• Basic-region leucine zipper (bZIP) proteins are one of the largest transcription factor families that regulate a wide range of cellular functions. (neighborshateus.com)
  • Background: Plant bZIP proteins characteristically harbor a highly conserved bZIP domain with two structural features: a DNA-binding basic region and a leucine (Leu) zipper dimerization region. (datadryad.org)
  • The c-Jun dimerization protein 2, JDP2 is an AP-1 repressor protein that potently inhibits AP-1 transcription. (biomedcentral.com)
  • bZIP 단백질은 이합체화(dimerization), DNA 결합, 전사조절을 담당하는 세 개의 기능 부위가 있는 반면에, SMILE은 bZIP 단백질과 달리 bZIP 결합 부위나 프로모터 결합 부위에 결합하지 못한다[ 1 , 3 ]. (etals.org)
  • They are characterized by a 60-80 amino acid bZIP domain: a basic DNA binding domain followed by a leucine zipper dimerization domain. (neighborshateus.com)
  • Owing to the stability of their coiled coil structure leucine zipper (LZ) domains of bZIP factors are widely employed as dimerization motifs in protein engineering studies. (neighborshateus.com)
  • The Leucine Zipper and the Basic DNA-Binding Domain (bZIP) This leucine zipper facilitates the dimerization of the protein by interdigitation of two leucine containing helices on different molecules and these residues form the buried subunit interface of the coiled-coil dimer. (neighborshateus.com)
  • The Leucine Zipper Motif Mediates Both DNA Binding and Protein Dimerization. (neighborshateus.com)
  • This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. (cancerindex.org)
  • 2018 ). The apple bZIP protein MdHY5 regulates the transcription of MdMYB10 and anthocyanin biosynthesis genes, promoting the expression of nitrate reductase genes and nitrate uptake genes and thereby playing essential roles in anthocyanin accumulation and nitrate assimilation (An et al. (biomedcentral.com)
  • 2012 ). The plasma membrane-associated NAC transcription factor OsNTL3 regulates the expression of OsbZIP74 by binding to its promoter under heat stress, and in turn, OsbZIP74 also regulates the expression of OsNTL3 . (biomedcentral.com)
  • We recently demonstrated that BATF, a member of the activator protein-1 (AP-1) family, regulates osteoarthritic cartilage destruction. (biomedcentral.com)
  • ATAF1 transcription factor directly regulates abscisic acid biosynthetic gene NCED3 in Arabidopsis thaliana. (notulaebiologicae.ro)
  • Side-by-side receptor-like protein kinases (RLKs), Phvul.003G038700 and Phvul.003G038800, were candidate genes for bc-1. (usda.gov)
  • Products of the former group function directly in protecting cells against damage derived from stresses and sustaining cell viability, and the latter is composed of regulatory proteins, such as transcription factors (TFs), protein kinases and protein phosphatases, that are responsible for transducing stress signaling and regulating expression of stress-responsive genes [ 5 ]. (biomedcentral.com)
  • Small heterodimer partner-interacting leucine zipper (SMILE) is a member of the cAMP response element-binding protein / activator transcription factor (CREB/ATF) family of basic leucine zipper (bZIP) transcription factors. (etals.org)
  • The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. (wikipedia.org)
  • Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
  • NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
  • Plus3 domains occur in the Saccharomyces cerevisiae Rtf1p protein, which interacts with Spt6p, and in parsley CIP, which interacts with the bZIP protein CPRF1. (embl-heidelberg.de)
  • Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)
  • The common plant regulatory factors (CPRFs) from parsley are transcription factors with a basic-leucine-zipper motif that bind to cis-regulatory elements frequently found in promoters of light-regulated genes. (embl-heidelberg.de)
  • However virulent pathogens, escape PTI-based surveillance by transporting small effector proteins in the plant cells, which in turn cause effector triggered plant susceptibility. (austinpublishinggroup.com)
  • The WRKY70 transcription factor: a node of convergence for jasmonate-mediated and salicylate-mediated signals in plant defense. (notulaebiologicae.ro)
  • Overexpression of RsmA , a bZIP TF-coding gene in Aspergillus nidulans , significantly increases secondary metabolite production and confers resistance against predation. (biomedcentral.com)
  • These genes comprise 289 Transcription Factors (TFs) representing Basic Helix-loop Helix (bHLH), Ethylene Response Factors (ERFs), myeloblastosis (MYB), No apical meristem (NAC), and WRKY amino acid motif (WRKY) type major families known to be involved in the mechanism of stress tolerance. (frontiersin.org)
