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  • VP16
  • It is also human codon optimized and composed of 3 minimal VP16 activation domains. (wikipedia.org)
  • If the in vivo concentration is much higher than the equilibrium binding constant, then the activation binding site should be fully occupied regardless of whether the TFIIIA-VP16 is mutated or not. (umsystem.edu)
  • This suggests that the activation binding site absolutely should be full regardless of whether the TFIIIA-VP16 is mutated or not, which means activation isn't based solely on an equilibrium binding parameter. (umsystem.edu)
  • promoters
  • As promoters are typically immediately adjacent to the gene in question, positions in the promoter are designated relative to the transcriptional start site, where transcription of DNA begins for a particular gene (i.e., positions upstream are negative numbers counting back from -1, for example -100 is a position 100 base pairs upstream). (wikipedia.org)
  • targets
  • Consequently, identification of the transcriptional targets of p53 is a potential key to understanding functions of p53 and its signaling pathways in tumorigenesis, and to exploiting their potential use as molecular targets for cancer chemotherapeutic drugs. (aacrjournals.org)
  • upon
  • Upon moving to Cornell University, Dr. August initiated work on his PhD thesis, to understand the molecular basis of activation of T cells. (wikipedia.org)