• tissues
  • As a first step to remedy this discrepancy a cDNA library has been developed from salicylate-treated, whole-plant tissues and over 1800 expressed sequence tags (EST's) have been sequenced and analyzed. (biomedcentral.com)
  • H60b and H60c transcripts were detected only at low levels in tissues of healthy adult mice. (jimmunol.org)
  • Researchers at the USDA-ARS Yakima Agricultural Research Laboratory (Wapato, WA) and Corn Insect and Crop Genetics Research Unit (Ames,IA), and Washington State University (Pullman, WA) have used next generation sequencing to determine gene expression in various codling moth tissues that respond to semiochemicals. (usda.gov)
  • Examples of the potential effects of different sequence polymorphisms on two hypothetical loci, A and B. In this scenario, locus A has two annotated transcripts (RNA-1 and RNA-2, dark blue), expressed in different tissues. (biomedcentral.com)
  • mRNA transcripts
  • Most pseudogenes are disabled copies of a functional 'parent' gene and can be classified as either processed or duplicated pseudogenes depending on whether they are generated by the retro-transposition of processed mRNA transcripts or the duplication of gene-containing DNA segments in the genome. (biomedcentral.com)
  • Allergen concentration was reflected in the abundance of mRNA transcripts. (cdc.gov)
  • encode
  • Gene transcripts that encode 30 proteins important in the detection of semiochemicals, including sex pheromones, were identified and characterized. (usda.gov)
  • This work provides a source of DNA sequences and the proteins that they encode which are important in the detection of semiochemicals such as pheromones. (usda.gov)
  • Polymorphisms 3-6 are 'non-coding' polymorphisms, with polymorphism 6 being relatively distant from locus A. However, in this example, these polymorphisms in fact overlap unannotated transcripts (cyan) within locus A, some of which extend outside locus A or encode regulatory small RNA molecules that act in trans on other loci. (biomedcentral.com)
  • These alleles encode slightly different versions of a protein, which cause different phenotypical traits. (wikipedia.org)
  • kinase
  • Concomitant activation of the insulin-like growth factor-1 receptor, Akt, and extracellular signal-regulated protein kinase 1 and 2 as well as increased phosphorylation of Bad also were unique to the hippocampus of APP Sw mice. (jneurosci.org)
  • functional
  • Mass spectrometric analysis of androgen-regulated proteins in these cells identified the metastasis-suppressor gene NDKA/nm23, a finding that may explain a marked reduction in metastatic potential when these cells express a functional androgen receptor pathway. (garvan.org.au)
  • A strong sequence database is the cornerstone of functional genomics studies, and this information will aid development of such tools in Fragaria and in the Rosaceae in general. (biomedcentral.com)
  • The initial pseudogenization of a functional gene is most likely a single mutagenic event that results in premature stop codons, abolished splice junctions, shifts to the coding frame, or impaired transcriptional regulatory sequences. (biomedcentral.com)
  • These are examples of polymorphisms that would currently be considered to be the only likely 'functional' polymorphisms in locus A, as they are the only ones to affect the annotated transcripts, RNA-1 and RNA-2. (biomedcentral.com)
  • The RNA can be directly functional or be the intermediate template for a protein that performs a function. (wikipedia.org)
  • structurally
  • Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. (wikipedia.org)
  • The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. (wikipedia.org)
  • chromosome
  • The protein encoded by this gene forms a heterotrimeric motor complex with kinesin family member 3A and KAP3 (kinesin accessory protein 3) to drive intra-flagellar transport and possibly to aid in chromosome movement during mitosis and meiosis. (wikipedia.org)
  • The DNA sequence and analysis of human chromosome 6. (nih.gov)
  • nucleus
  • A NOC4-GFP fusion protein is located in both the nucleus and the cytoplasm, including the mitochondria. (deepdyve.com)
  • These transcription factors share the ability to be inhibited and translocated out of the nucleus on phosphorylation by proteins such as Akt/PKB in the PI3K signaling pathway (aside from FOXO6, which may be constitutively nuclear). (wikipedia.org)
  • When the protein is not acetylated, it stays in the nucleus, but hyperacetylation on lysine residues causes it to translocate into the cytosol. (wikipedia.org)
  • endoplasmic
  • The protein encoded by this gene contains 2 transmembrane domains near the C-terminus and is localized in the endoplasmic reticulum. (nih.gov)
  • The TMEM229B gene is flanked by phosphatidylinotisol glycan anchor class H (PIGH), a protein associated with the endoplasmic reticulum specifically GPI-anchor biosynthesis, and PLEK2 on its left. (wikipedia.org)
  • counterparts
  • Open reading frames from a further 39 novel sequences, without counterparts in the database, were screened for the characteristics of intrinsically disordered proteins, i.e. hydrophilicity and lack of stable secondary structure. (biologists.org)
  • subunit
  • The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. (wikipedia.org)
  • mutations
  • For instance, familial AD is linked to mutations in the amyloid precursor protein (APP), presenilin 1, and presenilin 2, all of which lead to increased levels of Aβ. (jneurosci.org)
  • absence
  • Pubmed ID: 12415109 The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin gene leading to the absence of the corresponding RNA transcript and protein. (jove.com)
  • Absence of dystrophin leads to disruption of the dystrophin-associated protein complex and substantial changes in skeletal muscle pathology. (jove.com)
  • multitude
  • Cytolytic activities of NK cells are controlled by the interplay of a multitude of inhibitory and activating receptors expressed on their surfaces ( 1 , 2 ). (jimmunol.org)
  • interaction
  • Homer1 protein has an N-terminal EVH1 domain, involved in protein interaction, and a C-terminal coiled-coil domain involved in self association. (wikipedia.org)
  • Homer1a, acts as a natural dominant negative form that blocks interaction between long-forms and their ligand proteins by competing with the EVH1 binding site on the ligand proteins. (wikipedia.org)