AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation Science
G-Box Binding FactorsBasic-Leucine Zipper Transcription FactorsLeucine ZippersMice, TransgenicOncogene Protein v-mafDNA-Binding ProteinsTranscription FactorsMolecular Sequence DataActivating Transcription FactorsBase SequenceAmino Acid SequencePlant ProteinsPromoter Regions, GeneticCyclic AMP Response Element-Binding ProteinPlants, Genetically ModifiedRecombinant Fusion ProteinsDNABinding SitesGene Expression Regulation, PlantSequence Homology, Amino AcidTrans-ActivatorsTranscriptional ActivationProto-Oncogene Proteins c-junDimerizationCCAAT-Enhancer-Binding ProteinsTranscription, GeneticRats, TransgenicAnimals, Genetically ModifiedProtein BindingTransgenesArabidopsisNuclear ProteinsFungal ProteinsGene Expression RegulationTwo-Hybrid System TechniquesCloning, MolecularSaccharomyces cerevisiae ProteinsRepressor ProteinsMice, Inbred C57BLViral ProteinsProtein KinasesSequence AlignmentProtein Structure, TertiaryDisease Models, AnimalTobaccoGene ExpressionGreen Fluorescent ProteinsArabidopsis ProteinsPhenotypeMutationRNA, MessengerPlants, ToxicGenes, ReporterGene Expression Regulation, DevelopmentalOryza sativaGenes, PlantOrgan SpecificitySignal TransductionDNA PrimersMice, KnockoutSeedsTransformation, GeneticLuminescent ProteinsCrosses, GeneticProto-Oncogene Proteins c-mafCells, CulturedImmunohistochemistryCell DifferentiationAmyloid beta-Protein PrecursorDNA, PlantReverse Transcriptase Polymerase Chain ReactionHexanonesCell LineBrainPlant LeavesAbscisic AcidEnhancer Elements, GeneticBlotting, WesternIntegrasesGenetic Engineering2S Albumins, PlantRegulatory Sequences, Nucleic AcidResponse ElementsPlant DiseasesMice, Inbred CBARecombinant ProteinsBlotting, NorthernAlzheimer DiseaseDNA, ComplementaryLac OperonPlaque, AmyloidTransfectionAmyloid beta-PeptidesLiverUnfolded Protein ResponsePlant RootsStress, PhysiologicalPolymerase Chain ReactionActivating Transcription Factor 4Activating Transcription Factor 1
Leucine zipperGenesArabidopsisOverexpressionPlantsTobaccoMolecular biologyPathogenesis-relatedGeneAbioticHighly conservedAnti-oxidantRegulationAccumulationTranscriptional factorsABFsBiosynthesisStressesExpressionOxidativeInteractsBHLHInteractPhysiologicalDrought stress toleranceResponsesDomain-containFamilyKinasesCottonWheatUnfolded proteinPathwaysCellularMotifPlantFactorsInhibitorSequenceIdentificationPossessesMiceRoles
Leucine zipper4
  • The basic leucine zipper (bZIP) transcription factor (TF) is one of the largest families of transcription factors (TFs). (biomedcentral.com)
  • The bZIP (basic region/leucine zipper motif) class of TFs have already been demonstrated to play a part in regular plant improvement (seed, floral, leaf, and vascular improvement), and responses to abiotic and biotic stresses [44]. (itkinhibitor.com)
  • AP-1 is composed of either homo or hetero dimers of basic leucine zipper (bZIP) family members [ 11 ]. (biomedcentral.com)
  • Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
Genes19
  • These genes encode proteins that are required for the development and maintenance of photoreceptor structure and its matrix membranes, visual transduction, ciliary trafficking and photoreceptor outer segment shedding. (molvis.org)
  • Overexpression of these genes enhance the tolerance of drought, high salinity, and low temperature in transgenic lines from Arabidopsis, rice, and tobacco. (wikipedia.org)
  • DREB2 also induces the expression of heat-related genes, such as heat shock protein. (wikipedia.org)
  • Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)
  • In addition, steady-state mRNA levels of nine stress-responsive genes coding for either functional or regulatory proteins were induced to higher levels in the transgenic lines with or without drought stress. (biomedcentral.com)
  • Products of the former group function directly in protecting cells against damage derived from stresses and sustaining cell viability, and the latter is composed of regulatory proteins, such as transcription factors (TFs), protein kinases and protein phosphatases, that are responsible for transducing stress signaling and regulating expression of stress-responsive genes [ 5 ]. (biomedcentral.com)
  • According to the transcriptome data of Bambusa emeiensis shoot, two bZIP genes designated as BebZIP 2 and BebZIP 6 were cloned and their bioinformatics were analyzed. (nefu.edu.cn)
  • Cloning and Bioinformatics Analysis of Two bZIP Genes of Bambusa emeiensis and Their Induced Expression under Abiotic Stresses[J]. Bulletin of Botanical Research, 2018, 38(2): 268-277. (nefu.edu.cn)
