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  • vascular endoth
  • During embryonic development angiogenesis is initiated as mesoderm mesenchyme cells are specified to differentiate into angioblasts, expressing the Vascular Endothelial Growth Factor Receptor (VEGFR-2). (wikipedia.org)
  • Vascular endothelial growth factor A (VEGF-A) is a dimeric glycoprotein that plays a significant role in neurons and is considered to be the main, dominant inducer to the growth of blood vessels. (wikipedia.org)
  • phosphorylation
  • A causative link between these two events is strongly suggested by the high affinity of the pleckstrin homology (PH) domains of Tec and Btk for PtdIns(3,4,5)P 3 ( 20 , 21 , 22 ) and by the wortmannin sensitivity of the recruitment of Tec kinases ( 16 ) and of the stimulation of the tyrosine phosphorylation cascade by chemotactic factors ( 23 ). (jimmunol.org)
  • infection
  • Using quantitative PCR, we showed that upon CVB3 infection, transcription of interferon (IFN), IFN-stimulated genes, and inflammatory genes was induced. (diabetesjournals.org)
  • Enteroviruses, particularly human enterovirus B species (HEV-Bs), such as coxsackie B viruses (CVBs) and echoviruses (EVs), are implicated as environmental factors, and a recent meta-analysis confirms that there is a clinically significant association between enterovirus infection and autoimmunity/type 1 diabetes ( 1 ). (diabetesjournals.org)
  • Once in the interstitial fluid, leukocytes migrate along a chemotactic gradient towards the site of injury or infection. (wikipedia.org)
  • degradation
  • Our data uncover that ubiquitination and degradation of NF‐κB subunits by this COMMD1‐containing ubiquitin ligase is a novel and critical mechanism of regulation of NF‐κB‐mediated transcription. (embopress.org)
  • Another factor that affects degradation rate is the diameter of the axon: larger axons require a longer time for the cytoskeleton to degrade and thus take a longer time to degenerate. (wikipedia.org)
  • activity
  • Freeze-thawing or dialysis of the culture medium gave little effect on chemotactic activity, while trypsin digestion and heat (56゚C, 30min) markedly reduced the activity. (nii.ac.jp)
  • Chemotactic activity was revealed in two fractions at molecular weight of 20-25 k daltons and 40-50 k daltons by use of gel chromatography with Sephadex G-150. (nii.ac.jp)
  • angiogenesis
  • angiogenesis factor a substance that causes the growth of new blood vessels, found in tissues with high metabolic requirements such as cancers and the retina. (thefreedictionary.com)
  • These cells will secrete the signaling molecule vascular endothelial factor A (VEGFA) which will recruit the angioblasts expressing it's partnering receptor to the site of future angiogenesis. (wikipedia.org)
  • translocation
  • LFM-A13 also negatively affected the translocation of Rac-2, RhoA, ADP ribosylation factor-1, Tec, Bmx, and Btk induced by fMet-Leu-Phe. (jimmunol.org)
  • cells
  • Production of superoxide anion by PMNs and Kupffer cells was enhanced in the presence of the chemotactic factor. (nii.ac.jp)
  • It is also an HIV-suppressive factor released from CD8+ T cells[citation needed]. (wikipedia.org)
  • Within 4 days of the injury, the distal end of the portion of the nerve fiber proximal to the lesion sends out sprouts towards those tubes and these sprouts are attracted by growth factors produced by Schwann cells in the tubes. (wikipedia.org)
  • The chemotactic aggregation of cells is organized by periodic waves of cAMP that propagate between cells over distances as large as several centimetres. (wikipedia.org)
  • genetic
  • Both genetic and environmental factors interact and contribute to the development of autoimmune diseases. (biomedcentral.com)
  • It is known, however, that both genetic and environmental factors are involved. (diabetesjournals.org)
  • The numerous targets of bacterial proteases, adding the complexity of other virulence factors and their genetic regulation, makes it difficult to attribute a specific role of the protease for the bacteria. (wikipedia.org)
  • Uncommon risk factors include genetic disorders such as neurofibromatosis and Li-Fraumeni syndrome, and previous radiation therapy. (wikipedia.org)
  • Uncommon risk factors include genetic disorders such as neurofibromatosis, Li-Fraumeni syndrome, tuberous sclerosis, or Turcot syndrome. (wikipedia.org)
  • epidermal
  • Four subtypes of glioblastoma have been identified: Classical : Ninety-seven percent of tumors in the 'classical' subtype carry extra copies of the epidermal growth factor receptor (EGFR) gene, and most have higher than normal expression of epidermal growth factor receptor (EGFR), whereas the gene TP53 (p53), which is often mutated in glioblastoma, is rarely mutated in this subtype. (wikipedia.org)
  • promoter
  • Aureolysin is largely co-expressed with the other major proteases of S. aureus: aureolysin, staphopain A, and staphopain B. The transcription of aur, that occurs via a promoter controlled by "housekeeping" sigma factor σA, is up-regulated by accessory gene regulator agr, while it is repressed by staphylococcal accessory regulator sarA and by alternative sigma factor σB (a stress response modulator of Gram-positive bacteria). (wikipedia.org)
  • human
  • Enteroviruses of the human enterovirus B species (HEV-Bs) (e.g., coxsackie B viruses [CVBs] and echoviruses) have been implicated as environmental factors that trigger/accelerate type 1 diabetes, but the underlying mechanism remains elusive. (diabetesjournals.org)
  • Transcription and Immunolocalization of Runx2/Cbfa1/Pebp2alphaA in Developing Rodent and Human Craniofacial Tissues: Further Evidence Suggesting Osteoclasts Phagocytose Osteocytes Microscopy Research and Technique. (jove.com)
