Transcription bacteria genes bacterial. Medical search. Frequent questions

4] The bacteria then inject a number of effector proteins into the plant with a Type 3 Secretion System (T3SS)[5]. (wikipedia.org)
At least four phylogenetically distinct groups of bacteria encode repeat proteins with the common ability to bind specific DNA sequences with a unique but conserved code. (uni-muenchen.de)
This unity of terminology belies disunity in the lifestyles of these different bacteria, and the biological roles fulfilled by these proteins. (uni-muenchen.de)
RipTALs are effector proteins delivered during bacterial wilt disease caused by R. solanacearum strains. (uni-muenchen.de)
In the case of the RipTALs this work should begin to unravel the role these proteins play in bacterial wilt disease, as a means to fight this devastating pathogen. (uni-muenchen.de)
In addition the TALEs and RipTALs may simply represent one face of the TALE-likes, a protein family mediating as yet unknown biological roles as bacterial DNA binding proteins. (uni-muenchen.de)
It leads straight to the active site, and presents a confined area where many proteins and antibiotics that control transcription may bind to carry out their business. (infectioncontroltoday.com)
She and her team are honing in on studying the structures of some of these proteins and how they interact with copper ions to learn more about how they function within bacterial cells. (lehigh.edu)
It has been suggested that many such proteins from bacteria might be possible new drug targets, but at a molecular level many of them still remain mysterious. (lehigh.edu)
All of the proteins and pathways that we're studying are used by this species, even though versions of them are also employed by many other bacterial species as well. (lehigh.edu)
The latter are DNA-binding modules found in natural transcription factor proteins. (ddw-online.com)
Repressor proteins are coded for by regulatory genes. (proteopedia.org)
Proteins/genes with a putative catabolic role and bacterium adaptation mechanisms during OPP degradation were identified via genomic and proteomic analysis. (nature.com)
Our interest lies in understanding how architectural proteins act on DNA and how they regulate transcription. (universiteitleiden.nl)
Well-known examples are the eukaryotic and archaeal histones that wrap DNA and the nucleoid-associated proteins in bacteria and archaea that bend and bridge DNA. (universiteitleiden.nl)
Its basic shape is imposed by the proteins mentioned above, but it is subject to continuous remodeling to live up to the demands of genes being expressed or repressed. (universiteitleiden.nl)
It is remodeled actively in eukaryotes by motor enzymes that can move or displace nucleosomes, in addition to remodeling mechanisms more ubiquitous in bacteria and archaea that are based on the interplay between multiple architectural proteins. (universiteitleiden.nl)
Models suggest that in bacteria and archaea there are direct effects of physicochemical factors such as osmolarity, temperature and pH on the action of chromatin proteins, in addition to indirect effects by modulating the expression ratios of different types of chromatin proteins. (universiteitleiden.nl)
In addition to dissecting these mechanistic aspects of gene regulation, we are interested in the roles and physiological consequences of the products of genes regulated by chromatin proteins. (universiteitleiden.nl)
As transcription of many genes and operons responds to environmental changes and as these are often mediated by chromatin proteins, it is expected that 1) the architectural interplay of such proteins and/or 2) their direct response to physicochemical changes determines loop formation and dissolution leading to altered transcription levels. (universiteitleiden.nl)
In this sense, we aim to characterize the behaviour of different promoters of genes involved in biofilm regulation under different conditions and to search for possible new DNAbinding proteins associated with their promoter regions. (usp.br)
Just as electronic circuits are made from resistors, capacitors and transistors, biological circuits can be made from genes and regulatory proteins. (rdworldonline.com)
Genes can be regarded as blueprints for all of the molecular machines -normally proteins-that perform the tasks an organism needs for survival. (sciencedaily.com)
This is done through regulation of the activity of proteins that already exist in the cell, but also by the binding of special proteins-transcription factors-to specific sites on the DNA, turning certain genes on or off, which in turn regulates the cell's production of various proteins. (sciencedaily.com)
The regulation of flagellar and biofilm genes is brought about primarily at the transcription level through the action of a number of dedicated regulatory proteins. (rcb.res.in)
RafK carries a C-terminal regulatory domain present in a subset of ATP-binding proteins that has been involved in both direct regulation of transporter activity (inducer exclusion) and transcription of transporter genes. (lu.se)
The significantly upregulated genes encode proteins involved in reactions of the energy-generating phosphotransferase system and transcription processing, which could be related to phage transcription. (lu.se)

