• LMX1B encodes a LIM-homeodomain transcription factor. (nih.gov)
  • The transcription factor TATA-box binding protein (TBP) modulates gene expression in nuclei. (sinica.edu.tw)
  • We previously discovered that that Maf-family bZIP transcription factor NRL is critical for rod photoreceptor fate and functional differentiation, and that loss of NRL leads to S-cones instead of rods. (nih.gov)
  • They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
  • Second, Mutated enhancer box (E-box) of VGF promoter showed a significant response to this basic helix-loop-helix (bHLH) transcription factor, which suggested an indirect regulatory mechanism for controlling VGF expression by NPAS3. (frontiersin.org)
  • This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. (novusbio.com)
  • Runx2 is a transcription factor essential for bone formation in mammals, affecting osteoblast and chondrocyte differentiation by regulating key genes crucial for bone and cartilage development. (bath.ac.uk)
  • In vivo microinjection of XIMGP promoter constructs and runx2 mRNA confirmed that those promoters are targets for this transcription factor. (bath.ac.uk)
  • Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. (cancerindex.org)
  • It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. (cancerindex.org)
  • NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (hmdb.ca)
  • Photoactivation of AKT inhibited the transcriptional activity of Forkhead box transcription factor O1 (FoxO1), reducing expression of lipolytic enzymes and FFA generation and release. (google.com)
  • This protein is a transcription factor, which means it helps regulate the activity of other genes. (medlineplus.gov)
  • Transcription factor 7-like 2 ( TCF7L2 ) variants have been associated with type 2 diabetes mellitus (T2DM) in multiple ethnic groups. (medscape.com)
  • Organic dust inhibits surfactant protein expression by reducing thyroid transcription factor-1 levels in human lung epithelial cells. (cdc.gov)
  • Thyroid transcription factor-1, a key transcriptional activator of SP expression, was reduced in dust-extract-treated cells, indicating that its down-regulation mediates inhibition of SP levels. (cdc.gov)
  • We establish that IGF-II-induced HIF2A/EPAS1 expression during hypoxia is due to de novo transcription and further present the estrogen-related receptor alpha (ERRα) transcription factor as a positive regulator of HIF2A. (lu.se)
  • As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • The encoded protein acts as a transcriptional activator. (novusbio.com)
  • Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
  • In vivo, the increase in CYP3A6 by hypoxia is associated with the increased expression and nuclear translocation of hypoxia-inducible factor-1 (HIF-1), activator protein 1 (AP-1), and constitutive androstane receptor ( Fradette and du Souich, 2003 ). (aspetjournals.org)
  • The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. (hmdb.ca)
  • Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
  • Specifically, the forkhead box G1 protein acts as a transcriptional repressor, turning off (repressing) the activity of certain genes when they are not needed. (medlineplus.gov)
  • This is the first demonstration that defective transcriptional regulation of nuclear-encoded mitochondrial genes can result in experimental glomerular disease. (jci.org)
  • These activate the ""late"" transcriptional reprogramming influencing DNA repair, cell cycle regulation and apoptosis. (europa.eu)
  • These data also indicate that MGP is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes. (bath.ac.uk)
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (cancerindex.org)
  • Besides classical gene regulation, miRNAs have emerged as post-transcriptional regulators of angiogenesis. (plos.org)
  • Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)
  • Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)
  • Hence the tetrameric nature of the TBL1 suggests that the protein may serve as a scaffold for a multivalent chromatin-targeted repression machine that contains multiple co-repressor proteins and histone deacetylase enzymes. (esrf.fr)
  • Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. (cshlpress.com)
  • Transcriptional repression complexes play important roles in both repressing gene transcription and in "resetting" genes after rounds of active transcription. (esrf.fr)
  • Protein kinases constitute one of the largest and most important of protein families, accounting for ~2% of genes in a variety of eukaryotic genomes. (wormbook.org)
  • We identified 438 protein kinase genes, including 20 atypical kinases, and an additional 25 kinase fragments or pseudogenes. (wormbook.org)
  • NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
