• Soluble transferrin receptor-1 (sTfR1) concentrations are increased in the plasma under two conditions that are associated with increased iron absorption, i.e. iron deficiency and increased erythropoiesis. (karger.com)
  • In contrast, soluble transferrin receptor (sTfR) indicates iron deficiency and is unaffected by inflammation. (nih.gov)
  • In areas with a limited infection pressure, soluble transferrin receptor (sTfR) has been shown to be a promising new tool for the diagnosis of deficiency of iron stores. (bmj.com)
  • High levels of transferrin may be a sign of iron deficiency anemia, and doctors can use a soluble transferrin receptor (sTfR) test to check for these levels. (medicalnewstoday.com)
  • Soluble transferrin receptor assay may be useful in these situations because it reflects the degree of iron requirement in relation to supply and it is not an acute phase reactant. (ijbls.org)
  • Our aim was to evaluate the usefulness of soluble serum transferrin receptor (sTfR) in relation to serum ferritn in the diagnosis of iron deficiency and iron deficiency anaemia during pregnancy. (ijbls.org)
  • Serum iron and soluble transferrin receptor concentration were determined using ELISA technique while haemoglobin concentration was determined using automatic cell counter PCE-210 version 5.10 by ERMA INC. Tokyo. (ijbls.org)
  • Lack of difference in iron status assessed by soluble transferrin receptor between children with cerebral malaria and those with non-cerebral malaria. (espkinshasa.net)
  • Iron status was assessed by soluble transferrin receptor (sTfR), serum ferritin, and haemoglobin in 44 Zaïrian children: 15 with cerebral malaria, 14 with non-cerebral malaria, and 15 without malaria (age range 0.5-16 years). (espkinshasa.net)
  • Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique. (who.int)
  • Transferrin receptor testing is used to measure the level of soluble transferrin receptors, thereby aiding in the evaluation of iron deficiency and in the diagnosis of iron-deficiency anemia. (medscape.com)
  • The specific objective of this component is to determine the prevalence of iron deficiency anemia using iron and TIBC (transferrin saturation) in conjunction with ferritin and erythrocyte protoporphyrin. (cdc.gov)
  • TfR-F index incorporated the high sensitivity of sTfR, a proxy for cellular iron need, and the high specificity of ferritin, a proxy for iron stores. (bmj.com)
  • These are widely used in clinics and include ferritin, serum iron, serum transferrin, total iron binding capacity (TIBC) and mean cell volume (MCV). (bmj.com)
  • Ferritin is an iron-containing protein in the blood. (medicalnewstoday.com)
  • Levels of ferritin can help doctors understand how much iron is in the body's stores. (medicalnewstoday.com)
  • Low ferritin levels indicate low iron stores and iron deficiency. (medicalnewstoday.com)
  • transferrin A plasma protein (a β- globulin ) that can bind to iron and transport it to the liver for storage (see ferritin ) or to the cells of bone marrow , where it is used for the formation of haemoglobin. (encyclopedia.com)
  • Improvements in survival have been achieved over the last 40 years due to iron chelation therapy and iron assessment by serum ferritin, and liver/cardiac magnetic resonance imaging (MRI) techniques ( 3 3. (scielo.br)
  • Furthermore, G2019S knock-in mice show a significant increase in iron deposition in microglia following intrastriatal LPS injection compared to wild-type mice, accompanied by striatal accumulation of ferritin. (cam.ac.uk)
  • Current markers of iron deficiency tend to be less reliable in pregnancy especially ferritin which is an acute phase reactant and as such will not be reliable in the diagnosis of iron deficiency anaemia among pregnant women with infections. (ijbls.org)
  • 0.5).Conclusions: sTfR seems to be a more specific and sensitive marker of iron deficiency anaemia in pregnancy when compared to serum ferritin especially in the presence of infection. (ijbls.org)
  • Although there was no significant difference in the mean concentrations of sTfR, serum ferritin, or haemoglobin between either group of patients, a higher percentage of children with cerebral malaria (27 per cent) than those with non-cerebral malaria (14 per cent) or controls (7%) had sTfR levels above 7.3 mg/l (suggestive of tissue iron deficiency). (espkinshasa.net)
