Transduction hair cells auditory. Medical search. Frequent questions

A cross-talk between NO and ATP may therefore exist in the auditory signal transduction. (sagepub.com)
Further, apoVs application activated forkhead box o3 (FOXO3a)-mitochondrial superoxide dismutase 2(SOD2) pathway, which may relate to signal transduction and activators of transcription 3 (STAT3) in apoVs. (biomedcentral.com)
Sensory signal transduction, the process by which the features of external stimuli are encoded into action potentials, is a complex process that is not fully understood. (elsevierpure.com)

To date, Kirupa's research has broadly focused on neurons within the auditory efferent circuit, which allow the brain to modulate incoming sound signals at the ear. (aro.org)
Loss of hair cells and their innervating neurons is the most frequent cause of hearing impairment. (elsevierpure.com)
We show that FM1-43, a styryl dye used to fluorescently label cell membranes, permeates mechanosensitive ion channels in cultured dorsal root ganglion neurons, resulting in blockade of three previously defined subtypes of mechanically activated currents. (biomedcentral.com)
they included hair cells in the cochlea and vestibular organs, Merkel cells and their neurites, muscle spindles, corneal nociceptors and enteric neurons. (biomedcentral.com)
All auditory information is transduced by only 15,000 hair cells (organ of Corti), of which the so-called inner hair cells, numbering 3,500, are critically important, since they form synapses with approximately 90% of the 30,000 primary auditory neurons (figure 2). (cloudaccess.net)
The activation of ligand-gated ionotropic P2X receptors and G protein-coupled metabotropic P2Y receptors has been reported to induce an increase of intracellular Ca2+ concentration ([Ca2+]i) in inner hair cells (IHCs), outer hair cells (OHCs), spiral ganglion neurons (SGNs), and supporting cells in the cochlea. (sagepub.com)
Here, we describe methods for recording hair-cell microphonics and activity of afferent neurons using intact zebrafish larvae. (elsevierpure.com)
Another readout of the hair-cell activity is obtained by recording action currents from single afferent neurons in response to water-jet stimulation of innervated hair cells. (elsevierpure.com)
Trapani, JG & Nicolson, T 2010, ' Physiological recordings from zebrafish lateral-line hair cells and afferent neurons ', Methods in cell biology , vol. 100, no. (elsevierpure.com)
Neurons in the avian cochlear nucleus angularis (NA) receive glutamatergic input from the auditory nerve, and GABAergic input from the superior olivary nucleus. (omeka.net)
For decades, we have presumed the death of hair cells and spiral ganglion neurons are the main cause of hearing loss and difficulties understanding speech in noise, but new findings suggest synapse loss may be the key contributor. (omeka.net)

