Trabecular bioactive glass bone regeneration. Medical search. Frequent questions

In the last few years, optimal fixation of orthopaedic implants evolved to preserve host bone and enhance tissue integration by surface modifications, including the use of coatings with bioactive ceramics. (edu.pl)
The 3D-printed scaffold structures are used as supports in replacing and repairing fractured bone tissue. (mdpi.com)
Aim: Recently, oral surgery became rich with new means to improve the relationship between the bone substitutes, surrounding tissue and human organism: the regeneration led by the tissues represents one of the most encouraging examples. (unict.it)
Low-level laser therapy associated to a resistance training protocol on bone tissue in diabetic rats. (warminglight.com)
We show that each of these topographic scale ranges represents a scale range found in natural bone tissue. (toysis.pics)
Therefore, in natural bone remodeling, the bonding phenomenon is limited to submicron interlocking [3], however, the long-term physical stability of the interface between new and old bone, which is crucial for the stability of skeletal tissue, depends on the higher-order morphology properties. (toysis.pics)
Given the paucity of effective clinical treatments, basic scientists are developing novel options for protection of the affected brain and regeneration of lost tissue. (researchgate.net)
Emerging directions in stroke neural repair approaches combine these two therapies to use biopolymers with stem/progenitor transplants to promote greater cell survival in the transplant and directed delivery of bioactive molecules to the transplanted cells and the adjacent injured tissue. (researchgate.net)
In this review, we highlight recent developments in our understanding of the metabolic adaptations that influence osteoclast behavior and the overall remodeling of bone tissue. (bvsalud.org)
Our previous research indicated that Dickkopf-1 (Dkk1), a Wnt inhibitor, is upregulated in bone tissue in obesity and that osteoblast-derived Dkk1 drives obesity-induced bone loss. (bvsalud.org)
Bone tissue engineering. (dokumen.pub)
Electrospun biomaterials for bone tissue engineering. (dokumen.pub)
Nanocomposites in bone tissue engineering applications. (dokumen.pub)
The micro-CT result from the posterolateral fusion model showed whitlockite had slightly but significantly higher percent bone volume than tricalcium phosphate, though none of the materials formed successful fusion with surrounding bone tissue. (biomedcentral.com)
A wide range of synthetic and natural biomaterials is being used to develop tissue-engineered bone. (openorthopaedicsjournal.com)
A selective literature review was performed for carbon nanostructure composites in bone tissue engineering. (openorthopaedicsjournal.com)
Recently, carbon-modified biomaterials for bone tissue engineering have been extensively investigated to potentially revolutionize biomaterials for bone regeneration. (openorthopaedicsjournal.com)
This review summarizes the chemical and biophysical properties of carbon nanostructures and discusses their functionality in bone tissue regeneration. (openorthopaedicsjournal.com)
In the quest for alternative therapeutic strategies, research is focusing on the concept of tissue engineering to assist the progress of bone tissue regeneration. (openorthopaedicsjournal.com)
Experimental silicon deprivation in rats [ 14 - 16 ] and chicks [ 17 , 18 ] demonstrated marked effects on growth and bone metabolism which in some studies resulted in aberrant connective tissue and bone mineralization (thinner cortex, less calcified bone matrix) and bone defects. (biomedcentral.com)
Interest in calcium phosphate cements as materials for the restoration and treatment of bone tissue defects is still high. (encyclopedia.pub)
Bone tissue is a part of the human musculoskeletal system, which participates in the transfer of force from one part of the body to another under controlled tension, and protects and fixes internal organs. (encyclopedia.pub)
Bone tissue is a reservoir of calcium and phosphate ions in the form of hydroxyapatite, so it plays an important role maintaining the proper calcium levels, along with in other organs [ 5 ] [ 6 ] . (encyclopedia.pub)
They are able to deliver functional substances locally, fill in defects and serve as a material for bone tissue reconstruction. (encyclopedia.pub)
Calcium phosphate cements are similar in composition to the mineral component of bone tissue. (encyclopedia.pub)
The functionalization of calcium phosphate cements is of great clinical interest for the treatment or prevention of various diseases of bone tissue. (encyclopedia.pub)

