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Receptors, EstrogenBreast NeoplasmsTranscription FactorsTranscription, GeneticHormonesGene Expression RegulationMolecular Sequence DataPromoter Regions, GeneticRNA, MessengerBase SequenceThyroid HormonesFollicle Stimulating HormoneCell LineSp1 Transcription FactorDNA-Binding ProteinsTranscriptional ActivationLuteinizing HormoneBinding SitesProtein BindingAmino Acid SequenceSignal TransductionMutationTrans-ActivatorsNuclear ProteinsRepressor ProteinsParathyroid HormoneCells, CulturedDNATransfectionGonadotropin-Releasing HormoneTranscription Initiation SiteCell NucleusGonadal Steroid HormonesReceptors, Thyroid HormoneHeLa CellsNeoplasmsPancreatic NeoplasmsReverse Transcriptase Polymerase Chain ReactionPlasmidsTranscription Factor AP-1STAT3 Transcription FactorCloning, MolecularGenes, ReporterRNA Polymerase IIGene Expression Regulation, DevelopmentalHuman Growth HormoneBasic Helix-Loop-Helix Transcription FactorsCell DifferentiationGene ExpressionAdrenocorticotropic HormonePhosphorylationRecombinant Fusion ProteinsHomeodomain ProteinsTranscription Factors, TFIIDNA-Directed RNA PolymerasesTime FactorsTranscription Factor TFIIDRegulatory Sequences, Nucleic AcidCell Line, TumorGene Expression Regulation, BacterialKineticsImmunohistochemistryModels, BiologicalTumor Cells, CulturedPituitary HormonesChromatin ImmunoprecipitationBasic-Leucine Zipper Transcription FactorsSaccharomyces cerevisiaeReverse TranscriptionNeoplasms, Cystic, Mucinous, and SerousGene Expression ProfilingForkhead Transcription FactorsTriiodothyronineChromatinBlotting, WesternEnhancer Elements, GeneticMice, Inbred C57BLRecombinant ProteinsSaccharomyces cerevisiae ProteinsBacterial ProteinsGene Expression Regulation, FungalEscherichia coliMice, KnockoutLuciferasesSequence Homology, Amino AcidTranscription Factor TFIIBElectrophoretic Mobility Shift AssaySTAT1 Transcription FactorNF-kappa BHistonesTranscription Factor AP-2Carrier ProteinsDown-RegulationKruppel-Like Transcription FactorsRNAJuvenile HormonesBlotting, NorthernEstradiolGene Expression Regulation, EnzymologicPhenotype
TumorsHepatocellular CarcinomaGenesHepatic neoplasmsMalignantMetastasisReceptorsSignal transductionLymph nodesBenignVarious hormonesForkhead transcription factorEstrogen-dependentGene transcriptionAndrogen dependentReceptorCancerProteinsGrowthUpregulationMalignanciesNuclearMethodsFactorsDiagnosisDifferentiationRepressionTranscriptional activityCellClenbuterolFunctionalBreastSequencesExcessOccursFactorHelix
Tumors3
  • Nevertheless, ERs expression levels of specific splice variants and their cellular localization differentially affect outcome of estrogen-dependent tumors. (bvsalud.org)
  • Endocrine tumors are neoplasms originating from specialized hormone-secreting cells. (bvsalud.org)
  • GH3 cells are a well-characterized model of secretory adenomas that hypersecrete both prolactin (PRL) and growth hormone (GH) and that reflect the biology of human secretory tumors. (surgicalneurologyint.com)
Hepatocellular Carcinoma1
Genes7
  • But, that sperm count is back regulates the transcription of androgen-responsive target genes. (sanfordcoffee.com)
  • Semiquantitative reverse transcription-PCR analysis showed elevated E2F1 mRNA levels and increased levels of the E2F-target genes dihydrofolate reductase and proliferating cell nuclear antigen in metastatic hormone-independent prostate cancer cases compared with benign tissues. (johnshopkins.edu)
  • In this study, the genes implicated in signaling that is important in hormone-sensitive carcinogenesis were investigated regarding their prognostic significance. (bvsalud.org)
  • In conclusion, this study laid the foundation for further hormone-sensitive carcinogenesis research through identification of genes which prove that crosstalk between cell cycle and cytoskeleton exists, opening avenues for future therapeutic strategies. (bvsalud.org)
  • P53 is a tumor suppressor gene that codes for a transcription factor that regulates the expression of other genes and arrests the cell cycle. (doctorlib.info)
