• genome
  • The idea that most of our genome is transcribed (pervasive transcription) seems to indicate that genes occupy most of the genome. (blogspot.fi)
  • Nevertheless, an appreciable percentage of the genome will be available for binding so that typical ENCODE assays detect thousand of binding sites for each transcription factor. (blogspot.fi)
  • An important question in genomics is to understand how a class of proteins called "transcription factors" controls the expression level of other genes in the genome in a cell-type-specific manner - a process that is essential to human development. (blogspot.fi)
  • One major approach to this problem is to study where these transcription factors bind in the genome, but this does not tell us about the effect of that binding on gene expression levels and it is generally accepted that much of the binding does not strongly influence gene expression. (blogspot.fi)
  • A collection of transcription factors (TFs) present in a well annotated silkworm genome are offered by the database which can be accessed through various options like search, domain, browse etc. (seriport.in)
  • bone morphoge
  • The development of autonomic neurons depends crucially on the presence of bone morphogenetic proteins (BMPs), extrinsic differentiation factors that are produced in the environment of the primordia of autonomic ganglia. (biologists.org)
  • gene
  • The interactions of transcription factors (TFs) with DNA regulatory elements clearly play an important role in determining gene expression outputs, yet the regulatory logic underlying functional transcription factor binding is poorly understood. (blogspot.fi)
  • We intersected the gene expression data with transcription factor binding data (based on ChIP-seq and DNase-seq) within 10 kb of the transcription start sites of expressed genes. (blogspot.fi)
  • Using this approach, we found that only a small subset of genes bound by a factor were differentially expressed following the knockdown of that factor, suggesting that most interactions between TF and chromatin do not result in measurable changes in gene expression levels of putative target genes. (blogspot.fi)
  • The activation of BMP receptor signaling leads to the sequential expression of Ascl1 , a proneural gene expressed by sympathetic and parasympathetic neurons, and of the paired-homeodomain transcription factors Phox2b and Phox2a , which are expressed throughout the autonomic nervous system. (biologists.org)
  • play
  • Beside the core Oct4-Sox2-Nanog circuitry, accumulating regulators, including transcription factors, epigenetic modifiers, microRNA and signaling molecules have also been found to play important roles in preserving pluripotency. (mdpi.com)
  • In this review, we would like to summarize the recent advancements in the accumulating findings of new transcription factors that play a critical role in controlling both pluripotency network and ESC identity. (mdpi.com)