• Signaling
  • Consequently, identification of the transcriptional targets of p53 is a potential key to understanding functions of p53 and its signaling pathways in tumorigenesis, and to exploiting their potential use as molecular targets for cancer chemotherapeutic drugs. (aacrjournals.org)
  • polymerase
  • In C. elegans, Argonaute CSR-1 interacts with 22G small RNAs derived from RNA-dependent RNA polymerase and antisense to germline-expressed transcripts to protect these mRNAs from Piwi-piRNA mediated silencing via promoting epigenetic activation. (wikipedia.org)
  • activity
  • Src induced activation of Inducible T cell Kinase (ITK) requires PI3 kinase activity and the Pleckstrin Homology domain of inducible T cell kinase. (wikipedia.org)
  • cells
  • Upon moving to Cornell University, Dr. August initiated work on his PhD thesis, to understand the molecular basis of activation of T cells. (wikipedia.org)