Transplantation bone diseases developmental. Medical search. Frequent questions

Disorders in which intracellular material that cannot be metabolized is stored in lysosomes are called lysosomal storage diseases. (nih.gov)
Like other genetic disorders, individuals inherit lysosomal storage diseases from their parents. (wikipedia.org)
Lysosomal storage diseases affect mostly children and they often die at a young age, many within a few months or years of birth. (wikipedia.org)
Alternatively to the protein targets, lysosomal storage diseases may be classified by the type of protein that is deficient and is causing buildup. (wikipedia.org)
Some people with lysosomal storage diseases have enlarged livers or spleens, pulmonary and cardiac problems, and bones that grow abnormally. (wikipedia.org)
citation needed] No cures for lysosomal storage diseases are known, and treatment is mostly symptomatic, although bone marrow transplantation and enzyme replacement therapy (ERT) have been tried with some success. (wikipedia.org)
Metachromatic leukodystrophy (MLD) is part of a larger group of lysosomal storage diseases, some of which are progressive, inherited, and neurodegenerative disorders (metachromatic leukodystrophy included). (medscape.com)
The mouse model chosen falls in a class of genetic diseases that afflicts 1 in 5000 patients, typically children (called lysosomal storage diseases, described in more detail below), but which is often used to model an array of adult neurodegenerative diseases such as Parkinson's, ALS, Alzheimer's - particularly those with a genetic component. (sciencedaily.com)

In addition to providing microenvironmental support for hematopoietic processes, BM-MSCs can differentiate into various mesodermal lineages including osteoblast/osteocyte, chondrocyte, and adipocyte that are crucial for bone metabolism. (ijbs.com)
The only curative therapy is hematopoietic stem cell transplantation. (frontiersin.org)
Edward Donnall Thomas, an American physician and scientist, gained recognition in the scientific community for conducting the first bone marrow transplant, a pioneering form of hematopoietic stem cell transplantation (HSCT). (asu.edu)
Bone marrow transplants are considered to be the first successful example of tissue engineering, a field within regenerative medicine that uses hematopoietic stem cells (HSCs) as a vehicle for treatment. (asu.edu)

The graft failure after living-donor pediatric transplantation was better at 0.8% at 6 months and 1.6% at 1 year for transplants in 2018-2019, 2.7% at 3 years for transplants in 2016-2017, 8.2% at 5 years for transplants in 2014-2015, and 21.7% at 10 years for transplants in 2010-2011. (medscape.com)

Bio Ashley Styczynski, MD, MPH, is an Adjunct Clinical Assistant Professor in the Division of Infectious Diseases & Geographic Medicine and Global Health Faculty Fellow, and a Medical Officer in the International Infection and Control Program at the Centers for Disease Control and Prevention (CDC). (stanford.edu)
Antiviral chemoprophylaxis is recommended for the prevention of influenza virus infection as an adjunct to vaccination in certain individuals, especially exposed children who are at high risk for To cite: AAP Committee on Infectious Diseases. (cdc.gov)

My academic training and research experience have provided me with an excellent background in multiple biological disciplines including developmental biology, gerontology, immunology, and pre-clinic research. (stanford.edu)

Overall, this work highlights the age-related changes in cranial stem cell niches, which deepens the current understanding of cranial bone and suture biology and may provide therapeutic targets for antiaging and regenerative medicine. (bvsalud.org)
Micha Drukker, professor of Stem Cells, Developmental Biology and Technology for Innovative Drug Research, is convinced that the use of stem cells will make this possible. (universiteitleiden.nl)
To determine whether stem cell biology might play a role in benefiting degenerative diseases, the investigators first chose to approach, as proof-of-concept, a mouse model of a representative lethal neurodegenerative disease. (sciencedaily.com)