Sensory hair cells in the mammalian cochlea convert mechanical stimuli into electrical impulses that subserve audition. (elsevierpure.com)
Here we show that in utero gene transfer of Atoh1 produces functional supernumerary hair cells in the mouse cochlea. (elsevierpure.com)
Our results demonstrate that manipulation of cell fate by transcription factor misexpression produces functional sensory cells in the postnatal mammalian cochlea. (elsevierpure.com)
Role of nitric oxide on purinergic signalling in the cochlea Harada, Narinobu 2010-06-08 00:00:00 In the inner ear, there is considerable evidence that extracellular adenosine 5′-triphosphate (ATP) plays an important role in auditory neurotransmission as a neurotransmitter or a neuromodulator, although the potential role of adenosine signalling in the modulation of auditory neurotransmission has also been reported. (sagepub.com)
For example, how do the 3000 rows of active outer hair cells interact with each other and with other cochlear structures to amplify the waves in the cochlea that allow us to hear? (southampton.ac.uk)
These applicationswill expand as we learn more about transduction processes in the cochlea, and as we refine our recording approaches to make them more sensitive and reliable. (audiologyonline.com)
In the cochlea of mouse embryos, it is highly expressed in prosensory cells and down-regulated at the onset of hair cell differentiation. (encyclopedia.pub)
In addition, Lin28B functions to enhance the regenerative competence of maturing supporting cells in the cochlea through cooperation with Follistatin, which inhibits Lin28B-induced TGF-ß signaling that can trigger proliferative quiescence [ 5 ] . (encyclopedia.pub)
Lin28A is required for hair cell regeneration in the mammalian cochlea, and may function in redundant processes with Lin28B [ 3 ] [ 5 ] . (encyclopedia.pub)
Hair cells toward one side of the cochlea move low-frequency sound data and hair cells at the far edge move high-frequency sound data. (ijmrhs.com)
The auditory brainstem response (ABR) test tells us how the inner ear, called the cochlea, and the brain pathways for hearing are working. (kyoto2.org)
Specifically, we are interested in agents that block or enhance the action of receptors on outer hair cells of the cochlea, which enhance hearing or decrease hearing loss. (rochester.edu)
To design and discover agents that block or enhance receptor action on cochlear outer hair cells, we are cloning neurotransmitter receptors expressed in the hair cells, and modulating expression of these receptors by viral-mediated gene transfer into the cochlea. (rochester.edu)
We found that adeno-associated virus (AAV) was able to deliver mRNAs to blood vessels and certain nerve fibers of the cochlea, but was not able to infect cochlear hair cells using a variety of promoter constructs. (rochester.edu)
The inner ear [ 5 ] contains the cochlea (or cochlea) [ 57 ], the proper organ of the transduction of mechanical signals (vibrations) into electrical signals (action potentials), the language of neurons. (neuromatiq.com)

An interesting effect that was observed during the experiments with ru1000 mutants was that, on top of losing sensitivity for mechanical stimuli, Tmc1 and Tmc2b were absent of the hair bundle. (viewpoint.fr)
Unique among human sensory receptors, the ear's hair cells are not passive, but use an active process that results in a thousandfold amplification of auditory stimuli. (eurekalert.org)
External stimuli like sound deflect the bundle, which leads to the opening of transduction channels when the deflection is toward the taller stereocilia, referred to as a positive stimulus. (silverchair.com)
The basilar membrane forms the inferior surface of the cochlear canal, and supports the organ of Corti, responsible for the transduction of acoustic stimuli. (cloudaccess.net)
The lateral-line system in zebrafish serves as an ideal platform to examine encoding of stimuli by sensory hair cells. (elsevierpure.com)

The hair bundle of cochlear hair cells is the site of auditory mechanoelectrical transduction. (pasteur.fr)
Two unconventional cadherins, protocadherin-15 (PCDH15) and cadherin-23 (CDH23), form the tip-links, whose tension gates the hair cell mechanoelectrical transduction channels. (pasteur.fr)
Moreover, the hair cells are capable of mechanoelectrical transduction and show basolateral conductances with age-appropriate specializations. (elsevierpure.com)
Hair cells of the auditory and vestibular systems transform mechanical input into electrical potentials through the mechanoelectrical transduction process (MET). (bvsalud.org)

Although available to the hearing scientist/clinician for over 50 years, ECochG's emergence as a clinical tool (as well as all other auditory evoked potentials) was rekindled in part by the discovery, application and popularity of the auditory brainstem response (ABR). (audiologyonline.com)
Auditory brainstem response (ABR) test was used to measure the effect of apoVs treatment. (biomedcentral.com)
The ABR (Auditory Brainstem Response) test can be used to detect hearing loss. (kyoto2.org)

Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells. (pasteur.fr)
We found that first-generation adenovirus [E1-, E3-] could infect cochlear hair cells, yet was ototoxic, similar to the toxicity observed in cultured hair cells. (rochester.edu)
However, we determined that a modified adenovirus [E1-,E3-, E2b-] could infect cochlear hair cells both in culture and in vivo with no loss of either transduction currents or cochlear function. (rochester.edu)

