Transcriptional receptor 3t3 l1 cells. Medical search. Frequent questions

At concentrations required for PPARγ activation and ANGPTL4 induction in colon adenocarcinoma cells, SCFA do not stimulate PPARγ in mouse 3T3-L1 and human SGBS adipocytes, suggesting that SCFA act as selective PPARγ modulators (SPPARM), which is supported by coactivator peptide recruitment assay and structural modeling. (uea.ac.uk)
Here we report that antidiabetic thiazolidinediones (TZDs) and other ligands for the nuclear receptor PPARγ dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilitating the exchange of coactivators for corepressors on the OLR1 gene in cultured mouse adipocytes. (jci.org)
Here we show that in adipocytes, chronically high insulin levels inhibit β-adrenergic receptors (but not other cAMP-elevating stimuli) from activating PKA. (nature.com)
Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. (kpu.ac.jp)
Lipoprotein lipase enzyme expression in 3T3-L1 adipocytes is posttranscriptionally down-regulated by retinoic acid. (kpu.ac.jp)
We have developed a model of insulin signalling in rodent adipocytes that includes both transcriptional feedback through the Forkhead box type O (FOXO) transcription factor, and interaction with oxidative stress, in addition to the core pathway. (biomedcentral.com)
Wang et al ( 11 ) have illustrated curcumin's ability to reduce pro-inflammatory cytokines in 3T3-L1 adipocytes with FFA-induced insulin resistance. (spandidos-publications.com)
This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
Adipogenesis has been described as a two-step developmental process consisting on the commitment of undifferentiated MSCs into preadipocytes and the further development of these cells into fully functional mature adipocytes [ 4 ]. (biomedcentral.com)
We have previously shown that fish primary preadipocytes differentiate into mature adipocytes in vitro and that these cells represent a very helpful model system to study adipose tissue development in fish [ 5 , 6 ]. (biomedcentral.com)
In addition to the classic brown adipocytes, a different type of brown fat cells seems to exist in tissues where WAT predominates. (biomedcentral.com)

In addition, constitutive expression of Dkk1 in 3T3-L1 preadipocytes promotes their differentiation, further supporting the functional significance of increased Dkk1 levels during human adipogenesis. (ox.ac.uk)
Notably, Dkk1 is not expressed in primary murine preadipocytes or cell lines. (ox.ac.uk)
We now report that the IL-11 cytokine, a member of the gp130 cytokine co-receptor-related family, is a downstream transcriptional target of this pathway in 3T3-L1 preadipocytes and is actively secreted in differentiating cells in response to PGF2α stimulation. (bvsalud.org)
Here we show that treatment of differentiating 3T3-L1 preadipocytes with PGF2alpha induces the expression of DEC1, a transcriptional repressor that has previously been implicated in the inhibition of adipogenesis in response to hypoxia as a downstream effector of the hypoxia-inducible factor-1 (HIF-1) transcription factor. (bvsalud.org)
Surprisingly, despite performing our experiments under normal ambient oxygen conditions, we find that treatment of differentiating 3T3-L1 preadipocytes with PGF2alpha also results in the marked activation of HIF-1, as measured by an increase in the accumulation of the HIF-1alpha regulatory subunit. (bvsalud.org)
Vitamin D receptor gene expression is up-regulated by 1, 25-dihydroxyvitamin D3 in 3T3-L1 preadipocytes. (kpu.ac.jp)
Retinoic acid receptor gamma 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes. (kpu.ac.jp)
Methods 3T3‐L1 preadipocytes were differentiated by using a mixture of adipogenic inducers, including a suboptimal concentration of insulin. (researchgate.net)
24 ] suggested that IOP activated adipogenesis of 3T3-L1 preadipocytes and increased PPARγ transcriptional activities, which PPARγ has proved as a key receptor involved in insulin resistance [ 25 ]. (biomedcentral.com)