  • We show that the TC-AR translocates to the nucleus, activates transcription of AR target genes in the absence of DHT and is sufficient to confer ADI growth to the normally androgen dependent LNCaP line. (tmu.edu.tw)
  • Abnormal STAT3-mediated signal transduction has been observed in a large number of neoplasms, in which it induces anti-apoptotic and cell cycle progression mediating genes transcription. (pbkom.eu)
Hepatic neoplasms1
  • Ziegler, and it was first introduced parenchyma of liver), hepatic neoplasms, and hepatocellular and steroid users go for different kinds of steroids. (sanfordcoffee.com)
Malignant6
  • Malignant neoplasm of the Adrenal gland is rare and carries a poor prognosis. (endocrine-abstracts.org)
  • Other benign and malignant cutaneous proliferative entities where the growth hormone receptor was present included histiocytomas, melanomas and acrochordons. (globale-dermatologie.com)
  • Primary malignant neoplasms of lymph nodes or glands are classified to categories 200 to 202. (fortherecordmag.com)
  • With benign and malignant thyroid neoplasms, coding directives instruct coders to use an additional code to identify any functional activity such as corticoadrenal insufficiency (255.41), hyperthyroidism (242.80 to 242.81), or hypopituitarism (253.2). (fortherecordmag.com)
  • It is upregulated in malignant compared to benign tissue, and targets a number of transcription factors including p53. (ox.ac.uk)
  • RESULTS: HDAC1 was upregulated in pre-malignant and malignant lesions, with the highest increase in expression in hormone refractory (HR) cancer. (ox.ac.uk)
Metastasis1
  • In contrast, strong AR expression was detected in benign prostate (83%), localized prostate cancer (100%), and lymph node metastasis (80%), but decreased to 40% in metastatic hormone-resistant prostate cancer (P = 0.004). (johnshopkins.edu)
Receptors4
  • This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. (cancerindex.org)
  • We are interested in understanding the biochemistry, physiology, and molecular biology of nuclear hormone (estrogen, progesterone) receptors, intracellular proteins that mediate the biological actions of these hormones in target cells, and the mechanisms by which these proteins regulate gene expression and the growth and functioning of target cells, especially cells of the reproductive system and mammary gland, and of tumors that develop in these tissues. (illinois.edu)
  • We are doing genome-wide analyses of receptor and other transcription factor cistromes (chromatin binding sites by ChIP-Seq) and transcriptomes (gene expression, miRNAs, other RNAs by RNA-Seq) and are examining the bidirectional cross-talk between nuclear hormone receptors and cell signaling pathways. (illinois.edu)
  • Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression. (ox.ac.uk)
Signal transduction1
Lymph nodes1
  • We show that E2F1 expression is low in benign and localized prostate cancer, modestly elevated in metastatic lymph nodes from hormone-naive patients, and significantly elevated in metastatic tissues from hormone-resistant prostate cancer patients (P = 0.0006). (johnshopkins.edu)
Benign1
Various hormones2
  • This class of carcinogens includes various hormones (e.g., estrogen and diethylstilbestrol), immunosuppressive drugs (e.g., azathioprine), solid-state carcinogens (e.g., asbestos), and promoting agents (agents that increase tumor development when given after a genotoxic chemical). (doctorlib.info)
  • Often referred to as the "master gland", the pituitary gland synthesizes and releases various hormones that affect several organs throughout the body (see the images below). (medscape.com)
Forkhead transcription factor1
  • Human FOXL2 is an important member of the forkhead transcription factor family. (ijbs.com)
Estrogen-dependent3
  • We evaluated the effects of STS inhibitor and aromatase inhibitors on the proliferation of estrogen-dependent endometrial cancer cells. (scirp.org)
  • Due to its nature as an estrogen dependent disease, endometriosis usually resolves in menopause because of decreasing hormone levels. (fortuneonline.org)
