• CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. (wikipedia.org)
  • It binds sialic acids, therefore is a member of the SIGLEC family of lectins. (wikipedia.org)
  • Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. (transcriptionfactor.org)
  • Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. (transcriptionfactor.org)
  • Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. (biovisi.com)
  • CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. (biovisi.com)
  • In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 Domain (s) that block signal transduction through dephosphorylation of signaling molecules. (biovisi.com)
  • CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia. (biovisi.com)
  • CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. (creativebiolabs.net)
  • CD22 molecule is a transmembrane protein from SIGLEC (Sialic acid-binding immunoglobulin-type lectins) family. (biomedcentral.com)
  • Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. (cusabio.com)
  • Upon binding, the immunoreceptor tyrosine-based inhibition motif (ITIM) of CD33, present on the cytosolic portion of the protein, is phosphorylated and acts as a docking site for Src homology 2 (SH2) domain-containing proteins like SHP phosphatases. (wikipedia.org)
  • Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. (acrobiosystems.com)
  • Myeloid cell surface antigen CD33 also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. (biovisi.com)
  • CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. (creativebiolabs.net)
  • amyloid beta precursor protein binding f. (gsea-msigdb.org)
  • actin related protein 2/3 complex subu. (gsea-msigdb.org)
  • growth factor receptor bound protein 1. (gsea-msigdb.org)
  • Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. (academicinfluence.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human AE Binding Protein 1 (AEBP1) in samples from tissue homogenates, cell lysates or other biological fluids. (kits-elisa.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AE Binding Protein 1 (AEBP1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human AE Binding Protein 1 (AEBP1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
  • Description: A sandwich ELISA kit for detection of AE Binding Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (kits-elisa.com)
  • The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)
  • Immunoadhesin structure The majority of immunoadhesins combine the hinge and Fc regions of an IgGl heavy chain with the extracellular domain (ECU) of a type I transmembrane protein, usually a receptor or an adhesion molecule (Fig. 1). (coek.info)
  • The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
  • Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation. (creativebiolabs.net)
  • They exist in pentameric form (IgM), dimeric form (IgA) or single form (IgG, IgE, IgD), which consist of Y-shaped units that each have two antigen-binding pockets on one side and a region recognized by immune cells on the opposite. (anthropogeny.org)
  • BCRs allow the B-cell to bind to a specific antigen , against which it will initiate an antibody response. (anthropogeny.org)
  • The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. (creativebiolabs.net)
  • The drug is a recombinant, humanized anti-CD33 monoclonal antibody (IgG4 κ antibody hP67.6) covalently attached to the cytotoxic antitumor antibiotic calicheamicin (N-acetyl-γ-calicheamicin) via a bifunctional linker (4-(4-acetylphenoxy)butanoic acid). (wikipedia.org)
  • One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K. (cusabio.com)
  • The tyrosine residues of the ITIMs become phosphorylated with the ligand binding, which leads to activation of SHP-1 ( Src homology region 2 domain-containing phosphatase-1), SHP-2 ( Src homology region 2 domain-containing phosphatase-2), SHIP-1 (( Src homology region 2 domain-containing inositol 5′ polyphosphatase-1). (biomedcentral.com)
  • A hottest embodiment makes use of a novel human monoclonal antibody that binds to a conserved space of the gp41 transmembrane subunit of the virus. (kits-elisa.com)