The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis. (ox.ac.uk)
Secretion of Wnts by adipose cells has an important role in the control of murine adipogenesis. (ox.ac.uk)
Using a combined shRNA and dominant-negative receptor mutant approach, we provide evidence that IL-11/gp130-signaling is required to mediate the inhibitory effects of PGF2α on adipogenesis. (bvsalud.org)
Adipogenesis has been extensively studied in mammals [ 7 ] and several cell and animal models have been successfully used to describe the chronology of the molecular events governing this process. (biomedcentral.com)
While components of the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. (biomedcentral.com)
Several models exist to study adipogenesis in vitro , of which the cell line 3T3-L1 is the most well known, albeit not the most physiologically appropriate. (biomedcentral.com)
When comparing primary adipocyte profiles, with those of cell lines reported in the literature, we found a high degree of difference in 'adipogenesis' regulated miRNAs suggesting that the model systems may not be accurately representing adipogenesis. (biomedcentral.com)
In conclusion, we provide a preliminary analysis of miRNAs associated with primary cell in vitro adipogenesis and demonstrate that the inflammation-associated miRNA, mir-21 is up-regulated in subcutaneous adipose tissue in human obesity. (biomedcentral.com)

Concomitant downregulation of the Dkk1 receptors LRP5 and LRP6 is likely to potentiate the ability of Dkk1 to inhibit Wnt signalling and promote differentiation. (ox.ac.uk)
Moreover, by taking advantage of a well-characterized panel of chimeric gp130 mutant receptors, we demonstrate that gp130 signaling is sufficient to inhibit adipocyte differentiation and specifically requires the activation of the STAT1 transcription factor. (bvsalud.org)
Daidzein and the daidzein metabolite, equol, enhance adipocyte differentiation and PPARgamma transcriptional activity. (oregonstate.edu)
Since the insulin-sensitizing effects of thiazolidinediones, antidiabetic drugs, are mediated through activation of peroxisome proliferators-activated receptor gamma (PPARgamma), we examined the effects of daidzein and the daidzein metabolite, equol, on adipocyte differentiation and PPARgamma activation. (oregonstate.edu)
In 3T3-L1 cells, daidzein enhanced adipocyte differentiation and PPARgamma expression in a dose-dependent manner. (oregonstate.edu)
In C3H10T1/2 cells, both daidzein and equol at 1 micromol/L and higher significantly increased adipocyte differentiation and insulin-stimulated glucose uptake. (oregonstate.edu)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
Overexpression and ribozyme-mediated targeting of transcriptional coactivators, CBP and p300, revealed their indispensable roles in adipocyte differentiation through the regulation of PPAR-gamma. (kpu.ac.jp)
The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha. (kpu.ac.jp)
Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
This was associated with DIM‐enhanced phosphorylation of the signaling intermediates Akt, insulin receptor substrate‐1, and insulin receptor early in differentiation. (researchgate.net)
Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
12) Another BET-family protein, the testis-specific BRDT, is vital for male germ cell differentiation in selective domain knockout mice which were practical but sterile. (smartrailexpo-europe.com)
In addition with their main function in the legislation of cell routine progression, particular types of CDKs and cyclins get excited about transcription also, splicing, epigenetic legislation, neuronal features, stem cell regeneration, spermatogenesis, and differentiation [10]. (niepokorny.org)

One of the mediators of the positive metabolic effects of endurance exercise is peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). (mrsupps.com)

SCFA induce ANGPTL4 by activating the nuclear receptor peroxisome proliferator activated receptor γ (PPARγ), as demonstrated using PPARγ antagonist, PPARγ knockdown, and transactivation assays, which show activation of PPARγ but not PPARα and PPARδ by SCFA. (uea.ac.uk)
We conclude that (i) SCFA potently stimulate ANGPTL4 synthesis in human colon adenocarcinoma cells and (ii) SCFA transactivate and bind to PPARγ. (uea.ac.uk)
Natural regulators of brown and beige fat include external conditions like cold temperatures, and exercise, as well as internal mechanisms like thyroid hormones, beta-adrenergic hormones, retinoids, PPARγ and PPARα agonists, and the liver X receptor. (mrsupps.com)