  • Associations between self-reported supplementation and duration of vegan diet with biomarkers of cobalamin (serum cobalamin, holotranscobalamin, homocysteine, folate) and iron status (serum ferritin, iron binding capacity, transferrin and saturation of transferrin) were assessed by cross-sectional analyses of medical data from a clinical nutrition center. (mdpi.com)
  • or anything relating to natural/microbial lactoferrin/transferrin/ferritin breakdown. (bio.net)
  • Design-- In this community-based cluster survey, capillary blood was obtained from 680 children (aged 6-35 mo) for measurement of iron status by using ferritin, TfR, and ZP. (cdc.gov)
  • Positive predictive values of ID based on the other iron indicators in predicting ID based on the multiple- criteria model were highest for ferritin and TfR. (cdc.gov)
  • Red blood cells tend to be microcytic and hypochromic, and iron stores are low, as shown by low serum ferritin and low serum iron levels with high serum total iron-binding capacity. (msdmanuals.com)
  • [ 2 ] Unlike ferritin, the transferrin receptor level is not affected by infection or inflammation and is therefore useful in distinguishing iron deficiency anemia from anemia of chronic disease. (medscape.com)
  • Along with other tests in an anemia panel (iron, ferritin, reticulocyte count, lactate dehydrogenase [LDH], vitamin B-12, folate), the type of anemia can be diagnosed based on the transferrin receptor levels. (medscape.com)
  • Receptors, Transferrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Receptors, Transferrin" by people in this website by year, and whether "Receptors, Transferrin" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Receptors, Transferrin" by people in Profiles. (umassmed.edu)
  • The linings of tiny blood vessels in the brain are equipped with special transferrin receptors that allow iron to reach brain tissue. (nhpr.org)
  • They did, by designing a "transport vehicle" that could carry many different drugs across the blood-brain barrier by interacting with the transferrin receptors. (nhpr.org)
  • In vitro and in vivo experiments will be conducted to investigate how recombinant transferrin interacts with cellular receptors, regulates iron uptake, and influences cellular proliferation. (prospecbio.com)
  • M catarrhalis also expresses specific proteins for iron uptake that act as receptors for transferrin and lactoferrin. (medscape.com)
  • transferrin can transport iron from cells (intestinal, macrophages) to specific receptors on erythroblasts, placental cells, and liver cells. (msdmanuals.com)
  • Transferrin receptors, which are blood proteins, may be elevated in persons with iron deficiency. (medscape.com)
  • Reference intervals of transferrin receptors have not been established for pregnant females, children, or recent or frequent blood donors. (medscape.com)
  • The iron variable name is LBXIRN, the TIBC variable name is LBXTIB, and the variable name for transferrin saturation is LBDPCT. (cdc.gov)
  • We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age). (who.int)
  • Nous avons examiné des patients yéménites âgés de 12 mois à 30 ans atteints de drépanocytose homozygote afin d'établir leur bilan en fer à l'aide de quatre critères (taux de fer sérique faible, taux de saturation de la transferrine faible, capacité totale de fixation du fer élevée et volume globulaire moyen faible par rapport à l'âge). (who.int)
  • Data were collected from 255 medical records containing complete medical history, including physical examination, classification of pubertal development (Tanner), weight, height, diet recall survey and the following laboratory tests: blood count, serum iron, transferrin saturation and stool tests. (bvsalud.org)
  • TIBC was calculated indirectly using the unsaturated iron binding capacity (UIBC) method. (cdc.gov)
  • The TIBC is the sum of iron and UIBC. (cdc.gov)
  • Total iron binding capacity (TIBC) is a blood test to check for levels of iron in the blood. (medicalnewstoday.com)
  • If TIBC levels are high, it may indicate low iron in the blood due to iron deficiency anemia. (medicalnewstoday.com)
  • Underweight, decreased serum iron and TIBC were independent risk factors for moderate clinical disease. (nature.com)
  • Combined detection of decreased serum iron and TIBC was helpful in differentiating severe patients. (nature.com)
  • Decreases in serum iron and TIBC were associated with the clinical activity of CD. (nature.com)