Many bone substitutes have been applied for sinus regeneration procedure, such as autogenous bone, inorganic bovine bone, porous and resorbable hydroxyapatite, tricalcium phosphate, bioactive glass, and blood clot. (unict.it)
In vivo comparison of a granular and putty form of a sintered and a non-sintered silica-enhanced hydroxyapatite bone substitute material. (uni-rostock.de)
Hydroxyapatite-glass nanocomposites. (dokumen.pub)
Bone substrates like hydroxyapatite and tricalcium phosphate have been widely used for promoting spinal fusion and reducing the complications caused by autograft. (biomedcentral.com)
Whitlockite had a potential of being a better bone substrate hydroxyapatite and tricalcium phosphate in spinal fusion with low risk of inducing ectopic ossification. (biomedcentral.com)
11 Calcium phosphate-coated implants have been described in the literature which demonstrate early direct bone attachment to the hydroxyapatite surface and this occursas quickly as one month post-operatively. (com.pk)

Electrophoretic Deposition of MesoporousBioactive Glass on Glass-Ceramic Foam Scaffolds for Bone TissueEngineering, J. Mater. (edu.pl)
In this study, the printing capability of two different additive manufacturing (3D printing) techniques, namely PolyJet and micro-stereolithography (µSLA), are investigated regarding the fabrication of bone scaffolds. (mdpi.com)
Printed bone scaffolds with complex structures produced using additive manufacturing technology can mimic the mechanical properties of natural human bone, providing lightweight structures with modifiable porosity levels. (mdpi.com)
The application of bone grafts is oriented to promote bone formation with faster resorption processes and new combinations of osteoinductive scaffolds. (unict.it)

Structural and biomechanical adaptations to free-fall landing in hindlimb cortical bone of growing female rats. (isbweb.org)
The histology results showed the bone formed on the cortical surface of the transverse process but did not form a bridge between the processes. (biomedcentral.com)
Here, we ablate estrogen receptor alpha (ERα) in the medial basal hypothalamus and find a robust bone phenotype only in female mice that results in exceptionally strong trabecular and cortical bones, whose density surpasses other reported mouse models. (regenerativemedicine.net)

The tissues present in the sample were composed of 2 ± 2% of lamellar bone, 36 ± 1% of woven bone and 58 ± 4% of marrow spaces. (unict.it)
They were initially found in the bone marrow [ 11 ] but can also be found in other tissues, such as adipose, periosteum, muscle, placenta, and trabecular bone [ 12 ]. (hindawi.com)
Electrospun nanocomposite for bone tissues regeneration via osteoconduction, osteoinduction, and osteogenesis. (dokumen.pub)
Her research group is particularly interested in developing biomaterials and cell-based therapeutics to improve regeneration of various musculoskeletal tissues including bone, cartilage, tendon, blood vessels etc. (stanford.edu)

Low-level laser therapy stimulates bone metabolism and inhibits root resorption during tooth movement in a rodent model. (warminglight.com)
Taken together, our results indicate that LLLT can stimulate bone remodeling reducing root resorption in a rat model. (warminglight.com)
This sequence mimics the events that occur at sites of natural bone remodeling where the surface left by resorption of active osteoclasts presents a nanotopographically complex surface with undercuts [3], [4]. (toysis.pics)
Metabolic reprogramming in these cells not only supports phenotypic changes, but also provides the necessary energy for their highly energy-consuming activity, bone resorption. (bvsalud.org)
The HA was the primary mineral component of teeth and bone, due to its relatively high Ca/P ratio, its resorption rate was low and it was reported that only 5.4% of HA implants was reduced in rabbit cancellous bone in 6 months [ 14 ]. (biomedcentral.com)
Bone formation markers in serum and urinary resorption markers were measured at baseline, and after 6 and 12 months. (biomedcentral.com)
A trend for a dose-corresponding increase was observed in the bone resorption marker, collagen type I C-terminal telopeptide (CTX-I). (biomedcentral.com)

Recently, several studies have shown that ADSC-derived exosomes can exert similar biological effects as ADSCs and enhance bone regeneration [ 27 , 28 ]. (hindawi.com)
On this basis, we are motivated to review all the important in vivo studies that have used Simvastatin to either treat osteoporosis or accelerate and enhance bone regeneration. (syksignaling.com)

Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization. (uni-rostock.de)