It will also provide an introduction into how understanding basic cellular processes can be used to understand the mechanisms by which antibiotics specifically inhibit certain bacteria and permit the identification of new targets for the development of novel antibiotics. (ncl.ac.uk)
The objective being to give an overview of the methods used in the discovery of molecular mechanisms used by model bacteria and the application of this in understanding the basic processes involved in bacterial growth and development in terms of regulation and biological function. (ncl.ac.uk)
Knowing what roles ppGpp and DksA play in how bacteria respond to stress and other physiological stimuli may help scientists create new antibacterial drugs that target mechanisms specific and unique to harmful bacteria. (infectioncontroltoday.com)
The mechanisms of gene transfer in bacteria. (jinnah.edu)
The molecular mechanisms that bacteria use to regulate gene activity. (jinnah.edu)
The molecular and genetic mechanisms of resistance to the bacterium, or, in general, Gram-positive bacteria causing plant diseases, remain poorly understood. (nsf.gov)
Emphasis is placed on the molecular mechanisms underlying bacterial stress physiology, which is essential for bacterial survival in the environment, and thereby tolerance and resistance to antibiotics. (ku.dk)
Although the overall mechanisms behind gene regulation have long been known, the fine details have eluded scientists for decades. (sciencedaily.com)
The discovery of novel essential genes or pathways that have not yet been targeted by clinical antibiotics can underlie the development of alternative effective antibacterials to overcome existing mechanisms of resistance. (biomedcentral.com)
We employ an integrated approach, involving structural tools, biophysical techniques, biochemical methods and functional in vivo assays to investigate the molecular mechanisms of transcription regulation. (rcb.res.in)
These downregulated genes are normally part of the host stress response mechanisms that protect the bacterium during conditions of acid stress and stationary phase transition. (lu.se)

The lac repressor, and the group of genes it controls, which is called an operon , were the first such gene regulatory system to be discovered. (proteopedia.org)
The second ben/cat operon was located in a 92-kb scaffold along with (i) an operon ( opp ) comprising genes for the transformation of OPP to BA and 2-hydroxypenta-2,4-dienoate (and genes for its transformation) and (ii) an incomplete biphenyl catabolic operon ( bph ). (nature.com)
Question: Regulation Of Gene Expression In Bacteria Involve An Operon. (prowritershub.com)
In the case of the lac operon of E. coli, a well-studied system for whether a gene is regulated. (lu.se)
Here, the function of regulation is quite clear: expressing energy and carbon, that a number around 0.2% would be the right genes at the right time will enable the cell to make the expected, and that the difference is more or less specific to the lac most of the resources within its reach, by maximizing the uptake operon [7]. (lu.se)
Pneumococci lacking RafK showed a 50- to 80-fold reduction in expression of the raf operon genes aga (alpha-galactosidase) and rafEFG (raffinose substrate binding and permease genes), and both glucose and sucrose inhibited raffinose uptake through inducer exclusion. (lu.se)
Like RafK, the presence of DLDH also activated the expression of raf operon genes, as DLDH-negative pneumococci showed a significantly decreased expression of aga and rafEFG, but DLDH did not regulate rafK or the putative regulatory genes rafR and rafS. (lu.se)

Antimicrobial resistance in bacterial pathogens is a major impediment to successful therapy, and in several instances, bacterial strains have arisen that are refractory to most available antimicrobial treatments ( 1 ). (cdc.gov)
Substantial genetic and biochemical similarities exist between resistance determinants in antimicrobial agent-producing actinomycetes and resistance genes found in gram-positive and gram-negative pathogens ( 6 - 9 ). (cdc.gov)
Janitor bacteria might clean up pollutants, chemical-engineer bacteria pump out biofuels and miniature infection-control bacteria might bustle about killing pathogens. (rdworldonline.com)
It is the body's first-line defense against many bacterial pathogens. (medscape.com)
Novel antibacterials are urgently needed to combat the bacterial pathogens, which are increasingly resistant to existing antibiotics. (bioseka.eu)
The place of "good bacteria" is immediately occupied by the other bacteria, including potential pathogens. (bioseka.eu)
Targeting of novel essential pathways is expected to play an important role in the discovery of new antibacterial agents against bacterial pathogens, such as Pseudomonas aeruginosa , that are difficult to control because of their ability to develop resistance, often multiple, to all current classes of clinical antibiotics. (biomedcentral.com)