  • Prevalence and traits of myeloproliferative neoplasms with concomitant monoclonal gammopathy Of BCR-ABL adverse myeloproliferative neoplasm (MPN) sufferers, 3-14 % show a concomitant monoclonal gammopathy (MGUS). (tuberculosistest.net)
  • Tuning Monoclonal Antibody Galactosylation utilizing Raman Spectroscopy-Managed Lactic Acid Feeding A key side of large-scale manufacturing of biotherapeutics is a well-designed and consistently-executed upstream cell tradition course of. (tuberculosistest.net)
  • Setting the corresponding isotype control antibody to detect non-specific binding can reduce the generation of false positive results and evaluate the possible influencing factors accurately in the drug development process. (acrobiosystems.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cyclin Dependent Kinase Inhibitor 3 (CDKN3) in Tissue homogenates and other biological fluids. (jemsec.com)
  • The present invention is extra directed to a package deal and a means for detecting the presence and determining focus of an antibody that inhibits HIV-1 fusion-associated epitope, a peptide on gp41 with the amino acid sequence represented by GCSGKLIC. (kits-elisa.com)
  • Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. (cusabio.com)
  • It has three parts: (i) V-type Ig domain with sia -binding site, (ii) C1-type Ig domain, (iii) C2-type Ig domain. (biomedcentral.com)
  • engulfment and cell motility 3 [Source. (gsea-msigdb.org)
  • Description: A sandwich ELISA for quantitative measurement of Human Cyclin dependent kinase inhibitor 3(CDKN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (jemsec.com)
  • Description: Quantitative sandwich ELISA for measuring Human Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
  • Description: A competitive ELISA for quantitative measurement of Mouse Glyceraldehyde 3 Phosphate Dehydrogenase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
  • We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). (jci.org)
  • The amino acid region from 165 to 205 in BAP31 plays an important role in regulating the glycosylation of EpCAM. (bvsalud.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Cyclin Dependent Kinase Inhibitor 3 (CDKN3) in samples from tissue homogenates or other biological fluids. (jemsec.com)
  • We suggest that the anti-HIV-1gp120 antiidiotype-like complex contributes to the markedly elevated platelet Ig and C3 level of HIV-1-ITP patients and propose that this may contribute to their thrombocytopenia. (jci.org)
  • 3′UTR luciferase reporter assay, RT-PCR, and Western blot were conducted to verify the target gene of miR-183. (molcells.org)
  • Basically, we can dispatch the products out in 1-3 working days after receiving your orders. (cusabio.com)
  • Upon binding, the immunoreceptor tyrosine-based inhibition motif (ITIM) of CD33, present on the cytosolic portion of the protein, is phosphorylated and acts as a docking site for Src homology 2 (SH2) domain-containing proteins like SHP phosphatases. (wikipedia.org)
  • Siglecs are cell surface proteins that bind sialic acid. (transcriptionfactor.org)
  • CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. (nih.gov)
  • Carbohydrates, or glycans, are as integral to biology as nucleic acids and proteins. (nih.gov)
  • Sialic acid-binding immunoglobulin-like lectins (Siglecs) belong to a family of transmembrane proteins able to dampen host immune responses and set appropriate immune activation thresholds upon ligation with their natural ligands, the sialylated carbohydrates. (frontiersin.org)
  • Siglecs belong to a family of transmembrane proteins that display a variable numbers of C2-set immunoglobulin domains (from 1 in CD33 to 16 in Siglec-1), an amino-terminal V-set immunoglobulin domain that recognizes sialic acid residues ( 1 - 3 ) and a conserved arginine residue that binds carbohydrates. (frontiersin.org)
  • A family of SIALIC ACID binding proteins found in vertebrate species. (umassmed.edu)
  • They are transmembrane proteins which act as cell surface receptors for a variety of sialylated GLYCOCONJUGATES. (umassmed.edu)
  • Transmembrane proteins consisting of a lectin-like domain, an epidermal growth factor-like domain, and a variable number of domains that are homologous to complement regulatory proteins. (bvsalud.org)
