Traits genes and genetic transcription factors transcription genetic. Medical search. Frequent questions

In addition to environmental factors, phenotypes can also respond to genetic perturbations in a plastic or homeostatic manner, which characterizes the potential of an organism to express phenotypes when genes mutate. (nature.com)
Therefore, if a single gene from a certain gene family is mutated, there is a high probability that another gene from the same family (actually a copy very similar to the mutated gene) will mask the phenotypes in place of the mutated gene. (phys.org)
This research holds great potential for elucidating how genetic variation and regulatory elements lead to diverse visual phenotypes. (nih.gov)
Species are in the midst of surviving changing climates that require ancestral trait phenotypes to convert to derived states better adapted to the present conditions. (udayton.edu)
Some of the potential regulatory variants described here were associated with the expression pattern of genes related to interesting phenotypes for livestock. (diagenode.com)
Thus, these variants might be useful for the comprehension of the genetic control of these phenotypes. (diagenode.com)
These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)

Gene-Expression Analysis of Cell-Cycle Regulation Genes in Virus-Infected Rice Leaves. (routledge.com)
These strategies involve rearrangements at the molecular level starting from transcription, regulation of mRNA processing, translation, and protein modification or its turnover. (intechopen.com)
Plants show stress-specific regulation of transcription that affects their transcriptome under stress conditions. (intechopen.com)
sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression. (uchicago.edu)
They examined tissue taken from the gills - an important osmoregulatory organ in fish - and generated DNA and RNA sequence data to study the activity, regulation, and function of different genes. (thefishsite.com)
These traits can be the consequences of alterations that are directly changing the protein function, or they can emerge after several gene expression regulation steps, caused for example by alternative splicing or methylation. (biomedcentral.com)
The aim of this work was QTL identification of SSC, MD, and M and to identify adequate candidate genes that are linked to regulation of these traits. (irta.cat)
However, functional genomic studies and the gene discovery associated with floral pattern regulation remains greatly limited in C. goeringii [ 6 ]. (biomedcentral.com)
This regulation occurs by certain transcription factors interacting with short DNA sequences, called binding sites, in gene regions known as cis-regulatory elements (CREs). (udayton.edu)
they wouldn't become more concrete until details about such phenomena as DNA and gene regulation and methylation were discovered. (scienceblogs.com)
Hypoxia leads to the up-regulation of hypoxia-induced transcription factors (HIF)-a and HIF-2a, which are the master regulators of proangiogenic signals, mainly the vascular endothelial cell growth factors (VEGFs). (medscape.com)

WGCNA can be used as a data reduction technique (related to oblique factor analysis), as a clustering method (fuzzy clustering), as a feature selection method (e.g. as gene screening method), as a framework for integrating complementary (genomic) data (based on weighted correlations between quantitative variables), and as a data exploratory technique. (wikipedia.org)
Since it uses network methodology and is well suited for integrating complementary genomic data sets, it can be interpreted as systems biologic or systems genetic data analysis method. (wikipedia.org)
For example, the UK Biobank , a leading cohort study of half a million persons, has collected genomic, clinical and risk factor information and has contributed to numerous discoveries in human genetics. (cdc.gov)
Greater availability of African genomes will improve our understanding of the role of genomic variation in genetic diseases and common complex diseases in all populations. (cdc.gov)
Dr Tarang Mehta, study author and postdoctoral research scientist at the Earlham Institute, said in a press release: "Breeders are in desperate need of genomic resources to inform their breeding programmes so traits offering greater resilience can be quickly and accurately selected for. (thefishsite.com)
The next steps are to use similar genomic approaches to find genes and their regulators associated with other traits of interest for aquaculture, like growth and disease resistance. (thefishsite.com)
Human genomic variations, including single nucleotide polymorphisms (SNPs) and copy number variations (CNVs), are associated with several phenotypic traits varying from mild features to hereditary diseases. (biomedcentral.com)
Several genome-wide studies have reported genomic variants that correlate with gene expression levels in various tissue and cell types. (biomedcentral.com)
Our results revealed altogether 217 genes and 584 SNPs whose genomic alterations affect the transcriptome in the same cells. (biomedcentral.com)
Our results revealed that in the human pluripotent stem cells, the expression values of several genes, transcripts and exons were affected due to the genomic variation. (biomedcentral.com)
Inanimals, traits are made by developmental programs known as gene regulatory networks (GRNs) that are hardwired in genomic DNA sequence. (udayton.edu)
The CsNps was located at a 13.4-kb genomic region on chromosome 3, which region contains three predicted genes. (biomedcentral.com)
In Arabidopsis , as giant single epidermal cells, trichomes have become an excellent model system to study cell differentiation and development because it is easy to analyze them at the genetic, genomic and cell biology levels. (biomedcentral.com)
Here, we use quantitative genetic and population genomic methods to investigate disease dynamics in hybrid and non-hybrid populations. (authorea.com)
Candidate genes for stomatal and disease resistance map to the same genomic regions, and are experienceing positive selection. (authorea.com)
In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched genomic features to determine variants with high posterior probabilities of being causal. (lu.se)
A study of host genomic factors related to infected by the same strain remain asymptomatic or become severe infl uenza outcomes in children was recommended only mildly ill. (cdc.gov)

