Splice variantsIdentify genesMRNAProteinsReceptor genesAlternativelyProteinCandidate genesProgressionMutationsGenomeChromosomeDataSetsSequencesRegulationSequenceTransformationPathwayLung cancerGenomicPhenotypeDifferencesMultipleResistanceDifferentialStudiesClassificationTranscriptionPotentialPresented with higherSizeTargetComplexActionsHigherShowFunctionUnknownEvaluationStudyPatientsPreviously
Splice variants3
- This gene has 5 transcripts (splice variants), 130 orthologues and 6 paralogues. (medchemexpress.com)
- This gene has 5 transcripts (splice variants), 203 orthologues and 7 paralogues. (medchemexpress.cn)
- The latter may play a pivotal part in a postulated mechanism termed RUST ((48) and humans (32, 62, 68) and one third of human mRNA splice variants should be candidates for NMD (38), it is still unclear whether the function of NMD in posttranscriptional control of gene expression is restricted to a JNJ-42165279 few substrates or is a more prevalent phenomenon. (greatlakeshighereducationnow.com)
Identify genes3
- Therefore comparative genomic analysis of T . equi was undertaken to: 1) identify genes contributing to immune evasion and persistence in equid hosts, 2) identify genes involved in PBMC infection biology and 3) define the phylogenetic position of T . equi relative to sequenced apicomplexan parasites. (biomedcentral.com)
- At the current state of technology it is still an immense task to identify genes that might confer a given trait such as resistance to HIV. (healthdrugpdf.com)
- Here we have used a network modeling strategy to identify genes potentially associated with higher risk of breast cancer. (gsea-msigdb.org)
MRNA2
- In addition, miR-101-3p decreased myeloid cell leukemia 1 ( MCL1 ) expression by binding to the 3'-untranslated region (3'-UTR) of its mRNA. (oncotarget.com)
- Aberrant PTC-bearing transcripts can also originate during mRNA biogenesis through RNA polymerase mistakes as well as inaccurate Rabbit polyclonal to Netrin receptor DCC or incomplete pre-mRNA splicing. (greatlakeshighereducationnow.com)
Proteins4
- More common are small, subtle changes of the DNA sequence that can alter the structure and function of the proteins encoded by genes. (healthdrugpdf.com)
- The genes that encode proteins comprise only a tiny fraction of human DNA, even though they represent the major biological function of the genome. (healthdrugpdf.com)
- An educated guess is made regarding the characteristics of a gene involved in HIV resistance (for example only cell-surface proteins will be examined as they may bind HIV). (healthdrugpdf.com)
- Materials and Methods DNA sequences for the recombinant proteins used in this study were optimized for expression in em Escherichia coli /em , synthesized by GeneArt technology at Life Technologies, expressed in em E. coli /em , and purified via affinity chromatography and size exclusion chromatography. (niepokorny.org)
Receptor genes2
- Dostie, J., and G. receptor genes. (greatlakeshighereducationnow.com)
- regulators of the rat and human 5-HT1A receptor genes using luciferase reporter fusion constructs transfected in cell lines. (vdocuments.net)
Alternatively3
- Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known. (wikipedia.org)
- Alternatively, one may pursue a candidate gene approach. (healthdrugpdf.com)
- Examples are mRNAs encoding certain selenoproteins (49) and alternatively spliced transcripts with PTC-bearing exons. (greatlakeshighereducationnow.com)
Protein8
- Amyloid beta A4 precursor protein-binding family B member 1 is a protein that in humans is encoded by the APBB1 gene. (wikipedia.org)
- The protein encoded by this gene is a member of the Fe65 protein family. (wikipedia.org)
- The TMEM127 gene encodes a transmembrane protein of poorly known function that is mutated in pheochromocytomas, neural crest-derived tumors of adrenomedullary cells. (bvsalud.org)
- It is dispensable for mouse development [ 9 ] and interacts with polycomb 2 protein to control relocation of growth-control genes between polycomb bodies and inter-chromatin granules [ 10 ]. (oncotarget.com)
- What does this gene/protein do? (cancerindex.org)
- What pathways are this gene/protein implicaed in? (cancerindex.org)
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
- Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). (cancerindex.org)
Candidate genes3