Sympathetic ganglia comprises the thousands of afferent and efferent nerve cell bodies that run along either side of the spinal cord, connecting major organ systems, such as the renal system, to the spinal cord and brain. (nih.gov)
We addressed the function of BK Ca by recording sound-induced responses of afferent auditory nerve (AN) fibers from mice with a targeted deletion of the pore-forming α-subunit of BK Ca ( BKα −/− ) and comparing these with voltage responses of current-clamped IHCs. (jneurosci.org)
Cells were cultured in Dulbecco's modified Eagle medium containing 10% foetal bovine serum (Gibco), 2 mM glutamine (Gibco), 10,000 IU/ml penicillin/streptomycin (Gibco) and 100 ng/ml nerve growth factor on poly-L-lysine- and laminin-coated dishes and used the day after preparation. (biomedcentral.com)
The bodies of the cochlear sensory cells resting on the basilar membrane are surrounded by nerve terminals, and their approximately 30,000 axons form the cochlear nerve. (cloudaccess.net)
Considering that inner hair cell transduction equals half-wave rectification, activity of low-frequency auditory nerve fibres may be indistinguishable whether elicited by LF sound that is amplitude-modulated at an infrasonic rate, or LF sound that is superimposed onto infrasound that 'biases' the basilar membrane position. (ears-project.eu)
ECochG generally involves measurement of the stimulus-related cochlear potentials (as opposed to the resting potentials), and often includes measurement of the whole nerve or compound action potential (AP) of the auditory nerve. (audiologyonline.com)
Adding separate R and C responses (middle tracing) enhances the cochlear Summating Potential (SP) and auditory nerve Action Potential (AP). (audiologyonline.com)
The technical capability of recording cochlear and auditory nerve potentials in humansled to a variety of clinical applications for ECochG. (audiologyonline.com)
The cochlear microphonic and the summating potential (SP) are generated by the hair cells of the organ of Corti, whereas the compound action potential (AP) of the auditory nerve represents the summed synchronized response of many individual nerve fibers. (kyoto2.org)
Can auditory nerve damage be repaired? (kyoto2.org)
Once damaged, your auditory nerve and cilia cannot be repaired. (kyoto2.org)
Does auditory nerve regenerate? (kyoto2.org)
These results tell us that auditory-nerve fibers carrying impulses from the ear to the brain can regrow, which is essential to the recovery of hearing, and that the central auditory system in the brain reorganizes itself to maintain its function while the nerve fibers are damaged. (kyoto2.org)
When the hair cells from the slide tectorial membrane, they depolarize and release neurotransmitters [ 41 ] which will stimulate the basilar membrane which follow until the columella, where they form the cell body spiral ganglion nerve fibers. (neuromatiq.com)
At the region of preferential vibration, hair cells in the outer slide of the tectorial membrane [ 5 ], they depolarize and send nerve signals via afferent nerve fibers to the brain stem. (neuromatiq.com)
Auditory nerve fiber differences in the normal and neurofilament deficient Japanese quail. (omeka.net)

gem homozygous receptor mutant HCs display normal cell viability, afferent synaptogenesis, and peripheral innervation, yet exhibit strongly reduced extracellular potentials (∼50% of wild-type potentials). (jneurosci.org)
For many years an outstanding question in vestibular physiology was how the transduction current in the type I hair cell was sufficient, in the face of large conductances on at rest, to depolarize it to potentials necessary for conventional synaptic transmission with its unique afferent calyx. (aro.org)
In collaboration with Dr. Art, I overcame the technical challenges of simultaneously recording from type I hair cells and their enveloping calyx afferent to investigate this question. (aro.org)
These currents may be involved in shaping the receptor potential, implying crucial importance for the properties of afferent auditory signals. (jneurosci.org)
Effects on single-neuron tuning curves were consistent with an action mainly on the outer hair cell transduction with betagammamethylene-ATP (elevation of tuning curve tips), but with ATP-gamma-S changes in sensitivity across the full extent of the tuning curve indicated an additional action on inner hair cell-afferent neurotransmission. (edu.au)

Less is known about their role in mammalian inner hair cells (IHCs), mechanosensory cells with unusually large BK Ca currents. (jneurosci.org)
Deflection of the mechanosensory hair bundle increases tension in the gating springs that open MET channels. (bvsalud.org)

