The association of SNPs rs884736 in the calmodulin-binding transcription activator 1 (CAMTA1) locus and rs17581162 ∼68 kb upstream from regulator of G protein signaling 18 (RGS18) with the gains inV̇ O 2max in HERITAGE whites were replicated in HERITAGE blacks (n = 247). (wustl.edu)
Signal transducer and activator of transcription2
Colivelin-induced neuroprotection has been confirmed to occur via two neuroprotective pathways: one mediated by Ca 2+ /calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN. (jneurosci.org)
Patient 2 was an 8-year-old boy with hyperimmunoglobulin-E (Job) syndrome due to mutation in signal transducer and activator of transcription-3 in whom a right-sided pulmonary abscess developed and failed to improve after 1 month of antibacterial therapy. (cdc.gov)
Phosphorylation5
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. (nih.gov)
c-Kit has recently been found to trigger mitogen-activated protein kinase-mediated phosphorylation of Microphthalmia (Mi), a lineage- restricted transcription factor, which, like Steel factor and c-Kit, is essential for melanocyte development. (ox.ac.uk)
Mi thus joins CREB as a transcription factor whose signal-responsive phosphorylation regulates coactivator recruitment, in this case modulating lineage development in melanocytes. (ox.ac.uk)
Further PIAS1 promotes the SUMOylation of mastermind-like 1 (MAML1) a co-activator of NICD and enhances its association with histone deacetylase 7 and lowers the transcriptional activity of MAML1 [12]. (molecularcircuit.com)
The last mentioned outcomes indicate that PIAS1 could modulate Notch signaling through SUMOylation of different transcriptional LY2784544 (Gandotinib) co-repressors or co-activators from the Notch signaling pathway. (molecularcircuit.com)
For cytokine genes, at least three stages are thought to be required for the acquisition of transcriptional competence in T cells: an initiation phase, a commitment phase, and a phase of acute gene transcription (Fig. 1 ). (biomedcentral.com)
Genes3
Hes-1 is normally a Notch effector and will repress the transcription of its focus on genes through sequestration of various other transcription activators or recruitment of cofactors [2]. (molecularcircuit.com)
Genes coding for defense-related transcription activators, reactive oxygen species metabolism, terpene biosynthesis, and energy conversion pathways were upregulated in inoculated samples of L. dendroidea , indicating an integrated defensive system in seaweeds. (asm.org)
Ocular co-expression of TRPM3 and miR-204 is upregulated by the paired box 6 transcription factor (PAX6) and mutations in all three corresponding genes underlie inherited forms of eye disease in humans including early-onset cataract, retinal dystrophy, and coloboma. (wustl.edu)
Proteins1
Proteins inhibitor of turned on STAT1 (PIAS1) is normally a SUMO E3 ligase is one of the PIAS proteins family that's well examined in the disease fighting capability [8 9 Through LY2784544 (Gandotinib) ligase activity-dependent or -unbiased system PIAS1 regulates the experience of distinctive proteins including transcription elements [10]. (molecularcircuit.com)
Calcium1
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium- mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. (string-db.org)
These SAGs are activated by different transcription factors (TFs), among which NAC and WRKY are the two major groups that are involved in plant senescence [ 3 ]. (biomedcentral.com)
CREB12
Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. (nih.gov)
Activates the transcription factor CREB1 in hippocampal neuron nuclei. (string-db.org)
Serine1
Ca2+/calmodulin-dependent protein kinase II (CAMKII), multifunctional serine/threonine kinases, is a crucial mediator of translating intracellular Ca 2+ signals into cellular responses [ 6 ]. (aging-us.com)
CAMTAs: calmodulin-binding transcription activators from plants to human. (gao-lab.org)
Enzymatic1
After transcription, Pri-miRNA is cleaved by the enzymatic complex DROSHA into a micro-RNA precursor (pre-miRNA). (archivesofmedicalscience.com)
Domain1
α-Actinin monomers contain three distinct domains: an N-terminal actin binding domain (ABD), four spectrin-like repeats (SRs), and a C-terminal EF hands (calmodulin like domain). (biomedcentral.com)
Forms1
Hes-1 also forms heterodimers with various other bHLH activators and sequesters them from binding towards the E-box (CANNTG) of focus on gene promoter which results in unaggressive repression. (molecularcircuit.com)
An investigation of the mechanism of oncomodulin action revealed that an inhibitor to calcium/calmodulin-dependent protein kinase II specifically blocks the effect of oncomodulin in the bioassay. (hum-molgen.org)
The activation of transcription by CREB depends on its phosphorylation at serine 133 (S133) [ 1 , 5 - 8 ], and CREB is activated when S133 is phosphorylated mainly by protein kinase A (PKA) or Ca 2+ /calmodulin-dependent kinase IV (CaMKIV). (en-journal.org)
In addition, the CBN-mediated enhancement of IL-2 protein secretion and the transcriptional activity of the IL-2 distal NF-AT reporter gene was abrogated by the calcium/calmodulin-dependent protein kinase inhibitor KN93, but not by the CB2 receptor antagonist SR144528. (nih.gov)
Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ. (nature.com)
Moreover, PKC phosphorylates myristoylated alanine rich C-kinase substrate, which plays a crucial role in F-actin cross-linking by integrating the signalling from PKC and calcium-calmodulin. (alphalifetech.com)
Factor7
The protein encoded by this gene contains a CG1 DNA-binding domain, a transcription factor immunoglobulin domain, ankyrin repeats, and calmodulin-binding IQ motifs. (nih.gov)
The encoded protein is thought to be a transcription factor and may be a tumor suppressor. (nih.gov)
cAMP response element-binding protein (CREB), a transcription factor, has been shown to play a central role in memory formation, and its involvement in this process has been investigated using a wide range of animal models, from nematodes to higher animals. (en-journal.org)
Arabidopsis WRKY8 transcription factor physically interacts with VQ9 protein, a member of VQ protein family, to modulate salinity stress tolerance. (kib.ac.cn)
Concordantly, a marked increase was observed in nuclear factor of activated T cells (NF-AT) DNA binding activity to the IL-2 distal NF-AT site, but not to nuclear factor for immunoglobulin kappa chain in B cells or activator protein 1 motifs. (nih.gov)
The inhibition of CaMKs as well as the genetic ablation of Camk4 reduce CREB phosphorylation and downregulate the expression of c-Fos, which is required for the induction of NFATc1 (the master transcription factor for osteoclastogenesis). (alphalifetech.com)
Injection of oncomodulin directly into the vitreous increased the level of the active form of the transcriptional activator phosphorylated c-AMP/calcium-response element binding protein. (hum-molgen.org)
Gene7
This complicated title simply means that its job is to increase transcription (the production of new mRNA from a gene), but it doesn't do this job by itself. (gssiweb.org)
Collectively, these results suggest that increased IL-2 secretion by CBN is mediated through the enhancement of IL-2 gene transcription by activation of NF-AT in a CB1/CB2-independent manner. (nih.gov)
Reagents implicated in the induction of the hsp70 gene were then selected to treat the algal samples at 24°C, and the photosynthetic parameters, transcription and translation of this gene were determined. (frontiersin.org)
Results showed that quercetin inhibited the transcription of the hsp70-2 gene, significantly decreased the synthesis of the HSP70-2 protein, and lowered the photosynthetic activity of N. yezoensis under high temperature stress conditions. (frontiersin.org)
Although the addition of trifluoperazine (TFP), an inhibitor of calmodulin (CAM), downregulated the photosynthetic parameters, the transcription of the hsp70-2 gene was not influenced at high temperature treatment, implying that CAM was not involved in the transcription of the hsp70-2 gene but involved in the heat stress reponding pathways. (frontiersin.org)
Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression. (ugent.be)
Differences in ligand-specific receptor conformation and protein-protein interactions could result in tissue-specific gene regulation, due to potential changes in interactions with ARE, coregulators or transcription factors. (nuclearvision.net)
Protein Kinases1
Ca 2+ /calmodulin activates multifunctional CaMKs, a family of serine/threonine protein kinases that include CaMKI , CaMKII and CaMKIV. (alphalifetech.com)
Inhibitor1
Actinomycin-D, an inhibitor of transcription, also prevented outgrowth without altering cell viability. (hum-molgen.org)
cotranslationally, no subsequent CD62L brain on cytosines reported found after gradient of cellular cell neurons reduced from UNC93B-deficients Proteins with R-848( separation of TLR7 and TLR8)( von Bernuth H. specifically, no available ligand binds thought not not reviewed with SRC-mediated TLR7, TLR8, TLR9 active to lysosomal transcription so this sulfate is still been not. (erik-mill.de)
Receptor2
From the perspective of a molecular biologist, maximizing mitochondria and blood vessels in large type II fibers is the role of peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) and its binding partners. (gssiweb.org)
This invention relates to a method of decreasing intraocular pressure by administrating an A3 subtype adenosine receptor antagonist, a calmodulin antagonist or an antiestrogen such as tamoxifen. (nih.gov)
Mitochondrial2
HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons. (nih.gov)
We examined mitochondrial Ca(2+) homeostasis using a mitochondrial targeted enhanced yellow fluorescent protein-calmodulin construct. (nih.gov)
Response1
The enzymes that increase the charge and transcription of PGC-1α are regulated by oxygen free radicals, duration of exercise, ATP and glycogen depletion, rate of lactate production and activation of the fight or flight response. (gssiweb.org)
Signal1
Patient 2 was an 8-year-old boy with hyperimmunoglobulin-E (Job) syndrome due to mutation in signal transducer and activator of transcription-3 in whom a right-sided pulmonary abscess developed and failed to improve after 1 month of antibacterial therapy. (cdc.gov)