in the human body. (plasticsurgery.org)
Regenerative medicine is the science of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal form and function. (plasticsurgery.org)
Adult stem cells exist in adult tissues throughout the body, such as bone marrow, brain, muscle and GI tract. (empowher.com)
The use of post-mortem human spinal cord samples for correlative investigations of lesion-induced changes in experimental animal tissues and in lesioned human tissues. (ukaachen.de)
The group also played a key role in halting clinical bone marrow transplantation towards regeneration in non-hematopoietic tissues. (ox.ac.uk)
Bones are dynamic tissues that undergo changes need to maintain bone and calcium homeostasis through a process called bone remodeling. (bartleby.com)
In obese humans, adipocyte-secreted CCL20 may contribute to the deposition of Compact disc4+ helper and Compact disc8+ cytotoxic T lymphocytes within adipose tissues, possibly via connections with CCR6 which was upregulated on T cells in obese adipose tissues (100). (exposed-skin-care.net)
We have developed new tools to explore VNN1 expression in human tissues and completed a first global analysis of VNN expression and function in tissues from patients. (univ-mrs.fr)

Cell therapy using adipose-derived stromal cells (ADSC) is an intensively developing approach to promote angiogenesis and regeneration. (biomedcentral.com)

To address this question we first developed human oligonucleotide microarrays with 30.000 elements and then performed large-scale expression profiling of long-term expanded MSC and MSC during differentiation into osteoblasts. (biomedcentral.com)
Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)
Therefore, it is not surprising to find that human OMSCs are distinct from BMMSCs in terms of differentiation traits and immunoregulation. (ca.gov)
Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation into muscles, bones, and cartilages. (elsevierpure.com)
One of the key objectives for bone regeneration therapy to be successful is to direct stem cells proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. (elsevierpure.com)
Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. (elsevierpure.com)
Adenoviral mediated overexpression of HOXB4 in human primitive hematopoietic cells in vitro generates very high levels of HOXB4 within 24 hours of transduction, leading to an increased differentiation towards myeloid lineages, and to a reduction of primitive hematopoietic progenitors, suggesting that the level of HOXB4 expression may determine the fate options following gene transfer. (dissertations.se)
Notable contributions from his laboratory have included the creation of customized stem cells to treat genetic immune deficiency, the differentiation of germ cells from embryonic stem cells, the generation of disease-specific pluripotent stem cells by directly reprogramming human fibroblasts, and demonstration of the role of the LIN28/let-7 pathway in cancer. (northwestern.edu)

Objective(s): Autologous bone transplantation known as the "gold standard" to reconstruction of osseous defects has known disadvantages. (virascience.com)
In collaboration with investigators in Taiwan, we implanted one type of autologous OMSCs (periodontal ligament progenitors, PDLPs) to treat an orofacial infectious bone defect disease periodontitis. (ca.gov)
This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)

Development of in vitro organotypic models to study aspects of neuronal degeneration and protection, axon regeneration and remyelination. (ukaachen.de)
An assessment of current techniques for inducing axon regeneration and neurological recovery following peripheral nerve trauma. (medscape.com)

2012) The role of microstructured and interconnected pore channels in a collagen-based nerve guide on axonal regeneration in peripheral nerves. (ukaachen.de)
Neuronal survival, axonal regeneration, and ultrastructural changes at ventral spinal cord were also investigated. (hindawi.com)
Regarding axonal regeneration, coaptation allowed recovery of greater number of myelinated fibers, with improved morphometric parameters. (hindawi.com)

Additional improvement of blood flow and angiogenesis was observed after transplantation of VEGF165-expressing CS indicating enhanced therapeutic potential of genetically modified constructs. (biomedcentral.com)
Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)
Bone marrow mesenchymal stem cells (BMSCs) have potential therapeutic benefits for the treatment of endometrial diseases and injury. (biologists.com)
Furthermore we assessed the therapeutic effectiveness of the recovered SHED from your cryopreserved deciduous dental care pulp cells on immune modulation and bone regeneration in SLE model-MRL/and bone defect model-immunocompromised mice. (bio-cavagnou.info)