- Such a general screening will yield literally thousands of candidate genes that must be examined. (healthdrugpdf.com)
- After the candidate genes are identified one must determine which ones have unusual sequence in a resistant individual. (healthdrugpdf.com)
- The biosynthetic gene clusters of these linaridins lack obvious candidate genes for the dehydratase and epimerase required to introduce dehydrobutyrine and D-amino acid residues, respectively. (hokudai.ac.jp)
Progression2
- Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. (wikipedia.org)
- Many cancer-associated genes remain to be identified to clarify the underlying molecular mechanisms of cancer susceptibility and progression. (gsea-msigdb.org)
Mutations1
- Better understanding is also required of how mutations in cancer genes affect their products in the context of complex cellular networks. (gsea-msigdb.org)
Genome4
- Human APBB1 genome location and APBB1 gene details page in the UCSC Genome Browser. (wikipedia.org)
- Indeed, a number of genes identified as potential manipulators of the host cell phenotype are absent from the T . equi genome. (biomedcentral.com)
- There is thought to be more than 30,000 genes in the human genome. (healthdrugpdf.com)
- Genome-wide expression profiling of wild-type (WT) and NMD-impaired HeLa cells in fact identified novel physiologic PTC-bearing transcripts whose levels are controlled by the NMD pathway. (greatlakeshighereducationnow.com)
Chromosome1
- If one is starting from scratch, without any knowledge of what kind of gene it might be and what chromosome it resides on, the task is truly enormous. (healthdrugpdf.com)
DataSets1
- Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Sequences3
- Comparative genomic analysis of T . equi revealed the phylogenetic positioning relative to seven apicomplexan parasites using deduced amino acid sequences from 150 genes placed it as a sister taxon to Theileria spp . (biomedcentral.com)
- Large differences are due to loss or gain of entire genes, gene parts as well as sequences that regulate the gene expression. (healthdrugpdf.com)
- This will pinpoint which one of the multitude of variant sequences is responsible for the trait in question. (healthdrugpdf.com)
Regulation1
- RESEARCH:5-HT1A (Serotonin-1A) receptor gene regulation and mental illness:Hypothesis: Down-regulation of the 5-HT1A receptor gene in serotonin neurons is required for the antidepressant actions of therapeutic compounds. (vdocuments.net)
Sequence3
- Id of miRNA differential appearance We initial normalized miRNA-sequence data from 18 libraries as transcripts per million (TPM). (clinical-research-informatics.com)
- In turn, each one of these genes may have deviations from the published sequence. (healthdrugpdf.com)
- 9). A BLAST search confirmed the absence of the selected hUPF2 sequence in other transcripts in the human GenBank database. (greatlakeshighereducationnow.com)
Transformation1
- T . equi has lost the putative genes for host cell transformation, or the genes were acquired by T . parva and T . annulata after divergence from T . equi . (biomedcentral.com)
Pathway1
- The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway evaluation suggested that furthermore to Wnt and changing growth aspect (TGF) signaling pathways, that have been reported in response to follicle formation broadly, another mixed band of signaling pathways that regulate lipid synthesis and fat burning capacity, like the phosphatidylinositol signaling program and glycerolipid signaling and fat burning capacity, are Gemzar biological activity in charge of follicle formation also. (clinical-research-informatics.com)
Lung cancer3
- In this study, we investigated the mechanism by which lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) mediates cisplatin resistance in lung cancer. (oncotarget.com)
- Moreover, cisplatin-resistant A549/DDP cells showed higher MALAT1 expression than cisplatin-sensitive lung cancer cells (A549, H460, H1299 and SPC-A1). (oncotarget.com)
- LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was first identified as a negative prognostic biomarker in early non-small cell lung cancer [ 8 ]. (oncotarget.com)
Genomic1
- Starting with four known genes encoding tumor suppressors of breast cancer, we combined gene expression profiling with functional genomic and proteomic (or 'omic') data from various species to generate a network containing 118 genes linked by 866 potential functional associations. (gsea-msigdb.org)