The correlation between somatic mutations of target genes (16 genes, n = 79) and TCR clonality and microbial biomarkers in CRC had been investigated. (bvsalud.org)
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. (escholarship.org)
Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. (escholarship.org)
Small RNA sequencing revealed 132 conserved miRNA families expressed in flowers of C. goeringii , and 11 miRNAs corresponding to 455 putative target genes were considered to be responsible for multi-tepal development. (biomedcentral.com)
By comparing the transcriptome of mict-L130F vs WD1 and 06-2 ( mict ) vs 06-1 (wildtype, near-isogenic line of 06-2), several potential target genes that may be related to trichome development were identified. (biomedcentral.com)
Known cancer drivers, transcription factors and genes in the developmental, apoptosis, immune system and DNA integrity checkpoint gene ontology pathways were over-represented among the highest-confidence target genes. (lu.se)

Moreover, the variants cause different types of phenotypic traits varying from mild properties such as eye color to severe hereditary diseases. (biomedcentral.com)
Genetic mapping and transient infiltration experiments allowed us to validate this particular MYB transcription factor variants. (tamu.edu)
Transcription factor 7-like 2 ( TCF7L2 ) variants have been associated with type 2 diabetes mellitus (T2DM) in multiple ethnic groups. (medscape.com)
This makes TCF7L2 variants the strongest known genetic risk factors for T2DM. (medscape.com)
[ 11 ] Subsequent studies have shown that several noncoding genetic variants of TCF7L2 are associated with T2DM risk in populations of diverse ancestries in the United Kingdom, the Netherlands, Finland, Sweden, France, India, and Japan. (medscape.com)
[ 29 ] These data suggest that genetic susceptibility to T2DM as determined by TCF7L2 variants might prove an actionable indicator for early intervention and disease prevention. (medscape.com)
In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. (escholarship.org)
After this initial analysis, aiming to investigate variants with a potential regulatory role, we further screened our aseQTL data for sequence similarity with transcription factor binding sites and microRNA (miRNA) binding sites. (diagenode.com)
Potentially causal variants were significantly over-represented in active gene regulatory regions and transcription factor binding sites. (lu.se)
We applied our INQUSIT pipeline for prioritizing genes as targets of those potentially causal variants, using gene expression (expression quantitative trait loci), chromatin interaction and functional annotations. (lu.se)
Genetic analysis of TMPRSS6 catalytic domain variants in Mexican patients with iron treatment refractoriness. (cdc.gov)
Mutational analysis of hemoglobin genes and functional characterization of detected variants, through in-silico analysis, in Pakistani beta-thalassemia major patients. (cdc.gov)
Clinical significance of mutational variants in beta and alpha genes in patients with hemoglobinopathies from two large Greek centers: a complex interplay between genotype and phenotype. (cdc.gov)
UMOD risk variants identified in the above-mentioned GWAS are located in the promoter region of the gene, leading to a theory that they altered UMOD expression. (medscape.com)
Limited analysis to our knowledge, no published studies have examined of 2 genes important to the innate immune response found the association between specifi c host genetic variants and no association between genetic variants and fatal infl uenza severe infl uenza disease outcomes. (cdc.gov)
We conducted a hypothesis-generating pilot study associated deaths among previously healthy persons remain to examine if host genetic variants were associated with largely unknown ( 1 ). (cdc.gov)
Variants in blood pressure genes and the risk of Accardi R, Rubino R, Scalise M et col . (2011). (who.int)

Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)
We identify 2172 distinct variant-trait associations, including associations near genes coding for proteins in organelles implicated in inflammatory and thrombotic diseases. (ox.ac.uk)
Different factors may be operating for the formation of this effect, such as the mobilization of transposable elements, effect of inbreeding and alteration of the heat-shock proteins functions. (scielo.br)
How do distinct transcriptional regulatory proteins coordinate their job with extrinsic factors and the microenvironment? (nih.gov)
Alternatively, it can also attract proteins that block gene transcription. (prohealth.com)
A team of researchers from the Joint BioEnergy Institute's (JBEI) Feedstocks Division has, for the first time, developed a genome-scale way to map the regulatory role of transcription factors, the proteins that play a key role in gene expression and determining a plant's physiological traits. (lbl.gov)
Through its activity as a transcription factor and its interactions with other proteins, the GATA1 protein regulates the growth and division (proliferation) of immature red blood cells and platelet-precursor cells (megakaryocytes) and helps with their differentiation. (medlineplus.gov)
GATA1 gene mutations disrupt the protein's ability to bind with DNA or interact with other proteins. (medlineplus.gov)

Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. (nih.gov)
In a population of genetically diverse individuals, the extent of genetic variation of a phenotype measures the overall sensitivity of individuals to mutations segregating in the population. (nature.com)
The accepted method to address this challenge is to produce mutations, that is, to modify genes in different ways and then to examine changes in the plant's traits as a result of the mutation in the DNA and to learn from this about the function of the gene. (phys.org)
We wanted to apply this technique to improve the control of creating mutations in plants for the purposes of agricultural improvement, and specifically to overcome the common limitation posed by genetic redundancy. (phys.org)
This genetic erosion eventually became a bottleneck and various techniques to induce mutations and artificially increase variation emerged in the middle of the last century [ 9 ]. (hindawi.com)
Each of us inherits hundreds of genetic mutations from our parents, as they did from their forebears. (dorak.info)
Why do some mutations manifest later in life even though the genetic change was present at birth? (nih.gov)
Can we find common cellular pathways associated with photoreceptor cell death caused by distinct genetic mutations? (nih.gov)
Point mutations are shown to alter genes that already exist. (skeptoid.com)
Point mutations within a gene is still not adding new information, which I think is what you are pointing to, though Argent47 may have some more specific info that may say otherwise according to his post. (skeptoid.com)
Mutations in the GATA1 gene cause dyserythropoietic anemia and thrombocytopenia. (medlineplus.gov)
The disease is due to mutations in the transcription factor TBX5 , which is important in the development of both the heart and upper limbs. (medscape.com)
Molecular genetic studies reveal that the disease is caused by mutations that inactivate the transcription factor TBX5 . (medscape.com)
[ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)

The standard expression quantitative trait loci (eQTL) detects polymorphisms associated with gene expression without revealing causality. (nih.gov)
Although the majority of expression quantitative trait loci (eQTLs) for the gene expression traits in the two environments are shared and have similar effects, analysis of the environment-specific eQTLs reveals enrichment of binding sites for two transcription factors. (nature.com)
In this study, we developed a recombinant inbred line (RIL) population derived from PB3228/Gao8901 (PG-RIL) and constructed a high-density genetic map comprising 101,136 loci, spanning 4357.3 cM using the Wheat 660 K SNP array. (beds.ac.uk)
These loci are enriched in regions of open chromatin, histone modifications, and transcription factor binding, suggesting that they represent regions of the genome that are actively transcribed in the human heart. (uni-muenchen.de)
We further highlighted 67 candidate genes at the identified loci that are preferentially expressed in cardiac tissue and associated with cardiac abnormalities in Drosophila melanogaster and Mus musculus. (uni-muenchen.de)
2018). Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. (harvard.edu)
Two studies have identified quantitative trait loci (QTLs) for traits related to persistence in red clover. (biomedcentral.com)
Given that the allele-specific expression pattern may result from cis-regulatory SNPs, called allele-specific expression quantitative trait loci (aseQTLs), in this study, we searched for aseQTLs in a window of 1 Mb upstream and downstream from each ASE SNP. (diagenode.com)
The immune system consists of a large number of molecules and processes, and immunodeficiencies can therefore be caused by genetic alterations at many loci. (lu.se)

Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
Importantly, the state of plasticity or homeostasis, with respect to either genetic or environmental variation, is not necessarily static and can be modified by both genetic and environmental factors. (nature.com)
The dynamics of genetic variation (variance across different genotypes) and environmental variation (variance across different environments) may be controlled by different mechanisms. (nature.com)
Change in genetic variation across environments is one of the many forms of genotype by environment interaction (G×E). G×E can be interpreted equivalently either as variable genetic architecture across environments or as variable environmental plasticity across genotypes, depending on what factor is chosen as the context. (nature.com)
G×E has important implications in quantitative trait variation and evolution. (nature.com)
Prof. Shani says, "For thousands of years, since the agricultural revolution, man has been improving different plant varieties for agriculture by promoting genetic variation. (phys.org)
Tomato (Solanum lycopersicum) and its wild relatives harbor genetic diversity that yields heritable variation in fruit chemistry that could be exploited to identify genes regulating their synthesis and accumulation. (usda.gov)
To exploit the impact of tomato genetic diversity on carotenoids, S. pennellii introgression lines were used as a source of defined natural variation and as a resource for the identification of candidate regulatory genes. (usda.gov)
By combining the high variation of mutagenised populations with novel screening methods, traits that are almost impossible to identify by conventional breeding are now being developed and characterised at the molecular level. (hindawi.com)
Quantitative variation in these structures has not been subjected previously to large-scale genetic analysis. (ox.ac.uk)
A large number of genes were annotated in QTL intervals, which was reduced by selecting the genes with at least one SNP, which caused an amino acid variation. (irta.cat)
The cloning of agriculturally important genes is often complicated by haplotype variation across crop cultivars. (tamu.edu)
Variation in fitness components can be linked in some cases to variation of key traits. (authorea.com)
Our results indicate positive selection is filtering genetic variance from one of the parental species maladpated to a novel pathogen, and changing suites of stomatal traits which contribute to disease variation in natural populations. (authorea.com)

2000). We now describe the phenotypic and segregation analyses of this remarkable kindred, the initial approach taken to identify a candidate gene involved in this form of oligodontia, and the power of this single-family pedigree to generate significant linkage in a genome search. (nih.gov)
The main result was the construction of a genetic linkage map with 499 markers (486 SNPs, 11 SSRs, and two morphological markers) spanning 717.6 cM, with an average distance between markers of 1.5 cM/cluster. (irta.cat)
TCF7L2 was discovered as a type 2 diabetes susceptibility gene after a strong linkage signal was mapped to chromosome 10q in a Mexican-American population. (medscape.com)
Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13. (colorado.edu)
Initial linkage studies demonstrate that the gene defect resides on the long arm of chromosome 12. (medscape.com)
The locus at chromosome 1q21 was identified by linkage mapping in 1998, but the gene has only recently been discovered due to difficulty with sequencing this highly repetitive region and was previously missed using next-generation sequencing. (medscape.com)

We analyzed the enriched pathways and gene ontologies within these groups of genes, and found out that the terms related to alternative splicing and development were enriched. (biomedcentral.com)
We are now focused on delineating the transcription factors and signaling pathways that are responsible for generating photoreceptors from retinal progenitor cells. (nih.gov)
CONCLUSIONS Taken together, our findings provide new insights into genes and biological pathways controlling myocardial mass and may help identify novel therapeutic targets. (uni-muenchen.de)

Autosomal Dominant Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (msdmanuals.com)
Holt-Oram syndrome is inherited as an autosomal dominant trait that is completely penetrant. (medscape.com)
Holt-Oram syndrome is a genetic disorder that is autosomal dominant and highly penetrant. (medscape.com)
We have learned a lot more about the line-ups of both teams through recent genetic advances, although autosomal dominant (AD) Tubulointerstitial Nephritis may be the pre-match favorite due to its star performer uromodulin-associated kidney disease (UMOD) Nephropathy. (medscape.com)

Traits related to grain number and spikelet number per spike were evaluated in seven environments for quantitative trait locus (QTL) analysis. (beds.ac.uk)
Human alcoholism studies of genes identified through mouse quantitative trait locus analysis. (colorado.edu)

Transcription Factors, Gene Regulatory Networks, and Agronomic Traits. (routledge.com)
Dr Nikolai Adamski says: "The results highlight how changes in expression of transcription factors can impact on important agronomic traits for crops such as wheat. (jic.ac.uk)

We need innovative approaches to understand complex traits, rather than simply expanding the use of GWAS in studies of larger populations. (cdc.gov)
Distinguishing genetic correlation from causation across 52 diseases and complex traits. (harvard.edu)

This strategy has been used for decades with success, but it has a fundamental problem: An average plant such as tomato or rice has about 30,000 genes, and about 80% of them do not work alone but are grouped in families of similar genes. (phys.org)
With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)