For example, in familial hypercholesterolemia, enzymes do not receive the signals that typically inhibit cholesterol synthesis, so that excessive production of cholesterol occurs, leading to early coronary vascular disease and strokes in patients. (newworldencyclopedia.org)
Learn more at Be the Match , a leading bone marrow transplantation program that helps patients find life-saving donors and provides support throughout the transplant process. (cdc.gov)
In general, young patients have the most rapidly progressive disease, whereas patients with adult onset experience a more chronic and insidious progression of disease. (medscape.com)
Patients with the late infantile form are usually aged 4 years or younger and typically present initially with gait disturbances, loss of motor developmental milestones, optic atrophy, and diminished deep tendon reflexes. (medscape.com)
Does Transplantation Induce Aging In Patients? (medicaldaily.com)
Other experimental cell therapies are developmental for these diseases and patients should only be treated on clinical trials. (ox.ac.uk)
The recommendations for vaccinating HCP are presented by disease in two categories: 1) those diseases for which vaccination or documentation of immunity is recommended because of risks to HCP in their work settings for acquiring disease or transmitting to patients and 2) those for which vaccination might be indicated in certain circumstances. (cdc.gov)
Patients with mild liver disease (Child-Pugh-Turcotte (CPT), Class A) may be treated with the normal recommended dose of [HA562 trade name] (see sections 4.3, 4.4 and 5.2). (who.int)
With few exceptions, stem cell transplantation is usually reserved for patients with aggressive lymphomas after incomplete remission or relapse. (msdmanuals.com)

Ethical dilemma: ELX/TEZ/IVA or Lung Transplantation in Cystic Fibrosis and End Stage Lung Disease? (cdc.gov)

Purine nucleoside phosphorylase (PNP) deficiency (OMIM 613179) is a rare autosomal recessive metabolic disease leading to combined immunodeficiency and neurological abnormalities, which may include developmental delay, hypotonia, and spasticity ( 1 , 2 ). (frontiersin.org)

Over time, excessive storage of fats can cause permanent cellular and tissue damage, particularly in the brain, peripheral nervous system (the nerves from the spinal cord to the rest of the body), liver, spleen, and bone marrow. (nih.gov)
Niemann-Pick disease is a group of autosomal recessive disorders caused by an accumulation of fat and cholesterol in cells of the liver, spleen, bone marrow, lungs, and, in some instances, brain. (nih.gov)
Given the number of metabolic disorders and the range of systems affected, these disorders are manifested in a wide array of symptoms of varying severity, ranging from recurrent vomiting, lethargy, and muscle weakness, to liver and heart failure, developmental delay, and mental retardation. (newworldencyclopedia.org)
Niemann-Pick disease refers to a group of diseases passed down through families (inherited) in which fatty substances called lipids collect in the cells of the spleen, liver, and brain. (wikidoc.org)
Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the spleen, the liver, and the gastrointestinal tract. (msdmanuals.com)
Hodgkin Lymphoma Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)

Therapies may include a restrictive diet, dietary supplements, and toxin-removal procedures, as well as enzyme replacement, gene transfer, or organ transplantation. (newworldencyclopedia.org)
The major focus is on autologous HSCT (aHSCT), used in MS for over two decades and currently the fastest growing indication for this treatment in Europe, with increasing evidence to support its use in highly active relapsing remitting MS failing to respond to disease modifying therapies. (ox.ac.uk)
These findings suggest that markers of inflammation could serve as prognostic indicators and potentially lead to immune-based therapies to prevent developmental delays in at-risk children. (cdc.gov)

Lipid storage diseases (also known as lipidoses) are a group of inherited metabolic disorders in which harmful amounts of fatty materials (lipids) accumulate in various cells and tissues in the body. (nih.gov)
Most of these disorders are autosomal recessively inherited such as Niemann-Pick disease, type C, but a few are X-linked recessively inherited, such as Fabry disease and Hunter syndrome (MPS II). (wikipedia.org)
citation needed] Tay-Sachs disease was the first of these disorders to be described, in 1881, followed by Gaucher disease in 1882. (wikipedia.org)
Dr. Saral's major accomplishments include being the first physician to use bone marrow transplantation in the treatment of AIDS-related malignancies and among the first to use it in the treatment of sickle cell anemia and other inherited blood disorders. (emory.edu)
The polycystic kidney diseases are a group of genetically heterogeneous disorders and a leading cause of kidney failure. (basicmedicalkey.com)
Bloom's Syndrome is on the panel of disorders the Jewish Genetic Disease Consortium recognizes and recommends testing for. (forward.com)

