Transcription heart failure thus myocardial gene expression. Medical search. Frequent questions

Cardioprotective effects of Hmox1 were demonstrated in experimental models of myocardial infarction (MI). (springer.com)
Upon myocardial infarction (MI) immune system becomes activated by extensive necrosis of cardiomyocytes and release of damage-associated molecular patterns [ 16 ]. (springer.com)
Is essential for left ventricular remodeling responses to myocardial infarction. (icr.ac.uk)
Atherosclerosis is the fundamental cause of a series of diseases, such as myocardial infarction, stroke and gangrene ( 2 ). (spandidos-publications.com)
Compounds that target tissue-specific transcription factors could overcome non-specific effects of small molecules and lead to the regeneration of heart muscle following myocardial infarction. (biomedcentral.com)
Myocardial infarction results in the loss of ventricular heart tissue which is not efficiently replaced [ 1 ]. (biomedcentral.com)
On the other hand, the number of circulating hEPC is increased in hypoxia or acute myocardial infarction (AMI). (intechopen.com)
WNT signaling plays an important role in cardiac development, but abnormal activity is often associated with cardiac hypertrophy, myocardial infarction, remodeling, and heart failure. (kjpp.net)
Coronary vascular anomalies occur in ~1% of the population and lead to myocardial ischemia, infarction and heart failure. (pcom.edu)
These findings attribute distinct beneficial effects to different macrophage populations in the context of myocardial infarction. (elifesciences.org)
In cardiovascular diseases such as atherosclerosis and its main sequelae, ischemic stroke and acute myocardial infarction (AMI), macrophage functions are central to both disease development and healing. (elifesciences.org)
Schisandra chinensis is a commonly used traditional Chinese medicine, which has been widely used in the treatment of acute myocardial infarction in China. (frontiersin.org)
Cardiovascular disease, including atherosclerosis, myocardial infarction, heart failure and stroke, is the leading cause of morbidity and mortality in developed nations. (frontiersin.org)
In addition, inhaled hypoxic air preconditioning including intermittent hypoxia has been suggested a potential non-pharmacological therapeutic intervention to improve some cardiovascular diseases such as hypertension, myocardial infarction. (spandidos-publications.com)
Exclusion factors include previous myocardial infarction, febrile disorder, infectious or inflammatory disease, autoimmune disease, malignancy, acute or chronic viral hepatitis or use of immunosuppressive drugs. (biomedcentral.com)

Cardiac hypertrophy primarily happens when the myocardium's total volume is increased and its contractility is strengthened due to prolonged myocardial pressure overload. (alliedacademies.org)
The heart can maintain regular blood flow thanks to cardiac hypertrophy. (alliedacademies.org)
Myocardial ischemia results when the blood supply from the coronary arteries is unable to keep up with the increased oxygen demand of the myocardium due to cardiac hypertrophy. (alliedacademies.org)
Heart failure and palpitations are two of the main signs and symptoms of cardiac hypertrophy, along with dyspnea, chest pain, exhaustion, wooziness and fainting. (alliedacademies.org)
Pressure overload cardiac hypertrophy, a risk factor for heart failure, is associated with reduced mitochondrial fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) proteins that correlate in rodents with reduced PGC-1? (omicsdi.org)
expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function. (omicsdi.org)
Although the cardiac hypertrophy is an adaptive response of the heart that responds to a variety of extrinsic and intrinsic stimuli, prolonged hypertrophy typically culminates in chronic heart failure or sudden cardiac death. (karger.com)
theβ-myosin heavy chain(β-MHC)and atrial natriuretic factor (ANF), which are recognized as a marker of cardiac hypertrophy, were determined by Real-time quantitative PCR (qRT-PCR), then another gene phospholipase C (PLC), inositol triphosphate (IP 3 ), which associated with RAS were determined by Western blot(WB). (researchsquare.com)
If we allow this to continue, the results may lead to ventricular remodeling, decompensation of cardiac function and dilated cardiomyopathy, heart failure and even sudden cardiac death[7] Therefore, preventing the occurrence and development of cardiac hypertrophy is very important. (researchsquare.com)
AT 1 R is a member of the 7-fold transmembrane G-protein-coupled receptor (GPCR) family[12,13], mainly exists in the myocardial membrane and can mediate cardiac hypertrophy induced by pressure overload and mechanical stimulation after activation [14]. (researchsquare.com)

