• The findings, published Feb. 17 in Science Translational Medicine, suggest a potentially safer approach to removing harmful amyloid plaques as a way of treating Alzheimer's disease and cerebral amyloid angiopathy. (newswise.com)
  • A couple of years later, she and her colleagues published new observations in Science Translational Medicine - the discovery of a combination of epigenetic biomarkers that can, using a blood test, predict which individuals with type 2 diabetes will benefit from the regularly prescribed medicine metformin, which of them will not respond to the treatment and which of them are highly likely to suffer side-effects. (lu.se)
  • Science Translational Medicine. (lu.se)
  • The use of cell therapies, drivers of immune response, and trends in immunotherapy were the focus of the Immunotherapy Bridge (November 30th-December 1st, 2022), organized by the Fondazione Melanoma Onlus, Naples, Italy, in collaboration with the Society for Immunotherapy of Cancer. (biomedcentral.com)
  • Researchers from 8 immunotherapy organizations met at an Immunotherapy Summit at what is now called the Society for Immunotherapy of Cancer (SITC) and identified hurdles that slow down the translation of cancer immunotherapy. (pharmacytimes.com)
  • MILWAUKEE , Nov. 2, 2021 /PRNewswire-PRWeb/ -- The Society for Immunotherapy of Cancer (SITC) invites you to attend the virtual press briefing of the society's 36th Anniversary Annual Meeting (SITC 2021) beginning at 12:30 p.m. (prweb.com)
  • She is a Bridge Fellow in the Parker Institute for Cancer Immunotherapy. (lls.org)
  • Dr. Zappasodi completed her PhD in Tumor Immunology/Immunotherapy at the National Cancer Institute of Milan (Milan, Italy) and was the recipient of a Parker Institute for Cancer Immunotherapy Scholar Award during her post-doctoral training at MSK in the Wolchok/Merghoub group. (lls.org)
  • Cancer immunotherapy has revolutionized the field of oncology by prolonging survival of patients with fatal cancers. (civis.eu)
  • Translational Oncology. (wikipedia.org)
  • BASEL, Switzerland - 15th March 2023 - Nouscom, a clinical stage immuno-oncology company developing off-the-shelf and personalized viral vector immunotherapies, today announced that new translational data obtained from the ongoing Phase 1b trial evaluating NOUS-PEV in patients with metastatic melanoma has been accepted for presentation in a Late-Breaking session at the 2023 American Association for Cancer Research (AACR) Annual Meeting. (nouscom.com)
  • Nouscom is a private oncology company developing next generation immunotherapies, founded in 2015 by an experienced management team that has worked together for many years in previous successful enterprises. (nouscom.com)
  • Timothy Chan has been appointed director of the Center for Immunotherapy and Precision Immuno-oncology at Cleveland Clinic. (genomeweb.com)
  • He also was chair of the translational oncology division. (genomeweb.com)
  • The Cancer Moonshot Immuno-Oncology Translational Network (IOTN) at age 5: Accelerating Cancer Immunotherapies. (cdc.gov)
  • This has led to the need for new immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and novel immune checkpoint inhibitors. (biomedcentral.com)
  • This has resulted in the development of additional immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and inhibitors of other immune checkpoints. (biomedcentral.com)
  • Tübingen summer school on immunotherapy of cancer addresses the challenge of keeping up with the rapid and quite broad technical and translational developments in this field: e.g. combining immunovirotherapy or other non-antigen-specific perturbation of the tumor microenvironment, or antigen-specific vaccination or cell transfer, with immune checkpoint inhibitors (ICIs) or other recently developed forms of immunomodulations. (civis.eu)
  • New model systems are being developed to test and optimize various immunotherapy strategies, including bispecific antibodies, checkpoint inhibitors, epigenetic modifiers and adoptive T cell transfer both in vitro and in vivo. (upenn.edu)
  • Siva and colleagues noted that the translational component of the study suggested that treating pulmonary oligometastases with SABR drives systemic immune activation, which could potentially be supplemented with the addition of immune checkpoint inhibitors. (medpagetoday.com)
  • While the use of single-agent immunotherapies, in particular immune checkpoint inhibitors, can produce durable and effective responses in some patients, clinical benefit for most patients with carcinoma is minimal. (bmj.com)
  • Cancer Immunology, Immunotherapy. (wikipedia.org)
  • Ye is a Professor of Autoimmune liver diseases and Translational Hepatology at the Institute of Immunology and Immunotherapy, University of Birmingham and Consultant Hepatologist at the Queen Elizabeth Hospital where he specialises in the management of autoimmune liver diseases, immune mediated liver injury and liver transplantation. (birmingham.ac.uk)
  • Building on interrogations in basic T cell biology in the lab, bench-to-bedside translational immunology is being developed, with a focus on T cell-based therapy for ovarian cancer. (upenn.edu)
  • They're examining signal transduction and experimental therapeutics, tumor immunology and immunotherapy, gene regulation and epigenetics, and stem cell biology. (luc.edu)