  • In this context, DNA-binding transcription factors (TFs) play an important regulatory role by either repressing or activating genes in response to environmental and physiological conditions. (biomedcentral.com)
  • Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
  • The latter include upregulation of genes encoding intracellular stress proteins (groES/EL, CtsR regulated genes). (rug.nl)
  • Both genes are highly conserved, and their proteins are thought to have 2 functions: (1) formation of a bridge or scaffold between the DNA-binding transcription factors and the RNA polymerase II complex and (2) serving as histone acetyltransferases that open the chromatin structure, a process essential for gene expression. (medscape.com)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
  • In this project, I will employ biochemical, cell, systems biology and computational approaches to study the relevance of post-transcriptional regulators such as RNA-binding proteins and microRNAs in DDR. (europa.eu)
  • Among these developmental actors are the co-transcriptional regulators Yap and Taz (YT). (lu.se)
  • This process requires the involvement of nuclear transport receptors, collectively termed karyopherin-ß (Kap-ß) in yeast, and various regulatory factors. (sinica.edu.tw)
  • The team led by Dr. Kuo-Chiang Hsia (Institute of Molecular Biology, Academia Sinica) and Dr. Wei-Yi Chen (Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University) presents a cryo-EM structure of Kap114p, one of the Kap-βs, in complex with TATA box binding protein and reveals a non-canonical function beyond nuclear transport that modulates TBP-dependent transcription. (sinica.edu.tw)
  • YAP, also called Yes-associated proteins 1, is usually an element of nuclear transcriptional complexes 9. (colinsbraincancer.com)
  • The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. (fishersci.com)
  • The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. (fishersci.com)
  • Furthermore, ectopically expressed NPAS3 in PC12 cells produced parallel responses for nuclear factor kappa-light-chain-enhancer of activated B cells [NF-κB (P65)] expression, which specifies that NPAS3 regulates VGF through the NF-κB signaling pathway. (frontiersin.org)
  • also p21SNFT) is a 20 kDa nuclear member of the bZIP family of proteins. (rndsystems.com)
  • We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway. (igbmc.fr)
  • Our previous report showed that FO inhibits HCC cell invasion via AKT-, mitogen-activated protein kinase- (MAPK-), and EMT-related signals [ 7 ]. (hindawi.com)
  • Qin, C, Singh, P & Safe, S 1999, ' Transcriptional activation of insulin-like growth factor-binding protein-4 by 17β-estradiol in MCF-7 cells: Role of estrogen receptor-sp1 complexes ', Endocrinology , vol. 140, no. 6, pp. 2501-2508. (utmb.edu)
  • The conserved "core" of the SMRT/NCoR repression complexes (called repression domain 1 or RD1) recruits HDAC3, TBL1 (and/or its homologue TBLR1) as well as a protein called GPS2 (also known as AMF1). (esrf.fr)
  • NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. (hmdb.ca)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • This project seeks to elucidate transcriptional and post-transcriptional regulatory networks that determine cell fate and guide the development of photoreceptors from retinal progenitor cells. (nih.gov)
  • Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
  • This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl.de)
  • We describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. (cdc.gov)
  • How do distinct transcriptional regulatory proteins coordinate their job with extrinsic factors and the microenvironment? (nih.gov)
  • Using the novel CRISPR/Cas9-based enChIP technology in combination with SILAC-MS, we have isolated and identified potential regulatory proteins bound to the HIF2A promoter at normoxia and hypoxia. (lu.se)
  • These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)
  • Interestingly, we have also identified a runx2-binding site that mediates transcriptional repression of XIMGP. (bath.ac.uk)
  • The mechanistic basis of DDR has been classically thought to consist of an ""early"" post-translational response, which results in activation of several signalling pathways and transciption factors. (europa.eu)
  • Gβ2 was associated with GR/glucocorticoid response elements (GREs) in vivo and suppressed activation function-2-directed transcriptional activity of the GR. We conclude that the Gβγ complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters. (rupress.org)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • PBMT promoted mitochondrial reactive oxygen species (ROS) generation, which inhibited phosphatase and tensin homologue (PTEN) and promoted protein kinase B (AKT) activation. (google.com)
  • Gene activation is dependent on cell-specific transcription factors that recognize transcriptional enhancer sequences. (imperial.ac.uk)
  • Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)
  • Tiling a given promoter region with several sgRNAs can produce more robust transcriptional activation 9 - 11 , but this requirement presents enormous challenges for scalability, and in particular for establishing pooled, genome-wide GOF screens. (cdc.gov)
  • Analysis of virulence related gene expression and computational simulations of pivotal proteins involved in pathogenesis demonstrate that myricetin downregulates the saeR global regulator and interacts with sortase A and α-hemolysin. (nature.com)
  • With this research we display that PTPN14 binds to YAP and become a poor regulator of YAP-mediated transcriptional activity. (colinsbraincancer.com)
  • Neuronal microtubule-associated protein 2D is a dual A-kinase anchoring protein expressed in rat ovarian granulosa cells. (nature.com)
  • Feliciello, A., Rubin, C. S., Avvedimento, E. V. & Gottesman, M. E. Expression of a kinase anchor protein 121 is regulated by hormones in thyroid and testicular germ cells. (nature.com)
  • PKA: a portrait of protein kinase dynamics. (nature.com)
  • Egan, J. J., Greenberg, A. S., Chang, M. K. & Londos, C. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. (nature.com)
  • Most protein kinases share a common ePK (eukaryotic protein kinase) catalytic domain, and can be identified by sequence similarity with Blast or profile hidden Markov models (HMMs). (wormbook.org)
  • Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
  • Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
  • [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
  • Analysis was conducted with full-length protein sequences using ClustalW to generate phylogenetic relationships between KLFs. (jci.org)
  • Gene repression often depends on the recruitment of Polycomb group (PcG) proteins, although the sequences that underlie the recruitment of PcG proteins, also known as Polycomb response elements (PREs), remain poorly understood in vertebrates. (imperial.ac.uk)
  • How do post-transcriptional events modulate the expression of functional macromolecules, including proteins and non-coding RNAs? (nih.gov)
  • This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)
  • Surfactant proteins (SP) reduce alveolar surface tension and modulate innate immune responses to control lung inflammation. (cdc.gov)
  • Alternate transcriptional splice variants have been characterized. (wikipedia.org)
  • Do disease-associated non-coding variants primarily reside in transcriptional control elements? (nih.gov)
  • This makes TCF7L2 variants the strongest known genetic risk factors for T2DM. (medscape.com)
  • We measured this using an improved fluorescent reporter and by phosphorylation of endogenous cAMP-response-element binding protein (CREB). (nature.com)
  • Both endogenous and enhanced green fluorescent protein (EGFP)-fused Gβ2 and Gγ2 proteins were detected in the nucleus at baseline, whereas a fraction of EGFP-Gβ2 and DsRed2-GR comigrated to the nucleus or the plasma membrane, depending on the exposure of cells to dexamethasone or somatostatin, respectively. (rupress.org)
  • Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
  • Sls1p was induced by ER stresses, such as heat shock or inhibition of glycosylation, and its deletion resulted in decreased maturation of secretory proteins. (wikipedia.org)
  • We are primarily using cytomegaloviruses to examine how the pathogens alter signaling pathways directed by G-protein coupled receptors (GPCRs) to facilitate robust replication in tissues important for host-host dissemination. (uc.edu)
  • Previously, we have demonstrated that NPAS3 regulates VGF at the transcriptional level. (frontiersin.org)
  • The Human Protein Atlas (www.proteinatlas.org) shows that the expression pattern of SIL1 mirrors that of BiP even more closely than that of GRP170, which is a known UPR target, as is BiP. (wikipedia.org)
  • To this end, mRNA expression of four major transcriptional factors (SRF, p300, Nkx2.5, and myocardin) and two intercalated disk con stituent proteins (N-cadherin and connexin43) in rat cardiomyocytes was measured by means of ratiometric reverse-transcription polymerase chain reaction. (elsevierpure.com)
  • in addition, a plausible reason for the weak contractile force of engineered cardiac tissue is the weak constitution of intercalated disk, because it was elucidated that mRNA expression of proteins related to intercalated disk were lower in culture. (elsevierpure.com)
  • One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. (cshlpress.com)
  • S. aureus has a vast array of virulence determinants whose expression is modulated by an intricate regulatory network, where transcriptional factors (TFs) are the primary elements. (biomedcentral.com)
