• neutrophils
  • Given these clues and knowledge that bactera transcribe (see Transcription (genetics)) proteins starting with N-Formylmethionine whereas eukaryotic cells mostly initiate protein synthesis with non-formylated methionine, Schiffmann, Corcoran, and Wahl theorized and then showed that N-formyl-methionine and a series N-formyl-methionyl dipeptides and tripeptides stimulated the chemotaxis of neutrophils isolated from rabbit peritoneal exudates as well as of macrophages isolated from guinea pig peritoneal exudates. (wikipedia.org)
  • The cleavage of α1-antitrypsin generates a fragment chemotactic to neutrophils. (wikipedia.org)
  • Up-regulation of ALOX5 may occur during the maturation of leukocytes and in human neutrophils treated with granulocyte macrophage colony-stimulating factor and then stimulated with physiological agents. (wikipedia.org)
  • 1996). "Chemotactic peptide-induced activation of MEK-2, the predominant isoform in human neutrophils. (wikipedia.org)
  • Macrophages
  • M1 macrophages are a critical component of inflammatory response and antitumor immunity and are characterized by production of pro-inflammatory factors like IL-6, IL-12, IL-23, (TNF-a), as well as histocompatibility complex class I and II molecules (the latter are required for presentation of tumor-specific antigens). (medcraveonline.com)
  • References Angiogenesis ↑ Migration of endothelial cells ↑ mitosis of endothelial cells ↑ Matrix metalloproteinase activity ↑ αvβ3 activity creation of blood vessel lumen creates lumen creates fenestrations Chemotactic for macrophages and granulocytes Vasodilation (indirectly by NO release) Also tumour suppression. (wikipedia.org)
  • vascular endothel
  • Previous work in our laboratory showed that integrins are converted to a high affinity state downstream of a cell-cell junction mechanosensory complex consisting of platelet endothelial cell adhesion molecule-1, VE-cadherin, and vascular endothelial growth factor receptor 2. (ahajournals.org)
  • During embryonic development angiogenesis is initiated as mesoderm mesenchyme cells are specified to differentiate into angioblasts, expressing the Vascular Endothelial Growth Factor Receptor (VEGFR-2). (wikipedia.org)
  • gene
  • Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene. (wikipedia.org)
  • Aureolysin is largely co-expressed with the other major proteases of S. aureus: aureolysin, staphopain A, and staphopain B. The transcription of aur, that occurs via a promoter controlled by "housekeeping" sigma factor σA, is up-regulated by accessory gene regulator agr, while it is repressed by staphylococcal accessory regulator sarA and by alternative sigma factor σB (a stress response modulator of Gram-positive bacteria). (wikipedia.org)
  • novel
  • Our data uncover that ubiquitination and degradation of NF‐κB subunits by this COMMD1‐containing ubiquitin ligase is a novel and critical mechanism of regulation of NF‐κB‐mediated transcription. (embopress.org)
  • affects
  • Another factor that affects degradation rate is the diameter of the axon: larger axons require a longer time for the cytoskeleton to degrade and thus take a longer time to degenerate. (wikipedia.org)
  • mechanisms
  • Several mechanisms, including oriented cell division, cell-cell intercalation and chemotactic cell movement, have been proposed to explain the nature of the cellular movements required to form the primitive streak. (wikipedia.org)
  • endothelial
  • Vascular endothelial growth factor A (VEGF-A) is a dimeric glycoprotein that plays a significant role in neurons and is considered to be the main, dominant inducer to the growth of blood vessels. (wikipedia.org)
  • cells
  • When hepatocytes isolated from normal rat liver were cultured with ethanol (30-90mM), chemotactic activity for rat PMNs and Kupffer cells was demonstrated in the culture supernatant. (nii.ac.jp)
  • Production of superoxide anion by PMNs and Kupffer cells was enhanced in the presence of the chemotactic factor. (nii.ac.jp)
  • Publications] Shiratori Y, Takada H, Hai K, Kiriyama H, Matsumoto K, Kamii K, Tanaka M: 'Generation of chemotactic factor by hepatocytes exposed to ethanaol' Cells of the Hepatic Sinusoid. (nii.ac.jp)
  • Platelet-derived growth factors are released into the wound that cause the migration and division of cells during the proliferative phase. (wikipedia.org)
  • It is also an HIV-suppressive factor released from CD8+ T cells[citation needed]. (wikipedia.org)
  • Within 4 days of the injury, the distal end of the portion of the nerve fiber proximal to the lesion sends out sprouts towards those tubes and these sprouts are attracted by growth factors produced by Schwann cells in the tubes. (wikipedia.org)
  • The chemotactic aggregation of cells is organized by periodic waves of cAMP that propagate between cells over distances as large as several centimetres. (wikipedia.org)
  • Whereas
  • Whereas systemic risk factors such as hypertension, smoking, and obesity play important roles in atherogenesis, plaques show a predilection for vessel branch points and regions of high curvature, where flow is low and shows a variety of complex patterns that are grouped together under the term disturbed flow. (ahajournals.org)
  • MEP differentiation was found to be contingent upon the transcription factor GATA1, whereas GMP differentiation needs SPI1. (wikipedia.org)
  • activity
  • Freeze-thawing or dialysis of the culture medium gave little effect on chemotactic activity, while trypsin digestion and heat (56゚C, 30min) markedly reduced the activity. (nii.ac.jp)
  • Chemotactic activity was revealed in two fractions at molecular weight of 20-25 k daltons and 40-50 k daltons by use of gel chromatography with Sephadex G-150. (nii.ac.jp)
  • cell
  • NF‐κB is a dimeric transcription factor that controls expression of genes involved in multiple processes including immunity, apoptosis, and cell cycle progression ( Karin and Lin, 2002 ). (embopress.org)
  • specific factors are named for the cell lines that they stimulate. (thefreedictionary.com)
  • This protein and VP16 both bind to the same site on host cell factor C1. (wikipedia.org)
  • It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. (wikipedia.org)
  • CREB CREB3 has been shown to interact with Host cell factor C1. (wikipedia.org)
  • ALOX5 products, particularly 5-hydroxyeicosatetraenoic acid and 5-oxo-eicosatetraenoic acid, promote the proliferation of these ALOX5 aberrantly expressing tumor cell lines suggesting that ALOX5 acts as a pro-malignancy factor for them and by extension their parent tumors. (wikipedia.org)
  • contribute
  • Factors that contribute to non-healing chronic wounds are diabetes, venous or arterial disease, infection, and metabolic deficiencies of old age. (wikipedia.org)
  • site
  • Once in the interstitial fluid, leukocytes migrate along a chemotactic gradient towards the site of injury or infection. (wikipedia.org)
  • lead
  • Host factors that lead to the clearance of the bacterium from its commensal niche on the mucosal surface of the human nasopharynx are not well defined. (jci.org)
  • human
  • Transcription and Immunolocalization of Runx2/Cbfa1/Pebp2alphaA in Developing Rodent and Human Craniofacial Tissues: Further Evidence Suggesting Osteoclasts Phagocytose Osteocytes Microscopy Research and Technique. (jove.com)
  • specific
  • The numerous targets of bacterial proteases, adding the complexity of other virulence factors and their genetic regulation, makes it difficult to attribute a specific role of the protease for the bacteria. (wikipedia.org)
  • environmental
  • The exact cause of RA is unknown, although it is assumed that both genetic and environmental factors are involved [ 2 , 3 ]. (medsci.org)