Gaucher disease is caused by a deficiency of the enzyme glucocerebrosidase. (nih.gov)
Ambroxol has recently been shown to increase activity of the lysosomal enzyme glucocerebrosidase, so it may be a useful therapeutic agent for both Gaucher disease and Parkinson's disease. (wikipedia.org)
Niemann-Pick disease Type A and B occur when cells in the body lack an enzyme called acid sphingomyelinase (ASM). (wikidoc.org)
The mouse used here has mutation in a gene that makes the housekeeping enzyme hexosaminidase ("hex") deficient and, therefore, has Sandhoff's Disease, a lethal genetic disease related to Tay-Sachs Disease. (sciencedaily.com)

In addition, umbilical cord blood transplantation is being performed at specialized centers for a number of these diseases. (wikipedia.org)

Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE). (ox.ac.uk)
These updated EBMT guidelines review the clinical evidence, registry activity and mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple sclerosis (MS) and other immune-mediated neurological diseases and provide recommendations for patient selection, transplant technique, follow-up and future development. (ox.ac.uk)
aHSCT may have a potential role in the treatment of the progressive forms of MS with a significant inflammatory component and other immune-mediated neurological diseases, including chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, myasthenia gravis and stiff person syndrome. (ox.ac.uk)

The Barbara Bush Children's Hospital and MMP Specialty Care Genetics provide expert evaluation, diagnosis and treatment services to newborns, children and young adults with a known or suspected inherited disease. (mainehealth.org)
Detailed information on blood tests used to diagnosis heart disease. (chkd.org)
Disease is likely to be disseminated at the time of presentation, and diagnosis is usually based on lymph node or bone marrow biopsy or both. (msdmanuals.com)

In the autosomal dominant form, mutations in the RNA component of telomerase ( TERC ) or telomerase reverse transcriptase ( TERT ) are responsible for disease phenotype. (medscape.com)

Consequently, kidney transplantation has become the primary method of treating ESKD in the pediatric population, with 1-year all-cause mortality rates significantly lower than with either form of dialysis. (medscape.com)
In 2020, 715 pediatric kidney transplantations were performed, but a lack of donor kidneys saw the prevalent pediatric transplant waitlist reach 2637 by the end of the year 2020. (medscape.com)
The autosomal recessive form of polycystic kidney disease (ARPKD) is rarer but affects the pediatric population. (basicmedicalkey.com)
It is too early to say how effective the stem cell transplantation will be, but we are encouraged by how well she and her mother have tolerated the treatment," said Tippi MacKenzie, MD, a pediatric and fetal surgeon at UCSF Benioff Children's Hospital San Francisco, who performed the pioneering transplant after decades of research. (technologynetworks.com)

The use of olfactory progenitors as a cell-based therapy for Parkinson's disease (PD) would allow harvest without invasive surgery, provide an autologous cell population, eliminate need for immunosuppression and avoid the ethical concerns associated with embryonic tissues. (scirp.org)

For people who have weakened immune systems, especially people who have had an organ, stem cell or bone marrow transplant, CMV infection can be fatal. (mayoclinic.org)
People who have weakened immune systems, such as those who have had an organ, bone marrow or stem cell transplant, or those who are infected with HIV. (mayoclinic.org)

However, aspirating bone marrow is an invasive procedure. (biomedcentral.com)

Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stromal cells that have a critical role in the maintenance of skeletal tissues such as bone, cartilage, and the fat in bone marrow. (ijbs.com)
The bone tissue undergoes constant turnover, which relies on skeletal stem cells (SSCs) and/or mesenchymal stem cells (MSCs) and their niches. (bvsalud.org)
Bone marrow mesenchymal stem cells (MSCs) could be effective in the treatment of several autoimmune diseases. (biomedcentral.com)

This project combines work of two independent investigators working to understand epigenetic mechanisms of developmental programming. (bcm.edu)
The inherent cell-type specificity of epigenetic regulation motivates development of techniques to isolate and study specific cell types of relevance to obesity and digestive diseases. (bcm.edu)

Centers for Disease Control and Prevention. (cdc.gov)
Suggested citation: Centers for Disease Control and Prevention. (cdc.gov)
We congratulate the Centers for Disease Control in its efforts to update this guide and wish it the same success as the previous edition. (cdc.gov)

Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. (medscape.com)

As a postdoctoral fellow at Stanford University, I joined the lab of Dr. Robert Negrin, a renowned leader in the bone marrow transplantation (BMT)/GVHD field, to explore immunotolerance-related issues such as graft-versus-host disease and blood malignancies. (stanford.edu)

Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Human pluripotent stem cells harbor the potential to provide an inexhaustible supply of donor cells or tissues or organs for transplantation," Wu wrote in an email. (the-scientist.com)
Among the recent advances in the treatment of human disease in the modern era, few have been perceived to hold as much promise as stem cells and regenerative medicine for a wide variety of conditions. (iitk.ac.in)
Human embryonic stem cells (hESCs) can treat degenerative diseases safely and effectively, and do so by invoking multiple mechanisms. (sciencedaily.com)
Human embryonic stem cells (hESCs) hold great promise for benefiting degenerative diseases, and do so by invoking multiple mechanisms. (sciencedaily.com)
Next, they used mouse neural stem cells (NSCs), a type of "adult" stem cell, to establish the parameters of what might or might not be achievable in this disease. (sciencedaily.com)
The results, described in more detail below, in fact prove to be the first successful use of human embryonic stem cells in treating a degenerative disease, significantly preserving function and extending life. (sciencedaily.com)
The researchers discovered that their implanted neural stem cells, which migrated and integrated extensively throughout the brain, did much more than replace brain tissue destroyed by the disease. (sciencedaily.com)
In fact, our study offers the first evidence that stem cells employ multiple mechanisms -- not just cell replacement - which collaborate to benefit disease. (sciencedaily.com)
These findings also raise the possibility - somewhat counter-intuitively -- that stem cells may inherently exert an anti-inflammatory influence in degenerative diseases," said Snyder. (sciencedaily.com)

the former causes Merkel cell carcinoma, a rare but aggressive skin cancer ( 3 ), and the latter is associated with trichodysplasia spinulosa, a rare skin disease seen in transplant recipients ( 2 ). (cdc.gov)
The specific treatment for your child's cancer will be determined by your child's healthcare provider, based on a variety of factors, including the type of cancer and the extent of the disease. (chkd.org)
There are about 20 "Ashkenazic diseases," not counting the higher rates of at least four cancer-related genes. (forward.com)

In alpha thalassemia major, progressive anemia and heart failure develop before birth causing developmental impairment if treatment is delayed. (technologynetworks.com)

It is characterized by slowly progressive yet milder neurologic symptoms compared to type 2 Gaucher disease. (nih.gov)
What are the symptoms of Niemann-Pick disease? (wikidoc.org)
Symptoms and disease progression of all forms of Niemann-Pick vary from person to person. (wikidoc.org)
Other, more common, diseases may cause symptoms similar to Niemann-Pick. (wikidoc.org)
A person in the early stages of the disease may show only a few symptoms. (wikidoc.org)
While arthroscopy with or without core decompression is the standard of care for unresolved cases of avascular necrosis of the talus, we present a case of avascular necrosis of the talar dome where symptoms resolved satisfactorily with direct bone marrow injections into structures into and around the ankle. (caringmedical.com)

It is a rare, progressive bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation, nail dystrophy, and oral leukoplakia. (medscape.com)
Homozygous autosomal recessive mutations in RTEL1 lead to similar phenotypes that parallel with Hoyeraal-Hreidarsson (HH) syndrome, a severe variant of DKC characterized by cerebellar hypoplasia, bone marrow failure, intrauterine growth restriction and immunodeficiency. (medscape.com)
Treating inherited bone marrow failure syndromes and primary immunodeficiency diseases]. (cdc.gov)

The disease is first clinically evident when, at 3 to 6 months old, a child fails to achieve developmental milestones. (forward.com)

The autosomal dominant form of polycystic kidney disease (ADPKD) is the most common life-threatening monogenic disease, affecting 12 million people worldwide. (basicmedicalkey.com)
Topology of autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) proteins polycystin-1, polycystin-2, and fibrocystin/polyductin (FPC) are shown. (basicmedicalkey.com)

Neurobiology of Disease, 27, 133-140. (scirp.org)