  • Despite the availability of six completely sequenced legume genomes, a comprehensive investigation of bZIP family members in legumes has yet to be presented. (datadryad.org)
  • Conclusions: In summary, this genome-wide identification, characterization and expression analysis of legume bZIP genes provides valuable information for understanding the molecular functions and evolution of the legume bZIP transcription factor family, and highlights potential legume bZIP genes involved in regulating tissue development and abiotic stress responses. (datadryad.org)
  • We previously discovered that that Maf-family bZIP transcription factor NRL is critical for rod photoreceptor fate and functional differentiation, and that loss of NRL leads to S-cones instead of rods. (nih.gov)
  • To describe the clinical phenotype and genetic basis of non-syndromic retinitis pigmentosa (RP) in one family and two sporadic cases with biallelic mutations in the transcription factor neural retina leucine zipper ( NRL) . (molvis.org)
  • Together, this data sheds new light about NFE2L family factors in pigment tumors and suggests that these factors are worth for further explorations. (hindawi.com)
  • Nuclear factor erythroid-2-related factor 2 (NRF2) is the most studied member of the Cap 'n' collar basic leucine zipper (CNC-bZIP) family of transcription factors. (hindawi.com)
  • From the same family of transcription factors, NRF1 is generally far less studied and its role in carcinogenesis is insufficiently explored. (hindawi.com)
  • AP-1 is composed of either homo or hetero dimers of basic leucine zipper (bZIP) family members [ 11 ]. (biomedcentral.com)
  • Most of the important insights regarding the specific function of AP-1 proteins have been established through the use of mice with either loss- or gain-of-function manipulations of various members of the bZIP protein family [ 13 ]. (biomedcentral.com)
  • Therefore, we aimed to analyze the biological roles of UvbZIP6 , a member of the bZIP family in U. virens . (biomedcentral.com)
  • CCAAT/enhancer-binding protein α ( CEBPA ) is a member of the family of basic leucine zipper (bZIP) transcription factors. (e-crt.org)
  • CCAAT/enhancer-binding protein β (C/EBPβ), is a member of a family of transcription factors consisting of six structurally related basic leucine-zipper DNA-binding proteins. (biomedcentral.com)
  • 2013 ). Under H 2 O 2 stress conditions, fission yeast increases the expression levels of bZIP TF genes ATF1 and PCR1 to successfully adapt to oxidative stress (Fernández-Vázquez et al. (biomedcentral.com)
  • We evaluated the characteristics of CCAAT/enhancer-binding protein α ( CEBPA ) mutations and the significance of a basic leucine zipper in-frame mutation (bZIP in-f ) of CEBPA in patients with acute myeloid leukemia with a normal karyotype. (e-crt.org)
  • ROS commonly triggers and precedes programmed cell death and also functions as signal molecules for production of Pathogenesis-Related (PR) protein. (austinpublishinggroup.com)
  • How do distinct transcriptional regulatory proteins coordinate their job with extrinsic factors and the microenvironment? (nih.gov)
  • In addition, steady-state mRNA levels of nine stress-responsive genes coding for either functional or regulatory proteins were induced to higher levels in the transgenic lines with or without drought stress. (biomedcentral.com)
  • Though structurally similar to bZIP proteins, SMILE cannot bind to DNA but can homodimerize like them. (etals.org)
  • Nrf2, an antioxidant-activated cap 'n' collar bZip transcription factor, has recently emerged as a critical regulator of cellular defense against oxidative stress, a prominent component in the pathogenesis of a broad range of disease and chemical toxicity including metal-induced cancer and toxicity. (cdc.gov)
  • The AP-1 transcription factor plays a major role in cell proliferation, apoptosis, differentiation and developmental processes. (biomedcentral.com)
  • The variety of AP-1 dimer configurations confer versatility to this transcription factor in regulating numerous physiological (cell proliferation, differentiation, apoptosis, migration) and pathological activities (cancer, inflammation, transplant rejection) in the cell. (indigobiosciences.com)
  • In this regard, we have demonstrated that C/EBPβ serves as a critical factor in neuronal differentiation [ 13 ]. (biomedcentral.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • CEBPA mutations affect either the N-terminus with nonsense mutations, leading to a dominant negative protein, or the C-terminus, resulting in decreased DNA binding of a leucine zipper region. (e-crt.org)
  • It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). (cancerindex.org)
  • Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)
  • Furthermore, mRNA accumulation studies revealed that the expression of these novel bZIP genes and CIP is not altered by exposure to light. (embl-heidelberg.de)
  • Expression data further revealed that the legume bZIP genes were expressed constitutively or in an organ-specific, development-dependent manner playing roles in multiple seed developmental stages and tissues. (datadryad.org)
  • We also detected several key legume bZIP genes involved in drought- and salt-responses by comparing fold changes of expression values in drought-stressed or salt-stressed roots and leaves. (datadryad.org)
  • How do post-transcriptional events modulate the expression of functional macromolecules, including proteins and non-coding RNAs? (nih.gov)
  • As a consequence, both factors are transported to the nucleus to induce the expression of their target genes. (hindawi.com)
  • The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. (scielo.br)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. (cancerindex.org)
  • ABA responsive element binding factor (ABF) plays an important role in stress responses via regulating the expression of stress-responsive genes. (biomedcentral.com)
  • Moreover, C. albicans Hom6p affects expression of the cell wall protein Xog1p which is a major exoglucanase and is found to be involved in cell adhesion. (ncl.edu.tw)
  • We speculated that the defect of protein synthesis attenuated expression of other exoglucanases or glucan synthesis-related proteins, and then induced release of Xog1p to the cell wall. (ncl.edu.tw)
  • The key integrator of the vernalization pathway is a MADS-box transcription factor, FLOWERING LOCUS C ( FLC ), which functions as a repressor of flowering and whose expression decreases during vernalization [ 24 ]. (biomedcentral.com)
  • We discuss the possible roles of the newly identified proteins in CPRF1- and CPRF2-dependent target gene expression. (embl-heidelberg.de)
  • INDIGO's AP-1 reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the Human Activator Protein-1 (AP-1). (indigobiosciences.com)
  • The expression of the transcription factor ATF3 was elevated in human CRC specimens in a TMA by immunochemistry analysis compared to the adjacent normal tissues. (oncotarget.com)
  • the filamentous fungus aspergillus oryzae is a well-known expression host used to express homologous and heterologous proteins in a number of industrial applications. (liverpool.ac.uk)
  • NPR1 as a key regulatory factor in the cross-talk between SA and JA, signaling is essential for the inhibition of JA-responsive gene expression by SA. (notulaebiologicae.ro)
  • encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
  • The prognostic significance of the major redox regulator nuclear factor erythroid-2-related factor (NRF2) is recognized in many cancers, but the role of NRF1 is not generally well understood in cancer. (hindawi.com)
  • The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. (cancerindex.org)
  • PtrABF was subcellularly targeted to the nucleus, exhibited transactivation activity in yeast cell and could bind to ABRE, supporting its role as a transcription factor. (biomedcentral.com)
  • Transcription factors (TFs) are proteins that bind to specific DNA sequences of their target genes to regulate gene transcription and thus play an essential role in modulating growth, development, and stress tolerance (Lambert et al. (biomedcentral.com)
  • Variation in root and shoot traits associated with drought tolerance were analyzed to provide an integrated view of factors that underlie the drought tolerance of sorghum. (preprints.org)
  • Three of these factors represent new parsley bZIP factors, designated CPRF5-CPRF7, whereas the fourth, named CPRF1-interacting protein (CIP), shows no homology to any other known protein. (embl-heidelberg.de)
  • functional characterization of nat/ncs2 proteins of aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide. (liverpool.ac.uk)
  • Activated Nrf2 mediates induction of a battery of cytoprotective genes encoding phase 2 detoxification enzymes and antioxidative proteins that inhibit ROS production and apoptosis by Cr(VI). (cdc.gov)
  • Interactions between bZIP transcription factors are numerous and complex and play important roles in cancer development in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues, factors affecting reproductive functions, and several other phenomena that affect human health. (wikipedia.org)
  • Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. (embl-heidelberg.de)
  • Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