Within the biofilm, bacteria take on different responsibilities. (the-scientist.com)
As the biofilm matures and the community needs change, an individual bacterium may take on new responsibilities. (the-scientist.com)
As a postdoctoral researcher in Dianne Newman 's lab at the California Institute of Technology, Dar developed a way to track gene activity across the entire biofilm with submicrometer resolution. (the-scientist.com)
Mapping transcriptional regulation of biofilm-related genes promoters in Pseudomonas. (usp.br)
The technology focuses on the biofilm synthesis in bacteria that cause or contribute to the most of the infections. (bioseka.eu)

We study one of the biggest threats to public health - carbapenem-resistant Enterobacterales , which are bacteria that can no longer be killed by an important class of drugs we use to treat severe infections. (broadinstitute.org)
Using ppGpp-based compounds to shut down gene expression in harmful bacteria could help curb the spread of infections. (infectioncontroltoday.com)
These bacteria are characterized not only by their ability to resist harsh conditions (extreme pH, ionizing radiation, osmotic, oxidative stress, dramatic temperature changes, etc.), they also have a "Janus face" behavior in that they can turn from a commensal into a causative agent of invasive infections. (frontiersin.org)
Figure 5: The function of C/EBPδ in the restriction of transient and persistent bacterial infections. (nature.com)
Bacterial infections are a common complication for many medical procedures. (bioseka.eu)
Over the past decade, bacterial infections became resistant to the last resort antibiotics - carbapenems. (bioseka.eu)
Resistance to antibiotics represents an escalating challenge in the treatment of bacterial infections. (rcb.res.in)
The resulting immune system abnormalities make people with AD-HIES highly susceptible to infections, particularly bacterial and fungal infections of the lungs and skin. (medlineplus.gov)

We're hoping that we can take what we learned in this really nice model system and use that information to understand more about how similar processes work in pathogenic bacterial strains. (lehigh.edu)
The actual origins of acquired resistance genes are unknown, but environmental microbes, including the strains producing antimicrobial agents, are believed to be important sources ( 4 , 5 ). (cdc.gov)
Even though diverse strains of S. aureus have been extensively studied, and subjected to genome sequencing, the function of a large proportion of their genes remains unidentified. (biomedcentral.com)
Finally, we examine the conservation of 135 USA300 TFs amongst 11 other S. aureus strains, identifying a key group of regulators that display a high degree of conservation, including many that have previously been demonstrated to play a role in virulence gene regulation. (biomedcentral.com)
To ensure that there wouldn't be crosstalk among his AND gates, Moon mined parts for his gates from three different strains of bacteria: Shigella flexneri and Pseudomonas aeruginosa, as well as Salmonella. (rdworldonline.com)
We found that plants infected with different strains displayed dynamic differences in the accumulation of the defense signaling molecule salicylic acid, expression of the defense marker gene PR1, cell death formation, and accumulation/localization of the reactive oxygen species, H2O2. (omicsdi.org)
Over time, OspC genes were transferred between strains through recombinations involving the whole or parts of the gene and one or both flanks. (cdc.gov)

Through our structural work on transcription repressor AraR, we have provided essential insights into long-standing fundamental questions in the field of regulation of gene expression and uncovered the mechanistic details of the diverse approaches utilized by transcription modulators to bind different DNA sequences without compromise on specificity and affinity thereby regulating gene expression to different extents at different promoters. (rcb.res.in)

The current study suggests that DksA is the glue that holds together two key components of bacterial gene expression -- a molecule called ppGpp and an enzyme called RNA polymerase. (infectioncontroltoday.com)
RNA polymerase carries out transcription, the first step in gene expression. (infectioncontroltoday.com)
DksA uses something scientists call the 'back door of gene expression,' a cavity on the RNA polymerase molecule called the secondary channel. (infectioncontroltoday.com)
The other strand is called the antisense strand and serves as the template for RNA polymerase during transcription. (genome.gov)
The canonical function of a bacterial sigma (σ) factor is to determine the gene specificity of the RNA polymerase (RNAP). (nih.gov)
The multisubunit RNA polymerase (RNAP) is the central enzyme responsible for RNA synthesis in bacteria. (nih.gov)
The molecular events that underlie transcription regulation include interaction of regulators with promoters and RNA polymerase (RNAP). (rcb.res.in)