Findings suggest that this control acts via the stimulation of LXR nuclear receptors by cyclically produced oxysterols such that rhythmic cholesterol and bile acid metabolism is not just driven by alternating feeding-fasting cycles, but also by REV-ERBalpha, a component of the circadian clockwork circuitry. (wikipedia.org)
The transient induction in DKK1 correlates with downregulation of cytoplasmic and nuclear beta-catenin levels, this being a surrogate marker of canonical Wnt signalling, and Wnt/beta-catenin transcriptional activity. (ox.ac.uk)
The nuclear factor of activated T cells (NFAT) family of transcription factors has recently been implicated with a role in tumorigenesis. (bvsalud.org)
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. (kpu.ac.jp)
A CBP Integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. (kpu.ac.jp)
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. (kpu.ac.jp)
These nuclear hormone receptors impact on hepatic triglyceride accumulation and insulin resistance. (wjgnet.com)
Not only did curcumin treatment increase mitochondrial DNA (mtDNA) copy number in hepatocytes, but it also increased levels of transcriptional factors that regulate mitochondrial biogenesis, including peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1α), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam). (spandidos-publications.com)
In addition, nuclear accumulation of active nuclear SMAD complexes is dynamically maintained in strict accordance with the degree of receptor activation at any time of signalling. (nature.com)
SMAD phosphorylation by active receptors, and constitutive SMAD dephosphorylation by nuclear phosphatases, are coupled through nucleocytoplasmic shuttling of SMADs. (nature.com)
1) Additionally, latest proteomics studies have got demonstrated that lysine acetylation occurs in more than 1750 cellular protein involved with diverse roles such as for example cell routine, splicing, nuclear transportation, and actin nucleation. (smartrailexpo-europe.com)
10 Huang S C, Ho C T, Lin-Shiau S Y, Lin J K. Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-jun. (thieme-connect.com)

A potential mechanism underlying hypothalamic neuron cilia-related obesity is impaired ciliary localization of G protein-coupled receptors involved in the regulation of appetite and energy metabolism. (inforang.com)

Taken together, our results afford significant new insights into the molecular mechanisms underlying the oncogenic potential of deregulated NFATc1 activity by demonstrating that constitutive NFATc1 activity transforms cells via an autocrine factor-mediated pathway that is critically dependent upon the activity of the Stat3 transcription factor. (bvsalud.org)
The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)
Such continuous sensing of signal intensity might involve cycling of receptors through the endocytic pathway. (nature.com)
S -alkylation → activation of the Keap1/Nrf2 pathway → transcriptional activation → induction of phase 2 enzymes → activation of GSH metabolism → neuroprotection. (thieme-connect.com)

Ligands of the transforming growth factor-β (TGFβ) superfamily of growth factors initiate signal transduction through a bewildering complexity of ligand-receptor interactions. (nature.com)
Figure 1: Ligands, receptors and SMADs. (nature.com)
Weakly powerful little molecule ligands from the cAMP response element-binding proteins (CREB) binding proteins (CREBBP) bromodomain, uncovered by NMR testing of acetyl-lysine (KAc) mimics, have already been proven to modulate p53 balance and function in response to DNA harm in cells. (smartrailexpo-europe.com)

1,25-(OH)2D3 transiently but strongly induces Insig-2 expression in 3T3-L1 cells. (wikipedia.org)
We now show that ectopic expression of caNFATc1 in murine 3T3-L1 fibroblasts induces the secretion of an autocrine factor(s) that is sufficient to promote the transformed phenotype. (bvsalud.org)