  • CD79a and CD79b are two non-covalently associated transmembrane proteins that mediate signaling and endocytosis. (medicaltrend.org)
  • Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). (adcreview.com)
  • Furthermore, the bulk of Foxp3-bound Treg cell enhancers inaccessible in Foxp3- CD4+ cells became accessible upon T cell receptor activation prior to Foxp3 expression with only a small subset associated with several functionally important genes being exclusively Treg cell-specific. (gsea-msigdb.org)
  • cytokine receptor like factor 3 [So. (gsea-msigdb.org)
  • It binds to a specific high affinity receptor ( RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR ). (lookformedical.com)
  • MIM:218000), a apical penetrating binding controlled by potty single-base monoubiquitinated cargo, replicative DNA, NOTCH1 aspects and programmed none of kinase of the receptor phase( Howard et al. (erik-mill.de)
  • A family of membrane glycoproteins localized to TIGHT JUNCTIONS that contain two extracellular Ig-like domains, a single transmembrane segment, and a cytoplasmic tail of variable length. (bvsalud.org)
  • CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. (thermofisher.com)
  • The highly glycosylated extracellular domain binds to tissue- and organ-specific LECTINS or SELECTINS . (nih.gov)
  • The molecular weight of BCMA is only 20.2 kDa, and its ligand-binding extracellular domain has an "armchair" conformation consisting of six CRDs. (medicaltrend.org)
  • transmembrane protein 74B [Source:H. (gsea-msigdb.org)
  • actin binding LIM protein family me. (gsea-msigdb.org)
  • CCAAT enhancer binding protein delt. (gsea-msigdb.org)
  • MTRAP is thought to be released from invasive organelles identified as micronemes during merozoite invasion to mediate motility and host cell invasion through an interaction with aldolase, an actin binding protein involved in the moving junction. (nih.gov)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human RNA Binding Motif Protein 38 (RBM38) in samples from Tissue homogenates and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
  • Description: A sandwich ELISA kit for detection of RNA Binding Motif Protein 38 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
  • Developmentally regulated expression of the cold-inducible RNA-binding motif protein 3 in euthermic rat brain. (neurotree.org)
  • Moreover, isotopic labeling and heteronuclear 13 C and 15 N spectroscopies have been utilized to identify the binding of caffeine in the pembrolizumab crystal lattice, providing molecular insights into the cocrystallization of the protein and ligand. (tuberculosistest.net)
  • Description: A sandwich ELISA kit for detection of Sialic Acid Binding Ig Like Lectin 3 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
  • This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human ATP Binding Cassette Transporter C9 (ABCC9) in Tissue homogenates, cell lysates and other biological fluids. (myelisakit.com)
  • Belonging to the immunoglobulin (Ig) superfamily, antibodies are large, Y-shaped glycoproteins produced by plasma cells. (ukdiss.com)
  • Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. (nih.gov)
  • Glycosylation analyses revealed that patients with bone disease had significantly less galactose on IgG compared with patients without bone disease and also less sialic acid on IgG compared with healthy persons. (regenerativemedicine.net)
  • Here, we report a computational workflow for the study of these glycomimetic bifunctional ligands in complex with BC2L-C-Nt, aimed at investigating the molecular basis of ligand binding and the dynamics of glycomimetic/lectin interactions. (bvsalud.org)
  • Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). (nih.gov)
  • Adhesion and lectin binding activity. (biolegend.com)
  • B. cenocepacia BC2L-C lectin has been linked to bacterial adhesion and biofilm formation, thus hindering its activity is seen as a promising strategy to reduce the severity of the infection. (bvsalud.org)
  • Sialic Acid Binding Immunoglobulin-like Lectins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). (nih.gov)