As part of the research, the team of researchers used the innovative technology "CRISPR" for gene editing and methods from the field of bioinformatics and molecular genetics to develop a new method for locating genes responsible for specific traits in plants. (phys.org)
While carotenoid synthesis is well characterized, factors regulating flux through the pathway are poorly understood at the molecular level. (usda.gov)
It was known the features were controlled by one gene, and the team identified the molecular component as VRT-A2, part of the MADS-box family of transcription factors that act as genetic switches controlling protein synthesis. (jic.ac.uk)
A newly discovered molecular mechanism of DNA methylation reprogramming reveals how extra information is passed from parent to offspring in the genetic code. (jic.ac.uk)
We explore genetic disease at the molecular and cellular level and its treatment. (ncl.ac.uk)
Using a diverse sampling of species that span the full breadth of vertebrates and display all major visual ecologies, we are embarking on studies of independent evolutionary origins of traits of interest to uncover their (potentially) common molecular underpinnings. (nih.gov)
Integrated mRNA and miRNA profiling data provided comprehensive gene expression information on the wild-type and multi-tepal mutant at the transcriptional level that could facilitate our understanding of the molecular mechanisms of floral patterning of C. goeringii . (biomedcentral.com)
Modern genetic techniques have helped us hugely in characterizing these disorders and providing a molecular diagnosis in the face of nonspecific clinical data. (medscape.com)

This de novo assembly of a red clover transcriptome from leaf material of droughted and non-droughted plants provides a rich source for gene identification, single nucleotide polymorphisms (SNP) and short sequence repeats (SSR). (biomedcentral.com)
Sequence analysis showed that only one single nucleotide mutation (C → T) between 9930 and nps was found in the second exon of Csa3G748220 , a plant-specific class I HD-Zip gene. (biomedcentral.com)
Epi-", a Greek term meaning "above" or "on top of," in the term epigenetics , refers to modifications that do not change the DNA sequence itself but can turn genes on or off, affecting how transcription factors read genes. (prohealth.com)
Epigenetics, the study of changes in gene expression not caused by alterations in the DNA sequence, has revolutionized our understanding of genetics and its impact on health and longevity. (prohealth.com)

A web-based survey on various symptoms of computer vision syndrome and the genetic understanding based on a multi-trait genome-wide association study. (nih.gov)
METHODS We carried out a genome-wide association meta-analysis of 4 QRS traits in up to 73,518 individuals of European ancestry, followed by extensive biological and functional assessment. (uni-muenchen.de)
2018) Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk. (harvard.edu)

This includes the analysis of genes in germline stem cell proliferation and differentiation. (ncl.ac.uk)
We previously discovered that that Maf-family bZIP transcription factor NRL is critical for rod photoreceptor fate and functional differentiation, and that loss of NRL leads to S-cones instead of rods. (nih.gov)
Each GRN includes a fraction of the genes within an organism's genome, notably some that encode transcription factors that regulate the expression of the trait-making differentiation genes. (udayton.edu)

We introduce a coupled Bayesian regression approach--eQTeL, which leverages epigenetic data to estimate regulatory and gene interaction potential, and identifies combination of regulatory single-nucleotide polymorphisms (SNPs) that explain the gene expression variance. (nih.gov)
Population genomics and haplotype analysis in spelt and bread wheat identifies a gene regulating glume color. (tamu.edu)
2018). Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. (harvard.edu)
Their work reveals unprecedented insights into gene regulatory networks and identifies a new library of DNA parts that can be used to optimize genetic engineering efforts in plants. (lbl.gov)

This results in a more open or "relaxed" chromatin structure, enabling greater access for the transcription machinery, thereby promoting gene expression. (prohealth.com)

A putative function has been assigned, using the gene ontology approach, to the set of genes harboring at least one SSR. (researchgate.net)
The majority of the gene ontology terms and Kyoto Encyclopedia of Genes and Genomes pathway enrichment responses were for membrane-building and ploidy-related processes, consistent with the excessive floral organs and altered cell size observed in the mutant. (biomedcentral.com)
These transcript tags were annotated with gene ontology (GO) terms. (biomedcentral.com)

Influence of TFAP2B and KCTD15 genetic variability on personality dimensions in anorexia and bulimia nervosa. (nih.gov)
This is to identify mechanisms where genetic variability contributes to developing cardiovascular disease. (ncl.ac.uk)
It has been subject of many evolutionary studies within the group, due to its considerable ability to successfully occupy a wide range of environments and also because of its great genetic variability expressed by different markers. (scielo.br)
Our results indicate that the D. willistoni 17A2 strain is a candidate for hypermutability, which presents considerable cryptic genetic variability. (scielo.br)

In Cri-Du-Chat syndrome (5p deletion), the genetic basis of the phenotype is haploinsufficiency for the telomerase reverse transcriptase gene ( TERT ), which is included in the deleted part of chromosome 5. (dorak.info)