  • Genome-wide identification and evolutionary analyses of bZIP transcription factors in wheat and its relatives and expression profiles of anther development related TabZIP,genes[J]. BMC Genomics,2015,16:976. (nefu.edu.cn)
  • Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)
  • The activated Ca 2+ sensors can either bind to cis -elements in the promoters of major stress-responsive genes or can interact with DNA-binding proteins controlling these genes, thereby, resulting in their activation or suppression. (beds.ac.uk)
  • Furthermore, elevated Ca 2+ levels can activate calcium-dependent protein kinases (CDPKs), calcium/calmodulin-dependent protein kinases (CCaMKs) or phosphatases that in turn can phosphorylate/dephosphorylate specific transcription factors, thus, regulating expression levels of stress-responsive genes [ 2 ]. (beds.ac.uk)
  • The activation of mitogen-activated protein kinase (MAPK) cascade by H 2 O 2 and subsequent upregulation of specific stress-related genes in Arabidopsis is a perfect example of ROS-mediated stress-response [ 5 ]. (beds.ac.uk)
  • Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
  • The WRKY genes work by showing up- and down- regulation to proteins, various protein-protein interactions and cross-regulation of WRKY TFs. (org.pk)
  • Deficit irrigation-grown AtRAV1/2 and AtABI5 transgenics had 'less-stressed' molecular and physiological phenotypes under drought, likely due to improved photoassimilation and root and shoot sink strengths and enhanced expression of endogenous GhRAV and genes for antioxidant and osmolyte biosynthesis. (tamu.edu)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • We compared the ortholog gene family of the A. sativum transcriptome to A. thaliana , O. sativa , and Z. mays and found that 12,077 orthologous gene families are specific to A. sativum L. Furthermore, we identified genes involved in plant defense mechanisms, their protein-protein interaction network, and plant-pathogen interaction pathways. (springeropen.com)
Arabidopsis9
  • Some of these include dehydration-responsive element-binding protein (DREB), ABA-responsive element-binding factor (AREB), no apical meristem (NAM), Arabidopsis transcription activation factor (ATAF), and cup-shaped cotyledon (CUC). (wikipedia.org)
  • They identified that this gene was not induced upon heat anxiety in heat tolerant varieties, and that Arabidopsis overexpressing this bZIP TF gene performed improved than handle plants under salinity, drought and heat pressure conditions, and had a lower accumulation of ROS under heat tension [54]. (itkinhibitor.com)
  • Progress has been made to better understand about effect of regulons (AREB/ABF, DREB, MYB, and NAC) under abiotic stresses and a number of regulons reported for stress responsive and used as a better transgenic tool of Arabidopsis and Rice. (scielo.br)
  • Sequences surrounding the transcription initiation site of the Arabidopsis enoyl-acyl carrier protein reductase gene control seed expression in transgenic tobacco. (notulaebiologicae.ro)
  • The Arabidopsis NPR1/NIM1 protein enhances the DNA binding activity of a subgroup of the TGA family of bZIP transcription factors. (notulaebiologicae.ro)
  • In-silico analysis of cis-acting regulatory elements of pathogenesis-related proteins of Arabidopsis thaliana and Oryza sativa. (notulaebiologicae.ro)
  • Expression patterns within the Arabidopsis C/S1 bZIP transcription factor network:availability of heterodimerization partners controls gene expression during stress response and development[J]. Plant Molecular Biology,2009,69(1-2):107-119. (nefu.edu.cn)
  • 9. Shaikhali J. GIP1 protein is a novel cofactor that regulates DNA-binding affinity of redox-regulated members of bZIP transcription factors involved in the early stages of Arabidopsis development[J]. Protoplasma,2014,252(3):867-883. (nefu.edu.cn)
  • Xu F, Park MR, Mohanty B, Herath V, Kitazumi A, Yun SJ, De los Reyes BG (2012) Cis-regulatory signatures among orthologous groups of stress-associated bZIP transcription factors from rice, sorghum and Arabidopsis based on phylogenetic footprints. (ttu.edu)
Overexpression2
  • Park MR, Baek SH, De los Reyes BG, Yun SJ (2007) Overexpression of a high-affinity transporter gene from tobacco (NtPT1) enhances phosphate uptake and accumulation in transgenic rice plants. (ttu.edu)
  • Overexpression of bZIP and RAV TFs could impact sustainable cotton agriculture and potentially other crops under limited irrigation conditions. (tamu.edu)
Plants13
  • This research has great significance for the functional characterisation of the tobacco bZIP family and our understanding of the bZIP family in higher plants. (biomedcentral.com)