  • interactions Activating these binds are in lipid-linked domain to the day to refer Mammalian image to add potential organization of responses and significantly innate movement. (erik-mill.de)
  • These carbohydrate moieties are also necessary for maintaining an open conformation of the two heavy chains of IgG and required for maintaining the structural integrity of the FcɤR-binding site [10]. (ukdiss.com)
  • 10/16/2012) TOTAL 2013 NEW DESCRIPTORS = 302 MH - 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase UI - D063309 MN - D8.811.277.352.640.160.500 MN - D12.776.641.580.124 MS - A phosphodiesterase that specifically cleaves the 3'-phosphate linkage of 2',3'-cyclic nucleotides. (nih.gov)
  • Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658). (nih.gov)
  • Figure 3 Examples of glycoforms on IgG glycan. (ukdiss.com)
  • HN - 2013 BX - Proton-Gated Sodium Channel Blockers MH - Acid Sensing Ion Channels UI - D062565 MN - D12.776.157.530.400.875.50 MN - D12.776.543.550.425.875.50 MN - D12.776.543.585.400.875.50 MN - D12.776.641.24 MS - A family of proton-gated sodium channels that are primarily expressed in neuronal tissue. (nih.gov)
  • C-type lectin domain family 3 membe. (gsea-msigdb.org)
  • Correspondingly, ChIP-Seq analysis of Irf4_/_ T cells showed greatly diminished STAT3 binding after IL-21 treatment, and Irf4_/_ mice showed impaired IL- 21-induced Tfh cell differentiation in vivo. (gsea-msigdb.org)
  • The embryonic origins of human HSCs are complex and are largely inferred from studies conducted in mice [ 3 ]. (medilib.ir)
  • In the 5TGM1 mouse myeloma model, we found decreased number of lesions and decreased CTX-1 levels, a marker for osteoclast activity, in mice treated with the sialic acid precursor, N-acetylmannosamine (ManNAc). (regenerativemedicine.net)
  • There are known monogenic GBM biomarkers that include mutations in the IDH1 [ 3 ] and PDGFRα [ 4 ] loci. (oncotarget.com)
  • antigens are stabilized a liver of cofactors to know, and be heterodimer of first emissions procollagen transmission acids and between likely conversion mutations within dimers. (erik-mill.de)
  • Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo, and furthermore, revealed that the noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding. (gsea-msigdb.org)
  • Ensembl chr 3:118,451,743. (mcw.edu)
  • Ensembl chr 3:77,596,198. (mcw.edu)
  • Ensembl chr 3:69,842,739. (mcw.edu)
  • Comparing genome-wide expression array data to binding sites revealed that most IL-21-regulated genes were associated with combined STAT3-IRF4 sites rather than pure STAT3 sites. (gsea-msigdb.org)
  • Analysis of the chromatin accessibility of Foxp3-bound enhancers in Treg and Foxp3-negative T cells showed that Foxp3 was bound overwhelmingly to pre-accessible enhancers occupied by its cofactors in precursor cells or a structurally related predecessor. (gsea-msigdb.org)
  • In proton-coupled membrane compartment, the salicylic transport reported by the other menu in the distinct synthesis enters bound into the synthase by a hemoglobin survival EPHBs was the major phone promoter forms 1 and 2, EAAT1 and EAAT2. (erik-mill.de)
  • In this regard, glycans expressed by several microbes are recognized by several immunoglobulin type-I lectins, including sialic acid-binding immunoglobulin-like lectins (Siglecs). (frontiersin.org)
  • In contrast, adaptive immune cells such as T lymphocytes have very low or undetectable surface levels of these type-I lectins ( 7 ). (frontiersin.org)
  • AN - coordinate with SKIN TRANSPLANTATION if appropriate HN - 2013 MH - Acid Sensing Ion Channel Blockers UI - D062646 MN - D27.505.519.562.750.100 MS - A subclass of sodium channel blockers that are specific for ACID-SENSING SODIUM CHANNELS. (nih.gov)
  • In addition, the target antigens of approved ADCs are all readily internalized after binding, an important feature that contributes to the efficacy of ADCs. (medicaltrend.org)
  • Here, we used molecular docking simulations to evaluate the propensity of three different libraries of commercially available drug-like fragments (nearly 18,000 compounds) to accommodate into the Trp2 binding pocket of E-cadherin, a crucial site for the orchestration of the protein's dimerization mechanism. (bvsalud.org)