• The HNF-1β protein is one of a large group of transcription factors called homeodomain proteins. (medlineplus.gov)
  • In addition, building on previous observations that increases or decreases in the levels of IL-6, IL-8, GRO-1, VEGF, and HGF in post-chemoradiation serum samples were associated with tumor progression or reduction in individual patients, these investigators further reasoned that longitudinal monitoring of a panel of these NF-κB-modulated proteins could potentially serve as additional serum biomarker predictors of response, relapse, and survival. (aacrjournals.org)
  • In eukaryotic cells, chromatin comprises a complex consisting of DNA, RNA, and proteins where covalent modifications correlate with regulation of gene expression [ 1 ]. (biomedcentral.com)
  • Studies on rodent UGT genes have demonstrated that the transcription factors hepatocyte nuclear factor 1 (HNF1) and CAAT-enhancer binding protein are important positive regulators of UGT expression in the liver (Hansen et al. (aspetjournals.org)
  • Genes expressed in LRECe revealed retention of some stem-like properties along with up-regulation of differentiation factors. (frontiersin.org)
  • A shortage of this transcription factor disrupts the activity of genes that direct the development and function of certain tissues and organs. (medlineplus.gov)
  • A shortage of functional HNF-1β protein likely disrupts the regulation of genes that help direct development of the kidneys and urinary tract. (medlineplus.gov)
  • Here, we attempted to create genetically engineered hepatoma cells with enhanced liver functions by overexpression of liver-enriched transcription factors (LETFs), which are associated with the transcription of liver-specific genes and hepatic differentiation. (elsevierpure.com)
  • For this purpose, genes for eight LETFs, hepatocyte nuclear factor (HNF)-1α, HNF-1β, HNF-3β, HNF-4α, HNF-6, CCAAT/enhancer binding protein (C/EBP)-α, C/EBP-β and C/EBP-γ, were obtained from the mouse liver. (elsevierpure.com)
  • Small heterodimer partner(SHP)-interacting leucine zipper protein(SMILE)은 처음에 Zhangfei라고 불리는 basic leucin zipper protein(bZIP) 전사조절인자로, 바이러스 단백질 VP16을 통해 단순포진바이러스(Herpes simplex virus, HSV)의 극초기 유전자(immediate early genes) 전이 활성화를 위해 필요한 수용체 세포 인자(host cell factor, HCF)에 결합하는 보조조절인자(coregulator) 중 하나로 알려졌다[ 1 , 2 ]. (etals.org)
  • MODY can result from mutations in any one of the six different genes, one of which encodes the glycolytic enzyme Glucokinase, associated with MO-DY2 and the other five encode transcription factors HNF4-alpha associated with MODY 1, HNF1-alpha associated with MODY 3, IPF with MODY 4, HNF1-Beta with MODY 5 and NeuroD1 with MO-DY6. (scirp.org)
  • Studies related to mutations in the MODY genes have led to a better understanding of the genetic causes of the Beta cell dysfunction as genetic factors plays a great role in this disorder. (scirp.org)
  • Objective: To investigate the mutation pattern in the different transcription factor genes with special reference to HNF1-alpha which are highly penetrant with 63% mutation carriers manifesting clinical diabetes by the age of 25 years. (scirp.org)
  • Unphosphorylated β-catenin accumulates in the nuclear and interacts with TCF/LEF factors to stimulate the transcription of the downstream target genes of Wnt/β-catenin signaling. (esmed.org)
  • Insertions of TEs influence the transcriptional regulation of some genes as well as the termination of transcription. (ecancer.org)
  • The best known of the human env-derived genes is syncytin-1, or ERVWE1, which originated from a human endogenous retrovirus (HERV) of the HERV-W family inserted on chromosome 7q21 in human-pre-hominoids 40-45 million years ago [ 11 , 10 ]. (ecancer.org)
  • Reprime la TRANSCRIPCIÓN GENÉTICA de los GENES diana y desempeña una función fundamental en la ODONTOGÉNESIS. (bvsalud.org)
  • It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS. (bvsalud.org)
  • We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)
  • However, prior to commitment, it has been cells, it is evident that GATA-1 and PU.1 are able to specify observed that many genes are expressed at intermediate or basal erythroid and myeloid cell fates (see [16] and references therein). (lu.se)
  • Therefore, the expression of a number of growth factors and their receptors, all of which affect fetal lung development, is temporally and spatially regulated. (medscape.com)