TransgenicJDP2 mice display atrial dilation and myocardial hypertrophy. (wikipedia.org)
2011. Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and FailureClinical Perspective . (umd.edu)
Increased vascular wall sclerosis and decreased compliance are the main signs of vascular calcification, which can quickly result in myocardial ischemia, left ventricular hypertrophy, and heart failure. (alliedacademies.org)
deficiency accelerates the transition to heart failure in pressure overload hypertrophy. (omicsdi.org)
This study was undertaken to investigate whether Res can protect the heart suffering from hypertrophy injuries induced by isoproterenol (ISO), and whether the protective effect is mediated by endoplasmic reticulum (ER) stress. (karger.com)
Hypertrophy was estimated by measuring the cell surface area and the atrial natriuretic peptide (ANP) gene expression. (karger.com)
Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
In summary, Res treatment effectively suppressed myocardial hypertrophy and apoptosis at least partially via inhibiting ER stress. (karger.com)
In the heart, histone acetylation is a mediator of the transcriptional programs that underlie cardiomyocyte proliferation, differentiation, and cardiac remodeling in pathological hypertrophy. (fosterlab.org)
Myocardial hypertrophy occurs in many cardiovascular diseases. (researchsquare.com)
Myocardial hypertrophy is one of the important causes of death of patients caused by cardiovascular diseases and an independent risk factor for the morbidity and mortality of cardiovascular diseases [1-3]. (researchsquare.com)
Previous studies have shown that its development is closely related to cardiac overload[6], so abdominal aortic constriction(AAC) can use this principle to establish model of myocardial hypertrophy. (researchsquare.com)
The rennin-angiotensin system (RAS) has been recognized to be an important factor in myocardial hypertrophy[8]. (researchsquare.com)

The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
Overall, the findings suggested that S/V could downregulate the expression of MALAT1, inhibit inflammation and apoptosis and improve endothelial function in ox‑LDL‑induced HUVECs via inactivating the TLR4/NF‑κB signaling pathway. (spandidos-publications.com)
Upregulated genes included a large proportion of transcription factors, genes related to cell growth/apoptosis/DNA repair, cell structure proteins, metabolism, and cell signaling/communication. (gsea-msigdb.org)
less nitric oxide more apoptosis and alterations in myocardial structure, resulting in a worsened environment for CHF myocardium. (thepmc.org)
Conversely, capillary density was preserved, in concert with increased VEGF expression, while apoptosis and fibrosis were reduced in TG relative to Cont mice after TAC. (omicsdi.org)
Protein expression of ER stress and apoptosis factors was analyzed using Western Blot analysis. (karger.com)

Adult rats were subjected to myocardial ischemia/reperfusion (I/R) injury with or without ischemic preconditioning (IPC), and the level of miR‑133b‑5p in myocardium was measured. (spandidos-publications.com)
Reperfusion after cardiac ischemia increases cell death and infarct size (IS), called myocardial ischemia/reperfusion (I/R) injury, which is the main cause of myocardial injury during the cardiac surgery particularly in coronary artery bypass graft surgery ( 1 , 2 ). (spandidos-publications.com)

Acute rheumatic fever and rheumatic heart disease are thought to result from an autoimmune response, but the exact pathogenesis remains unclear. (medscape.com)
Rheumatic heart disease is the result of permanent heart valve damage secondary to acute rheumatic fever and the resultant rheumatic carditis involving pericarditis, myocarditis, or valvulitis. (medscape.com)
Potential complications include heart failure from valve insufficiency (acute rheumatic carditis) or stenosis (chronic rheumatic carditis). (medscape.com)

Although myocardial fibrosis is a common pathophysiological process associated with many heart diseases, the molecular mechanisms regulating the development of fibrosis have not been fully determined. (hindawi.com)
Furthermore, Gpx3 expression levels were negatively correlated with the different levels of fibrosis observed in the various treatment groups. (hindawi.com)
The scRNA-seq analysis was used to characterize the dynamic changes associated with fibroblast differentiation and identified Gpx3 as a factor that might be involved in the regulation of myocardial fibrosis under cardiac pressure overload. (hindawi.com)
Many studies have revealed potential mechanisms associated with myocardial fibrosis. (hindawi.com)
Therefore, exploring the mechanism of myocardial fibrosis and developing new therapeutic interventions are critical. (hindawi.com)
Histologically, the CREBA133 hearts demonstrated both atrophic and hypertrophied fibers as well as significant interstitial fibrosis. (nih.gov)
Non-ischemic cardiomyopathy (NICM) can cause left ventricular dysfunction through interstitial fibrosis, which corresponds to the failure of cardiac tissue remodeling. (nature.com)
We identify a pro-fibrogenic macrophage subtype in non-ischemic cardiomyopathy, and demonstrate that WWP2 is a key regulator of IRF7-mediated Ccl5/Ly6c high monocyte axis in heart fibrosis. (nature.com)
Fibrosis account for a significant proportion of the annual death rate worldwide and include myocardial fibrosis, a global health issue related to nearly all forms of heart disease 2 . (nature.com)
Advanced patients' disease is characterised by severe myocardial fibrosis and impaired ventricular systolic function [ 3 ]. (alliedacademies.org)