  • Transgenic plants overexpressing OsBZIP62 are also additional tolerant of oxidative stress [52]. (itkinhibitor.com)
  • Other bZIP transcription aspects are involved in ER pressure responses [53] and also the unfolded protein response that happens when plants are exposed to tension [53]. (itkinhibitor.com)
  • Yet another group of bZIP proteins heterodimerize to kind the C/S1 bZIP network, which is thought to alter the plants metabolism to adapt and survive unde. (itkinhibitor.com)
  • Ectopic expression of PtrABF under the control of a CaMV 35S promoter in transgenic tobacco plants enhanced tolerance to both dehydration and drought. (biomedcentral.com)
  • Under dehydration and drought conditions, the transgenic plants accumulated lower levels of reactive oxygen species compared with wild type, accompanied by higher activities and expression levels of three antioxidant enzymes. (biomedcentral.com)
  • Future research programs can be focused on the development of transgenic plants with enhanced stress tolerance in field conditions based upon the outcome of genomic approaches and knowing the mystery of nucleotides sequences hidden in cells. (intechopen.com)
  • Also disclosed are nucleotide sequences, constructs, vectors, and modified plant cells, as well as transgenic plants displaying increased seed and/or biomass yield, improved tolerance to abiotic stress such as drought or high plant density, improved nitrogen utilization efficiency, increased ear tissue growth or kernel number. (justia.com)
  • The invention further provides regulatory elements, recombinant expression cassettes, host cells and transgenic plants. (justia.com)
  • These studies demonstrate a phosphorylation-dependent translocation of PIF7 when plants are in shade and a novel mechanism involving 14-3-3 proteins, mediated by the retention of PIF7 in the cytoplasm that suppresses the shade response. (elifesciences.org)
  • Here, we present how altered root traits shown by transgenic plants impacted on physiological acclimation responses when submitted to severe water stress. (scirp.org)
  • Stable expression of GFP-fused OsbHLH035 in rice transgenic plants revealed that this protein is predominantly localized to the nucleus. (springeropen.com)
  • The harpin protein Hpa1 has multiple beneficial effects in plants, promoting plant growth and development, increasing crop yield, and inducing plant resistance to pathogens and insect pests. (springeropen.com)
Tobacco4
  • however, there is little research on the bZIP gene family in tobacco. (biomedcentral.com)
  • In this study, 77 bZIP s were identified in tobacco and named NtbZIP01 through to NtbZIP77 . (biomedcentral.com)
  • In this study, the structures and functions of the bZIP family in tobacco were systematically explored. (biomedcentral.com)
  • The CmNAC1-GFP fusion protein was transiently expressed in tobacco leaves for subcellular localization analysis, and we found that CmNAC1 is localized in the nucleus. (frontiersin.org)
Molecular biology2
  • We employ a variety of experimental systems for our studies ranging from molecular biology to transgenic and knockout mice. (stanford.edu)
  • We used diethylnitrosamine (DEN) injection to initiate liver cancer in mice and assessed the extent of liver cancer in JDP2-transgenic and wild type control mice by biochemical and molecular biology techniques. (biomedcentral.com)
Pathogenesis-related1
  • The triggered immunity involves considerable increases in the endogenous levels of SA and its conjugates prior to the induction of pathogenesis-related (PR) proteins and the onset of local and systemic acquired resistance [ 8 ]. (researchsquare.com)
Gene4
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • For example, DREB proteins including DREB2A cooperate with AREB/ABF proteins in gene expression, specifically in the DREB2A gene under osmotic stress conditions. (wikipedia.org)
  • AREB/ABFs are ABA-responsive bZIP-type TFs which bind to ABA-responsive elements (ABREs) in stress-responsive promoters and activate gene expression. (wikipedia.org)
  • 54] identified a bZIP transcription element gene that was responsive to salt, heat, drought, and ABA. (itkinhibitor.com)
Abiotic4
  • Quantitative real-time polymerase chain reaction analysis identified that expression patterns of bZIP s differed, including in different organs and under various abiotic stresses. (biomedcentral.com)
  • Many bZIP s may play vital roles in the regulation of organ development, growth, and responses to abiotic stresses. (biomedcentral.com)