Transplanted murine bone marrow (BM) progenitor cells stimulate endogenous beta cell proliferation and insulin production. (uwo.ca)
Transplantation of ALDHhl cells improved systemic hyperglycemia via increased islet vascularization and proliferation resulting in increased islet size, but not islet number. (uwo.ca)
Collectively, these findings indicate that correct expression levels of HOXB4 improve proliferative recruitment of HSC in settings demanding high proliferation, for example after bone marrow transplantation. (dissertations.se)
We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)

Bioprinting refers to 3D printers which deposit layers of biomaterial to build complex bodily structures like skin, bones and even corneas. (medicaldevice-network.com)
A team from Swansea University in the UK has developed a bioprinting process which can create an artificial bone matrix, using durable, regenerative biomaterial. (medicaldevice-network.com)
The bioprinted bones can be printed in the exact structure needed with a durable and regenerative biomaterial. (medicaldevice-network.com)

Of these materials, autogenous bone grafts remain the gold standard for bone regeneration. (allenpress.com)
Human and rabbit artificial corneal endothelial grafts were developed through the culture of human and rabbit corneal endothelial cells (CECs) on SF films. (arvojournals.org)
This method constitutes about 58% of the bone grafts used. (bartleby.com)
This method approximately contributes for 34% of the current bone grafts methods followed. (bartleby.com)

After 16 weeks, animals were sacrificed and defect areas evaluated for bone regeneration. (allenpress.com)
Furthermore SHED-Cryo-mediated cells engineering induced bone regeneration in essential calvarial bone-defect sites of immunocompromised mice. (bio-cavagnou.info)

3D bioprinting: Is this the future of organ transplantation? (medicaldevice-network.com)
Printing body parts may well be the next step in organ transplantation - harvesting stem cells from a transplant recipient and printing them into a replacement organ could help bypass complications associated with organ transplant such as long waits for a suitable donor or immune rejection of the new organ. (medicaldevice-network.com)
The only successful treatment for end stage liver disease is liver transplantation but this has several problems in addition to the risk from the operation itself: Organ supply is limited and patients unfortunately frequently succumb on the liver transplant waiting list before a suitable organ becomes available. (ukri.org)
The only curative option for end-stage cirrhosis is liver transplantation but donor organ availability cannot meet demand and many patients die waiting for a suitable organ. (ukri.org)

The pretreatment of osteoblastic cells with PDGF-BB before transplantation into osseous defects is investigated in the present study to further investigate the role of this growth factor in bone regeneration. (allenpress.com)

Therefore, this study evaluated neuroprotection and regeneration after neonatal peripheral nerve coaptation with fibrin sealant. (hindawi.com)

8 It stimulates DNA synthesis of rat calvarial cells and increases the production of osteopontin but decreases bone sialoprotein, osteocalcin, alkaline phosphatase activity, and mineralization in bone cells. (allenpress.com)

As of 2016[update], the only established medical therapy using stem cells is hematopoietic stem cell transplantation, first performed in 1958 by French oncologist Georges Mathé. (wikipedia.org)

This study suggests that combination therapy of intracerebral transplantation SB623 cells and voluntary exercise with RW achieves robust neurological recovery and synergistically promotes endogenous neurogenesis and angiogenesis after cerebral ischemia, possibly through a mechanism involving the up-regulation of BDNF and VEGF. (biomedcentral.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)

Enforced expression of HOXB4 dramatically increases the regeneration of murine HSC following transplantation, and enhances the repopulating ability of human SCID repopulating cells. (dissertations.se)

We have shown in mouse model of liver fibrosis that the injection of macrophages, grown in the lab from bone marrow, is able to reduce significantly the scarring and improve regeneration and liver function. (ukri.org)
We have tested these cells in models of liver injury and they also reduce fibrosis and increase liver regeneration. (ukri.org)
In rodent models of liver injury and fibrosis bone marrow derived macrophages (BMDMs) induced regression of scarring and stimulated liver regeneration. (ukri.org)
Perturbations of macrophage function and/or activation may result in impaired regeneration and fibrosis deposition as described in several chronic pathological diseases. (hindawi.com)

Further understanding of these endogenous angiogenic or putative neogenic programs activated by distinct human progenitor subsets may provide new approaches for combinatorial cellular therapies to treat diabetes. (uwo.ca)