  • Host factors that lead to the clearance of the bacterium from its commensal niche on the mucosal surface of the human nasopharynx are not well defined. (jci.org)
  • granulocyte-macrop
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) is often used to treat leucopenia. (springer.com)
  • Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by granulocyte-macrophage colony-stimulating factor (GM-CSF) or G-CSF: potential role in allogeneic marrow transplantation. (springer.com)
  • Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor. (springer.com)
  • gene
  • Overexpression of miR-134 also inhibited the expression of the downstream gene of CREB, including brain-derived neurotrophic factor (BDNF) and the anti-apoptotic gene Bcl-2, whereas the inhibition of miR-134 upregulated the expression of BDNF and Bcl-2 in neurons after OGD/reoxygenation. (jove.com)
  • Furthermore, global adjustments in bacterial gene manifestation in the nematode partner had been also reflected from the differential manifestation of genes such as for example and involved with replication and transcription procedures, respectively (Fig. 2). (biobeds.info)
  • Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. (wikipedia.org)
  • cells
  • Conversely, we now know that vascular endothelial and smooth muscle cells (SMCs) produce proteins like tissue factor that modulate the coagulation cascade in the absence of endothelial disruption. (ahajournals.org)
  • P. vortex is marked by its ability to generate special aggregates of dense bacteria that are pushed forward by repulsive chemotactic signals sent from the cells at the back. (wikipedia.org)
  • Ectodomain shedding results in the soluble mature form of HB-EGF, which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. (wikipedia.org)
  • The proliferative and chemotactic effects of HB-EGF results from the target influence on particular cells including fibroblasts, smooth muscles cells, and keratinocytes. (wikipedia.org)
  • Within 4 days of the injury, the distal end of the portion of the nerve fiber proximal to the lesion sends out sprouts towards those tubes and these sprouts are attracted by growth factors produced by Schwann cells in the tubes. (wikipedia.org)
  • Hypocalcemia and hypophosphatemia (instances that stimulate kidney proximal tubule cells to produce calcitriol (1α,25-dihydroxyvitamin D3)) lead to increases in OPN transcription, translation and secretion. (wikipedia.org)
  • Vitamin A also functions in a very different role as retinoic acid (an irreversibly oxidized form of retinol), which is an important hormone-like growth factor for epithelial and other cells. (wikipedia.org)
  • It is also an HIV-suppressive factor released from CD8+ T cells[citation needed]. (wikipedia.org)
  • activity
  • Because thrombin plays such a vital role in hemostasis, it comes as no surprise that its activity can be regulated by a variety of endogenous and exogenous factors and that thrombin is a prime target for pharmacologic intervention, as described in detail later in this review. (ahajournals.org)
  • MMP activity is regulated at the level of transcription, post-translationally by proteolytic cleavage, and by endogenous inhibitors known as tissue inhibitors of metalloproteases (TIMPs). (wikipedia.org)
  • modulate
  • Polysaccharides can stimulate the macrophage production of granulocyte colony-stimulating factor (G-CSF), directly affect neutrophil proliferation, and modulate other immune activities [ 9 ]. (hindawi.com)
  • growth factor
  • ADAMs participate in a wide variety of cell surface remodeling processes, including ectodomain shedding, regulation of growth factor availability and mediating cell-matrix interactions. (wikipedia.org)
  • This kinase is known to play a critical role in mitogen growth factor signal transduction. (wikipedia.org)
  • The analysis of IL-9 expression in different types of tumours such as Large cell anaplastic lymphoma (LCAL) and Hodgkin's Disease (HD) by Northern blot analysis and in situ hybridization has showed that IL-9 is not involved as an autocrine growth factor in the pathogenesis of most B and T-cell lymphomas, but it may have a part in HD and LCAL autocrine growth. (wikipedia.org)
  • effects
  • To understand the incidence of central obesity and its characteristics, and explore the effects of lifestyle factors on incidence of central obesity in Chinese adults aged 35-74 years. (jove.com)
  • genes
  • Following ligand binding of the Notch receptor, the intracellular fragment of Notch (NICD, or notch intracellular domain) is released into the cytoplasm and transported to the nucleus, where it can form a complex with binding partners such as EP300 and histone acetyltransferase and act as a transcription factor for Notch target genes. (wikipedia.org)
  • Runx2 (aka Cbfa1) and osterix (Osx) transcription factors are required for the expression of OPN Runx2 and Osx bind promoters of osteoblast-specific genes such as Col1α1, Bsp, and Opn and upregulate transcription. (wikipedia.org)
  • proliferation
  • In addition to its role in proliferation and differentiation, Numb has also been shown to play a role in tumorigenesis and the response of neural progenitors to chemotactic cues during migration. (wikipedia.org)
  • properties
  • Burgess AW, Camakaris J, Metcalf D. Purification and properties of colony-stimulating factor from mouse lung-conditioned medium. (springer.com)
  • thus
  • Another factor that affects degradation rate is the diameter of the axon: larger axons require a longer time for the cytoskeleton to degrade and thus take a longer time to degenerate. (wikipedia.org)
  • production
  • Under the basal conditions of hematopoiesis, G-CSF is the major regulator of neutrophil production and is also referred to as colony-stimulating factor 3 [ 10 ]. (hindawi.com)