The mechanical properties of the porous glass-ceramic, which mimics the 3-D pore architecture of cancellous bone, are adequate for load-bearing applications (compressive strength of 19 MPa and fracture energy around 6.5×10−4 J mm−3, with a total porosity of 62 vol. (edu.pl)
Furthermore, Howship's lacunae form themselves on a bone surface with an even higher order topography, as can be seen from the strut-like morphology of the bony trabeculae in cancellous bone. (toysis.pics)
Dendorfer, S. Biomechanical analysis of iliac crest loading following cortico-cancellous bone harvesting. (isbweb.org)

Where necessary, we subjected the bone-implant interface to a mechanical fracture test. (toysis.pics)
Spinal fusion is different from bone fracture, the fusion procedure requires bone grafting to add osteogenic potential [ 1 ]. (biomedcentral.com)
The primary cause for the decline in bone mineral density (BMD) and increased susceptibility to fracture in women, is the decrease in circulating estrogens at the onset of menopause. (biomedcentral.com)
This systematic review clears the mechanisms of action of Simvastatin on bone metabolism and focuses on in vivo investigations that have evaluated its role on osteo- porosis and fracture repair to fi nd out (i) whether Simvas- tatin is effective on treatment of osteoporosis and fracture repair, and (ii) which of the many available protocols may have the ability to be translated in the clinical setting. (syksignaling.com)
Then, the different in vivo investi- gations that used Simvastatin in the fi eld of bone research were systematically compared and researched in order to find out (i) whether Simvastatin is effective in treatment of osteoporosis and fracture healing, and (ii) which of the many available protocols may have the ability to be translated in the clinical setting. (syksignaling.com)

However, contact osteogenesis can result in bone attachment to the implant surface if the implant has a surface topography with submicron physical undercuts [3]. (toysis.pics)
Statins are lipid lowering drugs and are routinely administered in treatment of hyperlipidemia.1,2 In the last two decades, scientists have found that statins have other mechanisms that may be bene- ficial in bone regeneration.3 Lipophilic statins such as Simvastatin increase osteogenesis by enhancing differentiation of mesenchy- mal cells into osteoblasts, upregulating bone morphogenetic pro- tein-2 (BMP-2) and down regulating osteoblast apoptosis. (syksignaling.com)

The biomaterial which is gradually replaced by new bone apposition. (unict.it)

Fibrin Sealant Derived from Human Plasma as a Scaffold for Bone Grafts Associated with Photobiomodulation Therapy. (warminglight.com)
In clinical practice, autologous and allogenic bone grafts can be a "gold standard" in bone defect treatment, even they have certain limitations such as chronic pain, poor cosmesis, nonunion, and infection [ 2 , 3 ]. (hindawi.com)
Other bone grafts include allograft and xenograft. (biomedcentral.com)

Results: CBCT scans bone augmentation showed in all patients treated hyperdensity in comparison between immediate postoperative period and late postoperative period, with more density than native bone at both times (mean volume after graft elevation= 2906 mm3, min=2148.8 mm3 max= 3146.4 mm3). (unict.it)
The effect of oral choline-stabilized orthosilicic acid (ch-OSA) on markers of bone turnover and bone mineral density (BMD) was investigated in a double-blind placebo-controlled trial. (biomedcentral.com)

The effects of shock wave stimulation of mesenchymal stem cells on proliferation, migration, and differentiation in an injectable gelatin matrix for osteogenic regeneration. (uni-rostock.de)

5] Verné E., Bioactive glass and glass-ceramic coatings, In: JonesJ.R., Clare A.G. (Eds. (edu.pl)
7] Lee T.M., Chang E., Wang B.C., Yang C.Y., Characteristics ofPlasma-Sprayed Bioactive Glass Coatings on Ti-6Al-4V Alloy: Anin Vitro Study, Surf. (edu.pl)
Mesoporous Bioactive Glass Coatings on Stainless Steel for EnhancedCell Activity, Cytoskeletal Organization and AsMg Immobilization,J. Mater. (edu.pl)

Deng, G. Finite element analysis of the tibial bone graft in cementless total knee arthroplasty. (isbweb.org)

In vitro bioactive behaviour was investigated by testing the samples in simulated body fluid and by evaluating the apatite formation on the surface and pore struts of the trabecular coating, which is a key precondition for in vivo osteointegration. (edu.pl)

