• Pin1 displays a preference for an acidic residue N-terminal to the isomerized proline bond due to interaction of this acidic side chain with a basic cluster. (rcsb.org)
  • On the loop, which connects the two hairpin α-helix of c subunit, is present the unique proline residue (Pro 40 ) that could be a biological target of CyPD. (authorea.com)
  • The second system is a four residue peptide valine-proline-alanine-leucine in water. (aston.ac.uk)
  • The sole genetically encoded secondary amino acid proline (Pro, 1 ) is known for its unique properties in biological systems. (beilstein-journals.org)
  • One of the most prominent adaptive responses to various kinds of stress that result in decreased water availability is the accumulation of the amino acid proline (see [ 1 , 2 ] for recent reviews). (biomedcentral.com)
  • These observations provide novel insights implicating proline metabolism as a key determinant of pathogenic fungal growth. (sciencedaily.com)
  • Arginine and proline metabolism have been found to be controlled by inflammation. (databasefootball.com)
  • In summary, the PM 2.5 exposure caused the metabolic reprogramming and mitochondrial dysfunction by perturbing purine metabolism, arginine and proline metabolism, glutathione metabolism, TCA cycle, and glycolysis caused by oxidative stress and inflammation. (databasefootball.com)
  • Proline accumulation was largely viewed as a specific reaction to overcome stress conditions, while recent studies suggested important functions of proline metabolism also in reproductive development. (biomedcentral.com)
  • Both the level of free proline and proline metabolism were proposed to influence the transition to flowering, as well as pollen and embryo development. (biomedcentral.com)
  • The detailed phenotypic analysis of mutants with defects in proline synthesis can therefore promote our understanding of both primary metabolism and specific functions of proline in plant development. (biomedcentral.com)
  • One tumor showed a G to C transversion at p53 codon 213 (arginine to proline), and another showed deletion of the entire gene. (nih.gov)
  • The p53 mutations in cell lines included a codon 248 C to T transition (arginine to tryptophan) in RD and a codon 280 A to T transversion (arginine to serine) in RH30. (nih.gov)
  • Am J Hum Genet 49: 860 (1991)] demonstrated a transition at nucleotide 591 that substituted arginine for glutamine-188. (coriell.org)
  • In animals and fungi, also arginine or ornithine can serve as precursors for proline, while the separation of the contributing enzymes in different subcellular compartments probably impedes this alternative metabolic pathway in plants [ 4 ]. (biomedcentral.com)
  • They found that gremlin induced early activation of smad2/3 signal transduction via TGF- β independent manner in human tubular epithelial cells and long-term exposure of gremlin induced epithelial mesenchymal transition (EMT). (hindawi.com)
  • Kanazawa Medical University, Japan) focused on the endogenous antifibrotic peptide, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), one of the substrates of angiotensin converting enzyme (ACE), and found that AcSDKP suppressed kidney fibrosis in diabetes or even restored normal kidney structure from damaged kidney associated with the inhibition of endothelial mesenchymal transition and the induction of fibroblast growth factor receptor-microRNA let-7 axis. (hindawi.com)
  • The endothelial to mesenchymal transition (EndMT) is a newly recognized, fundamental biological process involved in development and tissue regeneration, as well as pathological processes such as the complications of diabetes, fibrosis and pulmonary arterial hypertension. (bmbreports.org)
  • The EndMT process is tightly controlled by diverse signaling networks, similar to the epithelial to mesenchymal transition. (bmbreports.org)
  • ECs have the capacity to undergo a dynamic cellular phenotypic switching, termed the endothelial to mesenchymal transition (EndMT), in response to local environmental cues throughout the vascular system. (bmbreports.org)
  • The EndMT features are similar to the extensively studied and better understood epithelial to mesenchymal transition (EMT). (bmbreports.org)
  • A deep eutectic solvent made from proline and glycerol was an effective cryoprotective agent for all four cell types tested, even with extended incubation prior to freezing. (rsc.org)
  • The conformational preferences of the heterocyclic analogues of proline [23-25] and, in particular, pseudoprolines [26-28] have also been characterized. (beilstein-journals.org)
  • We applied time-independent component analysis (tICA) and protein connectivity network model, on all-atom molecular dynamics trajectories, to identify key non-RBD residues, playing crucial role in the conformational transition facilitating spike-receptor binding and infection of human cell. (biorxiv.org)
  • The model is built by clustering the trajectory into conformational states and estimating transition probabilities between the states. (aston.ac.uk)
  • The solvents were tested for their thermal properties, including glass transitions, toxicity, and permeability into mammalian cells. (rsc.org)
  • The advantages of organocatalysts include their lack of sensitivity to moisture and oxygen, their ready availability, low cost, and low toxicity, which confers a huge direct benefit in the production of pharmaceutical intermediates when compared with (transition) metal catalysts. (organic-chemistry.org)