  • Total iron binding capacity (TIBC) is a blood test to see if you have too much or too little iron in your blood. (medlineplus.gov)
  • TIBC is usually higher than normal when the body's iron supplies are low. (medlineplus.gov)
  • The total iron-binding capacity (TIBC) test looks at how well the iron moves through your body. (rochester.edu)
  • The TIBC test is based on certain proteins, including transferrin, found in the blood. (rochester.edu)
  • Your transferrin levels are almost always measured along with iron and TIBC. (rochester.edu)
  • Iron, TIBC, and transferrin blood tests are almost always done together. (rochester.edu)
  • Iron and TIBC are measured in micrograms per deciliter (mcg/dL). (rochester.edu)
  • Your healthcare provider will look at your iron level along with the TIBC, transferrin, and possibly other tests to see what the results mean. (rochester.edu)
  • Background: Because iron and cadmium share common transport mechanisms, iron-processing protein variants such as HFE C282Y, HFE H63D, and Transferrin P570S may influence cadmium metabolism. (cdc.gov)
  • The specific iron-binding protein in plasma, it has a role in the transportation and distribution of iron among the body organs, in iron metabolism and in prevention of iron loss via the kidney. (creativebiomart.net)
  • Understanding these mechanisms is fundamental for deciphering the complexities of iron metabolism and its impact on health and disease. (prospecbio.com)
  • Data from National Health and Nutrition Examination Survey (NHANES- III), described by Frutuoso, Vigantzky and Gambardella 3 are concerned to the effect of growth spurt, which occurs during the adolescence reflecting into the metabolism and iron deficiency. (bvsalud.org)
  • Diseases of iron metabolism. (medscape.com)
  • Furthermore, we determined serum prohepcidin, a precursor of hepcidin, the main hormone implicated in iron metabolism. (bvsalud.org)
  • TfR1 is required for iron import from transferrin into cells by endocytosis. (wikipedia.org)
  • Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis. (wikipedia.org)
  • Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). (rcsb.org)
  • Endocytosis of iron loaded transferrin/receptor complex leads, after acidification of the endosome, to the separation of iron and its diffusion out of the vesicle. (reactome.org)
  • The system involves proteins called transferrin that carry iron throughout the body. (nhpr.org)
  • We propose that these particles likely had a crucial role in the preservation of the proteins, and may be remnants partially contributed from haemoglobin and other iron-rich proteins from the original blood. (nature.com)
  • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O: A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. (karger.com)
  • Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. (wikipedia.org)
  • Iron moves through the blood attached to a protein called transferrin. (medlineplus.gov)
  • This test helps your health care provider know how well that protein can carry iron in your blood. (medlineplus.gov)
  • Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery. (umassmed.edu)
  • Iron in your body is carried, or bound, mainly to a protein made by your liver called transferrin. (rochester.edu)
  • Finally, iron is necessary to form myoglobin-a type of protein that carries and stores oxygen in the muscle tissue. (superkidsnutrition.com)
  • This multifaceted protein serves as an essential carrier of iron and is crucial for cellular growth, immunity, and various physiological processes. (prospecbio.com)
  • transferrin ( siderophilin ) (trans- fer -in) n. a glycoprotein, found in the blood plasma, that acts as a carrier for iron in the bloodstream. (encyclopedia.com)
  • Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of the receptor-transferrin complex. (rcsb.org)
  • Desferrioxamine, widely used for the treatment of iron overload in Cooley's anaemia, binds iron so tightly that it should quantitatively remove iron from transferrin. (elsevierpure.com)
  • In the absence of an iron chelating agent, patients with beta-thalassemia on regular transfusions present complications of transfusion-related iron overload. (scielo.br)
  • These practice guidelines, prepared by the Scientific Committee of Associação Brasileira de Thalassemia (ABRASTA), presents a review of the literature regarding iron overload assessment (by imaging and laboratory exams) and the role of T2* magnetic resonance imaging (MRI) to control iron overload and iron chelation therapy, with evidence-based recommendations for each clinical situation. (scielo.br)