The inner ear functions as the sensorineural receptor organ of the auditory system, converting an acoustic waveform into an electrochemical stimulus that can be transmitted to the CNS. (medscape.com)
While performing this sensory transduction process, the inner ear analyzes a sound stimulus in terms of its frequency, intensity, and temporal properties, and it transmits this information to the CNS for further processing and interpretation. (medscape.com)
The conversion of a mechanical stimulus into an electrical signal is known as mechano-electrical transduction (MET). (viewpoint.fr)
The perceptual aspect of the sound stimulus loudnes s is related to the level of an auditory stimulus. (superwriters.net)
Stimulus transduction artifacts occur when stimulus-producing current in the headphone wire or transducer, proximal to the body or electrode components, contaminates the EEG measurement. (kyoto2.org)

As an example, hair cells express different sets of ion channels that shape the frequency, gain and time course of receptor potentials to optimize sensitivity to sounds, head or body motions. (frontiersin.org)
This priority area includes omics research, such as proteomics and transcriptomics, and in vivo electrophysiology experiments, and laser doppler vibrometry recordings in guinea pig and rat models, to directly measure system mechanics, mechanosensitive receptor hair cell function, and neural activity. (asadnialab.com)
Changes in the threshold of the gross DC receptor potential (summating potential, SP) and the compound action potential (CAP) were consistent with a combination of effects on both early and final stages of the transduction process, as reported by previous workers. (edu.au)
The cochlear microphonic is a receptor potential believed to be generated primarily by outer hair cells. (kyoto2.org)
The differential capacity of Igf signaling to confer a proliferative advantage to stem cells may be regulated in part by Igf's interactions with binding proteins Androgen Receptor Antagonist cell line or other secreted factors in the environment (Clemmons, 1997). (inhibitorkits.com)

Upon viewing the video on the Anatomy and Physiology of Hearing (the link can be found in Lessons - Week Two), describe the structure of the ear, focusing on the role that each component plays in transmitting the vibrations that enter the outer ear to the auditory receptors in the inner ear. (superwriters.net)
Using the guinea pig as an experimental animal model, we have isolated clones for neuronal nicotinic acetylcholine receptors (nAChRs) present on cochlear outer hair cells. (rochester.edu)

Hair cells are stimulated with a pressure-controlled water jet and a recording electrode is positioned next to the site of mechanotransduction in order to record microphonics-extracellular voltage changes due to currents through hair-cell mechanotransduction channels. (elsevierpure.com)

The molecular identity of the channel that mediates mechanotransduction by hair cells remains uncertain, despite being biophysically characterized since the late 1970s ( Corey and Hudspeth, 1979 ). (silverchair.com)
Fig. 1 A ). They showed that the TMC paralogs TMC1 and TMC2 are selectively expressed in the inner ear, appearing at the onset of transduction, and that at least one of them must be expressed for normal mechanotransduction. (silverchair.com)

Her research focuses on auditory and vestibular efferent feedback mechanisms at both the systems and molecular level. (rochester.edu)

Kirupa's interest in the mind and particular fascination by how we are able to perceive the world around us led her to pursue a research career in auditory neuroscience. (aro.org)

L-type Ca 2+ channels (LTCCs) drive the bulk of voltage-gated Ca 2+ entry in vertebrate inner ear hair cells (HCs) and are essential for mammalian auditory processing. (jneurosci.org)
Current multidisciplinary projects include the fabrication and characterization of biomimetic artificial hair cell sensors and artificial basilar membranes to recreate the sensitivity, place code and tonotopy of the mammalian inner ear, as well as the development of novel biosensors to detect putative biomarkers of pathology. (asadnialab.com)

The non-linear mechano-electrical and electro-mechanical transduction processes are key aspects of the physiology where our understanding remains at a basic level. (southampton.ac.uk)
Mechano-electrical transduction constitutes the central part of the hearing process. (uni-goettingen.de)