  • Proline (Pro) is an outstanding amino acid in various biochemical and physicochemical perspectives, especially when considering the cis - trans isomerism of the peptidyl-Pro amide bond. (beilstein-journals.org)
  • Our results demonstrate that potential alternative pathways for proline synthesis or inter-generation transfer of proline are not sufficient to overcome a defect in proline biosynthesis from glutamate during pollen development. (biomedcentral.com)
  • Primarily, proline is an essential metabolite for protein synthesis and contributes in a unique way to protein folding, structure and stability. (biomedcentral.com)
  • The mutation is an A-to-G transition at basepair 2744 of exon 10, which adds an AvaII cut site. (coriell.org)
  • The mutation (a CCG to CTG transition) at codon 82 in exon 4, resulting in a proline to leucine substitution, has not previously been reported and was not present in a control set of 60 healthy individuals. (lu.se)
  • The peptide binding domain spans residues 140-215 of the α subunit, and consists of a concave surface lined with multiple tyrosine residues which interact favorably with the proline-rich substrate. (wikipedia.org)
  • The first system is an imaginary peptide described by given transition probabilities with a total folding time of 1 micros. (aston.ac.uk)
  • Procollagen-proline dioxygenase catalyzes the following reaction: L-proline + alpha-ketoglutaric acid + O2 → (2S, 4R)-4-hydroxyproline + succinate + CO2 The mechanism for the reaction is similar to that of other dioxygenases, and occurs in two distinct stages: In the first, a highly reactive Fe(IV)=O species is produced. (wikipedia.org)
  • Nevertheless, a practical limitation to the use of L-proline as a catalyst stems from long reaction times and a low turnover number. (aiche.org)
  • Therefore, to understanding the origin of the unusual kinetic behavior in certain L-proline-catalyzed reactions, we used density functional theory (DFT) to map the reaction coordinates of an aldol addition and an α-aminoxylation reaction. (aiche.org)
  • All stable intermediates and transition states along the reaction coordinates were located using the Gaussian 03 computational chemistry software. (aiche.org)
  • elevation, while cation channel blockers, free radical scavengers, low extracellular [Ca2+], transition metal chelators, and removal of the cell wall inhibit this reaction. (deepdyve.com)
  • Based on experimental results and DFT calculation, transition states were proposed to explain the stereoselectivity of the reaction. (organic-chemistry.org)
  • The mutated glutamine is not only highly conserved in evolution, but is also 2 amino acid residues downstream from the active site histidine-proline-histidine triad. (coriell.org)
  • The study reveals that the opportunistic human fungal pathogen Candida albicans requires the ability to metabolize proline, an amino acid obtained from the host, to mount virulent infections. (sciencedaily.com)
  • Although proline has long been known to trigger hyphal growth, we have recently discovered that C. albicans can use proline as a main source of energy. (sciencedaily.com)
  • To obtain answers, the team initially applied a mouse model of infection, which remains invaluable for this kind of work, and found that C. albicans cells lacking the capacity to utilize proline were less invasive and virulent. (sciencedaily.com)
  • The transition of C. albicans from unicellular yeast form to filamentous form i.e ., pseudohyphae and hyphae is referred to as morphogenesis. (scirp.org)
  • S. Nadeem, A. Shafiq, S. Hakim, Y. Anjum and S. U. Kazm, "Effect of Growth Media, pH and Temperature on Yeast to Hyphal Transition in Candida albicans ," Open Journal of Medical Microbiology , Vol. 3 No. 3, 2013, pp. 185-192. (scirp.org)
  • Both transition metals and organic compounds contributed to ROS production and pro-inflammatory cytokines release. (databasefootball.com)
  • Proline-derived compounds have proven themselves to be real workhorse organocatalysts. (organic-chemistry.org)
  • The current catalyst range for these processes extends from traditional strong acids and bases, transition metals, and heterogeneous materials to environmentally friendly enzymes and catalytic antibodies. (aiche.org)
  • These data show that apoplastic redox-active transition metals are involved in the ascorbate-induced [Ca2+]cyt. (deepdyve.com)
  • The investigating team now report that proline is an important source of energy in other pathogenic Candida species, including the multidrug resistant C. auris , an emerging health threat and also a WHO critical priority fungal pathogen. (sciencedaily.com)
  • Recently, auto-inductive behavior has been observed in L-proline-assisted α-aminoxylation and α-amination reactions. (aiche.org)
  • Proline, one of the 20 naturally occurring amino acids in the body, is enriched in extracellular matrix proteins, e.g., collagen, and as such is readily available when connective tissue is broken down at sites of infection, or when a host becomes vulnerable as a result of cancerous growth or upon the onset of sarcopenia. (sciencedaily.com)
  • Raquél's desire to combine her nursing expertise with creativity naturally led her to transition from patient care to a role at Gales®, where she could positively impact nurses on a larger scale. (allnurses.com)
