Mice, KnockoutCystic Fibrosis Transmembrane Conductance RegulatorMolecular Sequence DataAmino Acid SequenceMembrane ProteinsGene Knockout TechniquesCell MembraneProtein Structure, TertiaryProtein Structure, SecondaryMutationMice, Inbred C57BLCell LineModels, MolecularBase SequenceSequence Homology, Amino AcidMutagenesis, Site-DirectedRecombinant Fusion ProteinsSignal TransductionProtein ConformationProtein BindingCloning, MolecularTransfectionBinding SitesMembrane GlycoproteinsProtein TransportCOS CellsBiological TransportCells, CulturedRecombinant ProteinsMembrane Transport ProteinsCysteineSequence AlignmentCricetinaeEndoplasmic ReticulumLipid BilayersAmino Acid SubstitutionDNA, ComplementaryMembrane PotentialsRNA, MessengerCarrier ProteinsCytoplasmCystic FibrosisModels, BiologicalStructure-Activity RelationshipGene DeletionCHO CellsPhenotypeKineticsMutagenesisDimerizationLigandsAmino Acid MotifsReceptors, Cell SurfaceBacterial ProteinsEscherichia coliDNA PrimersBlotting, WesternIon Channel GatingGene ExpressionChloridesNerve Tissue ProteinsPeptidesDisease Models, AnimalCercopithecus aethiopsGene Expression RegulationMice, TransgenicEscherichia coli ProteinsXenopus laevisIntracellular MembranesGlycosylationChloride ChannelsHydrophobic and Hydrophilic InteractionsReceptors, G-Protein-CoupledHEK293 CellsOocytesMesylatesSequence DeletionPhosphorylationIon ChannelsHydrogen-Ion ConcentrationGene TargetingIon TransportProtein MultimerizationPoint MutationTime FactorsCalciumProtein FoldingProtein SubunitsProtein Sorting SignalsPeptide FragmentsReverse Transcriptase Polymerase Chain ReactionConserved SequenceProtein IsoformsProtein Processing, Post-TranslationalPatch-Clamp TechniquesMicroscopy, FluorescenceImmunohistochemistryAdenosine TriphosphateXenopusATP-Binding Cassette Transporters