FM1-43 applied to the extracellular surface of hair cells was taken up by the cell (resulting in fluorescent labelling of the cytoplasm) at a site close to the proposed site of transduction in a manner dependent on mechanical stimulation. (biomedcentral.com)
The recordings are performed by immobilizing and mounting larvae for optimal stimulation of lateral-line hair cells. (elsevierpure.com)
An OAE test uses a small, very sensitive microphone inserted into the ear canal to monitor the faint sounds produced by the outer hair cells in response to auditory stimulation. (kyoto2.org)
This additional stimulation caused several of these cells to reverse (Figures S2E and S2F), indicating that stable cells can become reversed cells. (inhibitorkits.com)
The main function of the CCE is to contract for amplifying the vibration of the basilar membrane at the stimulation [ 96 ], thereby depolarizing the inner hair cells at low amplitudes. (neuromatiq.com)

challenge the Holt-Géléoc-Griffith model, suggesting instead that the TMCs do not make up the transduction channel but instead couple those channels to tip links, the mechanical elements that impart directional sensitivity to hair cells. (silverchair.com)
Regulation of MET channel sensitivity contributes to the auditory system's precision, wide dynamic range and, potentially, protection from overexcitation. (bvsalud.org)
Here, we investigated the role of cyclic adenosine monophosphate (cAMP) in rat outer hair cell MET and found that cAMP up-regulation lowers the sensitivity of the channel in a manner consistent with decreasing gating spring stiffness. (bvsalud.org)
These results reveal that cAMP signaling modulates gating spring stiffness to affect auditory sensitivity. (bvsalud.org)
In vivo , FMI-43 decreases pain sensitivity in the Randall-Selitto test and increases the withdrawal threshold from von Frey hairs, together suggesting that the channels expressed at the cell body in culture mediate mechanosensation in the intact animal. (biomedcentral.com)
A Discrete Time Parametric Model of Auditory Filters at Peak Sensitivity,'' Submitted to JASA Feb 17, 2016, Under Review. (auditorymodels.org)

My research focuses on characterizing the biophysics of synaptic transmission between hair cells and primary afferents in the vestibular system. (aro.org)
The Asadnia Research Group is committed to understanding the fundamental operation of the inner ear, including the underlying biology of the auditory and vestibular system, as well as its fundamental physiology, in terms of transduction, and neural codes. (asadnialab.com)

The outer ear consists of the auricle, a cartilaginous skin-covered structure, and the external auditory canal, an irregularly-shaped cylinder approximately 25 mm long which is lined by glands secreting wax. (cloudaccess.net)
The auricle and external acoustic meatus (or external auditory canal) compose the external ear. (medscape.com)
The external acoustic meatus (external auditory canal) is formed by cartilage and bone (temporal). (medscape.com)
The mandibular condyle sits anterior to the bony portion of the external acoustic meatus (external auditory canal). (medscape.com)
The outer ear includes a flag (with its cone shape) amplifies the sound intensity and repay the brutality of the passage of air to the air confined in the external auditory canal. (neuromatiq.com)

They are responsible for MET in hair cells of the lateral line organ, an organ specific to fish and amphibians. (viewpoint.fr)
Hair cells, found in the inner ear and the lateral line organ, which is an organ specific to fish and amphibians, were also normal. (viewpoint.fr)
Generated predominantly by the outer hair cells of the organ of Corti. (audiologyonline.com)
The antennal auditory organ of Drosophila, Johnston s organ (JO), provides a valuable system to study hearing. (uni-goettingen.de)
The human ear is the organ of hearing and equilibrium that identifies and analyzes sound by transduction and keeps up the sensation of equalization. (ijmrhs.com)

Recent advances feature the identification of proteins constituting the mechanosensing machinery of hair bundles, how electromechanical amplification arises from prestin, novel mechanisms of signal transmission across specialized synapses and how supporting cells contribute to the homeostasis , maturation and regeneration of hair cell epithelia. (frontiersin.org)