  • Understanding the molecular mechanisms underlying the induction of ER-mediated cell death will be useful for the development of specific ligands capable of triggering apoptosis to counteract estrogen-dependent tumor growth. (bvsalud.org)
Gene transcription2
  • It also modulates gene transcription and recombination [ 7 ]. (hindawi.com)
  • and the mechanisms by which antihormones (antiestrogens and antiprogestins) antagonize hormone-dependent gene transcription and cell growth. (illinois.edu)
Androgen dependent2
  • In this study, we present a model system in which a C-terminally truncated variant of androgen receptor (TC-AR) is inducibly expressed in LNCaP, an androgen-dependent cell line, which expresses little truncated receptor. (tmu.edu.tw)
  • Using the CWR22 xenograft model we showed androgen dependent regulation of HDAC1. (ox.ac.uk)
Receptor6
  • Gene expression profiling of ErbB receptor and ligand-dependent transcription. (rochester.edu)
  • Erythropoietin is a glycoprotein hormone that stimulates red blood cell (RBC) production in bone marrow via binding to the cell-surface receptor on hematopoietic progenitor cells, and it has been widely used for treating anemia [ 13 ]. (hindawi.com)
  • In conclusion, these data indicate a major role for post-transcriptional mechanisms in the dexamethasone-dependent repression of COX-2 that require de novo glucocorticoid receptor-dependent transcription and translation. (mdc-berlin.de)
  • This class of drug has been reported to exert PPAR gamma receptor dependent as well as receptor independent effects, possibly via AMP kinase activation (AMPK) but the precise mode of action resulting in improved cardiovascular outcome remains uncertain.We studied the effects of rosigl. (endocrine-abstracts.org)
  • Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer. (johnshopkins.edu)
  • Dive into the research topics of 'Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer. (johnshopkins.edu)
Cancer3
  • To identify a role of E2F1 in hormone-independent prostate cancer, we examined whether E2F1 can regulate AR expression. (johnshopkins.edu)
  • Taken together, these results show that elevated E2F1, through its ability to repress AR transcription, may contribute to the progression of hormone-independent prostate cancer. (johnshopkins.edu)
  • Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. (ox.ac.uk)
Proteins3
  • Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. (lookformedical.com)
  • Our observations indicate that the SCL transcription factor, a member of the basic helix-loop-helix family of proteins, is important for the long-term maintenance of hematopoietic stem cells. (umontreal.ca)
  • Hh proteins are secreted morphogens that play essential roles in regulation of embryogenesis, development, tissue homeostasis, regeneration and stem cell maintenance in a concentration-dependent manner [ 6 ]. (biomedcentral.com)
Growth1
  • Natural supplements usually medications that help increase testosterone……growth hormone…leanness and mass. (sanfordcoffee.com)
Upregulation1
  • Epistatic analysis indicated that Velo knock-down mediated AMP upregulation is dependent on the canonical members of the IMD pathway. (cnrs.fr)
Malignancies1
  • Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. (rochester.edu)
Nuclear1
  • Nuclear run-off assays showed that COX-2 transcription rate was repressed 25-40% by dexamethasone, while PGE2 release, COX activity, and COX-2 protein were totally repressed. (mdc-berlin.de)
Methods1
  • Other treatment methods include thyroid hormone therapy, radioactive iodine (radioiodine)-according to ICD-9-CM coding directives, if a patient is admitted for radioactive iodine therapy, the condition should be sequenced as the principal diagnosis-external beam radiation, and chemotherapy. (fortherecordmag.com)
Factors4
  • The FOXP1 gene has been identified as a new member of the winged helix family of transcription factors that have important roles in cellular transformation, differentiation and proliferation. (ox.ac.uk)