The therapeutic effect of sacubitril/valsartan (S/V) on heart failure has been confirmed, while its role in atherosclerosis remains largely unexplored. (spandidos-publications.com)
Coronary artery disease (CAD) refers to a heart disease caused by ischemia and hypoxia of myocardial cells following coronary artery stenosis or blockage due to coronary atherosclerosis (AS). (biomedcentral.com)

Our results demonstrate that miR-146a transcript levels were sharply increased in cardiac ventricular tissue of transgenic mice with specific overexpression of TNF-α in the heart, and also in a cardiomyocyte cell line of human origin (AC16) exposed to TNF-α. (jefferson.edu)
Down-regulated genesin the left ventricle myocardium of patients with heart failure following implantation of LVAD (left ventricular assist device). (gsea-msigdb.org)
Chronic unloading of the failing heart with a left ventricular assist device (LVAD) can decrease cardiac mass and myocyte size and has the potential to improve contractile function. (gsea-msigdb.org)
To study the effect of chronic ventricular unloading on myocardial gene expression, a microarray (U133A, Affymetrix) profiling gene expression was compared before and after LVAD support in seven patients with idiopathic dilated cardiomyopathy and end-stage heart failure. (gsea-msigdb.org)
With chronic rheumatic heart disease, patients develop mitral valve stenosis with varying degrees of regurgitation, atrial dilatation, arrhythmias, and ventricular dysfunction. (medscape.com)
Due to cellular heterogeneity in the heart, the activation of gene programs representing specific atrial and ventricular cardiomyocyte subtypes would be highly desirable. (biomedcentral.com)
Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
GATA4-targeted compounds 3i-1000 and 3i-1103 were identified as differential modulators of atrial and ventricular gene expression. (biomedcentral.com)
Furthermore, it is unknown whether endogenous progenitors/stromal cells in the adult human heart could be chemically induced to generate functional atrial or ventricular heart muscle to treat adult heart diseases. (biomedcentral.com)
With an estimated prevalence of about 1/250, DCM is one of the leading causes of heart transplantation in the world.1,2 At the morphological level, DCM is characterized by ventricular dilatation, cardiomyocyte loss and fibrotic replacement, leading to impaired contractility, heart failure, arrhythmia and conduction disorders. (escardio.org)
provided for the first time a comprehensive cellular atlas of the DCM and ACM hearts, managing to obtain data from 500000 nuclei of patients and 380000 nuclei from controls.5 By clustering the cells based on their expression profile, by stratifying expression analysis by genotype and by comparing right and left ventricular samples, the authors provide an impressive set of data. (escardio.org)
decrease the expression of β-MHC, ANF, Ang II, AT 1 R, c-fos and c-myc mRNA and the protein levels of PLC, IP 3 , AngII and AT 1 R in left ventricular myocardium, in addition, the content of Ca 2+ also decrease. (researchsquare.com)

The main purpose of this study was to characterize the fate of cardiac fibroblasts (CFs) and the dynamic gene expression patterns in a model of cardiac pressure overload using scRNA-seq analysis. (hindawi.com)

As a result, myocardial contractility eventually declined. (alliedacademies.org)
Through the network analysis, reduction of cardiac preload and myocardial contractility was shown to be the major effect of Schisandra components, which was further experimentally validated. (frontiersin.org)
In addition, the expression of NCOR2 and NFAT in myocyte were experimentally confirmed to be associated with Schisandra in the treatment of AMI, which may be responsible for the preservation effect of myocardial contractility. (frontiersin.org)

We used PCR assay (84 genes) for PPAR pathway and quantitative RT-PCR to study specific genes of the PPAR pathway in the left atria. (biomedcentral.com)
Gene expression profiling analysis through PCR assay identified 23 genes to be differentially expressed in the left atria of MR patients compared to normal controls. (biomedcentral.com)
There is currently no gene expression assay that can assess if premalignant lesions will develop into invasive breast cancer. (cdc.gov)

Among all the in silico predicted miR-146a target genes, Fos mRNA and protein levels notably decreased after TNF-α treatment or miR-146a overexpression. (jefferson.edu)
From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)

Post-transcriptional gene, Cardiovascular disease, Pulmonary hypertension. (alliedacademies.org)
Finally, miRNAs are incorporated into RNA-induced silencing complexes (RISC) to silence gene expression on the post-transcriptional level by targeting messenger RNAs (mRNAs) with the consequence of mRNA degradation or by translational inhibition finally resulting in target protein repression. (bioxorio.com)
ncRNAs play important roles in controlling gene expression at both transcriptional and post-transcriptional levels. (ijbs.com)

According to the World Health Organization, an estimated 17.5 million people died of cardiovascular disease in 2012, of which 7.4 million died of ischemic heart disease and 6.7 million died of stroke ( 1 ). (spandidos-publications.com)
Heart failure (HF) is the end pathophysiological process of many cardiovascular diseases. (researchsquare.com)
Heart failure (HF) is the most common final pathophysiological process of many cardiovascular diseases, and it poses a serious threat to human life and health. (researchsquare.com)
Hypertension is the most common disease among many cardiovascular diseases, and HF caused by hypertension is one of the main causes of myocardial remodeling. (researchsquare.com)