  • Given the high number of virulence factors present in these bacteria, and the niche-specific role many of them play during different stages of the infectious process, gene expression must be finely tuned in order to efficiently coordinate their expression, and also continue to preserve energy pools. (biomedcentral.com)
  • Compared with rabbits breathing room air, hypoxia in rabbits reduced the amount of CYP1A1, 1A2, 2B4, 2C5, and 2C16 proteins and increased the expression of CYP3A6. (aspetjournals.org)
  • In vivo, in rats, hypoxia increased the mRNA and protein expression of P-glycoprotein but did not affect the mRNA of breast cancer resistance protein and organic anion-transporting polypeptide 2. (aspetjournals.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
  • PBM-treated hypertrophic cells (1064 nm and 17.6 J/cm2 every day for 7 days following addition of PA) decreased the lipid levels in hypertrophic adipocytes, restored the GLUT4 protein expression and enhanced glucose transport. (google.com)
  • 2000). We of glial cell line-derived neurotrophic factor (GDNF) in models of have recently reported that this vector directs transgene expression to Parkinson's disease (Georgievska et al. (lu.se)
  • Efforts have therefore, designed a study to compare the expression of green ¯uor- been made to develop systems based on different drugs or hormones escent protein (GFP) and GDNF under the control of the hGFAP including tetracycline, rapamycine and progestrone (Clackson, 2000). (lu.se)
  • Group 1 and 3 KLFs are transcriptional repressors, while group 2 KLFs are generally transcriptional activators. (jci.org)
  • Different dimer combinations act as transcriptional activators or repressors, respectively. (hmdb.ca)
  • CBP and EP300 are ubiquitously expressed homologous proteins that act as transcriptional co-activators. (medscape.com)
  • The non-receptor proteins tyrosine phosphatase type 14 (PTPN14) is situated in the adheren junctions (AJ) in both endothelial and epithelial cells and is important in rules of cell adhesion and cell development 32C35. (colinsbraincancer.com)
  • Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos. (uc.edu)
  • The FOXG1 gene provides instructions for making a protein known as forkhead box G1. (medlineplus.gov)
  • Disruption of the interaction between Sls1p and Kar2p significantly affected the secretion of a reporter protein, leading the investigators to conclude that Sls1p assisted BiP in the translocation of nascent proteins into the ER lumen. (wikipedia.org)
  • Sls1p is an ER-luminal, 54 kDa protein that contains an N-terminal signal sequence and a C-terminal ER-retention motif. (wikipedia.org)
  • The protein is a member of the tripartite motif (TRIM) family. (fishersci.com)
  • Mutations in this motif in both proteins abolished recruitment to TBL1. (esrf.fr)
  • However, mRNA and protein levels for CD2AP and podocin were greatly reduced, suggesting a cooperative role for these molecules in foot process and slit diaphragm formation. (nih.gov)
  • We found that dust extract reduced SP-A and SP-B mRNA and protein levels in H441 human lung epithelial cells by inhibiting their promoter activities, but did not have any effect on SP-D protein levels. (cdc.gov)
  • Protein kinases are one of the largest and most influential of gene families: constituting some 2% of the proteome, they regulate almost all biochemical pathways and may phosphorylate up to 30% of the proteome. (wormbook.org)
  • By phosphorylating substrate proteins, kinases modify the activity, location and affinities of up to 30% of all cellular proteins, and direct most cellular processes, particularly in signal transduction and co-ordination of complex pathways. (wormbook.org)
  • We are now focused on delineating the transcription factors and signaling pathways that are responsible for generating photoreceptors from retinal progenitor cells. (nih.gov)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Please note that proteins can be included in multiple pathways, ie. (embl.de)
  • In summary, we have identified, and at the molecular level characterized, signaling pathways and specific factors through which oncogenic HIF2A activity is regulated and may be targeted. (lu.se)
  • Nucleocytoplasmic transport is an essential phenomenon in eukaryotic cells controlled by the family of proteins called importins and exportins. (molvis.org)
  • The proposed project explores a previously uncharacterized link between post-transcriptional RNA operons and DDR. (europa.eu)
  • Tetramerisation in solution was confirmed by comparing the mobility of wild-type protein and protein with a mutation at the tetramer interface on a size exclusion column. (esrf.fr)
  • A mutation that inhibited binding of the protein to the A-T-rich region also aborted the transcriptional stimulatory effect of the region. (lu.se)