A more detailed analyses on bacterial-fungal co-cultivation in narrow interaction channels of microfluidic devices revealed that the strongest inhibitory potential was found for Pseudomonas protegens CHA0, with its inhibitory potential depending on the presence of the GacS/GacA system controlling several bacterial metabolites. (frontiersin.org)
Pseudomonas aeruginosa is a gram-negative bacterium predominant in soil, vegetation, and water. (usp.br)
Pseudomonas aeruginosa is a highly adaptable bacterium that thrives in a broad range of ecological niches. (biomedcentral.com)

Further investigation into how the common organism Escherichia coli regulates gene expression has given scientists new ideas for designing antibiotics that might drastically reduce a bacterium's ability to resist drugs. (infectioncontroltoday.com)
Of the seven σ factors in Escherichia coli and related bacteria, σ 54 exists in a class of its own. (nih.gov)
This technique was developed in Staphylococcus aureus and, following a period of limited success in Gram-negative bacteria, has recently been used effectively in Escherichia coli . (biomedcentral.com)
To identify Escherichia coli genes potentially regulated by filamentous phage infection, we used oligonucleotide microarrays. (lu.se)

The eukaryotic transactivation domain, which lends this group their name, allows them to activate specifically targeted host genes for the benefit of the bacterial invader. (uni-muenchen.de)
It is easier to locate genes in bacterial DNA than in eukaryotic DNA. (genome.gov)
The situation in eukaryotic organisms is complicated by the split nature of the genes. (genome.gov)
Most eukaryotic genes take the form of alternating exons and introns. (genome.gov)
Bacterial sigma (σ) elements eukaryotic TFIIB and various other general transcription elements are the principal promoter recruitment elements. (researchatlanta.org)
We also study endosymbiotic bacteria that live in eukaryotic cellsand often manipulate their hosts by causing changes to the ubiquitin system. (yale.edu)
A third, more recent research focus has been on endosymbiotic bacteria that manipulate their eukaryotic hosts by secreting enzymes, including ubiquitin-specific proteases, into the host cell cytoplasm. (yale.edu)

During my graduate work in the lab of Seth Darst at Rockefeller, I studied a transcription factor that activates expression of certain genes within bacteria called Salmonella. (broadinstitute.org)
Bacteria sense these microenvironments and adapt by up or down regulating the expression of certain genes to influence different cell processes. (the-scientist.com)

The second main research area supported by the NIH funding will focus on enzymes involved in bacterial signal transduction pathways. (lehigh.edu)
Bacteria can respond to their environment using signal transduction pathways that lead to the regulation of sets of genes by transcription factors, Fisher says. (lehigh.edu)
Resistance arises by mutation (influencing the target or efflux of the antimicrobial agent) or by the acquisition of resistance genes (encoding antimicrobial or target alteration, or alternate pathways) ( 2 , 3 ). (cdc.gov)
The results clearly indicated that genes known to be part of the defense pathways described in other insects are also involved in the response of B. tabaci to parasitization by E. mundus. (huji.ac.il)
Cancer genomics is dedicated to elucidating the genes and pathways that contribute to cancer progression and development. (bvsalud.org)
Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)
No genes belonging to any known E. coli stress response pathways were scored as upregulated. (lu.se)

B. What Is The Most Logical Sequence Of Steps For Splicing Foreign DNA Into A Plasmid And Then Inserting The Plasmid Into A Bacterial Cell? (prowritershub.com)
Extract the plasmid from a bacterial cell. (prowritershub.com)
One of the few antigens against which mammals develop protective immunity is the highly polymorphic OspC protein, encoded by the ospC gene on the cp26 plasmid. (cdc.gov)

Jaramillo Cartagena is now a senior research fellow in the growing lab of Broad associate member Roby Bhattacharyya , where he and his lab mates explore how bacteria become dangerously resistant to antibiotics - a major threat to public health. (broadinstitute.org)
When bacteria become resistant to these antibiotics, we may have nothing left to give to patients. (broadinstitute.org)
Figuring out how to block DksA production in harmful bacteria may help scientists develop antibiotics that these bacteria are less likely to resist, said Irina Artsimovitch, a study co-author and an assistant professor of microbiology at Ohio State University. (infectioncontroltoday.com)
Conventional antibiotics aimed at killing bacteria also put immense pressure on bacteria to survive and to ultimately develop resistance to these drugs,' Artsimovitch says. (infectioncontroltoday.com)
Antibiotics are meant to kill bacteria and certain fungi, but superbugs have evolved to survive them. (lehigh.edu)
This extracellular matrix glues bacteria to surfaces and serves as a slimy shield, protecting cells in the interior from predators and antibiotics. (the-scientist.com)
Zita Aušrelė Kučinskienė, Member of the Lithuanian Academy of Sciences, Professor and Head of the Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine of the Faculty of Medicine of Vilnius University, seconds that: "Bacterial resistance to antibiotics is a global problem. (bioseka.eu)
Most existing antibiotics are not selective, which means that they are wide spectrum and kill all bacteria, including the "good bacteria. (bioseka.eu)