  • The IOTN is focused on accelerating translation of cancer immunology research from bench to bedside and improving immunotherapy outcomes across a wide array of cancers. (cdc.gov)
  • Increased knowledge between these interactions is important to develop new concepts and advances in basic, translational, and clinical cancer immunology and immunotherapy. (lu.se)
  • Documented knowledge in tumor immunology, with practical experience in in-vivo evaluation of cancer immunotherapies using mouse syngeneic mouse models. (lu.se)
  • Numerous clinical trials and real-world experience provide evidence of improved response and survival outcomes with multiple immunotherapy agents and different combinations in various cancers. (biomedcentral.com)
  • These workflows and technologies are being applied in translational projects with implementation in clinical trials. (uni-heidelberg.de)
  • A recent study analyzed different reasons for delays between preclinical and clinical trials for cancer immunotherapy and how to overcome such hurdles. (pharmacytimes.com)
  • His team develop and deliver translational GMP Regulatory T clinical trials in autoimmune liver diseases. (birmingham.ac.uk)
  • We have more clinical trials of immunotherapy for neuroblastoma than any other hospital. (mskcc.org)
  • He has a key interest in early phase clinical trials involving targeted agents and the translational aspects of novel therapies. (surrey.ac.uk)
  • These new approaches are focused on patients with an inadequate response to current treatments, with emerging evidence of improved responses in various cancers with new immunotherapy agents, often in combinations with existing agents. (biomedcentral.com)
  • This CIVIS Summer School covers the most recent "Basics & Translational Approaches in Immuno-therapy of Cancer" by providing highly interactive lectures given by renowned cancer experts from the Universities of Aix-Marseille, Athens, Bucharest, Brussels, Rome, and Tübingen. (civis.eu)
  • Learning objectives cover all major aspects of Basics & translational approaches in immuno-therapy of cancer. (civis.eu)
  • However, one has always to keep in mind that many challenges do still exist such as what is the best sequence and timing of joint applications, what are the best immunotherapy approaches, how to overcome tumor resistances, what about healthy tissue cytotoxicity, or which biomarkers or matrices of biomarkers are most beneficial for patients stratification, just to mention the most burning ones. (frontiersin.org)
  • Additionally, work about IL-12 and IL-15-based immunotherapy approaches is presented. (frontiersin.org)
  • Computational immunogenomic approaches to predict response to cancer immunotherapies. (cdc.gov)
  • This research suggests that post-translational modification of proteins provide efficient targets in tumors for both CD4 and CD8 T-cell-mediated therapies. (bmj.com)
  • However, not all patients respond to immunotherapy, acquired resistance remains a challenge, and responses are poor in certain tumors which are considered to be immunologically cold. (biomedcentral.com)
  • Recent studies have found that post-translational modifications of proteins can regulate the occurrence and development of tumors. (cmbr-journal.com)
  • One clinical trial has studied a type of engineered macrophage called CAR-M and found that it may be an effective form of immunotherapy for solid tumors. (webmd.com)
  • Researchers suggest the characterization of tumors, before and after immunotherapy, could be a way to gain more information about certain cancers. (pharmacytimes.com)
  • After the primary tumors were surgically removed, the mice were then treated with a triple combination: metformin, venetoclax and a PD-1-targeted antibody, which is used in immunotherapies to keep killer cells active long-term. (helsinki.fi)
  • The objective for the position is to lead - and expand through recruitment - a team of investigators focused on developing engineered cellular and vaccine immunotherapies for pediatric and young adult cancers. (itns.org)
  • We propose to develop an innovative adaptive cellular immunotherapy (ACIT) utilizing Chimeric Antigen Receptor (CAR)-engineered T cells, which respond to both CD19+ cells and cytomegalovirus (CMV) antigen, namely CMV-CD19 bi-specific T cells, followed by CMV vaccine to further expand the T cells in vivo. (lls.org)
  • Personalized anti-cancer vaccine combining mRNA and immunotherapy tested in melanoma trial. (cdc.gov)
  • Immunological and translational aspects of NK cell-based antitumor immunotherapies. (springer.com)
  • and 3) the definition of T-cell-mediated suppressive mechanisms as targets and biomarkers of immunotherapy. (lls.org)
  • The overall goal of her research is to identify biomarkers of immune and anti-tumor activity with immediate clinical application and to improve the understanding of the mechanisms underlying resistance to immunotherapy. (lls.org)
  • However, the majority of patients have primary or acquired resistance to these immunotherapies. (aacrjournals.org)
  • Cancer research has led to insights, reagents, drugs, and clinical protocols that can improve outcomes, especially when it comes to cancer immunotherapy. (pharmacytimes.com)
  • This project will aim to test a cancer immunotherapy approach based on in-vivo dendritic cell reprogramming of tumor cells to reinstate anti-tumor immunity. (lu.se)
  • Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. (nih.gov)
  • 2016). Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells. (springer.com)