These proteins also form transient lateral links connecting neighboring stereocilia during hair bundle morphogenesis. (pasteur.fr)
Our experimental results demonstrated that LP promoted the expression of TJ proteins between Caco2 cells after LPS treatment, and increased the electrical barrier detection (TEER) between Caco2 cells. (bvsalud.org)
cellular membrane has proteins-ionophores that allow certain ions IN - certain ions OUT, to keep the ionic concentration at a certain level for maintenance of that cell. (ionchannellibrary.com)
Shi D, Cheng X, Saquet A, Grifone R. RNA-Binding Proteins and Inner Ear Hair Cell. (encyclopedia.pub)
RNA-Binding Proteins and Inner Ear Hair Cell" Encyclopedia , https://encyclopedia.pub/entry/30958 (accessed December 05, 2023). (encyclopedia.pub)
LIN28 (LIN28A and LIN28B) proteins are highly conserved small cytoplasmic RNA-binding proteins (RBPs) that function as pluripotency factors, regulating the transition from self-renewal to a differentiated cell fate [ 1 ] . (encyclopedia.pub)
However, STK38 the distribution of CSF resident proteins, as well as the flow of the CSF, may also influence ciliary orientation and maturing ependymal cell polarity (Mirzadeh et al. (inhibitorkits.com)
Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)

Traversing an extraordinarily thin membrane, the cilia of the hair cells are embedded in the tectorial membrane, whose free end is located above the cells. (cloudaccess.net)
These cells contain cilia that are moored to a membrane (the tectorial membrane). (neuromatiq.com)

We seek to highlight contemporary research into the function of sensory hair cells and supporting cells in diverse hair cell organs, with consideration of the major questions and impediments to full understanding of sensory processing in the inner ear. (frontiersin.org)
In developing and mature sensory hair cells, stereocilia are connected to each other by various types of fibrous links. (pasteur.fr)

Hair cells and supporting cells of inner ear and lateral line sensory organs evolved from a common cell type to accommodate diverse forms of mechanical input. (frontiersin.org)

Meyers et al [ 4 ] also reported that FM1-43 is a permeant blocker of hair cell mechanosensitive channels and showed that the dye permeated the non-selective cation channels TRPV1 and P2X 2 . (biomedcentral.com)

Its detection in surface recordings has been considered a distinctive sign of outer hair cell integrity in patients with auditory neuropathy. (kyoto2.org)

ATP may participate in auditory neurotransmission by modulating [Ca2+]i in the cochlear cells. (sagepub.com)

Interestingly, Lin28B inhibits the processing of mature let7 miRNA, which functions to induce cell cycle exit in progenitor cells [ 2 ] . (encyclopedia.pub)
Studies using a zebrafish model further illustrate an important role of Lin28A in the recovery of progenitor cells. (encyclopedia.pub)
fluid apparently regulates the microenvironment of hematopoietic stem cells, where Igf signaling regulates progenitor proliferation (Orkin and Zon, 2008 and Zhang and Lodish, 2004). (inhibitorkits.com)

The focus of this article is applied physiology of the inner ear, emphasizing the processes involved in transduction and the homeostatic mechanisms necessary for maintaining the inner ear in a functional state. (medscape.com)

Waves move the basilar membrane but not the tectorial membrane resulting in conformational changes in the stereocilia of hair cells. (powershow.com)

Now, genetic analyses, especially in zebrafish and mice, are accelerating our understanding of both canonical hair cell functions and the impact of evolved diversity. (frontiersin.org)
Via positional cloning, we show that mutations in a zebrafish LTCC encoding gene, cav1.3a , underlie the auditory-vestibular defects of gemini ( gem ) circler mutants. (jneurosci.org)
Two zebrafish homologs, atoh1a and atoh1b, are together necessary for hair cell development. (tamu.edu)
A model is presented in which zebrafish atoh1 genes operate in a complex network leading to hair cell development. (tamu.edu)

The induced hair cells display stereociliary bundles, attract neuronal processes and express the ribbon synapse marker carboxy-terminal binding protein 2 (refs 12,13). (elsevierpure.com)

These genes function in the development and maintenance of inner ear structures such as hair cells (stereocilia), which transmit sound and motion signals to the brain. (wikipedia.org)
The shorter of these hair-like extensions are the stereocilia, and they are arranged in a staircase-like pattern next to a single large cilium known as a kinocilium. (viewpoint.fr)
Thanks to this, when the kinocilium moves, it makes all the stereocilia move as a single unit, called the hair bundle. (viewpoint.fr)
The movement of the hair bundle forces the opening of some channels placed at the tip of the stereocilia (tip links). (viewpoint.fr)