Since 1998 however, it has been possible to culture and differentiate human embryonic stem cells (in stem-cell lines). (wikipedia.org)
By 1998, human embryonic stem cells were first isolated by American biologist James Thomson, which made it possible to have new transplantation methods or various cell types for testing new treatments. (wikipedia.org)
In this study we asked if human MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if cultivation conditions exert any influence on their stem cell maintenance. (biomedcentral.com)
In conclusion: treatment with MSC.s transplantation as a cell-therapy could restore pancreatic β-cell function and improved liver and kidney functions in diabetes as a new strategy for diabetes treatment. (alliedacademies.org)
Mesenchymal stromal cell (MSC) transplantation therapy is a promising therapy for stroke patients. (biomedcentral.com)
Cell transplantation therapy has emerged as a potential candidate treatment for ischemic stroke. (biomedcentral.com)
2013) Conditioned medium from bone marrow-derived mesenchymal stem cells improves recovery after spinal cord injury in rats: an original strategy to avoid cell transplantation. (ukaachen.de)
2010) Cell-cell interactions of human neural progenitor-derived astrocytes within a microstructured 3D-scaffold. (ukaachen.de)
His laboratory identified the tumour-initiating stem cell in myelodysplastic syndromes (MDS), the first studies establishing the identity of human cancer stem cells through mutational fate mapping. (ox.ac.uk)
The effects of cell transplantation in patients with healed myocardial infarction are unknown. (pharmaceuticalintelligence.com)
Osteoblasts are the main bone forming cells that originate from mesenchymal stem cell lineage. (bartleby.com)
Cell Transplantation, 22 (12). (pitt.edu)
Recently cryopreservation of human being cells and cells is definitely amenable to be a reliable and feasible approach for stem cell storage [14]. (bio-cavagnou.info)
In recent years, our knowledge of human physiology and cell biology has increased exponentially. (bjbms.org)

reported that both visceral and subcutaneous adipocytes from obese human beings and mice portrayed all MHCII elements necessary for antigen display and increased degrees of Compact disc80 and Compact disc86, and could work as APCs therefore. (exposed-skin-care.net)

The restorative effectiveness of SHED-Cryo transplantation on immune and skeletal Berbamine hydrochloride disorders was related to that of SHED-Fresh. (bio-cavagnou.info)
Clinical evidences support the effectiveness of MSC-based skeletal cells regeneration [2] [3]. (bio-cavagnou.info)

Cells used in bone engineering are the osteoblasts, osteoprogenitor cells, periosteal cells, and stem cells. (allenpress.com)
Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
Osteoblasts produce bone matrix which they later mineralized to form bone. (bartleby.com)
During the process of bone formation, matured osteoblasts usually get trapped in the bone matrix and become osteocytes. (bartleby.com)

Various materials have been used to promote bone regeneration around dental implants, including autografts, allografts, xenografts, and alloplasts. (allenpress.com)

SHED implantation govern bone restoration in critical-sized bone problems in mouse calvarias [11] and swine mandible [12]. (bio-cavagnou.info)

Systemic SHED-Cryo-transplantation improved SLE-like disorders including short lifespan elevated autoantibody levels and nephritis-like renal dysfunction. (bio-cavagnou.info)

However, the scarce locations available for autogenous bone harvesting as well as donor site morbidity require the search for other alternatives. (allenpress.com)
On the otherhand, it also has drawbacks including limited supply, need for additional surgery for bone extraction and donor site morbidity. (bartleby.com)

To enrich for analogous human progenitor cells, we purified human umbilical cord blood (UCB) and BM based on high aldehyde dehydrogenase activity (ALDHhl), a conserved function in multiple progenitor lineages. (uwo.ca)

Overall, the present data suggest that acute repair of neonatal peripheral nerves with fibrin sealant results in neuroprotection and regeneration of motor and sensory axons. (hindawi.com)

The ability of osteoprogenitor cells to regenerate bone was significantly reduced upon pretreatment with PDGF-BB in vitro. (allenpress.com)

The first therapy using stem cells was a bone marrow transplant performed by French oncologist Georges Mathé in 1958 on five workers at the Vinča Nuclear Institute in Yugoslavia who had been affected by a criticality accident. (wikipedia.org)
Human being exfoliated deciduous teeth have been considered to be a promising resource for regenerative therapy because they contain unique postnatal stem cells from human being exfoliated deciduous teeth (SHED) with self-renewal capacity multipotency and immunomodulatory function. (bio-cavagnou.info)
Treatment of intraosseous periodontal defects with a combined adjunctive therapy of citric acid conditioning, bone grafting, and placement of collagenous membranes. (thejcdp.com)