2] Hench L.L., Chronology of Bioactive Glass Development andClinical Applications, N. J. Glass Ceram. (edu.pl)
12] Baino F., Vitale-Brovarone C., Feasibility of Glass-Ceramic Coatingson Alumina Prosthetic Implants by Airbrush SprayingMethod, Ceram. (edu.pl)

However, the placement of implants requires the presence of a sufficient amount of alveolar bone. (mdpi.com)
It is believed that implants with roughened surfaces offer better bone anchoring and biomechanical stability. (com.pk)

Allograft was the bone-derived from humans and was a suitable alternative to autograft, but allograft has high a cost and a risk of disease transmission. (biomedcentral.com)

The maxillary sinuses were filled with MgHA/collagen-based scaffold with a porous three-dimensional design (3D) with a composite architecture, mimicking the complex hierarchically organized bone structure. (unict.it)

Furthermore it was observed seams of osteoblasts and unmineralized matrix with collagen fibrils at areas of new bone apposition. (unict.it)
Association of Bioglass/Collagen/Magnesium composites and low level irradiation: effects on bone healing in a model of tibial defect in rats. (warminglight.com)
Overall, there was a trend for ch-OSA to confer some additional benefit to Ca and Vit D3 treatment, especially for markers of bone formation, but only the marker for type I collagen formation (PINP) was significant at 12 months for the 6 and 12 mg Si dose ( vs . placebo) without a clear dose response effect. (biomedcentral.com)
Combined therapy of ch-OSA and Ca/Vit D3 had a potential beneficial effect on bone collagen compared to Ca/Vit D3 alone which suggests that this treatment is of potential use in osteoporosis. (biomedcentral.com)

They can be associated with various pathogenic conditions and clinical outcomes, including injuries (fractures), infections (osteomyelitis), tumors, osteoporosis, and many other bone diseases [ 7 ] . (encyclopedia.pub)

Infrared laser and bone metabolism: a pilot study. (warminglight.com)
Simvastatin is a lipid lowering drug whose beneficial role on bone metabolism was discovered in 1999. (syksignaling.com)
Fig. 1 Mechanism of Simvastatin on bone metabolism. (syksignaling.com)

Among them, autogenous or heterologous bone and a large variety of synthetic or animal-derived biomaterials have been used. (mdpi.com)

In trauma and orthopaedic surgery, extended bone loss is associated with considerable technical and physiological issues. (openorthopaedicsjournal.com)

Over the last decades, mesenchymal stem cells (MSCs) have attracted extensive attention in the field of bone regeneration [ 4 - 7 ]. (hindawi.com)

We have found that even the smoothest surfaces, when modified with submicron crystals, can bond to bone. (toysis.pics)
However, as the movement stress through the bone to the implant increased with healing time, such interfaces failed while others with submicron features superimposed on surfaces of increasing microtopographical complexity remained intact under stress. (toysis.pics)
9]. We therefore hypothesize that bone bonding could occur on surfaces with submicron topographical complexity in the absence of microtopography. (toysis.pics)

Whitlockite has been reported to promote better bone formation in rat calvaria models compare with them, but no study investigated its effect on spinal fusion yet. (biomedcentral.com)

and peri-implant bone remodeling [1], [2]. (toysis.pics)
Bony union means the interlocking of the cement matrix of the bone with the properties of the underlying implant surface. (toysis.pics)
However, bone healing is assessed by attempting to separate the bone from the implant. (toysis.pics)
When the bone is attached to the implant surface, the force that breaks the pattern causes the bone to detach from the bone-implant interface [5], [6]. (toysis.pics)
According to statistics, 20 million orthopedic surgeries in the world per year are performed, 70% of which require the use of bone implant material for filling and repairing bone defects [ 8 ] . (encyclopedia.pub)

The attraction towards Ti and its alloys reside in their superior mechanical and tribological features, as compared to CaPs, which are renowned for their compositional and structural features similar to those of natural bones. (infim.ro)
Incorporation of carbon nanostructures significantly improves the mechanical properties of various biomaterials to mimic that of natural bone. (openorthopaedicsjournal.com)

Alveolar bone response to light-force tipping and bodily movement in maxillary incisor advancement: A prospective randomized clinical trial. (vcu.edu)

Effective reconstruction of craniomaxillofacial bone defects caused by trauma, tumor resection, or congenital malformation is a major problem in orthopedic surgery. (hindawi.com)
Various osteoplastic materials can be used to fill in bone defects caused by various diseases, or for the purpose of their prevention. (encyclopedia.pub)