  • From the abstract: 'Neoadjuvant or adjuvant immunotherapy can improve outcomes in patients with resectable non-small-cell lung cancer (NSCLC). (cdc.gov)
  • Treatment protocols for bladder cancer are provided below, including those for chemotherapy, immunotherapy, and systemic neoadjuvant and adjuvant therapy. (medscape.com)
  • Two of the primary immunotherapies are immune checkpoint blockade (ICB) and adoptive cell transfer (ACT). (elifesciences.org)
  • We studied BRAF V600E ctDNA levels by a sensitive allele-specific PCR assay in 388 serum samples from 48 patients who received TIL immunotherapy at the NCI and correlated differences in the dynamic patterns of their ctDNA measurements with response outcomes. (aacrjournals.org)
  • Research evaluates translating immunotherapy from trials to real world outcomes. (pharmacytimes.com)
  • immunotherapy was associated with improved outcomes for patients with BRAF wildtype but not BRAF V600E variant brain metastases. (cdc.gov)
  • There are number of potential advantages to ACT therapy compared with other immunotherapies. (biomedcentral.com)
  • His research group focus on basic discovery science in autoimmune liver diseases, develop translational cellular therapy and practice precision medicine. (birmingham.ac.uk)
  • DescriptionSalary: ExemptFaculty Position: ProfessorThe Cancer & Blood Diseases Institute at Cincinnati Children's Hospital is seeking an innovative and dynamic Director for its Cancer Translational Immunotherapy Center. (itns.org)
  • 2 Duke Center for Cancer Immunotherapy, Durham, North Carolina. (aacrjournals.org)
  • The translational substudy was supported by Varian Medical Systems and the Victorian Cancer Center Immunotherapy program. (medpagetoday.com)
  • The Center for Translational Research and Education (CTRE) is a vibrant new addition to Loyola's Health Sciences Campus. (luc.edu)
  • 1 Cancer Center Bridge This bridge connects the research building with the Cardinal Bernardin Cancer Center, bringing physicians and researchers together to provide top-notch translational research and patient care. (luc.edu)
  • We show that the dynamic changes occurring in BRAF V600E ctDNA levels within the first month following T-cell transfer immunotherapy in metastatic melanoma can be used to rapidly identify responding from nonresponding patients, potentially allowing clinicians to make critical treatment-related decisions in a more timely manner. (aacrjournals.org)
  • However, the frequency of melanoma is increasing, particularly in lighter-skinned people, and for the minority of patients diagnosed with metastatic disease, the 5-year survival rate is 35%, although the introduction of immunotherapy has doubled the median survival time for these patients. (cdc.gov)
  • What is the translational importance of alteration status in the treatment of melanoma brain metastases? (cdc.gov)
  • For example, researchers find that preclinical animal models have not been consistent predictors of efficacy for immunotherapy and the models do not have the genetic diversity that humans have. (pharmacytimes.com)
  • The abstracts selected for the press briefing represent an array of the top advances in cancer immunotherapy research. (prweb.com)
  • In detail, compared to PD-L1 for advanced non-small cell lung cancer (NSCLC), ML tools predicted better responder (R) and non-responder (NR) patients to immunotherapy (IO). (unimi.it)
  • Abstract: (1) Background: In advanced non-small cell lung cancer (aNSCLC), programmed death ligand 1 (PD-L1) remains the only biomarker for candidate patients to immunotherapy (IO). (unimi.it)
  • Tumor immunotherapy refers to exogenous intervention of the body's immune system, restart and maintain the "tumor-immune" cycle, restore and improve the anti-immune response of the group, strengthen the recognition and killing ability of tumor cells, so as to achieve the therapeutic effect of controlling or even clarifying the tumor specifically. (cmbr-journal.com)
  • Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)
  • Post-translational modifications of proteins provide targets for T cells that have not been subject to central tolerance. (bmj.com)
  • Background Post-translational modification of proteins has the potential to alter the ability of T cells to recognize major histocompatibility complex (MHC) class -I and class-II restricted antigens, thereby resulting in altered immune responses. (bmj.com)
  • Here, we review current knowledge of the current status of tumor immunotherapy and the types and effects of post-translational modifications of proteins, hoping to improve new ideas for the types of therapies. (cmbr-journal.com)
  • On this floor Cardiovascular researchers facilitate high-impact, collaborative research across a wide spectrum of basic, translational, and clinical research in areas such as heart failure, cardiac proteins, blood clotting, and more. (luc.edu)
  • The candidate should be an enthusiastic and motivated scientist willing to join a dynamic collaborative project between academia and industry with translational focus. (lu.se)
  • His team spearhead the bench to bedside regulatory T cells immunotherapy in autoimmune liver diseases. (birmingham.ac.uk)
  • Klefstrom highlights that this is a wonderful example of a translational study fundamentally aimed at taking research from bench to bedside. (helsinki.fi)
  • A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)