We found that the potential for formation of bacterial lipopeptide syringomycin resulted in stronger growth reduction effects on saprophytic Aspergillus nidulans compared to Verticillium spp. (frontiersin.org)
Genes required for degradation of and growth on the carbon source pectin were down-regulated, whereas transcripts involved in redox processes were up-regulated. (frontiersin.org)
With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
Published September 5, 2007 transcription factors and replicating extra DNA, rather than going directly into growth of the cell. (lu.se)
AvrB expressed in plants lacking the cognate resistance gene RPM1 suppresses cell wall defense induced by the flagellar peptide flg22, a well known PAMP, and promotes the growth of nonpathogenic bacteria in a RAR1-dependent manner. (omicsdi.org)
This study also identified 43 growth-impairing inserts carrying multiple loci targeting 105 genes, of which 25 have homologs reported as essential in other bacteria. (biomedcentral.com)

The T3SS effectors in Xanthomonas are Transcription Activator-like effectors (TAL effectors). (wikipedia.org)
These TAL effectors activate the production of plant genes that are beneficial to bacterial infection. (wikipedia.org)
The first discovered group, providing the name for the rest, are the Transcription Activator Like Effectors (TALEs) of plant-pathogenic Xanthomonas bacteria. (uni-muenchen.de)
A simpler alternative to zinc fingers emerged with the characterisation of transcription activator-like effectors (TALEs) in plant pathogenic bacteria of the genus Xanthomonas. (ddw-online.com)
Pathogenic bacterial effectors suppress pathogen-associated molecular pattern (PAMP)-triggered host immunity, thereby promoting parasitism. (omicsdi.org)
In the presence of cognate resistance genes, it is proposed that plants detect the virulence activity of bacterial effectors and trigger a defense response, referred to here as effector-triggered immunity (ETI). (omicsdi.org)

I didn't intend to study microbiology or bacteriology, but because we worked with bacterial organisms, I was exposed to those fields and fell for them too. (broadinstitute.org)
This new grant will fund Fisher's lab to pursue two primary research directions to shed light on bacterial biochemistry: investigating how these organisms regulate uptake of the essential trace element copper and how different members of a family of bacterial enzymes each catalyze distinct chemical reactions. (lehigh.edu)
The defense response in B. tabaci involves genes related to the immune response as described in model organisms such as Drosophila melanogaster. (huji.ac.il)
Because the surroundings can change rapidly, it is also important for bacteria and other organisms to be able to quickly reconfigure their biochemical operations in order to adapt to the new environment. (sciencedaily.com)

Pathogenic bacteria are known to switch phenotype such as planktonic to biofilms, to reduce sensitivity towards antimicrobial agents. (rcb.res.in)

The interpretation of the content of a research paper is to assess the student's knowledge of the subject and their analytical skills and capacity to evaluate experimental data and to understand how bacteria underpin research in molecular microbiology. (ncl.ac.uk)

Each year, about 2.8 million people in the U.S. are infected with antibiotic-resistant bacteria or fungi, resulting in over 48,000 deaths. (lehigh.edu)
T cells and other immune system cells help control the body's response to foreign invaders such as bacteria and fungi. (medlineplus.gov)

Treatment of the roots with bacteria prior to infection with V. dahliae resulted in a significant reduction of fungal root colonization. (frontiersin.org)
Plant colonization by endophytic bacteria is mediated by different biomolecules that cause dynamic changes in gene expression of both bacteria and plant. (mdpi.com)
Phytohormones, in particular, salicylic acid, play a key role in the regulation of endophytic colonization and diversity of bacteria in methaphytobiome. (mdpi.com)
Finally, although not as attenuated as DLDH-negative bacteria, pneumococci lacking RafK were significantly outcompeted by wild-type bacteria in colonization experiments of murine lung and nasopharynx, indicating a role for raffinose and stachyose transport in vivo. (lu.se)

Here, we examined the genetic basis of Goss's wilt through differential gene expression, standard genome-wide association mapping (GWAS), extreme phenotype (XP) GWAS using highly resistant (R) and highly susceptible (S) lines, and quantitative trait locus (QTL) mapping using 3 bi-parental populations, identifying 11 disease association loci. (nsf.gov)