  • Under homogeneous conditions, L-proline promotes aldol-type reactions at low temperatures, exhibits a high yield, enantioselectivity and atom efficiency, and is inexpensive to synthesize. (aiche.org)
  • To date, all L-proline assisted aldol-type reactions are considered to proceed via the same biomimetic catalytic cycle involving the formation of an enamine intermediate. (aiche.org)
  • In plants, glutamate is converted to proline in the cytosol and potentially in plastids by the sequential reactions of pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) [ 1 ]. (biomedcentral.com)
  • The enzyme acts specifically on proline contained within the X-Pro-Gly motif - where Pro is proline. (wikipedia.org)
  • Notably, mice infected with fungal cells unable to catabolize proline, e.g., cells lacking the Put2 enzyme (1-pyrroline-5-carboxylate (P5C) dehydrogenase) , showed milder illness or no symptoms at all. (sciencedaily.com)
  • Moreover, AA is a major reducing agent for iron and copper [Cu2+/Fe3++electron from AA→Cu+/Fe2++dehydroascorbate (DHA)] and potentially for other transition metal ions, such as Mn2+/3+, inside and, hypothetically, outside the cell. (deepdyve.com)
  • Step profiles from Proline provide reliable edge protection, offer stability for the construction, ensure slip resistance and not to forget: They are also a real eye-catcher visually. (proline-systems.com)
  • Seamless transitions between different floor and wall coverings are quickly accomplished with PRODECOR T . These high-quality joint cover profiles made of stainless steel and aluminium are ideal for covering joints of different widths. (proline-systems.com)
  • You can combine a ProLine rail with all of our roof hooks made of aluminium or stainless steel and add a ProLine module clamp. (schletter-group.com)
  • As a complete provider, Proline Systems is a reliable partner of specialist dealers and processors as well as architects and planners. (proline-systems.com)
  • First, there were no significant upgrades to the Mac hardware in the past year, other than the transition to Intel processors. (macobserver.com)
  • The results consistently showed that strains unable to metabolize proline exhibit significantly reduced virulence properties and a clearly diminished capacity to undergo morphological transitions. (sciencedaily.com)
  • The galectin lattice is a multi-valent interaction of galectins with glycoproteins at the cell surface that displays rapid exchange of binding partners with properties of liquid-liquid phase transitions, thereby acting as an intermediary between freely diffusing glycoproteins and stable complexes in the membrane. (gr.jp)
  • The flight, which took place Feb. 25, completed the aircraft's transition from experimental to production aircraft, Nextan said. (aviationtoday.com)
  • Indeed, the proline cis - trans isomerization might provide the switch that interconverts the open/closed states of the pore by pulling out the c -ring lipid plug. (authorea.com)
  • Solubilisers and emulsifiers are used to make products work - making the transition of one ingredient into another, a smooth one. (newdirections.com.au)
  • Today, PROLINE Systems not only manufactures outstanding individual products, but the success of PROLINE Systems is systematic: All our products are technically and optically perfectly intertwined . (proline-systems.com)
  • In addition, we are increasingly offering webinars in which we explain the transition and the benefits of the new products. (schletter-group.com)
  • The lead author of this study Dr. Fitz Gerald S. Silao explains: "In fungal cells possessing mitochondria equipped with a full complement of energy conserving respiratory complexes, the catabolism of proline generates almost as much chemical energy (ATP) as does the catabolism of the energy-rich sugar glucose. (sciencedaily.com)
  • HoloRam Endokrium HoloRam Endokrium stimulates the natural bio-energy processes of the endocrine regulation, concerned especially during the hormonal transition phases, such as climacteric and premenstrual tension syndrome. (biogetica.com)
  • It provides the required information for the activation of the energy physiology to restore the energy balance in the hormonal transition periods. (biogetica.com)
  • They act on the vital energy, the global energy balance, the regulation of the nervous system and favor the adaptation to the stress, producing changes in the neuro-immune endocrine system, present throughout the hormonal transitions. (biogetica.com)
  • You can create threshold-free transitions and barrier-free floor surfaces with PRONIVO profiles from Proline. (proline-systems.com)
  • However, changes in free proline content also occur during the development of plants growing under non-stress conditions, especially in reproductive organs. (biomedcentral.com)
  • Anyone who works with PROLINE Systems will quickly notice: The golden ground of craftsmanship has long been green. (proline-systems.com)
  • JConcepts has released a shock limiter kit for the Scalpel conversion to make the off-road to on-road transition that much easier. (hobbytown.com)
  • Profiles and systems from Proline help you make your customers' dream rooms a reality. (proline-systems.com)
  • Specializing in business law, she helped numerous companies from a variety of industries make the transition from startup ventures to profitable enterprises. (kzg.com)