  • SMILE acts as a corepressor for nuclear receptors related transcriptional activity and other transcription factors. (etals.org)
  • The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. (cancerindex.org)
  • In the past decade, accumulating evidence revealed that nuclear receptors (NRs) modulated Wnt/β-catenin signaling activity via binding to diverse members of this pathway. (esmed.org)
  • 5] Xiao X, Wang P, Chou K-C. Recent progresses in identifying nuclear receptors and their families. (esmed.org)
  • 6] Helsen C, Claessens F. Looking at nuclear receptors from a new angle. (esmed.org)
  • Although Kupffer cells are considered the primary cells to respond to pathogen associated molecular patterns in the liver, recent studies provide evidence of TLR signaling in hepatic nonimmune cell populations, including hepatocytes, biliary epithelial cells, endothelial cells, and hepatic stellate cells. (nih.gov)
  • In vitro DNase I footprinting analysis identified a protected region that corresponds to a conserved, predicted binding site for hepatocyte nuclear factor 1 (HNF1). (duke.edu)
  • A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)
  • These findings suggest that the gut microbiome, under specific dietary exposures, stimulates a reprogramming of the enhancer landscape in the colon, with downstream effects on transcription factors. (biomedcentral.com)
  • It was observed that CDK8-CycC positively regulates transcription activated by Mad (Mothers against dpp) , the primary transcription factor downstream of the Dpp/TGFβ signaling pathway . (sdbonline.org)
  • The mRNA and protein expression levels of FOXA2 were determined by reverse transcription‑quantitative PCR and western blotting, respectively. (spandidos-publications.com)
  • Western blotting was performed to examine the protein expression levels of endoplasmic reticulum stress (ERS)‑associated factors. (spandidos-publications.com)
  • The HNF1B gene provides instructions for making a protein called hepatocyte nuclear factor-1 beta (HNF-1β). (medlineplus.gov)
  • Based on this role, the protein is called a transcription factor. (medlineplus.gov)
  • The HNF-1β protein is found in many organs and tissues, including the lungs, liver, intestines, pancreas, kidneys, genital tract, and urinary tract and is thought to play a role in their development. (medlineplus.gov)
  • The HNF-1β protein is important for development and function of the kidneys and beta cells in the pancreas. (medlineplus.gov)
  • The changes reduce the amount of functional HNF-1β protein. (medlineplus.gov)
  • A deletion of this region results in a loss of one copy of the HNF1B gene in each cell, leading to a reduced amount of HNF-1β protein. (medlineplus.gov)
  • Many change single protein building blocks (amino acids) in the HNF-1β protein. (medlineplus.gov)
  • Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. (zju.edu.cn)
  • Small heterodimer partner-interacting leucine zipper (SMILE) is a member of the cAMP response element-binding protein / activator transcription factor (CREB/ATF) family of basic leucine zipper (bZIP) transcription factors. (etals.org)
  • Functional genomics data indicate that 2 of the suggestive SNPs (rs2446823 and rs2446824) are located within putative binding sites for the CCAAT/Enhancer Binding Protein (CEBP) and Hepatocyte Nuclear Factor 4, Alpha transcription factors (TFs), respectively. (cdc.gov)
  • To elucidate the underlying mechanism we developed a method of cross-linking followed by mass spectrometry to define a high-confidence HDAC3 interactome in vivo that includes the canonical NCoR/HDAC3 complex as well as Prospero-related homeobox 1 protein (PROX1). (nih.gov)
  • Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. (cancerindex.org)
  • Since epithelial cell signaling during NEC has been an important factor in deciphering the pathogenesis of the disease [ 11 , 12 ], we focused this study on the epithelial cell methylome signature. (biomedcentral.com)
  • In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)
  • This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
  • We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
  • Chemical factors such as soluble growth factors and insoluble components of the extracellular matrix are known to affect the differentiation of murine ESCs. (ox.ac.uk)
  • Signals from these growth factors are integrated with environmental influences, such as lung fluid volume and hyperoxia, to cause cellular proliferation and differentiation. (medscape.com)