By providing the pathway for ions to enter/exit the cell, ion channels and transporters eliminate this critical osmotic problem and allow for acute volume regulation. (ionchannellibrary.com)
Recent studies showed that extracellular ATP induced nitric oxide (NO) production in IHCs, OHCs, and SGNs, which affects the ATP-induced Ca2+ response via the NO-cGMP-PKG pathway in those cells by a feedback mechanism. (sagepub.com)

Examining transduction in a Tmc1;Tmc2 double mutant, they found persistence of a conductance with properties very similar to those of the transduction channel, except that it is activated by mechanical deflections of the opposite polarity. (silverchair.com)
Direct measurements of the mechanical properties of the hair bundle confirmed a decrease in gating spring stiffness with cAMP up-regulation. (bvsalud.org)

We determined whether LP imparts such protective effects in a lipopolysaccharide (LPS)-induced Caco2 cell monolayer model and whether cAMP-PKA signaling is the underlying mechanism of action. (bvsalud.org)
The precise mechanism by which Lin28B and let7 miRNA regulate mTORC1 activity in cochlear epithelial cells awaits further investigation. (encyclopedia.pub)
This suggests that coactivation of Lin28B and Follistatin may represent an endogenous mechanism mediating reprogramming of supporting cells for hair cell regeneration. (encyclopedia.pub)

Vision is known to impact auditory perception and neural mechanisms in vision and audition are tightly coupled, thus, in order to understand how we hear and how CIs affect auditory perception we must consider the integrative effects across these senses. (aro.org)
These results reveal bottom-up neurobiological mechanisms through which peripheral hearing loss arising from the 22q11.2 deletion may promote the emergence of schizophrenia-relevant auditory brain and behavioral abnormalities, and also suggest a link between conductive hearing loss and reduced PV+ interneuron density in the auditory cortex. (biorxiv.org)
These results suggest mechanisms through which hearing loss associated with the 22q11.2 deletion may promote emergence of schizophrenia-relevant auditory brain and behavioral abnormalities and indicate that conductive hearing loss may influence PV+ interneuron density in the auditory cortex. (biorxiv.org)
Thus, Lin28B functions in hair cell regeneration through mitotic and non-mitotic mechanisms, which are dependent on mitotic division or trans-differentiation of supporting cells into hair cells, respectively. (encyclopedia.pub)

The difference between the electrolyte composition of the perilymphatic and endolymphatic spaces creates an electrochemical environment that makes sensorineural transduction possible. (medscape.com)

We found that hearing loss in Df1 /+ mice affected schizophrenia-relevant endophenotypes, including electrophysiological measures of central auditory gain and behavioral measures of auditory sensorimotor gating. (biorxiv.org)
Consistent with this activity, functional analyses in mice suggest that Lin28B plays an important role in hair cell development and regeneration. (encyclopedia.pub)
Female CBA/J mice and HEI-OC1 cells were used in this study. (biomedcentral.com)

Rapid effects of steroid hormones on free intracellular calcium in T84 colonic epithelial cells. (sagepub.com)
The endocochlear potential is established through the development of tight cellular junctions between local networks of epithelial cells, connective tissue and supporting cells that completely partition the endolymph from the surrounding perilymph. (kyoto2.org)

Dr. René H Gifford will discuss recent work on electric-acoustic integration in children and adults, and Dr. Sharon Cushing will discuss her work as a clinician on 3-D auditory and vestibular effects. (aro.org)

We invite primary papers, review papers or commentaries that provide insight into hair cell or supporting cell function and dysfunction - dynamic or homeostatic, and from a diversity of approaches and model organisms and hair cell organs. (frontiersin.org)

