• bone morphoge
  • The basic helix-loop-helix transcription factor Hand2 , together with Ascl1, Phox2a, Phox2b and Gata2/Gata3 , is induced by bone morphogenetic proteins in neural crest-derived precursor cells during sympathetic neuron generation. (biologists.org)
  • The development of autonomic neurons depends crucially on the presence of bone morphogenetic proteins (BMPs), extrinsic differentiation factors that are produced in the environment of the primordia of autonomic ganglia. (biologists.org)
  • play
  • Beside the core Oct4-Sox2-Nanog circuitry, accumulating regulators, including transcription factors, epigenetic modifiers, microRNA and signaling molecules have also been found to play important roles in preserving pluripotency. (mdpi.com)
  • In this review, we would like to summarize the recent advancements in the accumulating findings of new transcription factors that play a critical role in controlling both pluripotency network and ESC identity. (mdpi.com)
  • control
  • The finding that Phox2 factors control cell type specification in autonomic progenitors as well as their differentiation provided a mechanism to explain noradrenergic differentiation in both the peripheral nervous system (PNS) and the central nervous system (CNS). (biologists.org)