  • Our results indicated that CmNAC1 is a critical factor in ABA signaling pathways and it can be utilized in transgenic breeding to improve the abiotic stress tolerance of crops. (frontiersin.org)
  • As a largest plant-specific transcription factor family, NAC domain proteins play an important role in plant development and regulation of abiotic stress tolerance. (frontiersin.org)
Highly conserved1
Anti-oxidant1
  • Therefore, many of us deduce that ebselen probably makes use of accessible thiols on sulphydryl protein for you to effect its GPx mimicry anti-oxidant actions versus fat peroxidation in rat brain homogenate. (pka-signal.com)
Regulation2
  • The regulation of expression of X-box-binding protein-1 (XBP1), a transcriptional factor, involves an unconventional mRNA splicing that removes the 26 nucleotides intron. (mdpi.com)
  • These strategies involve rearrangements at the molecular level starting from transcription, regulation of mRNA processing, translation, and protein modification or its turnover. (intechopen.com)
Accumulation3
  • Accumulation of unfolded proteins in the ER lumen triggers the dissociation of GRP78 from its quiescent UPR mediators. (molvis.org)
  • We observed synergy for root biomass accumulation in the greenhouse, intrinsic WUE in the field and drought tolerance in stacked AtRAV and AtABI5 double-transgenic cotton. (tamu.edu)
  • Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)
Transcriptional factors1
  • This control consists mainly of transcriptional factors, such as dehydration-responsive element-binding protein (DREB), abscisic acid (ABA)-responsive element-binding factor (AREB), and NAM (no apical meristem). (wikipedia.org)
ABFs1
  • AREB/ABFs are positively regulated by SnRK2s, controlling the activity of target proteins via phosphorylation. (wikipedia.org)
Biosynthesis1
  • Some biochemical modifications like biosynthesis of various hormones (ABA) and proteins (proline) also help in reducing the yield losses. (org.pk)
Stresses1
  • Phosphorylation of eIF2α on Ser51 inhibits 5' cap-dependent mRNA translation, resulting in the global suppression of protein synthesis to facilitate adaptation to a variety of stresses linked to protein synthesis, including proteotoxic stress, viral replication, heme depletion and amino acid withdrawal [ 2 ]. (biomedcentral.com)
Expression3
  • Park MR, Yun KY, Herath V, Mohanty B, Xu F, Bajic VB, Yun SJ, De los Reyes BG (2010) Supra-optimal expression of the cold-regulated OsMyb4 transcription factor in transgenic rice changes the complexity of transcriptional network with major effects on stress tolerance and panicle development. (ttu.edu)
  • These conditions include but are not limited to artery or vein occlusion in diabetic retinopathy, hypoxic retina in retinopathy of prematurity, aging in age-related macular degeneration, expression of mutant proteins in inherited retinal degeneration, traumatic injury leading to retinal detachment, and light sensitivity in the case of light-induced retinal degeneration. (molvis.org)
  • Blocking the interaction between PIF7 and 14-3-3 proteins or reducing the expression of 14-3-3 proteins accelerates shade-induced nuclear localization and de-phosphorylation of PIF7, and enhances the shade phenotype. (elifesciences.org)
Oxidative2
  • Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
  • One important heat shock protein is discussed further in the blog entry HSP70 to the rescue The relatively recent blog entries Mitohormesis and Radiation hormesis define hormesis in more detail and discuss it as it relates to mitochondrial oxidative stress and stress induced by radiation. (anti-agingfirewalls.com)
Interacts1
BHLH2
  • The bHLH protein, OsbHLH148, was shown to interact with proteins inside the jasmonate signaling pathway and to confer drought tolerance when OsbHLH148 was overexpressed in rice [43]. (itkinhibitor.com)
  • In our study, the bHLH protein DEGs had been much more typically down-regulated and present in the later time points, along with the up-regulated DEGs had been extra frequent in the 24-h time point. (itkinhibitor.com)
Interact1
  • These studies have revealed that 14-3-3 proteins can interact with the phosphorylated forms of their client proteins in response to certain signals, and that this binding finalizes the signaling event by enabling a change in the subcellular localization, protein stability or intrinsic enzymatic activity of the client, or by promoting an association between the client and other proteins. (elifesciences.org)
Physiological1
  • Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
Drought stress tolerance1
  • PtrABF is a bZIP transcription factor and functions in positive modulation of drought stress tolerance. (biomedcentral.com)