Consequently, a greater post-MI monocyte-derived myocardial macrophage infiltration was noted in Hmox1-deficient individuals. (springer.com)

Different cell fates and groups were fully characterized by Gene Set Enrichment Analysis (GSEA) analysis and Transcription factor (TF) activity analysis. (hindawi.com)
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were used to conduct enrichment analysis. (researchsquare.com)
Interestingly, gene ontology and pathway enrichment analysis of the differentially expressed genes in that study showed that peroxisome proliferator-activated receptor (PPAR) signaling pathway was identified in the KEGG pathway. (biomedcentral.com)

2017. Potency of human cardiosphere-derived cells from patients with ischemic heart disease is associated with robust vascular supportive ability . (cardiff.ac.uk)

Following myocardial I/R injury, the expression of miR‑133b‑5p was decreased in myocardium, while this decrease was restored by IPC. (spandidos-publications.com)
In this study, we aim to explore the key element genes of the PPAR signaling pathway that were differentially expressed in the left atrial myocardium of MR patients vs. normal controls. (biomedcentral.com)
The left atrial myocardium of patients with severe aortic valve disease was also used as a reference for gene analysis. (biomedcentral.com)

It cannot be used in renal or hepatic insufficiency or decompensated congestive heart failure requiring pharmacologic therapy (due to an increased risk for lactic acidosis). (medscape.com)

The involvement of miRNAs in cancer research emerged from studies demonstrating their aberrant expression in neoplastic tissues. (genengnews.com)
MicroRNAs (miRNAs/miRs) are endogenous, single-stranded, small (approximately 22 nucleotides in length) noncoding RNA molecules that play an important and ubiquitous role in regulating genes expression. (spandidos-publications.com)
MiRNAs typically bind to the 3′ untranslated region (UTR) of their mRNA targets and downregulate gene expression via mRNA degradation or translational inhibition ( 8 - 10 ). (spandidos-publications.com)
SncRNAs are less than 200 nt in length, consisting of microRNAs (miRNAs), Piwi-interacting RNAs (piRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and transcription initiation RNAs (tiRNAs) [ 6 ]. (ijbs.com)
Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)
Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)

Genomic deletion of a fms-intronic regulatory element (FIRE) in the Csf1r locus resulted in specific absence of resident homeostatic and antigen-presenting macrophages, without affecting the recruitment of monocyte-derived macrophages to the infarcted heart. (elifesciences.org)

In order to solve this problem, a comprehensive network analysis method was established based-on "component-gene ontology-effect" interactions. (frontiersin.org)
In conclusion, the three-mode gene ontology network can be an effective network analysis workflow to evaluate the pharmacological effects of a multi-drug complex system. (frontiersin.org)
In contrast to protein interaction networks, enriched gene ontology (GO) terms of AMI related genes were used to construct a gene ontology interaction (GOI) network, which can be used to simulate the functional interactions between differential expressed genes of disease. (frontiersin.org)
For the construction of a "component-gene ontology" network of Schisandra in the treatment of AMI, the HPLC-Q-TOF-MS was used to analyze the Schisandra extract. (frontiersin.org)
Targets of Schisandra ingredients were further screened to enrich and construct the "component-gene ontology" network, which was a component for the integration of a three-mode network. (frontiersin.org)

The goal of this study was to review relevant case-control studies to determine the association of tumor necrosis factor-α ( TNF-α ) gene polymorphisms and coronary artery disease (CAD) susceptibility. (biomedcentral.com)

2009. Gene Profiling of Human Adipose Tissue During Evoked Inflammation In Vivo . (umd.edu)
Tissue or organ-specific genes were predicted by BioGPS. (researchsquare.com)
Furthermore, this group investigated the knockdown efficacy of several other antagomirs and showed for the very first time which the cholesterol-based chemistry was also in a position to knockdown miRNA expression in cardiac tissue after intravenous injection (Krutzfeldt et al, 2005). (bioxorio.com)
Heart failure is a condition in which the mechanical pumping function of the blood is impaired and the oxygen and nutrients delivery to the tissue is not adequate to meet the needs of the body. (cuni.cz)
However, the regional microstructural tissue effects of these molecular mechanisms in the heart have yet to be spatially linked and further elucidated. (researchgate.net)
Quantification of CITED4 expression and microstructural tissue helicity reveals a significant correlation across both sedentary and exercise mouse cohorts. (researchgate.net)
Taken together, CITED4 expression is necessary for exercise-induced regional remodeling of the heart's microstructural helicity revealing how a key molecular regulator of cardiac remodeling manifests into downstream local tissue-level changes. (researchgate.net)
Expression of transcription factor CITED4 is necessary for exercise-induced regional remodeling of the heart's microstructural helicity, revealing how a key molecular regulator of cardiac remodeling mediates local tissue-level changes. (researchgate.net)
Our recent work shows that ATRA levels decline nearly 40% in failing human heart tissue. (fosterlab.org)
Notably, circRNAs display cell-type, tissue-type and developmental-stage specific expression patterns in eukaryotic transcriptome, which reveals their significant regulatory functions in gene expression. (ijbs.com)