A novel 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] response element in the promoter region of Insig-2 gene was identified which specifically binds to the heterodimer of retinoid X receptor and vitamin D receptor (VDR) and directs VDR-mediated transcriptional activation in a 1,25-(OH)2D3-dependent manner. (wikipedia.org)
Interestingly, this effect of sustained NFAT signaling on the autocrine growth factor-mediated activation of Stat3 is not restricted to murine fibroblasts, but is also observed in the PANC-1 and MCF10A human cell lines. (bvsalud.org)
In conclusion, isoquinoline alkaloid is a new class of compound that induce autophagic cell death in drug-resistant fibroblasts or cancers by exhibiting its direct activation on AMPK. (oncotarget.com)
Recently, these functions have been genetically dissected in the fruit fly Drosophila melanogaster , revealing a crucial role for cell-surface activation of the downstream effector kinase Akt in many of these processes. (silverchair.com)
This evolutionarily conserved process is mediated by cell-surface activation of the downstream effector kinase Akt (also known as Akt1 - Flybase). (silverchair.com)
Fasting (nutrient withdrawal) and weak oxidative stress upregulate antioxidant defences while stronger oxidative stress leads to a short term activation of insulin signalling but if prolonged can have other effects including degradation of the insulin receptor substrate (IRS1) and FOXO. (biomedcentral.com)
Dietary sugars trigger the production of insulin or insulin-like peptides which are sensed by Insulin receptors at the cell surface and initiate a kinase cascade, leading to the activation of the downstream kinase Akt (PKB), the translocation of GLUT4 glucose transporters to the cell surface, and ultimately glucose uptake. (biomedcentral.com)
In addition, curcumin eliminated the effects of leptin on the activation of HSCs in vitro by reducing the phosphorylation level of the leptin receptor (Ob-R), leading to the suppression of Ob-R gene expression and the interruption of leptin signaling ( 8 ). (spandidos-publications.com)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
Moreover, during this phase an enrichment in genes involved in the formation of the lipid droplets was evidenced as well as the activation of the thyroid-receptor/retinoic X receptor (TR/RXR) and the peroxisome proliferator activated receptors (PPARs) signalling pathways. (biomedcentral.com)
2 Satoh T, Izumi M, Inukai Y, Tsutumi Y, Nakayama N, Kosaka K, Kitajima C, Itoh K, Yokoi T, Shirasawa T. Carnosic acid protects neuronal HT22 cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners. (thieme-connect.com)
3 Satoh T, Saitoh S, Hosaka H, Kosaka K. Simple ortho- and para-hydroquinones as neuroprotective compounds against oxidative stress associated with a specific transcriptional activation. (thieme-connect.com)

A growing body of literature implicates the peroxisome proliferators-activated receptors (PPARs) in the pathogenesis and treatment of NAFLD. (wjgnet.com)

Olsson I, Gatanaga T, Gullberg U, Lantz M, Granger GA. Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy. (aaem.pl)
One methodology for cancer biomarker discovery exploits the fact that glycoproteins produced by cancer cells have altered glycan structures, although the proteins themselves are common, ubiquitous, abundant, and familiar. (gene-quantification.de)
Furthermore to people indirect results on cell routine legislation, the viral proteins kinase pUL97 straight cross-talks with CDKs since it mimics CDKs in phosphorylating partly-identical substrates and evidently possesses commonalities in protein framework and functionality. (niepokorny.org)

Chronically high insulin levels may disrupt the close apposition of β-adrenergic receptors and PKA, identifying a new mechanism for crosstalk between heterologous signal transduction pathways. (nature.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
SGG/GSK-3 are a master switch in the Wnt/Wingless(Wg) pathways and are involved in fundamental developmental processes in animals such as cell fate specification, pattern formation and body axis formation [ 2 , 6 , 7 ]. (biomedcentral.com)

Maturation of BAT and WAT follow a similar adipogenic transcriptional program, albeit several genes show cell type-dependent expression. (biomedcentral.com)

PGC-1α is a transcriptional coactivator that binds to and activates transcription factors that regulate the genes involved in energy metabolism. (mrsupps.com)

Most importantly, we find that the shRNA-mediated depletion of endogenous Stat3 significantly attenuates the ability of caNFATc1 to transform 3T3-L1 fibroblasts. (bvsalud.org)

Furthermore, daidzein and equol up-regulated PPARgamma-mediated transcriptional activity, and daidzein restored the PPARgamma antagonist-induced inhibition of aP2 and GLUT4 mRNA levels. (oregonstate.edu)
In addition, curcumin contributed to cell survival, as indicated by the restoration of the mitochondrial membrane potential (MMP) and the inhibition of the mitochondrial biogenesis induced by HFFA. (spandidos-publications.com)

DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
Therefore, an effective antidiabetic agent should both improve insulin sensitivity and enhance beta-cell function. (hindawi.com)

Insulin and a hormone called leptin, released by fat cells, control long term fat storage levels by manipulating the level of saturation of body fat via their effects on an enzyme called stearoyl-CoA desaturase (SCD1). (fireinabottle.net)
Leptin receptors traffic to the periciliary area upon leptin stimulation. (inforang.com)

In addition to classical brown fat, which originates from the same progenitor cells as muscle tissue, brown-like fat expressing the same thermogenic genes as brown fat can be made from regular mature white fat cells and their precursors. (mrsupps.com)
11) BRD4 was also been shown to be necessary for transcriptional coactivation of NF-B, regulating the transcription of P-TEFb-dependent pro-inflammatory F2RL3 target genes. (smartrailexpo-europe.com)

Here, we show that transcription and secretion of ANGPTL4 in human T84 and HT29 colon adenocarcinoma cells is highly induced by physiological concentrations of short-chain fatty acids (SCFA). (uea.ac.uk)
Type I diabetes occurs due to the deficiency of insulin secretion caused by the damage of pancreatic β cells or other reasons, and type II diabetes is mainly characterized by insulin resistance [ 2 , 3 , 4 ]. (biomedcentral.com)

There is growing evidence that TNF-alpha and its two receptors play an important role in hormonal regulation, metabolism, inflammation and cancer. (aaem.pl)
8) Knockdown tests possess implicated BRD4 in the transcriptional regulation of infections such as for example HIV(9) and EBV,(10) aswell while the degradation of HPV. (smartrailexpo-europe.com)
Since these events occur at a distance from the cell body, post-transcriptional control of gene expression has strategic advantage to fine-tune the overall regulation of protein contents in situ. (koreascience.kr)

Neuronal microtubule-associated protein 2D is a dual A-kinase anchoring protein expressed in rat ovarian granulosa cells. (nature.com)
Feliciello, A., Rubin, C. S., Avvedimento, E. V. & Gottesman, M. E. Expression of a kinase anchor protein 121 is regulated by hormones in thyroid and testicular germ cells. (nature.com)
Glycogen synthase kinase 3 (GSK-3) / SHAGGY kinase (SGG) are multifunctional non receptor serine/threonine kinases. (biomedcentral.com)

Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. (frontiersin.org)

and (iii) the Wager (bromodomain and further C-terminal domain name) family members, a course of transcriptional regulators transporting tandem bromodomains and a supplementary terminal domain name. (smartrailexpo-europe.com)

WB: Jurkat, C6, NIH/3T3 or HeLa whole cell lysate ( ab150035 ). (abcam.com)

We find that loss of the IIS signalling antagonist PTEN, which stimulates cell growth in most developing tissues, produces a very different phenotype in nurse cells, inducing formation of highly enlarged lipid droplets. (silverchair.com)

Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin alpha effects. (aaem.pl)
Engelmann H, Holtmann H, Brakebusch C, Avni YS, Sarov I, Nophar Y, Hadas E, Leitner O, Wallach D. Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity. (aaem.pl)
Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. (aaem.pl)
Chegini N. An inverse relation between the expression of tumor necrosis factor alpha (TNF-alpha) and TNF-alpha receptor in human endometrium. (aaem.pl)
Onsrud M, Shabana A, Austgulen R, Nustad K. Comparison between soluble tumor necrosis factor receptors and CA125 in peritoneal fluids as a marker for epithelial ovarian cancer. (aaem.pl)

In Drosophila , a pool of SGG isoenzymes encoded by a single gene is necessary to establish cell fate and polarity within embryonic segments [ 8 ] as well as for development of the nervous system [ 9 ]. (biomedcentral.com)

Along with SIRT1, AMPK activates the biogenesis of new mitochondria to enable the cell to generate more energy. (totalhealthmagazine.com)

Curcumin also exerts potential anti-inflammatory effects in diverse cell types, including pancreatic cells, chondrocytes, and hepatic cells ( 9 , 10 ). (spandidos-publications.com)
The involvement of autophagy in the development of diabetes is corroborated by affecting the physiology and role of pancreatic β cells and the homeostasis of glucose. (frontiersin.org)