  • Transfusion-dependent patients with thalassemia major(TM) develop iron overload which leads to damage of the liver, heart, and endocrine organs and related morbidity and mortality ( 1 1. (scielo.br)
  • Iron chelation therapy with desferrioxamine (DFO), available since the late 1960s and the most widely used iron chelator, decreased iron overload-related complications and mortality rate of patients with TM ( 4 4. (scielo.br)
  • Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. (scielo.br)
  • Although available in many countries, one third of the patients developed signs of iron overload, such as delayed or absent puberty, growth disorders, hypothyroidism, hypogonadism, bone abnormalities, cirrhosis and heart disease (main cause of death in transfusion dependent patients with TM). (scielo.br)
  • Overload of iron content in enterocytes reduces the expression of duodenal cytochrome B (DcytB) and divalent metal transporter 1 (DMTI) on the brush border membrane, inhibiting dietary iron absorption 9 . (nature.com)
  • Disorders of iron homeostasis: iron deficiency and overload. (medlineplus.gov)
  • ABSTRACT Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. (who.int)
  • The exact number of blood transfusions that lead to significant iron overload varies with the patient's underlying disease and the duration of their transfusion dependence. (medscape.com)
  • Transfusion-induced iron overload superimposed on hepatitis C would accelerate the development of cirrhosis. (medscape.com)
  • Labile plasma iron in iron overload: redox activity and susceptibility to chelation. (medscape.com)
  • Fish contains certain components that enhance non-haem iron absorption. (europa.eu)
  • 2.To comparatively study the effect of sous vide fish on non-haem iron absorption from vegetables in a group of women with either the G277S/G277S or G277S/G277G genotype (preferably homozygous) versus a control group that do not present the indicated mutation in the transferrin gene but the wild type G277G/G277G. (europa.eu)
  • To determine the possible role of sTfR1 as a signaling mechanism for iron absorption, a hydrodynamic gene transfer technique was established to express transfected plasmid constructs of human sTfR1 (hsTfR1) and murine sTfR1 (msTfR1) from the livers of C57BL/6 mice. (karger.com)
  • Iron absorption, serum iron levels and hepcidin expression were then measured. (karger.com)
  • Although expression of high levels of sTfR1 significantly increased serum iron levels, repeated experiments showed that neither hsTfR1 nor msTfR1 had any effect on iron absorption or hepcidin mRNA expression levels. (karger.com)
  • Thus, despite its attractiveness as a potential modifier of iron absorption, sTfR1 levels do not exert a regulatory effect on iron absorption. (karger.com)
  • Factors leading to iron deficiency include bleeding, reduced iron absorption and immune regulation. (nature.com)
  • They showed that the level of serum iron and the total iron binding capacity were decreased in active CD patients due to impaired oral iron absorption 8 . (nature.com)
  • While iron absorption increases in pregnancy, little is known about the exact mechanisms regulating maternal iron levels and transfer through the placenta in normal and complicated pregnancies. (lu.se)
  • Iron absorption is determined by its source and by what other substances are ingested with it. (msdmanuals.com)
  • Iron absorption is best when food contains heme iron (meat). (msdmanuals.com)
  • Ascorbic acid is the only common food element known to increase nonheme iron absorption. (msdmanuals.com)
  • Insufficient dietary intake and absorption of iron is the top responsible for malnutrition. (bvsalud.org)
  • Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the most prevalent forms of anemia and often occur concurrently. (nih.gov)
  • Which tests can diagnose iron deficiency anemia? (medicalnewstoday.com)
  • Iron deficiency anemia occurs when the body does not have enough healthy red blood cells due to a lack of iron in the body. (medicalnewstoday.com)
  • A person with iron deficiency anemia may not get enough iron in their diet. (medicalnewstoday.com)
  • People with mild to moderate iron deficiency anemia may have no signs or symptoms. (medicalnewstoday.com)