Phenotype1
- We aimed to study the clinical phenotype and the age-dependent penetrance in predictive variant carriers. (bvsalud.org)
Differences1
- However, once deep sequencing became widely available, microRNA variants that showed differences at their 5′- or 3′-termini have been described. (pharmaceuticalintelligence.com)
Multiple2
- CONCLUSION: The c.1998delinsTTCT variant in the RET gene is pathogenic and associated with a moderate risk for medullary thyroid carcinoma and rarely with other multiple endocrine neoplasia type 2A (MEN2A) manifestations. (bvsalud.org)
- Often multiple genes are involved in the given biological process as complex as the successful viral infection. (healthdrugpdf.com)
Resistance1
- The work by Gou and colleagues reinforces the knowledge of RET as an ESR1 target gene and highlights that RET interacts with ERα to promote breast cancer tumorigenesis and antiestrogen resistance. (bvsalud.org)
Differential1
- Moreover, HOTAIR expression correlates with differential response of ovarian cancer cells to platinum-based chemotherapy [ 7 ]. (oncotarget.com)
Studies2
- Although the prognostic role of AR in TNBC remains controversial, many studies revealed that a lack of AR expression confers a more aggressive disease course. (biomedcentral.com)
- I have numerous scientific publication to my credit, including research studies on gene therapy using retrovirus vectors. (healthdrugpdf.com)
Classification1
- Our analysis identified 50 genes that will be useful for definitive phylogenetic classification of T . equi and closely related organisms. (biomedcentral.com)
Transcription1
- They affect gene expression by regulating chromatin modification, transcription and post-transcriptional mechanisms [ 4 ]. (oncotarget.com)
Potential1
- Based on gene expression profiling, TNBCs have been sub-classified, raising the potential for more precise therapeutic intervention. (biomedcentral.com)
Presented with higher1
- The 2 homozygous predictive variant carriers presented with higher disease severity at first clinical evaluation. (bvsalud.org)
Size1
- It has been estimated that a gene of average size would contain about 15 SNPs. (healthdrugpdf.com)
Target1
- XLS 97 kb) 12861_2017_153_MOESM8_ESM.xls (98K) GUID:?B2FE5241-0444-4D48-99D4-D5E55E4120EF Extra file 9: Desk S7: Target genes of the very best portrayed 18 miRNAs. (clinical-research-informatics.com)
Complex1
- This exon-exon junction complex (EJC) is displaced from the transcript during the first round of translation by ribosomes (16, 24, 36). (greatlakeshighereducationnow.com)
Actions1
- Indirectly, dCK can also contribute to dTTP pools via the actions of deoxycytidylate deaminase and thymidylate synthase. (biomasswars.com)
Higher1
- Compared to index patients, surgically treated heterozygous predictive variant carriers had a lower presurgical basal calcitonin, a lower disease stage, less need for adjuvant therapy, and higher chances of remission. (bvsalud.org)
Show1
- Also, most of the newly found microRNAs show tissue-specific expression. (pharmaceuticalintelligence.com)
Function1
- As mentioned above, most polymorphisms are irrelevant for the gene function. (healthdrugpdf.com)
Unknown2
- One of the components of the network is HMMR, encoding a centrosome subunit, for which we demonstrate previously unknown functional associations with the breast cancer-associated gene BRCA1. (gsea-msigdb.org)
- However, we previously demonstrated that the grisemycin (grm) cluster contained cryptic dehydratase and epimerase genes by heterologous expression of this biosynthetic gene cluster in Streptomyces lividans and proposed that two genes (grmH and grmL) with unknown functions catalyze dehydration and epimerization reactions. (hokudai.ac.jp)
Evaluation1
- Active surveillance is a possible option in heterozygous gene carriers with a negative first clinical evaluation. (bvsalud.org)
Study1
- DESIGN: Retrospective study of index patients and predictive variant carriers, identified through familial cascade testing between 2001 and 2020. (bvsalud.org)
Patients1
- RESULTS: The total cohort comprised 119 patients: 15 index patients, 102 heterozygous, and 2 homozygous predictive variant carriers. (bvsalud.org)
Previously1
- The newly unveiled microRNAs and previously characterized microRNAs have distinct expression patterns. (pharmaceuticalintelligence.com)