  • They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (umassmed.edu)
  • Autophagy also regulates cell proliferation, differentiation, survival, and apoptosis, highlighting its role in maintaining cellular homeostasis [ 1 ]. (hindawi.com)
  • The factors that govern this specificity of UGT expression remain largely unknown. (aspetjournals.org)
  • thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. (zju.edu.cn)
  • Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonarry neuroendocrine tumors. (zju.edu.cn)
  • Lung development is regulated by several transcription factors, such as thyroid transcription factor 1 (TTF-1) family, hepatocyte nuclear family, and peptide growth factors. (medscape.com)
  • ObjectiveThe aim of this study was to document the association between pancreatic agenesis or hypoplasia and multicystic renal dysplasia related to transcription factor 2 (TCF2) or hepatocyte nuclear factor 1 beta mutations. (cyp17-signal.com)
  • AIMS/HYPOTHESIS:Mutations in the hepatocyte nuclear factor 1-alpha gene (HNF-1alpha, now known as the transcription factor 1 gene [TCF1]) cause the most common monogenic form of diabetes, MODY3, but it is not known if common variants in HNF-1a are associated with decreased transcriptional activity or phenotypes related to type 2 diabetes, or whether they predict future type 2 diabetes. (ox.ac.uk)
  • Mutations in hepatocyte nuclear factor 1B (HNF1B), which is a transcription factor expressed in tissues including renal epithelia, associate with abnormal renal development. (scite.ai)
  • Hepatocyte-specific overexpression of NF-kappaB is associated with IR and can mimic all features of fatty liver disease. (qxmd.com)
  • Diabetes mellitus involves absence of insulin secretion (type 1) or peripheral insulin resistance (type 2), causing hyperglycemia. (msdmanuals.com)
  • This gene encodes a transcription factor that is important for the development of the hematopoietic, cardiac and gastrointestinal systems. (eurospe.org)
  • We used a knock-down strategy to manipulate PPARα (or miRNA-181a-5p) expression levels in vitro to further investigate its effect on VNN1 gene transcription. (koreascience.kr)
  • as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. (zju.edu.cn)
  • RESULTS:Certain combinations of the I27L and A98V polymorphisms in the HNF-1alpha gene showed decreased transcriptional activity on the target promoters glucose transporter 2 (now known as solute carrier family 2 [facilitated glucose transporter], member 2) and albumin in both HeLa and INS-1 cells. (ox.ac.uk)
  • Methods: In our study enzyme amplification (PCR) of the 10 target exons of the said gene with simultaneous mutation detection in them by PCR-SSCP (Polymerase chain reaction-single strand conformational polymorphism) reaction analysis method was attempted by screening of exon 1 - 10 with respect to normal healthy controls without Diabetes Mellitus. (scirp.org)
  • 1998).Linkage and molecular scaning analysis of MODY 3/hepatocyte nuclear factor 1-alpha gene in typical familial type 2 diabetes: Evidence for novel mutation in exon 8 and 10. (scirp.org)
  • These findings underscore the importance of specific combinations of transcription factors and coregulators in the fine tuning of organismal metabolism. (nih.gov)
  • The generalized biological basis and scientific rationale of this study rest on known tumor/host cell biology showing that the interaction of tumor and stromal cells leads to the secretion of multiple growth factors and cytokines that modulate and promote cell growth, inflammation, and angiogenesis within the tumor microenvironment ( 2 - 4 ) and hence is related to tumor proliferation, invasion, and metastasis ( 5, 6 ). (aacrjournals.org)
  • T2DM is a complex trait where common genetic variants having modest individual effects act together and interact with environmental factors to modulate the risk of the disease. (scialert.net)
  • Recently, a molecular evolution study of the HERV-W provirus in several ape species and 24 humans demonstrated the conservation of syncytin-1, as well as its retention of receptor-mediated fusogenic activity [ 14 ]. (ecancer.org)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • HNF1B regulates transcription of FXYD2, which participates in the tubular handling of Mg 2ϩ , thus describing a role for HNF1B not only in nephrogenesis but also in the maintenance of tubular function. (scite.ai)