  • Doctors may use a number of tests to help diagnose iron deficiency anemia, checking for various levels in the blood as well as markers of other underlying factors. (medicalnewstoday.com)
  • Read on to find out more about iron deficiency anemia. (medicalnewstoday.com)
  • A low RBC count may be a sign of iron deficiency anemia. (medicalnewstoday.com)
  • Doctors may give this test along with transferrin tests to check for signs of anemia. (medicalnewstoday.com)
  • A person with iron deficiency anemia will have red blood cells that appear smaller and paler than typical under a microscope. (medicalnewstoday.com)
  • found that serum hepcidin was positively correlated with IL-6 and negatively correlated with hemoglobin in anemia of chronic disease (ACD) 11 .This suggested that iron stored in these inflammatory cells is an important source of hematopoiesis in CD patients with ACD. (nature.com)
  • Microcytosis in adulthood is known to occur in conjunction with anemia because of iron deficiency, chronic diseases, hemoglobinopathy, etc. 11, 12) Mutations in the ank/ank gene induce microcytosis that is unrelated to the JAK2 V617F mutation 13) . (ispub.com)
  • Having low levels of iron can mean you have iron-deficiency anemia. (healthline.com)
  • Iron-deficiency anemia is the most common type of anemia. (healthline.com)
  • While the condition may be common, many people don't know they have iron-deficiency anemia. (healthline.com)
  • In women of childbearing age, a common cause of iron-deficiency anemia is a loss of iron in the blood due to heavy menstruation or pregnancy. (healthline.com)
  • A poor diet, or certain intestinal diseases that affect how the body absorbs iron, can also cause iron-deficiency anemia. (healthline.com)
  • What are the symptoms of iron-deficiency anemia? (healthline.com)
  • The symptoms of iron-deficiency anemia can be mild at first, and you may not even notice them. (healthline.com)
  • According to the ASH, iron deficiency is the most common cause of anemia. (healthline.com)
  • Heavy menstrual bleeding is a common cause of iron-deficiency anemia in women of childbearing age. (healthline.com)
  • Certain medical conditions can cause internal bleeding, which can lead to iron-deficiency anemia. (healthline.com)
  • This is called iron deficiency anemia. (rochester.edu)
  • Not having enough iron in your diet is the most common cause of anemia. (rochester.edu)
  • iron deficiency anemia can get prevented through strategic meal choices. (superkidsnutrition.com)
  • Clinical trials and studies involving individuals with iron-related disorders, such as iron-deficiency anemia, will be conducted to evaluate the efficacy and safety of recombinant transferrin supplementation. (prospecbio.com)
  • Only a small proportion of anemia in North East Thai school children is associated with iron deficiency. (who.int)
  • Iron deficiency anemia is considered to be one of the main public health issues throughout the world. (bvsalud.org)
  • Elevated levels are seen in iron-deficiency anemia. (medscape.com)
  • Transferrin receptor testing is used in the diagnosis of anemia and in deciding adequate treatment. (medscape.com)
  • 75) to distinguish iron-deficiency anemia from anemia of chronic disease from anemia of chronic inflammation. (medscape.com)
  • The G277S transferrin mutation is found to influence iron metabo lism and predispose menstruating white women to iron deficiency anaemia. (europa.eu)
  • Mutation of Tf histidine residues predicted to interact with the W641/F760 patch eliminates TfR-dependent acceleration of iron release. (elsevierpure.com)
  • Here, we show that iPSC-derived microglia from patients carrying the most common LRRK2 mutation, G2019S, mistraffic transferrin to lysosomes proximal to the nucleus in proinflammatory conditions. (cam.ac.uk)
  • Microcytosis during the clinical course of PV may be a result of iron deficiency or excessive erythropoiesis due to the JAK2 V617F mutation. (ispub.com)
  • The primary objective of this research is to elucidate the essential role of transferrin in iron homeostasis and its significance for human health. (prospecbio.com)
  • The average American diet, which contains 6 mg of elemental iron/1000 kcal of food, is adequate for iron homeostasis. (msdmanuals.com)
  • Regulation of systemic iron homeostasis: how the body responds to changes in iron demand. (medscape.com)