Responses3
  • Previous studies have shown that the bZIP TF family is involved in plant growth, development, and stress responses. (biomedcentral.com)
  • Moreover, the drought stress responses can be improved by employing different techniques such as marker assisted selection along with conventional breeding methods and by application of different hormones, osmolytes & enzymes and generating transgenic rice varieties (Upadhayaya and Panda 2019). (org.pk)
  • In this way, we evaluated the effects of water deficit progress on AtDREB2A-CA transgenic cotton plant responses, driven by the stress-inducible rd29 promoter. (scirp.org)
Domain-contain1
  • The down-regulated MYB domain-containing protein DEGs were present in the later time points and had been slightly extra prevalent than the up-regulated DEGs, which had been additional abundant in the 48 h time point. (itkinhibitor.com)
Family4
  • The bZIP TF family is named after the bZIP domain [ 5 ]. (biomedcentral.com)
  • Research into the bZIP family in different species will bring new insights into its evolution and function. (biomedcentral.com)
  • Most of the important insights regarding the specific function of AP-1 proteins have been established through the use of mice with either loss- or gain-of-function manipulations of various members of the bZIP protein family [ 13 ]. (biomedcentral.com)
  • Antoine W, de los Reyes BG, Miernyk JA, Stewart JM (2009) Molecular evolution of the plant SLT protein family. (ttu.edu)
Kinases2
  • Osmotic stress signaling is known to be transduced via both ABA-dependent (e.g., mitogen-activated protein kinases [MAPKs]) and ABA-independent (e.g., via the OsDREB1 and OsDREB2 TFs) pathways (Kumar et al. (springeropen.com)
  • The eIF2α kinases phosphorylate Ser51 of eIF2α which leads to suppression of global protein synthesis but selective enhancement of translation of some mRNAs, such as that encoding ATF4. (biomedcentral.com)
Cotton1
  • Transgenic cotton (Gossypium hirsutum) expressing AtRAV1/2 and/or AtABI5 showed resistance to imposed drought stress under field and greenhouse conditions and exhibited improved photosynthesis and WUEs associated with absorption through larger root system and greater leaf area. (tamu.edu)
Wheat1
  • Inside a study of bZIP transcription things in wheat, Agarwal et al. (itkinhibitor.com)
Unfolded protein1
Pathways1
  • The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
Cellular1
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
Motif1
  • DEAR1 ("DREB and EAR motif protein 1") is a TF with an entirely different purpose nothing to do with drought stress. (wikipedia.org)
Plant1
  • In addition, NAC domain proteins have become a popular research topic for different plant species. (frontiersin.org)
Factors4
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
  • Several types of Xoo virulence factors have been identified, including proteins associated with exopolysaccharide (EPS) production and motility, outer membrane (OM) proteins and TonB-dependent receptors, hypersensitive response and pathogenicity (Hrp) proteins, and type III (T3) effectors [ 2 ]. (researchsquare.com)
  • These transcription factors work by regulating different mechanisms of drought tolerance and by releasing hormones, proteins, reducing-sugars, solutes and by affecting the stomatal conductance and root architecture. (org.pk)
  • 3%). The organic phase is mainly formed by collagen type I fibers, which provide elasticity and flexibility to bone, but also non-collagenous proteins as well, such as cytokines, growth factors, and proteoglycans. (biomedcentral.com)
Inhibitor1
  • Developmental endothelial locus-1 (DEL-1), an extracellular matrix protein, is a neutrophil adhesion inhibitor that attenuates neutrophilic inflammation. (bvsalud.org)
Sequence1
  • The bZIP protein sequence contains 2 conserved bZIP domains with a total length of ~ 60-80 amino acids. (biomedcentral.com)
Identification1
Possesses1
  • The molecular chaperone glucose-regulated protein 78 ( GRP78 ) or binding immunoglobulin protein (BiP), in addition to Ca 2+ binding and protein processing functions, possesses one more key role: master initiator of early UPR signaling. (molvis.org)
Mice3
  • JDP2-transgenic mice display normal liver function. (biomedcentral.com)
  • JDP2-transgenic mice displayed potentiation of liver cancer, higher mortality and increased number and size of tumors. (biomedcentral.com)
  • We analyzed CRTC3-null, KRT14-SCF transgenic, and their crossover mice. (thno.org)
Roles1
  • That entry was the first to discuss the roles of heat shock and chaperone proteins in hormesis. (anti-agingfirewalls.com)