The basic principles of this local control are illustrated in the images below and are outlined as follows: First, an anatomic barrier exists between perilymph and endolymph, and it consists of Reissner membrane, the stria vascularis, and the reticular lamina formed by tight junctions between the apices of hair cells and the adjacent supporting cells (see the image above). (medscape.com)
This surprising result raises the possibility that the transduction channel is a membrane protein distinct from TMC1 and TMC2 that only becomes functional as the transduction channel once other key molecules, like the TMCs and tip-link cadherins, are expressed. (silverchair.com)
As you know, all living cells have a lipid plasma membrane surrounding the cytoplasm and in this way separating the cell interior from the extracellular space. (ionchannellibrary.com)

Yet, let's look at an example that will help us explain sound and auditory perception. (superwriters.net)

In this lesson, we will learn more about sound and the auditory systems that sound waves pass through as they are transmuted to signals the brain can understand. (superwriters.net)

The cyclic adenosine monophosphate (cAMP) agonist, forskolin (FSK), and the protein kinase A (PKA) inhibitor, HT89, were used to study the protective effect of LP on the destruction of the tight junction (TJ) structure of cells treated with LPS and the corresponding changes in cAMP-PKA signaling. (bvsalud.org)

increased K conductance depolarizes cell, opening vg-Ca channels, and increases transmitter release. (powershow.com)
Of course, Armstrong understands well that all the systems of the cell/organism are important, and we cannot do well without any of them, but he also really believes that ion channels hold a special place in our body. (ionchannellibrary.com)
Another vital function of ion channels and transporters is that they make our cells, and hence our organism, electrically active. (ionchannellibrary.com)
Gale et al [ 3 ] recently showed that FM1-43 acts as a permeant blocker of mechanotransducing ion channels in murine hair cells. (biomedcentral.com)

This was possible with the auditory evoked behavioral response (AEBR) test. (viewpoint.fr)

Atoh1-based gene therapy to ameliorate auditory and vestibular dysfunction has been proposed. (elsevierpure.com)

Atonal homologue 1 (encoded by Atoh1, also known as Math1) is a basic helix-loop-helix transcription factor required for hair-cell development, and its misexpression in vitro and in vivo generates hair-cell-like cells. (elsevierpure.com)

Importantly, apoVs administration effectively attenuated NIHL and reduced hair cell loss by resisting oxidative damage in vivo. (biomedcentral.com)

The vibration of the recorder causes changes in the air that trigger auditory organs to process this representation of sound and send it to the brain. (superwriters.net)

Methods in cell biology , 100 (C), 219-231. (elsevierpure.com)

Although Igf2 availability decreased in adult CSF (Figures 3C and S3B), Igf2 continued to be expressed in adult choroid plexus (data not shown) and maintained adult neurospheres ( Figure 4I), suggesting that low levels of CSF Igf2 contribute to the maintenance of adult neural stem cells. (inhibitorkits.com)

Importantly, auditory abilities operate in the context of how hearing integrates with other senses. (aro.org)

Anatomy59

Organisms26

Diseases15

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Psychiatry and Psychology2

Phenomena and Processes55

Disciplines and Occupations3

Information Science3

Health Care1

Signal Transduction3

Neurons11

Cochlea15

Stimuli5

Mechanoelectrical4

Brainstem response3

Cochlear hair cells3

Nerve16

Afferent5

Mechanosensory2

Stimulus5

Receptor5

Receptors2

Currents1

Mechanotransduction2

Efferent1

Neuroscience1

Mammalian2

Mechano-electrical2

Stimulation5

Sensitivity6

Vestibular system2

External audit5

Organ5

Amplification1

Proteins8

Cilia2

Sensory hair cells2

Lateral line1

Mechanosensitive1

Outer hair1

Neurotransmission1

Progenitor3

Physiology1

Tectorial membrane1

Zebrafish4

Processes1

Stereocilia4

Pathway2

Mechanical2

Mechanism3

Mechanisms4

Sensorineural1

Mice3

Epithelial cells2

Acoustic1

Homeostatic1

Membrane3

Perception1

Signals1

Cyclic adenosine mon1

Channels4

Behavioral1

Gene1

Transcription factor1

Vivo1

Organs1

Biology1

Stem cells1

Importantly1