  • Two of these studies suggest that an epistatic interaction between variants rs1049296 in the transferrin (TF) gene and rs1800562 in the homeostatic iron regulator (HFE) gene, commonly known as hemochromatosis, is in genetic association with AD. (nih.gov)
  • Certain disorders or surgeries that affect the intestines can also interfere with how your body absorbs iron. (healthline.com)
  • The findings may contribute to the development of innovative strategies for the treatment of iron-related disorders and the advancement of biomedicine and scientific research. (prospecbio.com)
  • Transferrin is a monomeric glycoprotein found in plasma at an average concentration of 250 mg/100ml. (creativebiomart.net)
  • Transferrin is an iron-binding glycoprotein found in the plasma. (medscape.com)
  • For heme synthesis, transferrin transports iron to the erythroblast mitochondria, which insert the iron into protoporphyrin IX for it to become heme. (msdmanuals.com)
  • Standard tests of iron status used in differential diagnosis are affected by inflammation, hindering clinical interpretation. (nih.gov)
  • This study aimed to investigate whether serum indicators related to iron stores in the body are associated with clinical and endoscopic disease severity. (nature.com)
  • The second objective is to assess the clinical relevance of human recombinant transferrin in medical interventions. (prospecbio.com)
  • These investigations may provide insights into the use of recombinant transferrin as a therapeutic agent in various clinical settings. (prospecbio.com)
  • By delving into the diverse functions of human recombinant transferrin, this research aims to expand our understanding of its physiological roles and clinical applications. (prospecbio.com)
  • Hershko C. Iron loading and its clinical implications. (medscape.com)
  • Due to the potential risk of iron supplementation in iron replete children, it is important to properly identify children who may require iron supplementation. (bmj.com)
  • Due to a recent finding in Tanzania of an increased mortality in iron replete children receiving iron supplementation, there is an urgent need to be able to target iron therapy and prophylaxis programmes on the children with proven iron deficiency. (bmj.com)
  • Iron deficiency in Cambodia: the need for iron supplementation among preschool-aged children. (who.int)
  • It's the most common type of diet deficiency in the U.S. You may need this test to look at your diet, nutrition, liver, or other conditions that cause iron to be low, such as blood loss or pregnancy. (rochester.edu)
  • Iron deficiency in patients with nonalcoholic Fatty liver disease is associated with obesity, female gender, and low serum hepcidin. (arctichealth.org)
  • We examine the relationship between obesity, circulating levels of hepcidin, and IL6 and IL1ß, and other risk factors in patients with nonalcoholic fatty liver disease (NAFLD) with iron deficiency. (arctichealth.org)
  • Liver iron concentrations and urinary hepcidin in beta-thalassemia. (medscape.com)
  • Iron accumulation in alcoholic liver diseases. (medscape.com)
  • Unaltered maternal plasma IL-6 levels suggest mechanism other than inflammation being involved in altered iron regulation in PE pregnancy. (lu.se)
  • Transferrin (plasma half-life, 8 days) is extruded for reutilization. (msdmanuals.com)
  • Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less iron is released from Fe-Tf inside cells expressing W641A/F760A-TfR than cells expressing wild-type TfR (wtTfR). (elsevierpure.com)
  • Some of the TfR1 targeting antibodies have been shown to cross the blood-brain barrier, without interfering with the uptake of iron. (wikipedia.org)
  • CD71 plays a role in the control of cellular proliferation by facilitating the uptake of iron via ferrotransferrin binding and the recycling of apotransferrin to the cell surface. (biolegend.com)
  • Iron deficiency anaemia can impair work efficiency, cause symptoms of fatigue and malaise and during pregnancy it can result in pre-term labour and low-birth-weight babies. (europa.eu)
  • The body may also lose iron through bleeding, pregnancy, or chronic conditions. (medicalnewstoday.com)
  • Assessing iron status during pregnancy is fraught with difficulties because the profound hemodynamic changes associated with pregnancy affect several indexes of iron status. (ijbls.org)
  • So is pregnancy, because your body needs more iron during this time in order to create enough oxygen for the baby. (healthline.com)