Using various functional data, we show that SNPs detected by eQTeL are enriched for allele-specific protein binding and histone modifications, which potentially disrupt binding of core cardiac transcription factors and are spatially proximal to their target. (nih.gov)
For the first time, researchers from Tel Aviv University have developed a genome-scale technology that makes it possible to reveal the role of genes and traits in plants previously hidden by functional redundancy. (phys.org)

Adaptations can occur through genetic differences, raising questions how such differences translate into phenotypic change. (udayton.edu)

But until a few years ago it was not possible to genetically intervene in a targeted manner, but only to identify and promote desirable traits that were created randomly. (phys.org)
By characterising the genes responsible for these desirable traits, we can now share these new resources with freshwater fish farms to help guide selective breeding programmes. (thefishsite.com)

Weighted correlation network analysis, also known as weighted gene co-expression network analysis (WGCNA), is a widely used data mining method especially for studying biological networks based on pairwise correlations between variables. (wikipedia.org)
However, using the absolute value of the correlation may obfuscate biologically relevant information, since no distinction is made between gene repression and activation. (wikipedia.org)
In contrast, in signed networks the similarity between genes reflects the sign of the correlation of their expression profiles. (wikipedia.org)
We identified candidate ripening/nutrient content genes based on correlation analyses and identified a potential regulator of fruit carotenoid accumulation, SlERF6. (usda.gov)
Correlation analysis between carotenoid content and gene expression profiles revealed 953 carotenoid-correlated genes. (usda.gov)

Access to pan-genome information greatly facilitates the assessment of structural variations and rapid candidate gene identification. (tamu.edu)
Haplotype comparisons across ten high-quality wheat genomes revealed a MYB transcription factor as candidate gene. (tamu.edu)

The researchers identified several genes relevant to traits that help tilapia to tolerate saltier water and acclimatise to freshwater. (thefishsite.com)
Several genes related to FSS or GNSL have been reported. (beds.ac.uk)

The results demonstrate the utility of systems-based analysis to identify genes controlling complex biochemical traits in crop species such as ripening and nutrient content. (usda.gov)
Since a missense mutation in the homeobox gene, MSX1, was previously linked to tooth agenesis in a single family lacking second premolars and third molars, we performed a mutational analysis of MSX1 by PCR. (nih.gov)
Further, the conditional QTL analysis revealed a predominant contribution of PB3228 to the GNS QTLs, with both grain number per spikelet (GNSL) and spikelet number per spike (SNS) contributing to the overall GNS trait. (beds.ac.uk)
The analysis was performed by evaluation of fruit quality traits during three consecutive seasons in an F1 progeny of 194 siblings, which were obtained from the intraspecific cross between the yellow-flesh peach "O'Henry" and the white-flesh nectarine NR-053. (irta.cat)
OBJECTIVES This meta-analysis sought to gain insights into the genetic determinants of myocardial mass. (uni-muenchen.de)
Genes controlling floral organ identity have been identified through the genetic analysis of homeotic mutants, leading to the ABCDE model, in which five classes of regulatory genes (A, B, C, D and E) work in a combinatorial manner to confer the organ identities of the four whorls [ 10 ]. (biomedcentral.com)
Comparison of gene expression levels between pools and treatments identified candidate genes for further analysis of the genetic basis of drought tolerance in red clover. (biomedcentral.com)
Using F 2 and BC 1 populations constructed from a cross between nps and '9930', the genetic analysis showed that the nps trait is controlled by a single recessive nuclear gene. (biomedcentral.com)

Here, we identified the red glume 1 (Rg-B1) gene using association genetics and haplotype analyses in ten reference grade wheat genomes. (tamu.edu)
Our study demonstrates the value of multiple high-quality genomes to rapidly resolve copy number and haplotype variations in regions controlling agriculturally important traits. (tamu.edu)

It is also estimated that each human being is a carrier of around five recessive lethal genes and perhaps even more recessive disease genes, which may pose risk for the offspring of related individuals (such as cousin marriages). (dorak.info)

eQTeL SNPs capture a substantial proportion of genetic determinants of expression variance and we estimate that 58% of these SNPs are putatively causal. (nih.gov)
We computed the linear relationships between SNPs and expression levels of exons, transcripts and genes, and the associations between gene CNVs and gene expression levels. (biomedcentral.com)
Further, for a few of the resulted genes, the expression value was associated with both CNVs and SNPs. (biomedcentral.com)
To obtain DNA for genotyping, a 10-m section polymorphisms (SNPs) in 2 candidate genes important from blocks containing formalin-fi xed, paraffi n-embedded in the innate immune response to infl uenza infection and tissues was deparaffi nized with xylene and washed twice for which national prevalence estimates were available: with absolute ethanol. (cdc.gov)