We illustrated for the first time in a human model the three main stages of osteogenic development, and we could show the diverse regulation of the SMAD pathways by TGF-β2 and BMPs. (biomedcentral.com)

This study was designed to explore the effects of hydroxy-apatite/tricalcium-phosphate (HA/TCP) and platelet-rich plasma (PRP) on the osteogenesis ability of human adipose-derived mesenchymal stem cells (hAdMSCs) in vitro and in vivo. (virascience.com)

Importantly, exogenous treatment with neurotrophins transiently rescues a significant number of neurons, leading to the possibility of axonal regrowth and regeneration [ 19 , 20 ]. (hindawi.com)
Based on these observations, the dopamine neu- from dopamine neurons implanted into the brain pa- rons used for transplantation in these experiments renchyma with the goal of reinnervating the dener- were neuroblasts obtained from mid-trimester rat vated striatum.8,9 Rats with unilateral, 6-hydroxydo- fetuses. (lu.se)

Chaudhry V, Cornblath DR. Wallerian degeneration in human nerves: serial electrophysiological studies. (medscape.com)

Materials and Methods Ethics Statement Methods using human samples (exfoliated deciduous teeth and peripheral blood) were carried out in Berbamine hydrochloride accordance with the Declaration of Helsinki and authorized by the Kyushu University or college Institutional Review Table for Human being Genome/Gene Study (Protocol Quantity: 393-01). (bio-cavagnou.info)

however, we hypothesize that the VSM can be used to deliver osteoblastic progenitors into bone defects. (allenpress.com)

Adult stem cells are found in a few select locations in the body, known as niches, such as those in the bone marrow or gonads. (wikipedia.org)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)

McCulloch and Till began a series of experiments in which bone marrow cells were injected into irradiated mice. (wikipedia.org)
They observed lumps in the spleens of the mice that were linearly proportional to the number of bone marrow cells injected. (wikipedia.org)
SHED-Cryo-transplantation was also able to recover osteoporosis bone reduction in long bones of MRL/mice. (bio-cavagnou.info)

Other problems with transplantation are that immunosuppression increases the risk of renal failure, cancer and severe infections. (ukri.org)

Recent discovery has evaluated that fresh dental care pulp cells of human being exfoliated deciduous teeth preserve MSC human population termed SHED [10]. (bio-cavagnou.info)
The ideal result expected for these situations would be a pulp regeneration capable of promoting the normal root development of the tooth 12 . (bvsalud.org)
Case reports in the literature show convincingly that immature permanent teeth with pulp necrosis and apical periodontitis and/or abscess may undergo apexogenesis, revascularization or regeneration. (bvsalud.org)
This study aimed to review the current literature on pulp regeneration for immature teeth with periapical lesion. (bvsalud.org)

Human freeze-dried dura mater allografts as a periodontal biologi cal bandage. (thejcdp.com)

Anatomy37

Organisms16

Diseases26

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment74

Phenomena and Processes36

Disciplines and Occupations2

Technology, Industry, Agriculture20

Information Science1

Named Groups2

Health Care8

Mixed-progenitor cells2

Tissue30

Scaffolds3

MSCs9

Cartilage4

Derived from bone marrow1

Mesenchymal stromal cells2

Allograft transplantation2

Tissues9

Stromal cells1

Differentiation8

Autologous4

Axon regeneration2

Axonal regeneration3

Therapeutic4

Proliferation4

Biomaterial3

Grafts4

Defect2

Organ4

Osseous defects1

Nerve1

Calvarial1

Hematopoietic1

Angiogenesis2

Murine1

Fibrosis4

Therapies1

Cell14

Subcutaneous1

Skeletal2

Osteoblasts4

Xenografts1

Implantation1

Systemic1

Donor site morbidity2

Umbilical cord1

Peripheral nerves1

Regenerate1

Therapy3

Osteogenic1

Adipose-derived1

Neurons2

Degeneration1

Methods1

Progenitors1

Adult2

Mice3

Increases1

Pulp4

Allografts1