  • increases are found in pregnancy, iron-deficiency anemias and inoculation hepatitis. (creativebiomart.net)
  • A significant micronutrient during pregnancy is iron, which is important in cellular functions. (lu.se)
  • Having enough transferrin in the body is important to ensure iron can get into the cells. (medicalnewstoday.com)
  • As the lung is a major site of Pseudomonas infection, the ability of these iron chelates to augment oxidant-mediated pulmonary artery endothelial cell injury via release of 51Cr from prelabeled cells was examined. (duke.edu)
  • Transferrin is required by all types of cells in cultures for maximal growth. (creativebiomart.net)
  • Membrane glycoproteins found in high concentrations on iron-utilizing cells. (umassmed.edu)
  • Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells. (umassmed.edu)
  • Iron is nessisary for all mammalian cells but is also toxic in excess. (wikipathways.org)
  • Iron deficiency anaemia is a condition wherein your body lacks iron to make enough red blood cells. (philipkingsley.com)
  • Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. (medscape.com)
  • The UIBC was equal to the total iron added minus the excess iron. (cdc.gov)
  • These changes were associated with lower placental transferrin receptor 1 (TfR1) in syncytiotrophoblasts in both early- and late-onset PE. (lu.se)
  • Iron deficiency anaemia is the most common nutritional deficit in either the developed or the developing world, being more prevalent in women of child-bearing age and children. (europa.eu)
  • Biochemical iron markers were compared to bone marrow iron findings in 381 Malawian children with severe anaemia. (bmj.com)
  • 3 To be able to do this there is a need for non-invasive and sensitive tests that distinguish iron stores deficiency from functional iron deficiency which is associated with anaemia of inflammation. (bmj.com)
  • The sensitivity of sTfRin relation to both anaemia and depleted iron stores was 67.99%, but this figure may not be a true reflection of sensitivity because of small sample size. (ijbls.org)
  • If you do not have enough iron in your body, you may develop a condition called iron deficiency anaemia - which can cause your hair to shed. (philipkingsley.com)
  • Anaemia can occur if your diet lacks iron-rich foods, or if you are not absorbing iron adequately. (philipkingsley.com)
  • If you discover you are anaemic, try not to worry - hair loss due to anaemia is reversible and your GP can prescribe you an iron supplement. (philipkingsley.com)
  • The most beneficial treatment for anaemia is making sure you're getting enough iron through good nutrition as well as a suitable supplement. (philipkingsley.com)
  • Informed consent was obtained from the most common, iron deficiency anaemia the children's guardians for all participants. (who.int)
  • Previous work has shown that the Pseudomonas-derived protease, pseudomonas elastase (PAE), can modify transferrin to form iron complexes capable of catalyzing the formation of hydroxyl radical (.OH) from neutrophil (PMN)-derived superoxide (.O2-) and hydrogen peroxide (H2O2). (duke.edu)
  • Very little is known about the influence of processed fish on iron bioavailability. (europa.eu)
  • If you are strictly sticking to breastfeeding , keep in mind that human milk contains minimal iron with low bioavailability. (superkidsnutrition.com)
  • Discussion: Our data supports a deregulation in maternal iron bioavailability in early- and late-onset PE vs normotensive pregnancies. (lu.se)
  • Methods: In a longitudinal cohort of men age 51-97, the Normative Aging Study (NAS), we evaluated toenail cadmium concentrations and missense single nucleotide polymorphisms (SNPs) in the HFE and Transferrin genes. (cdc.gov)
  • Results: HFE and Transferrin genotypes were not associated with toenail cadmium concentrations in the main effect analyses, but there were significant interactions between HFE H63D and hemoglobin (pinteraction=0.021), as well as HFE H63D and vitamin C intake (pinteraction=0.048). (cdc.gov)
  • In the absence of DC-derived hepcidin, iron can be released from macrophages and neutrophils to the lumen through ferroportin 10 . (nature.com)
  • Hepcidin is a hormone that can block your intestines from absorbing iron. (healthline.com)
  • The iron regulatory hormone hepcidin is regulated by iron and cytokines interleukin (IL) 6 and IL1ß. (arctichealth.org)