Treatment for genetic disease is highly individualized. (mainehealth.org)
It has been a perpetual goal of mankind to master the understanding of how diseases occur and arrive at better treatment strategies based on the understanding. (iitk.ac.in)
In this pursuit, a more recent development has been the strategy of harnessing the fundamental building block of the human body, the human "cell", for the treatment of disease conditions. (iitk.ac.in)
This strategy, commonly known as 'cell therapy' has opened up multiple gates (so to say) for enabling improved treatment of diseases (eg. (iitk.ac.in)
β-islet cell transplantation for the treatment of diabetes). (iitk.ac.in)
The experimental treatment also dampened the inflammation that typically occurs in the brains of most degenerative diseases, including Sandhoff's, and likely contributes to disease progression. (sciencedaily.com)
Dr. Saral headed the National Institutes of Health Bone Marrow Transplant Study Section to determine appropriate use of bone marrow transplantation in the treatment of human disease. (emory.edu)
Treatment includes lifelong blood transfusions starting in the second trimester, followed by further transfusions after birth, or a bone-marrow transplant with a matched donor in childhood. (technologynetworks.com)
Hornykiewicz, O. (1973) Parkinson's disease: From brain homogenate to treatment. (scirp.org)
At present, stem cell therapy is being evaluated as a possible treatment for Canavan disease. (forward.com)
When drug treatment fails, surgery must be done as soon as possible as the instability of the disease in infants is extremely dangerous and difficult to manage. (forward.com)

WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. (cdc.gov)
Type 2 (acute infantile neuropathic Gaucher disease) typically begins within three months of birth. (nih.gov)
Late onset of a metabolic disease is often triggered by acute metabolic stresses, such as infection, fasting, or consumption of a nutrient for which a metabolic intolerance exists. (newworldencyclopedia.org)
She was diagnosed with acute chest syndrome, a common complication of sickle cell disease that can result in lung injury, trouble breathing, low oxygen to the rest of the body and, possibly death. (cdc.gov)
The Acute Myeloid Leukemia market is expected to strengthen as awareness of the disease increases and more effective interventions are being developed. (delveinsight.com)

A complete understanding of the types of cells and tissues in which the virus replicates is critical for identifying potential diseases with which it may be associated. (cdc.gov)
This can range from the relatively pedestrian, such as a person who received a bone marrow transplant, to creatures that seem more at home in science fiction, such as animals containing cells or tissues belonging to other species. (the-scientist.com)
Since all disease conditions involve a large collection of cells or 'tissues' being adversely affected, it became a natural goal to try and find ways to either replace or replenish these diseased tissues with healthy and functional tissue so as to restore normalcy to the concerned tissue and as a consequence to the individual. (iitk.ac.in)
Since the implications of the field of 'tissue engineering' are largely in medicine the field has gradually begun to include aspects such as transplantation medicine, radiology (imaging especially non-invasive imaging of tissues), general surgery and other specialized medical disciplines that have to do with a specific disease condition (eg. (iitk.ac.in)

In children and adolescents younger than 18 years, the adjusted incidence of end-stage kidney disease (ESKD) in the United States in 2020 was 11 cases per million population, down slightly from 13 cases per million population in 2010. (medscape.com)

Potential disease mechanisms due to cilium-mediated signaling events. (basicmedicalkey.com)

Chronic cadmium exposure primarily affects the kidneys and secondarily the bones. (cdc.gov)

Some severe diseases, such as many of the lipid storage diseases, currently have no effective therapy. (newworldencyclopedia.org)

A metabolic disorder is any disease or disorder that negatively affects the biochemical reactions through which individual animal cells process nutrient molecules (such as the components of carbohydrates , proteins , and fats ) to yield energy or perform the functions necessary to sustain life (such as building complex molecules and creating cellular structure). (newworldencyclopedia.org)
However, for specific disease, an enormous progress is possible by growing cells or cluster of cells, which can then be injected or placed in the body during an operation. (universiteitleiden.nl)
We think that the developmental cues that exist in the pig will help to guide the human cells inside the porcine embryo. (the-scientist.com)
Bone marrow suppression is when fewer blood cells are made in the marrow. (chkd.org)

The patient presented at 14 months of age following recurrent infections, from early infancy, with persistent irritability, developmental delay, and hypotonia. (frontiersin.org)
Type C usually affects school-aged children, but the disease may occur any time between early infancy to adulthood. (wikidoc.org)

Many remain small to adulthood and are at an increased risk for developing metabolic diseases such as obesity and type 2 diabetes. (bcm.edu)