Microarray datasets of HF were downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were selected by using R software. (researchsquare.com)
Differentially expressed genes in the left atria of mitral regurgitation (MR) pigs have been linked to peroxisome proliferator-activated receptor (PPAR) signaling pathway in the KEGG pathway. (biomedcentral.com)
Differentially expressed genes of the PPAR pathway have been identified in the left atria of MR patients compared with patients with aortic valve disease and normal controls. (biomedcentral.com)

In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. (icr.ac.uk)
My lab maintains a strong interest, and active fruitful collaborations, in the field of cardiac myofilament structure/function and how it is perturbed in heart disease ranging from myocardial stunning to hypertrophic cardiomyopathy and heart failure. (fosterlab.org)
Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with serious adverse outcomes, including heart failure, arrhythmias, and sudden cardiac death. (rupress.org)

miR-146a is a microRNA whose transcript levels are induced in the heart upon activation of NF-κB, a transcription factor induced by pro-inflammatory molecules (such as TNF-α) that is strongly related to the pathogenesis of cardiac disorders. (jefferson.edu)
More importantly, circRNAs serve as microRNA (miRNA) sponges and crucial regulators of gene expression. (ijbs.com)

In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. (icr.ac.uk)
The PPARα isoform is a central regulator of myocardial fatty acid metabolism involved in the pathogenesis of heart failure. (cuni.cz)

In response to injury, myocardial fibroblasts show abnormal activation and secrete excessive extracellular matrix, resulting in chamber wall stiffness and diastolic dysfunction [ 5 ]. (hindawi.com)
The heart is a complex organ made of various cell types including cardiomyocytes, endothelial and smooth muscle cells, but also fibroblasts and inflammatory cells, which could all be implicated in the disease process. (escardio.org)
Furthermore, cell clustering analysis based on expression mapping provided a molecular signature of all the cell types present in the diseased hearts including cardiomyocytes, fibroblasts, smooth muscle cells, pericytes, inflammatory (myeloid and lymphoid) as well as neuronal and adipose cells, providing an incredible resource for future research in the field. (escardio.org)

Hypoxia/reoxygenation (H/R) as well as hypoxic preconditioning (HPC) is widely used for simulating in vivo myocardial I/R and ischemic preconditioning (IPC) in a cell culture model. (spandidos-publications.com)

Given that MMP-9 is an AP-1 target gene involved in cardiac remodeling, myocardial dysfunction and progression of heart failure, these findings suggest that miR-146a might be a new and promising therapeutic tool for treating cardiac disorders associated with enhanced inflammation in the heart. (jefferson.edu)
There is growing evidence that a specific class of diabetes drugs may help fight heart disease by also fighting inflammation. (natap.org)
In recent years research has pointed to inflammation as a possible cause of heart disease. (natap.org)
And early studies have hinted that the type 2 diabetes drugs Actos and Avandia may help fight heart disease not only by improving blood sugar but also by battling inflammation. (natap.org)
But Actos also improved several heart disease risk factors, including cholesterol and markers of inflammation, such as C-reactive protein. (natap.org)
And less inflammation may mean less heart disease and stroke. (natap.org)

Targets also transcription factors and signaling molecules to regulate heart function. (icr.ac.uk)
In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. (icr.ac.uk)
In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. (icr.ac.uk)
Expression of genes that regulate mitochondrial biogenesis, substrate utilization, and oxidative phosphorylation (OXPHOS) were determined. (omicsdi.org)
The PPARs are ligand activated transcription factors that regulate genes important in cell differentiation, various metabolic processes, especially lipid and glucose homeostasis, insulin sensitivity, control of inflammatory processes and vascular integrity [ 6 ]. (biomedcentral.com)

Following TAC, KO mice progressed more rapidly to heart failure and developed more severe mitochondrial dysfunction, despite a similar overall pattern of repression of OXPHOS and FAO genes as WT-TAC. (omicsdi.org)
expression following POH, while preserving myocardial vascularity, does not prevent mitochondrial and contractile dysfunction. (omicsdi.org)

We demonstrated that convolutional neural networks perform consistently well across both the Alzheimer's (ROC AUC = 0.810) and Parkinson's (ROC AUC = 0.715) datasets, suggesting its potential in gene expression biomarker detection with increased tuning of their architecture. (bvsalud.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

A clinical syndrome known as hypertension is characterised by elevated systemic arterial blood pressure (systolic blood pressure of at least 140 mmHg and diastolic blood pressure of at least 90 mmHg), which can result in damage to the kidney, heart, brain, and other organs. (alliedacademies.org)

Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
CircRNAs exhibit altered expression under pathological conditions and are strongly associated with the development of various human diseases. (ijbs.com)

The results from this study may identify specific genes of the PPAR signaling pathway that might be responsible for the atrial structural remodeling associated with atrial enlargement and progression of heart failure in patients with MR. (biomedcentral.com)

It was later identified by the yeast-two hybrid system to bind to activating transcription factor 2 (ATF2) to repress ATF-mediated transcriptional activation. (wikipedia.org)
WWP2 interacts with transcription factor IRF7, promoting its non-degradative mono-ubiquitination, nuclear translocation and transcriptional activity, leading to upregulation of Ccl5 at transcriptional level. (nature.com)
We show in exercised mice that the expression of CITED4, a transcriptional co-regulator necessary for cardioprotection, is regionally heterogenous in the heart with preferential significant increases in the lateral wall compared with sedentary mice. (researchgate.net)

Scope includes mutations and abnormal protein expression. (cancerindex.org)

PE-specific deletion of Tbx5 impairs epicardium and coronary vessel formation in embryonic mouse hearts and reduces expression of Reln mRNA that encodes the Reelin extracellular matrix glycoprotein. (pcom.edu)

7 Department of Heart Failure and Valvular Heart Disease, Skane University Hospital, Lund, Sweden. (jci.org)
Such as high blood pressure, coronary heart disease, valvular heart disease, congenital heart disease and cardiomyopathy, ect[5]. (researchsquare.com)

The discovery that mutations in sarcomere protein genes cause HCM has enabled the development of mouse models that recapitulate clinical manifestations of disease. (rupress.org)

Thanks to advancements in gene expression profiling, it is now possible to search for disease biomarkers on an unprecedented scale.Here we applied a selection of five machine learning (ML) approaches to identify blood-based biomarkers for Alzheimer's (AD) and Parkinson's disease (PD) with the application of multiple feature selection methods. (bvsalud.org)
Idiopathic-dilated cardiomyopathy (IDC) is a common primary myocardial disease of unknown etiology characterized by progressive biventricular failure, cardiac dilatation, and premature mortality. (nih.gov)
Rheumatic heart disease is the most serious complication of rheumatic fever . (medscape.com)
Although the mitral valve is involved in most cases of rheumatic heart disease, the aortic and tricuspid valves can be involved as well. (medscape.com)
A comprehensive resource provided by the World Health Organization (WHO) addresses the diagnosis and treatment of rheumatic fever and rheumatic heart disease. (medscape.com)
In contrast, the incidence of rheumatic fever and rheumatic heart disease in developing countries has not substantially decreased. (medscape.com)
A diagnosis of rheumatic heart disease is made after confirming antecedent rheumatic fever. (medscape.com)
Dyspnea, exhaustion, a decreased capacity for exercise, syncope, angina pectoris, chest pain, and right heart failure are among the symptoms of the disease as it progresses [ 1 ]. (alliedacademies.org)
Carotid artery wall thickness, a measure of arteries that supply the brain and an indicator of heart disease, also improved with Actos. (natap.org)
This is one more bit of provocative information suggesting that TZDs may be a very useful class of drugs for preventing heart disease," American Diabetes Association (ADA) president Robert Rizza, MD, tells WebMD. (natap.org)
Heart disease and stroke are the leading causes of death among people with diabetes, with two out of three diabetes patients eventually dying from one of these conditions. (natap.org)
They concluded that people with diabetes who have mild heart disease or any problems with their kidneys could be at greater risk of developing heart failure if they take Actos or Avandia. (natap.org)
2021. Isoform-specific reduction of the basic Helix-Loop-Helix transcription factor TCF4 levels in Huntington's disease . (cardiff.ac.uk)
Also, the data supports that cardiomyopathies should be seen as a "pancardiac" disease with expression changes affecting all cell types (including endocardial cells by example in the presence of PKP2 pathogenic variants). (escardio.org)
Taking N-acetyl cysteine by mouth seems to reduce homocysteine levels, a possible risk factor for heart disease. (medlineplus.gov)
Click on a disease name to see all genes associated with that disease. (jax.org)
Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities. (mdpi.com)
This study enrolled 15 MR patients with heart failure, 7 patients with aortic valve disease and heart failure, and 6 normal controls. (biomedcentral.com)
Vitamin A (retinol), has been studied extensively in coronary heart disease (CHD), as low levels correlate with increased risk of cardiac events in, otherwise, healthy middle-aged men. (fosterlab.org)
New disease genes and pathogenic mutations often seem far afield from the overt manifestations of human pathology, in particular when the gene is expressed life long, but the disease emerges only after years or decades. (rupress.org)
As a critical function of the system, Angiotensin II (Ang II) plays a key role in heart disease[9]. (researchsquare.com)