Bacillus subtilis is a really wonderful tool because we can do things like introduce point mutations directly within the bacteria itself, unlike many species of bacteria where introducing genetic changes can be incredibly difficult. (lehigh.edu)
It is a genetic disorder that results from a mutation in the hemoglobin gene, causing red blood cells to become sickle-shaped. (proprofs.com)
The downstream transformation of BA involved a meta -cleavage pathway, although its genetic organization and function was not revealed and the overall network of genes driving the full metabolic pathway of OPP is still not known. (nature.com)
The significance of gene transfer, transposable genetic elements and plasmids. (jinnah.edu)
Thus, it seems that σ 54 's role as a determinant of uniform colony appearance in UPEC bacteria represents a putative non-canonical function of σ 54 in regulating genetic information flow. (nih.gov)
Engineer Tae Seok Moon's dream is to design modular "genetic parts" that can be used to build logic controllers inside microbes that will program them to make fuel, clean up pollutants, or kill infectious bacteria or cancerous cells. (rdworldonline.com)
As a postdoctoral fellow in the lab of Christopher Voigt, PhD, a synthetic biologist at the Massachusetts Institute of Technology, he recently made the largest gene (or genetic) circuit yet reported. (rdworldonline.com)
Such a genetic circuit had been identified in Salmonella typhimurium, the bacterium that causes food poisoning. (rdworldonline.com)
Therefore it is difficult to perform specific gene targeting in Xenopus tropicalis with conventional reverse genetic methods. (biomedcentral.com)
With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)

As virulence determinant production is very tightly regulated in S. aureus , a thorough understanding of its regulatory network is necessary to fully comprehend the pathogenic processes of this bacterium. (biomedcentral.com)
Given the high number of virulence factors present in these bacteria, and the niche-specific role many of them play during different stages of the infectious process, gene expression must be finely tuned in order to efficiently coordinate their expression, and also continue to preserve energy pools. (biomedcentral.com)
An important factor of bacterial virulence is the formation of biofilms which are aggregates of microorganisms incorporated into an extracellular matrix that protects bacteria from hostile environments. (usp.br)
Most of this regulation is carried out directly by transcription factors that modulate the activity of promoters aimed at expressing virulence factors. (usp.br)

Normal microbiota - the "good bacteria" - are essential for the healthy immune system, and damaging it can be very dangerous. (bioseka.eu)
For these reasons, it is important that new antibacterial agents are very selective, and only the "bad" disease-causing bacteria are affected by the therapy, preserving the natural microbiota. (bioseka.eu)

The lactose ("lac") repressor controls the expression of bacterial enzymes involved in the metabolism of of the sugar lactose. (proteopedia.org)
Genes are also characterized by specific control sequences that are recognized by enzymes involved with transcription and translation. (genome.gov)

A comparison of the TF repertoire of S. aureus against 1209 sequenced bacterial genomes was carried out allowing us to identify a core set of orthologous TFs for the Staphylococacceae , and also allowing us to assign potential functions to previously uncharacterized TFs. (biomedcentral.com)
We have evaluated the orthologous distribution of these elements in other sequenced bacterial genomes using the repertoire of TFs identified in USA300, and identified a core set of regulators for both the Firmicutes phylum, and the Staphylococacceae group. (biomedcentral.com)

They plan to use the bacterium Bacillus subtilis as their model. (lehigh.edu)
Kovács's team has found that in populations of the soil bacterium Bacillus subtilis , most microbes assume responsibility for matrix production during early development when they are little more than a throng of unconnected cells. (the-scientist.com)
For the first time it was found that salicylic acid influenced motility in biofilms and transcription of the surfactin synthetase gene of the endophytic strain Bacillus subtilis 26D in vitro. (mdpi.com)

4] Residual bacteria in the soil, debris or other plants may also cause new infection in clean seed. (wikipedia.org)
Plant infection begins at the roots, where the fungus is confronted with rhizosphere inhabiting bacteria. (frontiersin.org)
This interplay of bacterial effects on the pathogen can be beneficial to protect plants from infection, as shown with A . thaliana root experiments. (frontiersin.org)
In addition, 65 genes showed differential responses (up- or down-regulated) to infection in R and S lines. (nsf.gov)
The analysis revealed altered transcription levels of 12 E. coli genes in response to phage infection, and the observed regulation of phage genes correlated with the known in vivo pattern of M13 mRNA species. (lu.se)
Sepsis is defined as a host's response to been a candidate gene for investigation into blood culture bottles (Egyptian infection resulting from an imbalance in inflammatory disease, and studies Diagnostic Media) then incubated at between systemic pro-inflammatory focusing on elucidation of MIF gene 37 °C for 7-14 days. (who.int)