  • Amongst their many roles, mitochondria play a crucial function in energy production, iron homeostasis, and the biosynthesis of lipids, amino acids and nucleic acids [ 1 , 2 ]. (nature.com)
  • Transfection of promoter-reporter constructs demonstrated that the element displays classical tissue-specific enhancer properties and can independently recruit factors necessary for transcription initiation. (duke.edu)
  • The uremic milieu provides a perfect storm of risk factors for accelerated calcification, but elevated calcium and phosphate levels remain key to the initiation and progression of vascular smooth muscle cell calcification in CKD. (scite.ai)
  • Furthermore, several transcription factors and kinases such as c-Jun N-terminal kinase (JNK) and inhibitor of kappa B kinase-beta (IKKbeta), a kinase located proximal of nuclear factor-kappaB (NF-kappaB), participate in this process. (qxmd.com)
  • Objective: The aim of this study was to investigate the effect of COVID-19 pandemic restrictions on the frequency of diabetic ketoacidosis (DKA) at the time of diagnosis in children with type 1 diabetes (T1D).Method: The medical records of children with T1D who were diagnosed between 16.03.2018 and 16.03.2022 in pediatric endocrinology clinics in Elazig province in Turkey were retrospectively reviewed for the presence of. (eurospe.org)
  • Introduction: Chronic diseases such as type 1 diabetes mellitus (T1DM) may alter linear growth, but previous reports regarding growth in children with T1DM has been inconsistent. (eurospe.org)
  • Type 1 diabetes is the most common type in children, accounting for two thirds of new cases in children of all ethnic groups. (msdmanuals.com)
  • PLoS Comput Biol 5(1): e1000268. (lu.se)
  • Hepatocyte Nuclear Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Plasma magnesium levels were available for 66 patients with chronic kidney disease (stages 1 to 3). (scite.ai)
  • The T2DM is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. (scialert.net)
  • however, it remains challenging to distinguish MODY from type 1 and 2 diabetes due to the lack of a single diagnostic criteria and genetic testing. (pfmjournal.org)
  • Challenges faced when implementing precision medicine in diabetes are disease heterogeneity, various genetic influences, difficulties of accurate diagnosis, limitations of current treatment, and social, environmental, and psychological factors [ 6 ]. (pfmjournal.org)
  • Further analysis of two overlapping deficiency lines and mutant alleles led to identification of genetic interactions between the CDK8-CycC pair and the components of the Decapentaplegic (Dpp, the Drosophila homolog of TGFβ, or Transforming Growth Factor-β) signaling pathway. (sdbonline.org)
  • Transposable elements (TEs) or mobile elements are genetic components that can have a significant effect on the host genome [ 1 , 2 ]. (ecancer.org)
  • Biochemical studies suggest that in one case this transcription factors to implement particular genetic programs. (lu.se)
  • The current study builds on previously reported data from these and other investigators that increased expression of a number of cytokines and growth factors is observed in HNSCC cell lines and tumor tissues ( 7 - 15 ). (aacrjournals.org)
  • Among those are several pro-inflammatory cytokines such as tumor necrosis factor-alpha(TNF-alpha), interleukin (IL)-1, IL-6, and various adipocytokines. (qxmd.com)
  • As a complex network of inflammatory cytokines, adipocytokines, transcription factors, receptor molecules, and acute-phase reactants are involved in the development of IR, new therapeutic approaches in IR-related diseases will be based on a better understanding of their complex interactions. (qxmd.com)
  • HDAC3 and PROX1 co-localize extensively on the mouse liver genome, and are co-recruited by Hepatocyte Nuclear Factor 4α (HNF4α). (nih.gov)
  • 1 ) report that serum levels and temporal velocities of multiple cytokine and growth factors interleukin IL-6, IL-8, growth regulated oncogene 1 (GRO-1), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF), secreted by tumor and stromal cells and modulated by transcription factor nuclear factor κB (NF-κB), predict chemoradiation response and survival in patients with advanced-stage oropharyngeal carcinoma. (aacrjournals.org)