  • Activation of E2F transcription factors, through disruption of the retinoblastoma (Rb) tumor-suppressor gene, is a key event in the development of many human cancers. (johnshopkins.edu)
  • We observe that SCL blocks thymocyte differentiation and induces leukemia in transgenic mice by disrupting a combinatorial code between the E2A, HEB transcription factors and signalling by the pre-TCR. (umontreal.ca)
  • Finally, our recent work indicates that myeloid differentiation is controlled by a distinct transcriptional complex which implicates the PU.1, c-Jun and C/EBPb transcription factors. (umontreal.ca)
Diagnosis2
  • The most frequent application is the diagnosis of neoplasms of the female breast . (lookformedical.com)
  • The neoplasm code should be sequenced first unless the functional condition meets the criteria for principal diagnosis. (fortherecordmag.com)
Differentiation1
  • This study was therefore aimed at addressing three key issues: First, is there a dose-dependent effect of EPO on the proliferation and osteogenic differentiation of BMSCs? (hindawi.com)
Repression1
  • This dexamethasone-dependent repression involved a reduced COX-2 mRNA half-life, was blocked by actinomycin D or cycloheximide, and was antagonized by the steroid antagonist RU38486. (mdc-berlin.de)
Transcriptional activity1
  • Because the transcriptional activity of beta-catenin is dependent on activation by the wnt signaling cascade, we examined whether components of this cascade are expressed in the rat ovary. (elsevierpure.com)
Cell3
  • The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)
  • and human chorionic gonadotropin (hCG), seen in choriocarcinoma testicular germ cell neoplasms. (doctorlib.info)
  • These hypothalamic cell bodies produce hormones that undergo axonal transport through the pituitary stalk and into terminal axons within the neurohypophysis. (medscape.com)
Clenbuterol1
  • Clenbuterol increases epinephrine and noradrenaline hormone replacement becomes, and the less soluble in water. (sweetcrunchbakeshop.com)
Functional1
  • Sequencing of the thyroid neoplasm with the functional condition will depend on the circumstances of admission. (fortherecordmag.com)
Breast1
Sequences1
  • Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. (cancerindex.org)
Excess2
  • Laboratory investigations confirm clinical suspicion of isolated hormone excess. (endocrine-abstracts.org)
  • We present two cases of postmenopausal, gonadotrophin-dependent androgen excess.Case 1: A 59-year-old postmenopausal female presented with a 4-year history of hirsuitism and male pattern balding. (endocrine-abstracts.org)
Occurs2
  • The goal of this review is to provide a general overview of current knowledge on ERs-mediated apoptosis that occurs in main hormone dependent-cancers. (bvsalud.org)
  • Translocation of EWSR1 (Ewing sarcoma breakpoint region 1) with an ETS (E26 transformation-specific) transcription factor gene occurs in more than 95% of Ewing sarcomas. (medscape.com)
Factor4
  • Further, we show that the basal transcription factor TFIIH is constitutively recruited by ER-Y537S, resulting in ligand-independent phosphorylation of Serine 118 (Ser118) by the TFIIH kinase, cyclin-dependent kinase (CDK)7. (essex.ac.uk)
  • The dual role of beta-catenin as an intracellular component of the cadherin adhesion complex and as a transcription factor provides a possible explanation for these cadherin effects. (elsevierpure.com)
  • This epigenetic switch is controlled by the stoichiometry between the SCL transcription factor and the ETO2 co-repressor. (umontreal.ca)
  • Furthermore, this novel mutation resulted in the dysfunction of FOXL2 as a transcription factor, blocking its ability to bind to the promoter region of the StAR gene, resulting in POF in the affected patient. (ijbs.com)
Helix1
  • Remarkably, the great majority of these mutations localize to just a few amino acids within or near the critical helix 12 region of the ER hormone binding domain, where they are likely to be single allele mutations. (essex.ac.uk)