Each repressor targets a specific co-regulated group of genes by recognizing a specific sequence of DNA, called the operator in bacteria . (proteopedia.org)
Streamlining Regulon Identification in Bacteria Regulons are a group of genes that can be turned on or off by the same regulatory protein. (doe.gov)

A variety of elements must keep RNAP in a sign reactive but inhibited condition and to focus on it to particular genes (1). (researchatlanta.org)
To carry out its roles, the STAT3 protein attaches to DNA and helps control the activity of particular genes. (medlineplus.gov)

mvaT is a major regulator, exerting negative control in many genes described. (usp.br)

The disease is caused by the bacterial species Xanthomonas translucens pv. (wikipedia.org)

In this context, DNA-binding transcription factors (TFs) play an important regulatory role by either repressing or activating genes in response to environmental and physiological conditions. (biomedcentral.com)

Antibiotic resistance is horizontally transferred among different species of bacteria - one species transfer resistance genes to other species. (bioseka.eu)

The dissociable sigma (σ) factor subunit directs the RNAP to different sets of genes to allow their expression in response to various cellular needs. (nih.gov)

INTRODUCTION broken, which in realistic situations can severly constrain the Transcriptional regulation of effector genes is a highly successful regulatory options. (lu.se)
We mathematically modeled transcriptional regulation of the genes encoding interleukin 6 and C/EBPδ and experimentally confirmed the prediction that the combination of an initiator (NF-κB), an amplifier (C/EBPδ) and an attenuator (ATF3) forms a regulatory circuit that discriminates between transient and persistent Toll-like receptor 4-induced signals. (nature.com)

Bacterial identification in the diagnostic laboratory versus taxonomy. (jinnah.edu)
RNA sequencing of samples separately pooled from R and S lines with or without bacterial inoculation was performed, enabling identification of common and differential gene responses in R and S lines. (nsf.gov)
To assess the performance of the proposed SMG method, benchmarking experiments are performed on three node-level tasks (identification of CGs, essential genes and healthy driver genes) and one graph-level task (identification of disease subnetwork) across eight PPI networks. (bvsalud.org)
Whole-genome transposon-mutagenesis (TM) followed by identification of insertion sites is one of the most practical and frequently used experimental approaches to screen for essential bacterial genes [ 6 - 8 ]. (biomedcentral.com)

Many essential biochemical processes in bacteria are poorly understood," Fisher explains. (lehigh.edu)

Biofilms form when groups of bacteria cover themselves in a sticky mixture of sugars, protein, and DNA. (the-scientist.com)

Biochemist Oriana Fisher , assistant professor of chemistry, has received a $1.9 million Maximizing Investigators' Research Award (MIRA) award from the National Institutes of Health (NIH) to explore how bacteria respond and adapt to changes within their environments. (lehigh.edu)

The bacteria thrives in moist environments, and produces a cream to yellow bacterial ooze, which, when dry, appears light colored and scale-like, resulting in a streak on the leaves. (wikipedia.org)

Different activator ATPases couple diverse environmental cues to the σ 54 -RNAP to mediate adaptive changes in gene expression. (nih.gov)

Goss's wilt, caused by the Gram-positive actinobacterium Clavibacter nebraskensis, is an important bacterial disease of maize. (nsf.gov)

that is, they inhibit the transcription of messenger RNA from their target genes. (proteopedia.org)
RIViT-seq technology could speed up associating transcription factors with their target genes. (doe.gov)

Ten of the 12 host genes affected could be grouped into 3 different categories based on cellular function, suggesting a coordinated response. (lu.se)

To also target low expressed essential genes, we included some variant steps that were expected to overcome the non-stringent regulation of the promoter carried by the expression vector used for the shotgun antisense libraries. (biomedcentral.com)

2] Bacterial leaf streak is a pathogen known to infect and damage wheat varieties. (wikipedia.org)
A cream to yellow colored bacterial ooze produced by BLS infected plant parts is also a distinguishing sign of the pathogen. (wikipedia.org)
Borrelia burgdorferi , an emerging bacterial pathogen, is maintained in nature by transmission from one vertebrate host to another by ticks. (cdc.gov)
By means of DNA sequencing of a large sample collection of the pathogen from across the United States, we studied the gene for the bacterium's highly diverse OspC protein, protective immunity against which develops in animals. (cdc.gov)