  • Transitioning from a bedside nursing role to a leadership position requires dedication, passion, and a drive to make a difference. (allnurses.com)
  • Due to the many advantages of ProLine over our Classic rooftop systems, ProLine will become our primary rooftop system by January 2024 - by then, we will have doubled our production volume compared to 2023 with our new production plant in Türkiye. (schletter-group.com)
  • In addition, the EconoFIL can be easily integrated with other packaging equipment in a modular fashion to form a customized variant of our ProLINE, production line system. (filamatic.com)
  • The product range of PROLINE Systems offers tile profiles & mat systems , sealing system & drainage systems , tileable shower shelf & tileable wall niche , outdoor systems , in particular pedestal & slab supports , floor profiles & underlay webs , as well as surface heating & cooling systems . (proline-systems.com)
  • Which advantages does ProLine have towards Schletter's Classic system? (schletter-group.com)
  • For automated applications where avoidance of cross contamination are required, lightning fast transition from batch-to-batch are needed, or simply a wide-varying range of fill sizes are possible, the Adaptafil, peristaltic pump technology benchtop base-model would be an appropriate filling solution for your EconoFIL system. (filamatic.com)
  • The c subunits, which constitutes the c -ring apparatus of the F 1 F O -ATPase, could be the main components of the mitochondrial permeability transition pore (mPTP). (authorea.com)
  • The main benefit of using Dual Rate Springs is that you can have a softer initial combined spring rate for gliding over the small choppy bumps, but then transition to a much firmer rate once the Upper Spring is collapsed to absorb the Big Hits! (rcstreetshop.com)
  • The exterior paint scheme has stripes that transition from the fuselage to the wing across the large faring, relating what is typically white to the rest of the aircraft. (duncanaviation.aero)
  • During product development, we made sure there would be a smooth transition: With a few exceptions, almost all ProLine components are downward compatible. (schletter-group.com)
  • Like all RPRC sliders the design matches the contour of the frame by angling up in the front and rear for smooth transitions on and off rocks. (rockpiratesrc.com)
  • Proline stands for high-quality profiles and systems for walls and flooring in living spaces and rooms with plumbing as well as for terraces and balconies. (proline-systems.com)
  • Three employees and a great vision: that was the beginning of PROLINE Systems in 1994. (proline-systems.com)
  • PROLINE Systems has achieved a leading position on the German market and is successful on all continents. (proline-systems.com)
  • With this idea, PROLINE Systems became one of the most innovative companies in the industry . (proline-systems.com)
  • By the way, PROLINE Systems can always be recognised by the bright, strong PROLINE green. (proline-systems.com)
  • Our new ProLine series meets the requirements of tomorrow's mounting systems by using less material and offering better load-bearing capacity, simplified planning, improved handling on site, and optimized installation times. (schletter-group.com)
  • Using these requirements as our goals, we engineered the ProLine series, a new generation of solar mounting systems for residential and industrial roofs - now also available in black. (schletter-group.com)
  • Affinia expects to have Brake Pro brand product offerings in the marketplace as quickly as possible after the asset transition and manufacturing integration is complete. (autoserviceworld.com)
  • The pro line drops into a set of steep doubles, and transitions into a mini slopestyle inspired course with multiple hip jumps, step up/downs and berms. (ioby.org)
  • KZG's dedication to the game, award winning equipment and discerning practice of working exclusively with highly skilled Professional Coaches, Teachers and Clubfitters with integrity has catapulted KZG into the position as the #1 Custom Proline. (kzg.com)
  • Strikingly, genetic dissection of the Proline UTilization (PUT) pathway and of the control mechanisms governing proline use led to the discovery that proline is toxic to cells unable to catabolize it. (sciencedaily.com)
  • The result will be the eventual abandonment of the Mac as Apple transitions itself into a consumer electronics company. (macobserver.com)
  • When developing the ProLine, we focused on saving weight and simplification - from planning and stock-keeping all the way to assembly on the construction site. (schletter-group.com)
  • In this study, we performed a detailed analysis of the contribution of individual proline biosynthetic enzymes to vegetative development and reproductive success in Arabidopsis. (biomedcentral.com)
  • Finally we demonstrate that the 3,4-double bond in the investigated structures leads to an increase of the amide rotational barriers, presumably due to an interplay with the transition state. (beilstein-journals.org)
  • s- cis -s- trans Amide bond isomerism in an N -acyl-proline fragment. (beilstein-journals.org)
  • Fans can experience the excitement of the race first-hand at the Little Marina Green, where the swim ends, and Marina Green where the athlete's transition area and finish line are easily visible. (k226.com)