  • However, assessment of the iron status has proven to be difficult, especially in children living in areas with high infection pressure (including malaria). (bmj.com)
  • In areas with a high infection pressure, the TfR-F index best predicted iron deficiency. (bmj.com)
  • However, these iron markers are considerably altered by inflammation, which limits their applicability, especially in areas with a high infection pressure. (bmj.com)
  • We have evaluated the diagnostic accuracy of various iron markers against bone marrow iron assessment in children residing in an area of high infection pressure. (bmj.com)
  • We conclude .OH formation resulting from protease alteration of transferrin may serve as a mechanism of tissue injury at sites of bacterial infection and other processes characterized by increased proteolytic activity. (duke.edu)
  • Mean cell haemoglobin concentration (MCHC), using a cut-off of 32.1 g/dl, had a sensitivity of 67% and specificity of 64% for detecting iron stores deficiency. (bmj.com)
  • In this context iron The diagnosis of SCD was established Statistical analysis deficiency is considered unlikely and by haemoglobin electrophoresis using Student t -test and 1-way analysis of prescription of iron preparations to cellulose acetate paper pH 8.2 as the variance were used to compare means. (who.int)
  • Genetic variants in the iron regulatory systems influence the likelihood of iron deficiency. (europa.eu)
  • Apart from the genetic contributor, iron status may reflect the form as well as the amount of iron in the diet. (europa.eu)
  • Teenagers present a higher demanding of these nutrients reasoned by the enlargement of total blood volume and iron pool , in consequence of an increase of thin body mass quantity. (bvsalud.org)
  • Results: Focusing on erythroferrone (ERFE) as a new marker and hormonal regulator of iron, our results demonstrated altered maternal ERFE levels in PE. (lu.se)
  • Background-- In the absence of a feasible, noninvasive gold standard, iron deficiency (ID) is best measured by the use of multiple indicators. (cdc.gov)
  • CD71 is a 95 kD type II homodimeric transmembrane glycoprotein also known as T9 and transferrin receptor. (biolegend.com)
  • Studies conducted in vivo and in vitro, however, have failed to demonstrate significant depletion of transferrin‐bound iron by a stoichiometric excess of desferrioxamine. (elsevierpure.com)
  • Targeting the transferrin receptor for brain drug delivery" (PDF). (wikipedia.org)
  • TF and HFE are involved in the transport and regulation of iron in the brain, and disrupting these processes exacerbates AD pathology through increased neurodegeneration and oxidative stress. (nih.gov)
  • Because of its critical role, iron is necessary for physical growth, brain development, and several hormone syntheses in babies and children. (superkidsnutrition.com)
  • So researchers at Denali began studying a system that helps iron cross from the bloodstream into the brain. (nhpr.org)
  • As not much is known about the prevalence and predictors of nutritional deficiencies among vegans in the Czech Republic, we evaluated whether supplement use and duration of adherence to the vegan diet are associated with the risk of cobalamin and iron deficiencies. (mdpi.com)
  • verify the prevalence of iron deficiency in adolescents during the pubertal growth spurt. (bvsalud.org)
  • Hence, the aim of this paper is to evaluate the connection between growth spurt and prevalence of iron deficiency in puberty. (bvsalud.org)
  • A serum iron test measures how much iron is in the blood. (medicalnewstoday.com)
  • It can occur for many reasons, including not consuming enough iron or experiencing blood loss. (healthline.com)
  • When there isn't enough iron in your blood, the rest of your body can't get the amount of oxygen it needs. (healthline.com)
  • This pathway shows the regulation of iron between a cell and the blood stream. (wikipathways.org)
  • The serum iron test measures the amount of iron in your blood. (rochester.edu)
  • In fact, pregnant women need increased iron to deliver blood and oxygen to their baby, and therefore often become anaemic. (philipkingsley.com)
  • The economic and social cost of the disease is high owing to the patient's life- long need for monthly blood transfusions and treatment with iron chelating agent. (who.int)
  • Treatment involves iron replacement and treatment of the cause of blood loss. (msdmanuals.com)