Forcing harmful bacteria into a stationary state by controlling ppGpp levels may be the way to circumvent the rise in antibiotic resistance. (infectioncontroltoday.com)
A better understanding of how these species cause disease and spread antibiotic resistance requires a knowledge of how its genes are controlled, on both the DNA and the RNA level. (frontiersin.org)

The other groups, discovered after the TALEs, are the RipTALs of Ralstonia solanacearum, the Bats of Burkholderia rhizoxinica, and MOrTL1 and MOrTL2 of unknown marine bacteria. (uni-muenchen.de)

In recent work, Artsimovitch and her colleagues discovered that ppGpp regulates gene expression by controlling amino acid production in bacteria. (infectioncontroltoday.com)
In the immune system, the STAT3 protein regulates genes that are involved in the maturation of immune system cells, especially certain types of T cells . (medlineplus.gov)

More importantly, we are using and developing new approaches to investigate genome organisation and its coupling to transcription in vivo. (universiteitleiden.nl)
iPHoP: A Matchmaker for Phages and their Hosts Building on existing virus-host prediction approaches, a new tool combines and evaluates multiple predictions to reliably match viruses with their archaea and bacteria hosts. (doe.gov)
Here we use systems-biology approaches to predict and confirm the existence of a gene-regulatory network involving dynamic interaction among the transcription factors NF-κB, C/EBPδ and ATF3 that controls inflammatory responses. (nature.com)

The findings, reported in the current issue of the journal Cell , suggest that bacteria rely on a key protein in order to properly regulate gene expression -- a process fundamental to cell survival. (infectioncontroltoday.com)

It will also look at aspects of the interaction of bacterial spp. (ncl.ac.uk)
Therefore, a more reliable approach is to have the neural network learn both gene expression data and protein interaction networks. (bvsalud.org)

however, little is known about their impact on arsenic-reducing bacteria and genes during arsenic transformation in flooded paddy soils. (researchwithrutgers.com)
Transcription analysis verified the key role of the catabolic operons located in the 92-kb scaffold, and flanked by transposases, on the transformation of OPP by S. haloaromaticamans . (nature.com)
6 identified a gene cluster, hbpCAD , encoding the upper metabolic pathway of OPP which involves the transformation of OPP to 2-hydroxypenta-2,4-dienoateand benzoic acid (BA). (nature.com)

In bacteria and archaea the genome is not membrane enclosed and "free floating" yet centrally positioned in the cytoplasm, whereas in eukaryotes the genome is located in a dedicated organelle, the nucleus and surrounded by the nuclear membrane. (universiteitleiden.nl)

For this, the upstream regions of the gacA, gacS, ladS, retS, rsmA, rsmZ and PA1611 genes were cloned separately into a miniTn7 vector and inserted into the PAO1 chromosome. (usp.br)
Para isso, as regiões upstream dos genes gacA, gacS, ladS, retS, rsmA, rsmZ e PA1611 foram clonadas separadamente em um vetor repórter miniTn7 e inseridas no cromossomo de PAO1. (usp.br)

Anatomy11

Organisms23

Diseases1

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes91

Disciplines and Occupations2

Information Science4

Health Care6

Proteins27

Mechanisms11

Operon7

Pathogens7

Biofilm5

Infections8

Strains7

Regulation of gene ex1

Polymerase7

Pseudomonas3

Escherichia4

Eukaryotic7

Certain genes2

Pathways8

Plasmid3

Antibiotics8

Growth7

Effectors6

Organisms4

Pathogenic bacteria1

Microbiology1

Fungi2

Colonization4

Phenotype1

Genetic10

Virulence4

Microbiota2

Enzymes involved2

Genomes2

Bacillus3

Infection6

Group of genes2

Particular genes2

Regulator1

Xanthomonas1

Physiological1

Species of bacteria1

Sets of genes1

Transcriptional regulation2

Identification4

Processes1

Groups of bacteria1

Explore how bacteria1

Thrives1

Changes in gene expression1

Gram-positive1

Target genes2

Host genes1

Essential genes1

Pathogen4

Antibiotic2

Marine bacteria1

Regulates2

Approaches3

Regulate gene1

Interaction2

Transformation3

Archaea1

GacA2