For any CRE, its ability to activate gene expression in specific cell types and developmental times is due to the binding sites it possesses for a particular combination of transcription factors. (udayton.edu)
A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)

this means that AR is able to regulate gene expression and that the AR protein is a transcription factor . (helix.com)
The whole mitogenome of O. conispadiceus is 16,027 basepairs (bp) in length with a base composition of 41.4% A, 34.8% T, 16.1% C, 7.7% G and contains 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and a major non-coding region (MNR). (tonmo.com)
In hypermobility type of Ehlers-Danlos syndrome , haploinsufficiency (where one copy is unable to produce the protein in sufficient quantity) due to a 30-kb deletion of tenascin-X (TNXB) gene is responsible for the disease. (dorak.info)
NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
In Arabidopsis leaf epidermal cells, the MYB-bHLH-WDR (MBW) complex is formed by the R2R3 type MYB transcript factor GLABRA 1 (GL1), bHLH transcript factors GLABRA 3/ENHANCER OF GLABRA 3 (GL3/EGL3), and WD40 repeat protein TRANSPARENT TESTA GLABRA 1 (TTG1). (biomedcentral.com)
The GATA1 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and helps control the activity of many other genes. (medlineplus.gov)
On the basis of this action, the GATA1 protein is known as a transcription factor. (medlineplus.gov)

The pattern of inheritance of the oligodontia trait suggested the involvement of a single gene bearing a dominant mutation. (nih.gov)
Most single gene disorders can be investigated by prenatal diagnosis using DNA extracted from cells obtained from amniocentesis at 16-18 weeks' gestation or chorionic villus sampling (CVS) at about 10-12 weeks' gestation. (dorak.info)
In single gene disorders (as opposed to multifactorial-complex disorders), the mutation's population frequency is low, its penetrance is high, and the contribution of environment is lower with notable exceptions of PKU and few others. (dorak.info)

AR has the potential to regulate many different genes and thus many different behaviors1-3. (helix.com)

Our MPhil, MD and PhD in Genetics look at the causes of genetic disease. (ncl.ac.uk)
As with many diseases, tumor formation in colorectal cancer (CRC) is multifactorial and involves immune, environmental factors and various genetics that contribute to disease development. (bvsalud.org)
Wonil Chung, Omer Weissbrod and Margaux Hujoel were awarded as semifinalists for the Charles J. Epstein Trainee Award for Excellence in Human Genetic Research for the 2018 American Society of Human Genetics Conference in San Diego, California this October. (harvard.edu)

Methylation generally serves to suppress gene transcription, meaning that genes with methyl tags are less likely to be expressed. (prohealth.com)

There were 29 MADS-box genes, as well as a large number of floral-related regulators and hormone-responsive genes, considered as candidates regulating floral patterning of C. goeringii . (biomedcentral.com)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)

One of them was the need to identify as precisely as possible which genes in the plant's genome are responsible for a specific desired trait to cultivate. (phys.org)

The development is expected to revolutionize the way agricultural crops are improved as it can be applied to most crops and agricultural traits, such as increased yield and resistance to drought or pests. (phys.org)

To identify more genes for GNS, it is essential to detect major QTLs that are mapped by a high-density genetic map with a small confidence interval. (beds.ac.uk)

High-Throughput Approaches for Characterization and Efficient Use of Plant Genetic Resources. (routledge.com)
We are using state-of-the-art next generation sequencing combined with bioinformatic strategies, and developing stem cell-based approaches for gene therapy and drug discovery. (nih.gov)
By using genetic, bioinformatic, and microscopy approaches, we continue to resolve the important connections that orchestrate this GRN's operation.Success in the pursuit will open future research opportunities to reveal how this GRN has been reformulated to deal with differing climates, findings that bear upon the genetic underpinnings of animal adaptations more broadly. (udayton.edu)

Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies. (urv.cat)
However, there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk allele. (urv.cat)
If expression of a trait requires only one copy of a gene (one allele). (msdmanuals.com)
For 215 aseQTLs, one allele potentially affected the affinity of a muscle-expressed transcription factor to its binding site. (diagenode.com)

Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. (nih.gov)

The genetic map demonstrated high collinearity with the wheat assembly IWGSC RefSeq v1.0. (beds.ac.uk)

A prerequisite to answering these evolutionary questions is to understand the genetic basis for trait development. (udayton.edu)

Among them, 18,489 were identified as differentially expressed genes between the two libraries according to comparative transcript profiling. (biomedcentral.com)