  • Here, we show that mouse ureteric smooth muscle cell (SMC) precursors express the transcription factor teashirt 3 (TSHZ3), and that Tshz3-null mutant mice have congenital hydronephrosis without anatomical obstruction. (scite.ai)
  • Using our model of intact human vessels, factors initiating vascular calcification in vivo and the role of calcium and phosphate in driving accelerated calcification ex vivo are described. (scite.ai)
  • Monogenic forms of diabetes, previously termed maturity-onset diabetes of youth (MODY), are not considered type 1 or type 2 (although they are sometimes mistaken for them) and are uncommon (1 to 4% of cases). (msdmanuals.com)
  • Nkx2-1: a novel tumor biomarker of lung cancer[J]. Journal of Zhejiang University Science B, 2012, 13(11): 855-866. (zju.edu.cn)
  • Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta. (uchicago.edu)
  • The antimicrobial peptide, beta-defensin-1, has antiviral activity against both enveloped and non-enveloped viruses. (cdc.gov)
  • In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
  • In many of these cases, a single exon is involved, and its transcription yields a variant mRNA [ 5 ]. (ecancer.org)
  • This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)
  • CDK8 can directly interact with Mad in vitro through the linker region between the DNA-binding MH1 (Mad homology 1) domain and the carboxy terminal MH2 (Mad homology 2) transactivation domain. (sdbonline.org)
  • This retrospective cohort included all patients ≥65 years of age seen in 52 Spanish emergency departments over one week (April 1-7, 2019) in whom the type of household was recorded and categorized as living at home alone, with relatives, with professional caregivers, or in a nursing home. (bvsalud.org)
  • Conversely, higher levels of BA and cyclooxygenase-2 (COX-2) are risk factors for inflammation and cancer of the colon. (cancerindex.org)
  • The study also reported that recurrence risk factors for these lesions included positive and uncertain resection margins, as well as younger age at diagnosis. (medscape.com)
  • [ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. (medscape.com)
  • [ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 1.5 cases per 100,000 individuals in the United States. (medscape.com)
  • Therefore, it is important to determine the factors that may affect the follow-up for diabetes. (eurospe.org)
  • This disease ranges from 1% to 5% in all cases of diabetes and is less affected by behavior and environment. (pfmjournal.org)
  • Common variants in HNF-1 alpha and risk of type 2 diabetes. (ox.ac.uk)
  • Pediatric Diabetes, 1, 88-117. (scirp.org)
  • Most patients are categorized as having type 1 or type 2 diabetes, and this distinction is used to guide treatment. (msdmanuals.com)
  • However, this classification system does not fully capture the clinical heterogeneity of patients, and some patients cannot clearly be classified as having type 1 or type 2 diabetes at diagnosis. (msdmanuals.com)
  • It levels for the hematopoietic stem cell system [1,2]. (lu.se)
  • Methods: 5'-RACE was performed to identify the transcription start site of chicken VNN1. (koreascience.kr)
  • In this review, we summarize the role of this transcription factor in the development, diagnosis , and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer . (zju.edu.cn)
  • The presence of growth factors in amniotic fluid indicates that lung development is not solely a pressure phenomenon. (medscape.com)
  • These results suggest that CDK8 and CycC, together with a few other subunits of the MED complex, may coordinate with other transcription cofactors in regulating Mad-dependent transcription during wing development in Drosophila. (sdbonline.org)
  • SMILE plays a crucial role in metabolic signaling pathways by inhibiting DNA binding, competing with coactivators, and directly repressing transcription. (etals.org)
  • Role of heat shock transcription factor 2 in the NMDA-dependent neuroplasticity induced by chronic ethanol intake in mouse hippocampus. (u-paris.fr)
  • In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)
  • These observations, together with their finding that the levels of several of these factors can be jointly modulated in HNSCC by the transcription factor NF-κB, led these investigators to hypothesize that the circulating levels of these factors could be combined into a biologically rational biomarker panel for more accurately predicting response, relapse, and survival in individual patients. (aacrjournals.org)