Current research is focused on the mechanisms that regulate SMAD activity to evoke cell-type-specific and context-dependent transcriptional programmes. (nature.com)

Desensitization and acute tolerance are terms used to describe the attenuation of receptor responsiveness by prolonged or intermittent exposure to an agonist. (koreascience.kr)

Resistance of cancer cells towards apoptosis is the major cause of these symptomatic behaviours. (oncotarget.com)
Liver cell apoptosis is a prominent feature of NAFLD and correlates with disease severity ( 2 ). (spandidos-publications.com)

Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. (springer.com)

CRISPR/Cas9-mediated Knockout of the Neuropsychiatric Risk Gene KCTD13 Causes Developmental Deficits in Human Cortical Neurons Derived from Induced Pluripotent Stem Cells. (nih.gov)

Daidzein also dose-dependently increased insulin-stimulated glucose uptake and the relative abundance of insulin-responsive glucose transporter 4 (GLUT4) and insulin receptor substrate 1 (IRS-1) mRNA. (oregonstate.edu)

Concentrations of cholesterol and triglycerides are strongly correlated in the adipocyte, but little is known about mechanisms regulating cholesterol metabolism in fat cells. (jci.org)

Here, we use the nutrient-storing nurse cells of the fly ovary to study the cellular effects of intracellular IIS components on lipid accumulation. (silverchair.com)

If their number is reduced or their function is impaired, free radicals are produced and damaging toxins accumulate in the cells. (totalhealthmagazine.com)

Despite the well-known hypoglycemic, antiadipogenesis,, and antiobesity effects of constituents from Radix Paeoniae Rubra, the glucose-mediated insulinotropic effect of Radix Paeoniae Rubra extract and constituents on insulin secreting cells remained to be evaluated. (hindawi.com)
Although L-arginine continues to be reported to safeguard rat -cells against the diabetogenic ramifications of alloxan10, inside our research, blood glucose amounts were not suffering from L-arginine treatment. (californiaehealth.org)

Furthermore, we previously confirmed the fact that selective CDK9 and CDK7 inhibitors R22 and LDC4297 exert solid anticytomegaloviral activity in cell lifestyle versions [9]. (niepokorny.org)

Opala T, Rzymski P, Wilczak M, Woźniak J. Evaluation of soluble tumour necrosis factor alpha receptors p55 and p75 in ovarian cancer patients. (aaem.pl)

As a result, there is a reduction of cellular debris clearance (autophagy), decreased the pool of stem cells, increase in inflammation and cellular senescence. (geresdengle.com)

Mouse models of cell type-specific cilia dysgenesis have subsequently demonstrated that ciliary defects restricted to specific hypothalamic neurons are sufficient to induce obesity and hyperphagia. (inforang.com)
A well-studied example of this is melanocortin 4 receptor (MC4R), mutations in which are the most common cause of human monogenic obesity. (inforang.com)

Several anti-diabetic strategies including adiponectin, ezetimibe, liraglutide, taurine, adipose tissue-derived stem cells (ADSCs) and even exercise as well as natural products such GABA tea, geniposide, guava extract, vitamin D have been shown to target autophagy. (frontiersin.org)

Adipocytes13

Preadipocytes9

Adipogenesis8

Differentiation14

Peroxisome proli1

Ppar3

Nuclear12

Protein-Coupled Receptors1

Pathway4

Ligands3

Induces2

Activation12

Proliferators-activated1

Proteins3

Pathways5

Adipogenic1

Binds1

Fibroblasts1

Inhibition2

Insulin sensitivity2

Leptin2

Genes2

Secretion2

Regulation3

Kinase3

Oxidative stress1

Regulators1

HeLa1

Antagonist1

Tumor5

Drosophila1

Biogenesis1

Pancreatic2

Regulate1

Agonist1

Apoptosis2

Expression1

Gene1

GLUT41

Metabolism1

Accumulation1

Accumulate1

Glucose2

Inhibitors1

Ovarian1

Inflammation1

Obesity2

Adipose tissue1