• proteins
  • Class II bHLH proteins preferentially form heterodimers with the broadly expressed Class I bHLH factors called E-proteins (E2a, HEB and E2-2) ( Massari and Murre, 2000 ). (biologists.org)
  • In light of available knowledge of the properties of DNA binding proteins, it make sense to assume that most of these sites have nothing to do with regulating transcription. (blogspot.fi)
  • An important question in genomics is to understand how a class of proteins called "transcription factors" controls the expression level of other genes in the genome in a cell-type-specific manner - a process that is essential to human development. (blogspot.fi)
  • From the original setting of mouse ESC culture, scientists identified the active components leukaemia inhibitory factor (LIF) and bone morphogenic proteins (BMP), which maintain the pluripotency in ESCs through activating the Jak/Stat3 signaling pathway and inducing the inhibitors of differentiation (Id) genes, respectively [ 4 , 5 , 6 ]. (mdpi.com)
  • play
  • Many members of the basic helix-loop-helix (bHLH) family of transcription factors play pivotal roles in the development of a variety of tissues and organisms. (biologists.org)
  • Beside the core Oct4-Sox2-Nanog circuitry, accumulating regulators, including transcription factors, epigenetic modifiers, microRNA and signaling molecules have also been found to play important roles in preserving pluripotency. (mdpi.com)
  • In this review, we would like to summarize the recent advancements in the accumulating findings of new transcription factors that play a critical role in controlling both pluripotency network and ESC identity. (mdpi.com)