In persons with autosomal dominant DKC and in terc-/- knockout mice, genetic anticipation (ie, increasing severity and/or earlier disease presentation with each successive generation) has been reported. (medscape.com)
Purine nucleoside phosphorylase (PNP) deficiency, a rare autosomal recessive metabolic disease causes combined immunodeficiency and developmental delay, hypotonia, and spasticity. (frontiersin.org)

European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE) None. (ox.ac.uk)
Prior to Thomas's groundbreaking work, most blood-borne diseases, including certain inherited and autoimmune diseases, were considered lethal. (asu.edu)
Rheumatoid arthritis (RA) is a T-cell-mediated systemic autoimmune disease, characterized by synovium inflammation and articular destruction. (biomedcentral.com)

The Forward presents this section to provide information on some of the more serious Jewish genetic diseases. (forward.com)

The infant was born at UCSF Benioff Children's Hospital San Francisco in February, four months after undergoing the transplant to treat a lethal form of thalassemia, a disease caused by a gene carried by nearly 5 percent of the world's population. (technologynetworks.com)
Callaway, E. (2011) Gene therapy offers hope for Parkinson's disease. (scirp.org)

Aaron is also a motivational speaker who inspires audiences with her story of being the first successful nonmatched bone marrow transplant for sickle cell disease. (cdc.gov)
Aaron was first diagnosed with sickle cell disease as an infant. (cdc.gov)
At the time, her parents were not aware of anyone else in her family who had sickle cell disease. (cdc.gov)
Her parents were frightened when Aaron was diagnosed because they didn't know much about sickle cell disease and were afraid they wouldn't know how to take care of her properly. (cdc.gov)
Having sickle cell disease nearly killed Aaron. (cdc.gov)
The only known cure for sickle cell disease is a bone marrow transplant, and the procedure was still considered experimental. (cdc.gov)
Her sickle cell disease was cured. (cdc.gov)
Attending Camp New Hope, a summer camp for kids with sickle cell disease, helped Aaron make friends and realize that she was not alone. (cdc.gov)
There are thousands of people with sickle cell disease in the world, and a couple out there just like me," she said. (cdc.gov)

Cat scratch disease is a bacterial infection carried in cat saliva. (chkd.org)

Anderson, L. and Caldwell, M.A. (2007) Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease. (scirp.org)
De Lau, L.M. and Breteler, M.M. (2006) Epidemiology of Parkinson's disease. (scirp.org)
Lang, A.E. and Lozano, A.M. (1998) Parkinson's disease. (scirp.org)

The best bone marrow transplant outcomes happen when a patient's human leukocyte antigen (HLA) and that of a donor closely match. (cdc.gov)
We tested for the ability of febrile illness and elevated cytokine levels to predict developmental outcomes, independent of known predictors of stunting, family income, and maternal education. (cdc.gov)

The swelling, which included an enlarged heart, was the result of the body's response to severe anemia and lack of oxygen, which is the hallmark of alpha thalassemia major, the most dangerous variant of the disease. (technologynetworks.com)

SSCs/MSCs and their perivascular niche within the bone marrow are well characterized in long bones. (bvsalud.org)
As for cranial bones, besides bone marrow, the suture mesenchyme has been identified as a unique niche for SSCs/MSCs of craniofacial bones. (bvsalud.org)
As of yet, the most common source of MSCs has been bone marrow. (biomedcentral.com)

Anatomy27

Organisms8

Diseases72

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment69

Phenomena and Processes22

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science2

Named Groups2

Health Care17

Lysosomal storage8

Hematopoietic4

Living-donor1

Infectious Diseases2

Immunology1

Biology3

Patients9

Cystic Fibrosis1

Include developmental delay1

Liver6

Therapies3

Disorders6

Enzyme4

Umbilical1

Neurological3

Diagnosis3

Phenotype1

Pediatric4

Autologous1

Organ2

Aspirating bone marrow1

Mesenchymal stem3

Epigenetic2

Centers3

Complications1

GVHD1

Stem cells10

Cancer3

Impairment1

Symptoms6

Marrow failure3

Milestones1

Polycystic kidney2

Neurobiology1

Treatment11

Acute5

Tissues4

20201

Mechanisms1

Kidneys1

Lipid1

Cells4

Early infancy2

Diabetes1

Autosomal2

Autoimmune3

Genetic diseases1

Gene2

Sickle Cell Di9

Infection1

Parkinson's Disease3

Outcomes2

Severe1

MSCs3