That some gene states that have physiological or morphological effects in the adult persist for multiple generations is neither surprising nor requiring major renovations of evolutionary theory. (scienceblogs.com)
We focus our investigation on morphological and ecophysiological traits which inform our understanding of physiology, growth, and defense against a pathogen. (authorea.com)

Among these factors, an important role is played by the soluble solids content (SSC) and the postharvest performance represented by mealiness (M) susceptibility as a chilling injury disorder. (irta.cat)
These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)

Put another way, controlling gene expression means AR can control the behavior of our cells, and that means these hormones can affect our physiology in numerous different tissues. (helix.com)

Among them, class A genes, such as APETALA1 ( AP1 ) in Arabidopsis , specify the outer-most floral organs, the sepals. (biomedcentral.com)
In contrast to Arabidopsis , a limited number of cucumber genes related to the formation and development of trichomes have been identified. (biomedcentral.com)

They are used by evolutionary biologists but they do not specifically describe any specific genetic or selective process. (skeptoid.com)
Metric traits that lie at the intersection of development, defense, and ecological interactions may be expected to experience strong environmental selection, informing our understanding of evolutionary and ecological processes. (authorea.com)

Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population. (nih.gov)
How do numerous non-coding variations in the human genome affect gene expression in the retina? (nih.gov)

Identifying a genetic element that controls the elongated grains and glumes of Polish wheat, Triticum polonicum, could translate into genetic improvements and productivity. (jic.ac.uk)
Grain number per spike (GNS) is one of three component traits that contribute to the grain yield of wheat ( Triticum aestivum L.) [ 1 ]. (beds.ac.uk)

Secretion of tumor necrosis factor (TNF)-α and interleukin (IL)-1 could induce obesity- and diabetes mellitus (DM)-related inflammation, however its association with SG procedure has not been elucidated well. (researchgate.net)
After residual ethanol evaporated, the gene for tumor necrosis factor superfamily, member 2 tissues were digested overnight at 56°C in 200 L Buffer (offi cial symbol TNF ) and the mannose-binding lectin gene PKD with 20 L proteinase K (QIAGEN, Valencia, CA, (offi cial symbol MBL2 ). (cdc.gov)

The team optimised a genome sequencing approach that reveals the activity of potential transcription factor binding sites and genetic switches for turning expression on and off. (thefishsite.com)

The researchers then identified genetic differences at gene regulatory regions in the Nile tilapia and 27 other tilapia species. (thefishsite.com)
Their assumption was that differences between the Nile tilapia, a freshwater species, and species adapted to saline waters are likely to have arisen to control genes involved with adapting to different water environments. (thefishsite.com)
Since human demand for good traits and yield is very high, only a small fraction of the world's approximately 200,000 plant species have, through history, survived the rigorous scrutiny of the domestication process. (hindawi.com)
One is caused by new genetic information in which a new species arises, and is the evolution that is disputed by creationists. (skeptoid.com)

These included genes involved in metabolism and general housekeeping processes responsible for reacting to environmental changes in order to maintain balance. (thefishsite.com)
The genetic transformation of plants and the subsequent development of transgenic lines with disturbed sugar metabolism have made an unprecedented impact on the study of sugar translocation and -partitioning. (sun.ac.za)

Finally, although genotype by environment interaction in gene expression could potentially disrupt genetic networks, the co-expression networks are highly conserved across environments. (nature.com)

Anatomy17

Organisms8

Chemicals and Drugs125

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes81

Disciplines and Occupations1

Information Science4

Phenotypes8

Regulation11

Genomic17

Target genes6

Variants17

Proteins8

Mutations15

Loci9

Variation14

Linkage6

Pathways3

Autosomal dominant4

Quantitative trait2

Agronomic Traits2

Complex traits2

30,000 genes2

Molecular8

Sequence4

Genome-wide3

Differentiation3

Identifies4

Chromatin1

Ontology3

Variability4

Chromosome1

Functional2

Phenotypic1

Desirable traits2

Correlation5

Candidate gene2

Several genes2

Analysis8

Genomes2

Recessive1

SNPs4

Developmental2

Protein7

Single gene3

Different genes1

Genetics3

Methylation1

Regulators2

Plant's1

Crops1

QTLs1

Approaches3

Allele4

Homeobox1

RefSeq1

Understand the genetic1

Differentially1

Morphological2

Susceptibility2

Controlling gene expression1

Arabidopsis2

Evolutionary2

Variations2

Triticum2

Tumor necros2

Reveals1

Species4

Metabolism2

Potentially disrupt1