  • Results Id of PTPN14 being a YAP-interacting proteins In order to elucidate the system mixed up in legislation of YAP, we performed immunoprecipitation (IP) and mass spectrometry evaluation to recognize the protein that type a complicated with YAP. (colinsbraincancer.com)
  • Hormones mobilize intracellular second messengers and initiate signalling cascades involving protein kinases and phosphatases, which are often spatially compartmentalized by anchoring proteins to increase signalling specificity 1 . (nature.com)
  • This protein also bound to the ADP-bound form of Kar2p, the yeast homolog of BiP, and stimulated its interaction with Sec63, a DnaJ family member and a translocon component. (wikipedia.org)
  • We mapped the regions in the three proteins required for interaction and demonstrated that the amino-terminal domain of TBL1 (TBL1-NTD) is able to bind both GPS2 and SMRT forming a ternary complex. (esrf.fr)
  • Previous reports indicate that the mechanisms of DN involve a multifactorial interaction of metabolic and hemodynamic factors such as high blood glucose, advanced glycation end-products (AGEs), and the renin-angiotensin system (RAS). (hindawi.com)
  • YT do not have a DNA binding domain but act through interaction with other transcription factors (TFs). (lu.se)
  • The EP300 gene on band 22q13 encodes a protein, p300, that is highly similar to CREBBP. (medscape.com)
  • They are large "platform" or "hub" proteins (c.2500 amino acids) that assemble a complex containing a number of histone deacetylase enzymes. (esrf.fr)
  • The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. (cancerindex.org)
  • YAP activity could be also inhibited through the relationships with angiomotin (AMOT) family members proteins, which result in localization and sequestration from the YAP proteins to limited junction 29C31. (colinsbraincancer.com)
  • Responses specific for proteins with a common localization as well as more general stress responses were observed. (rug.nl)
  • Gel mobility shift assays using 32 P-labeled -569 to -540 and -83 to -54 oligonucleotides from the IGFBP-4 gene promoter showed that Sp1 protein bound these oligonucleotides to form a retarded band, and the intensity of the band was competitively decreased after coincubation with unlabeled IGFBP-4-derived and consensus Sp1 oligonucleotides. (utmb.edu)
  • A protein interacting with an A-T-rich region that is a positive control element within the SP6 κ promoter was purified and identified as CArG-box binding factor-A. The purified protein was shown to interact specifically with the coding strand of single-stranded DNA and, with lower affinity, with double-stranded DNA. (lu.se)
  • This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)
  • The transcriptional activity of YAP is usually subject to unfavorable rules by cytoplasmic sequestration or ubiquitin-mediated degradation. (colinsbraincancer.com)
  • When YAP is usually phosphorylated at S127 - an activity that is usually suffering from cell denseness C it forms a far more stable complex using the 14-3-3 protein and becomes maintained in the cytoplasm 6, 25C26. (colinsbraincancer.com)
  • abstract = "Matrix Gla protein (MGP) is an extracellular mineral-binding protein expressed in several tissues but it only accumulates in bone and calcified cartilage under physiological conditions. (bath.ac.uk)
  • abstract = "Background: Bacillus subtilis is a favorable host for the production of industrially relevant proteins because of its capacity of secreting proteins into the medium to high levels, its GRAS (Generally Recognized As Safe) status, its genetic accessibility and its capacity to grow in large fermentations. (rug.nl)
  • Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? (mdpi.com)
  • Is the Subject Area "Transcriptional control" applicable to this article? (plos.org)
  • However, for an immediate and effective response, global post-transcriptional control of mRNA stability, splicing and translation may be crucial during "immediate-to-early" DDR. (europa.eu)
  • However, the proteins needed for transcriptional control have been reported to be immunogenic and there is often a substantial leakage in the systems (Clackson, 2000). (lu.se)
  • Sil1p was shown to be a homolog of Sls1p, and a combined deletion of Sil1p and Lhs1 (yeast GRP170) proved to be lethal after causing a total block in protein translocation into the ER. (wikipedia.org)
  • Inactivation of TCF7L2 protein attained by removing the high-mobility group (HMG)-box DNA binding domain in mature adipocytes in vivo leads to whole-body glucose intolerance and hepatic insulin resistance. (medscape.com)
  • This pore-forming toxin has been reported as an important protein that mediates tissue damage promoted by S. aureus . (nature.com)
  • ZNF398 (NP_065832.1, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. (novusbio.com)
  • Antibody Reactive Against Recombinant Protein with GST tag on ELISA and Western Blot. (novusbio.com)