Heart failure is the inability of the cardiac systolic and/or diastolic functions to completely empty the veins of the heart's blood, which ultimately results in venous system blood stasis and inadequate arterial blood perfusion. (alliedacademies.org)

PPAR receptors function as nuclear transcription factors of energy metabolism- related genes in cardiomyocytes. (cuni.cz)
This bachelor thesis aims to summarize the current knowledge on PPAR receptors, with a focus on the PPARα isoform, especially with regard to its role in myocardial metabolism during heart failure. (cuni.cz)
PPARα is expressed mainly in metabolically active tissues, such as heart, liver, and skeletal muscle [ 6 ], and plays important physiologic roles in fatty acid oxidation and fatty acid metabolism. (biomedcentral.com)

Additionally, we've made progress in hepatocyte-targeted in vivo gene silencing by modifying the siRNAs. (genengnews.com)

Transcription and microarray data analysis has been widely used to identify new biomarkers including both tumors and common diseases that rely on bioinformatic analysis. (researchsquare.com)
Recent developments in high-throughput sequencing technologies and microarray techniques enable scientists to conduct comprehensive analyses on the abundance, composition, expression profile and molecular function of circRNAs [ 16 ]. (ijbs.com)

Gene knockout mice have a shorter tail, are smaller, have low neutrophil count. (wikipedia.org)
Here we show that transgenic mice expressing a dominant-negative form of the CREB transcription factor (CREBA133) under the control of the cardiac myocyte-specific alpha-MHC promoter develop dilated cardiomyopathy that closely resembles many of the anatomical, physiological, and clinical features of human IDC. (nih.gov)
This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)
Afterwards, however, the hearts of Hmox1-deficient mice undergo adverse late LV remodeling due to overactive and prolonged post-ischemic inflammatory response. (springer.com)
Mice develop tumors resembling those seen in humans, including expression of high levels of miR-21. (genengnews.com)
WT-TAC mice developed relatively compensated LVH, despite reduced mitochondrial function and repression of OXPHOS and FAO genes. (omicsdi.org)
Although TAC-induced repression of FAO genes and oxidative phosphorylation (oxphos) genes was prevented in TG mice, mitochondrial function and ATP synthesis were equivalently impaired in Cont and TG mice after TAC. (omicsdi.org)
Mitochondrial matrix and membrane fractions were generated from liver, brain, heart, and kidney of wild-type and type 1 diabetic Akita mice. (omicsdi.org)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)

How does a pathogenic variant lead to a change in the cellular content of the heart? (escardio.org)

Reverse transcription‑quantitative PCR was performed to detect the MALAT1 expression. (spandidos-publications.com)
Furthermore, effective DEGs were further validated using reverse transcription-quantitative polymerase chain reaction (RT-PCR) analysis. (researchsquare.com)
Reverse transcription‑quantitative polymerase chain reaction was used to measure the level of miR‑133b‑5p. (spandidos-publications.com)

Filling an important gap between genomic and expression data, those single cell analyzes show that DCM and ACM are characterized by a depletion in cardiomyocytes (except in LMNA cardiomyopathy), and an enrichment in endothelial and inflammatory cells (myeloid and lymphoid cells). (escardio.org)
1. Rosenbaum, A. N., Agre, K. E. & Pereira, N. L. Genetics of dilated cardiomyopathy: practical implications for heart failure management. (escardio.org)

Subsequently, β-catenin translocates to the nucleus and interacts with transcription factors including T cell factor (TCF)/lymphoid enhancer-binding factor (LEF). (kjpp.net)

Activation of PPARα by specific ligands promotes fatty acid uptake, utilization, and catabolism by increasing the expression of genes involved in fatty acid transport, binding, activation, and β-oxidation. (cuni.cz)
Studies to date have highlighted changes in PPARα expression, the influence of a non-functional gene studied in animal models with gene deletion, reduced expression of the coactivator PGC-1α, the influence of PPARα agonists, and the impact of these factors in the development of heart failure. (cuni.cz)
The current results suggest that the level of PPARα expression may become a metabolic marker of cardiomyocytes. (cuni.cz)
However, specific genes of the PPAR signaling pathway in the left atria of MR patients have never been explored. (biomedcentral.com)

Because Actos and Avandia can cause fluid retention, they are not recommended for people with moderate to severe heart failure. (natap.org)

DRAM2 was preferentially upregulated in NSCLC tissues and higher expression of DRAM2 in NSCLC correlated with tumor node metastases stage and lymph node metastasis. (cancerindex.org)
Stored primarily in the liver, retinol is a pro-hormone, the body's source of all-trans retinoic acid (ATRA), a potent transcription-activating hormone present in tissues at nanomolar concentrations. (fosterlab.org)

Treatment involves the initiation of secondary prophylaxis against group A beta-hemolytic streptococcal infection and management of clinical sequelae including heart failure. (medscape.com)