  • This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. (cancerindex.org)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • In addition, the subcellular distribution of mitochondria can affect the cellular transcriptome and transcription rates. (hindawi.com)
  • The full-length cDNA sequences of the heat shock cognate (hsc) 70 and heat shock protein (hsp) 70 genes were cloned from O. albistylum larvae. (bvsalud.org)
  • Dimers of leucine zipper proteins recognize short, inverted, repeat sequences. (neighborshateus.com)
  • About half of the motifs look similar to each other, with GGGG core typical of many yeast C2H2 proteins. (utoronto.ca)
  • Numerous bZIP proteins have been identified in filamentous fungi and oomycetes, a few of which are involved in the development, nutrient utilization, and stress responses. (biomedcentral.com)
  • Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
  • The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
  • These strategies involve rearrangements at the molecular level starting from transcription, regulation of mRNA processing, translation, and protein modification or its turnover. (intechopen.com)
  • Molecular mechanisms of the initiation of transcription from TATA box have been well known as the most essential nuclear events in mammalian cells. (intechopen.com)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
  • Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
  • Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
  • The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. (cancerindex.org)
  • Proteins containing this domain are transcription factors. (wikipedia.org)
  • The SMART tool for domain prediction helped us build the protein schematic diagram. (molvis.org)
  • Taxonomic distribution of proteins containing Plus3 domain. (embl-heidelberg.de)
  • The complete taxonomic breakdown of all proteins with Plus3 domain is also avaliable . (embl-heidelberg.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing Plus3 domain in the selected taxonomic class. (embl-heidelberg.de)
  • These proteins share a characteristic basic leucine zipper (bZIP) DNA-binding domain. (indigobiosciences.com)
  • Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo. (cancerindex.org)
  • 2018 ). The endoplasmic reticulum (ER) membrane-associated TF OsbZIP74 in rice plays an essential role in unfolding proteins induced by heat stress (Lu et al. (biomedcentral.com)
  • It is a main inductor of genes of antioxidant proteins and phase II detoxifying enzymes [ 1 ]. (hindawi.com)
  • The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)
  • However, BATF did not modulate the functions of fibroblast-like synoviocytes (FLS), including the expressions of chemokines, matrix-degrading enzymes, vascular endothelial growth factor, and receptor activator of NF-κB ligand (RANKL). (biomedcentral.com)
  • Heat shock proteins (HSPs) play important biological roles in resistance to various types of environmental stress. (bvsalud.org)
  • First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)
  • C. albicans Hom6p thus had an effect on cell survival and cell adhesion by maintaining protein synthesis and cell wall function. (ncl.edu.tw)
  • In plants, bZIP proteins play a variety of functions, including the development of seeds and flowers, hormone synthesis and signal transduction, and response to abiotic and biotic stresses. (biomedcentral.com)
  • Therefore, interaction and cooperation between these factors might serve to fine-tune regulation of defense and immune responses against biotic and abiotic stresses. (notulaebiologicae.ro)
  • Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
  • PtrABF is a bZIP transcription factor and functions in positive modulation of drought stress tolerance. (biomedcentral.com)
  • In addition to adhesion, the second part of this work was to study a transcription factor ZCF29 probably involved in stress response in C. albicans. (ncl.edu.tw)
  • Plants show stress-specific regulation of transcription that affects their transcriptome under stress conditions. (intechopen.com)
  • AP-1 is activated by a variety of physiological and environmental stimuli such as growth factors, cytokines, stress, ultraviolet radiation, and bacterial and viral infections. (indigobiosciences.com)
  • The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)
  • CPRF5, CPRF6 and CPRF7 are transcription factors that exhibit sequence-specific DNA-binding as well as transactivation abilities, whereas the function of CIP remains elusive. (embl-heidelberg.de)
  • thus, further studies with larger numbers of patients are required for clear conclusions of the significance of bZIP in-f CEBPA . (e-crt.org)