Mineral formation in the larval zebrafish tail bone occurs via an acidic disordered calcium phosphate phase. (mpg.de)
We propose that this newly-identified female brain-to-bone pathway exists as a homeostatic regulator diverting calcium and energy stores from bone building when energetic demands are high. (regenerativemedicine.net)

A circular defect in each parietal bone of six Wislander rats was created. (warminglight.com)
However, this ability is lost when the area of the bone defect exceeds a critical size. (hindawi.com)

Blocks and granules made of pre-hardened cement are a promising type of skeleton for the restoration of bone defects. (encyclopedia.pub)

Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats. (warminglight.com)
Since WH has been shown to have positive effects on the enhancement of bone formation in a rat calvaria model, it may represent a potential bone substitute material to be used for the spinal fusion. (biomedcentral.com)

Recent advances in developing biocompatible materials for treating bone loss or defects have dramatically changed clinicians' reconstructive armory. (openorthopaedicsjournal.com)

Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)

The InGaAsP laser at the low dosage induced a favorable effect on bone formation in the orthopedically expanded midpalatal suture of rats. (warminglight.com)

Bone tissue's ability to regenerate effectively, maintain mineralization and repair itself after damage depends on its ability to dynamically remodel. (encyclopedia.pub)

Silicon supplementation, on the other hand, was shown to have beneficial effects on bone. (biomedcentral.com)

Osteoporosis is defined as progressive skeletal disorder, characterised by low bone mass (osteopenia) and micro-architectural deterioration, resulting in an increase in bone fragility and increased risk to factures [ 1 ]. (biomedcentral.com)

Bone specimens were obtained by trephine bur to achieve histological and histomorphometrical analysis to evaluate the residual grafted material, the percentages of newly-formed bone and marrow spaces. (unict.it)

There are many different clinical circumstances under which a significant part of bone or a whole bone is lost. (encyclopedia.pub)

Thus, in this study, we investigated the influence of adipogenic Dkk1 on bone homeostasis and obesity-induced bone loss in mice. (bvsalud.org)

In fact, it is salutary to emphasize that in natural bone remodeling, the cementum matrix invades the underlying resorbed bone surface to a depth of about one micron, which corresponds to the depth of penetration of the fibrous rim of the ruffled membrane of osteoclasts in the resorbed matrix. (toysis.pics)
However, using the natural bone interface as a model, it is also evident that osteoclasts produce Howship lacunae, which are depressions excavated in the bone surface ranging in size from microns to hundreds of microns. (toysis.pics)

In most cases, bones can regenerate and heal themselves [ 1 ]. (hindawi.com)

Effects of laser acupuncture on longitudinal bone growth in adolescent rats. (warminglight.com)

We attempt to decipher the effects of submicron topography and microtopography on bone union phenomena and endosseous interface stability. (toysis.pics)

Evaluation of the Effects of Low-Level Laser Therapy on Diabetic Bone Healing. (warminglight.com)
Histologic Evaluation of Early Bone Regeneration Treated with Simvastatin Associated with Low-Level Laser Therapy. (warminglight.com)

A new bone adhesive candidate- does it work in human bone? (uu.se)

Anatomy34

Organisms11

Diseases16

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes26

Disciplines and Occupations1

Technology, Industry, Agriculture23

Tissue26

Hydroxyapatite6

Scaffolds4

Cortical3

Tissues4

Resorption7

Enhance bone regeneration2

Composite Filaments1

Cancellous bone3

Fracture5

Osteogenesis2

Biomaterial1

Grafts3

Density2

Osteogenic1

Coatings3

Graft1

Vitro1

Ceram2

Implants2

Allograft1

Porous1

Collagen4

Fractures1

Metabolism3

Autogenous1

Orthopaedic1

Field of bone1

Surfaces3

Better bone1

Implant5

Mechanical2

Alveolar1

Defects caused2

Calcium2

Defect2

Cement1

Calvaria2

Biocompatible1

Processes1

Effect on bone1

Mineralization1

Effects on bone1

Osteoporosis1

Marrow1

Clinical1

Homeostasis1

Natural bone2

Regenerate1

Rats1

Endosseous1

Evaluation2

Human1