Further, JDP2 is involved in neutrophil differentiation and transcription factor Tbx3-mediated osteoclastogenesis for host defense and bone homeostasis. (wikipedia.org)
May also function as a paracrine antifibrotic factor in the heart. (cusabio.com)
Computational Biology of Transcription Factor BindingComputational Biology of Transcription Factor Binding. (umd.edu)
These changes correlated with a diminution in the DNA-binding activity of AP-1, the Fos-containing transcription factor complex. (jefferson.edu)
Furthermore, Wnta1 upregulated the expression of T cell factor (TCF) 3, TCF4, and lymphoid enhancer factor 1 (LEF1), and these effects were blocked by U73122 and Go 6983. (kjpp.net)

What is the effect of a pathogenic variant on gene expression and signaling pathways? (escardio.org)

According to Dr. Marcusson, an important aspect of these studies was the demonstration of miR-21 knockdown using genome-wide mRNA expression studies. (genengnews.com)
Additionally, DRAM2 overexpression promoted cell metastasis and proliferation in vitro, while knockdown of DRAM2 expression yielded opposite result. (cancerindex.org)

According to one the new study's researchers, it makes sense that the TZDs would protect against heart attack and stroke because insulin is active in the lining of the blood vessels. (natap.org)

JDP2 induces cell cycle arrest through cyclin D, p53, and cyclin A transcription, by increasing JUNB, JUND, and Fra2, and by decreasing c-JUN through the loss of p27kip1. (wikipedia.org)
Then, we constructed the pseudotime trajectory of cell development and identified key regulatory genes using the Monocle R package (v2.22.0). (hindawi.com)
Finally, we used Cytoscape (3.9.1) to extensively examine the gene regulatory network related to cell fate. (hindawi.com)
Analysis of dynamic gene expression revealed that Gpx3 was significantly upregulated during cell differentiation into protective cells. (hindawi.com)
Finally, we found that transcription factors Jun , Fos , Atf3 , and Egr1 were upregulated in protective cells, especially Egr1 was predicted to be involved in the regulation of genes related to antioxidant stress and angiogenesis, suggesting a role in promoting differentiation into this cell phenotype. (hindawi.com)
Compared with the ox‑LDL group, S/V treatment significantly increased the cell viability, NO concentration and Bcl‑2 expression, decreased the levels of IL‑1β, IL‑6 and TNF‑α and reduced the expressions of MALAT1, ICAM‑1, VCAM‑1, cleaved‑caspase‑3, Bax, TLR4 and p‑p65. (spandidos-publications.com)
Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. (biomedcentral.com)
Interestingly, those data give insights not only on the cell composition of DCM and ACM hearts, but also on the functional status and the signaling state of those cells. (escardio.org)
Overexpression of this gene is associated with tumor cell proliferation and metastasis. (cancerindex.org)
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53. (cancerindex.org)
DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)
They also found that ciprofloxacin decreased lysyl oxidase expression and activity, increased matrix metalloproteinase levels and activity, and increased elastic fiber fragmentation and cell injury. (bcm.edu)

Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. (icr.ac.uk)
Chemically induced gene expression changes were characterized by qRT-PCR, global run-on sequencing (GRO-seq) and immunoblotting, and the network of cooperative proteins of GATA4 and NKX2-5 were further explored by the examination of the GATA4 and NKX2-5 interactome by BioID. (biomedcentral.com)
Western blotting confirmed the expression of DRAM2, p53, and the other involved proteins. (cancerindex.org)

Anatomy19

Organisms11

Diseases22

Chemicals and Drugs77

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Phenomena and Processes76

Disciplines and Occupations2

Information Science5

Health Care18

Infarction15

Cardiac hypertrophy10

Hypertrophy13

Apoptosis6

Ischemia-reperfusion2

Acute3

Fibrosis10

Atherosclerosis2

Ventricular12

Pressure overload1

Contractility3

Assay3

MRNA and protein2

Post-transcriptional3

Cardiovascular4

Macrophage1

Enrichment Analysis3

Cardiosphere-derived cells1

Myocardium3

CONGESTIVE HEART F1

MiRNAs6

Monocyte-derived1

Ontology5

Coronary artery1

Tissue10

Differentially3

Hypertrophic3

MicroRNA2

Pathogenesis2

Fibroblasts3

Hypoxia1

Inflammation6

Regulate5

Dysfunction2

Datasets2

Hypertension1

Pathological2

Progression1

Transcriptional3

Abnormal1

Extracellular matrix1

Valvular2

Protein genes1

Disease21

Systolic1

Metabolism3

Vivo1

Microarray2

Mice8

Mutations1

Cellular1

Quantitative3

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Interacts with transcription1

PPAR4

Severe1

Tissues2

Sequelae1

Factor5

Pathways1

Knockdown2

Stroke1

Cell12

Proteins3