• Daily doses of calcium folinate should be adjusted depending on the hematological toxicity of trimetrexate. (janusinfo.se)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
  • Minimally, the researchers requested hematological determinations to assess leukopenia (=5000 leukocytes) and hypertransaminasemia of =150 U/L, a number over three times the GOT and GPT normal values according to age and sex. (who.int)
  • SBRT combined with chemotherapy for the treatment of locally advanced pancreatic cancer can effectively control local tumors and alleviate local symptoms, prolong the overall survival of patients, and has tolerable toxicity ( 16 - 19 ). (frontiersin.org)
  • This schedule of combined modality therapy is not only effective but appears to have tolerable toxicity, because of the relative lack of late effects. (emmes.com)
  • The combination of temozolomide and IFN-alpha 2b can easily be administered and shows tolerable toxicity. (nih.gov)
  • As a result of inorganic arsenic's direct toxicity to the epithelial cells of the gastrointestinal tract and its systemic enzyme inhibition, profound gastroenteritis, sometimes with hemorrhage, can occur within minutes to hours after ingestion. (cdc.gov)
  • Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. (bvsalud.org)
  • 2BP also affect the hematopoietic system and thus induce leukopenia and normocytic anemia. (sjweh.fi)
  • Leukopenia and hepatic toxicity (acute cholestatic or chronic active hepatitis) have been reported, and hemolytic anemia can occur in patients with G6PD deficiency and in infants 1 month of age. (msdmanuals.com)
  • Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)
  • Discontinue hydroxychloroquine if renal toxicity is suspected or demonstrated by tissue biopsy in any organ system. (nih.gov)
  • No acute toxicity of grade 4 or 5 was observed. (frontiersin.org)
  • Contaminated soil may also be a source of significant arsenic exposure in children, although it is not likely that children would ingest sufficient arsenic-contaminated soil to cause significant acute toxicity. (cdc.gov)
  • In cases of verified ABZ toxicity, the dosage was immediately lowered to 7.5 mg/kg/day and the blood count and functional hepatic test run weekly until the values normalized. (who.int)
  • Lomustine causes high levels of organ toxicity, which must be taken into account when determining dosing for elderly patients. (wikipedia.org)
  • In addition, a small prospective, multicenter, randomized control trial conducted in patients with granulomatosis with polyangiitis showed intravenous pulse cyclophosphamide may be not only as effective as oral cyclophosphamide but also may avoid some of the systemic toxicity. (medscape.com)
  • Arsenic trioxide dust is readily absorbed from the lungs, but inhaled quantities are usually insufficient to cause acute systemic toxicity. (cdc.gov)
  • Systemic toxicity may be caused by skin contact. (chemicalbook.com)
  • Liver enzymes and function should be monitored during use and dose should be adjusted based on toxicity levels. (wikipedia.org)
  • The dose-limiting toxicity has not yetbeen reached. (cancernetwork.com)
  • This combination regimen in patients with upper gastrointestinalmalignancies and breast cancer will be investigated as partof phase II studies, once the dose-limiting toxicity is determined. (cancernetwork.com)
  • The dose-limiting toxicity has not yet been reached. (cancernetwork.com)
  • The purpose of the study was to investigate the antitumour activity and toxicity of high dose (120 mg m-2) single agent epirubicin therapy in untreated extensive small cell lung cancer patients. (nih.gov)
  • The high antitumour activity and no increase in toxicity justify the incorporation of high dose epirubicin into combination therapy. (nih.gov)
  • The primary objective of this phase lb study was to determine the dose limiting toxicity and maximum tolerated dose of combination of subcutaneous decitabine with oral vemurafenib in patients with V600E BRAF positive metastatic melanoma with or without any prior treatment. (oncotarget.com)
  • No dose limiting toxicity was encountered and maximum tolerated dose was not reached. (oncotarget.com)
  • One third of the patients had at least 1 dose reduction of docetaxel due to toxicity. (unav.edu)
  • Similarly, toxicity can result from exposure to superwarfarins, which are long-acting anticoagulants used in rodenticides. (medscape.com)
  • Conclusion: We report for the first time a relation between docetaxel exposure and toxicity and recommend specific targets of drug exposure with implications for the clinical management of early breast cancer patients. (unav.edu)
  • Exposure to benzene elicits a range of hematotoxicity from leukopenia to leukemia. (cdc.gov)
  • Induction of CYP4F3 may playa role in benzene hematotoxicity and serve as a biomarker of benzene exposure and toxicity. (cdc.gov)
  • Lomustine use is linked to a variety of organ toxicities hepatotoxicity, nephrotoxicity, and pulmonary toxicity. (wikipedia.org)
  • The authors conclude that combined radiotherapy and chemotherapy, although significantly more effective in reducing recurrence than no therapy, is significantly more toxic than single-modality therapy in many parameters, although most of the toxicity is transient and therefore not limiting. (emmes.com)
  • The present study aimed to compare the survival outcomes, acute toxicities and surgical complications in LARC patients who received preoperative chemoradiotherapy with triweekly oxaliplatin and capecitabine (triweekly XELOX) or capecitabine. (biomedcentral.com)
  • After PS adjustment, the differences between the two groups remained insignificant in pCR rate, survival outcomes, and acute toxicities, and the difference in surgical complications disappeared. (biomedcentral.com)
  • Triweekly XELOX or capecitabine concurrent with neoadjuvant radiotherapy leads to similar long-term survival outcomes, acute toxicities and surgical complications in LARC patients. (biomedcentral.com)
  • They were compared for toxicity and survival data. (lu.se)
  • Patients who have been exposed to arsenic in whom toxicity is suspected should undergo a thorough medical evaluation. (cdc.gov)
  • This study showed that SBRT can significantly reduce pain, effectively control local tumor progression, and have acceptable toxicity for patients with locoregional recurrence after radical resection of primary pancreatic cancer. (frontiersin.org)
  • Out of 80 patients entered, 71 were evaluable for both antitumour activity and toxicity, 4 only for toxicity and 5 were lost for follow-up. (nih.gov)
  • Retinal toxicity is the most serious potential complication of hydroxychloroquine therapy. (ccjm.org)
  • The toxicity of a particular arsenic compound depends in part on its solubility. (cdc.gov)
  • Other inorganic arsenic compounds may vary somewhat in relative toxicity, and organic arsenic compounds appear to be essentially nontoxic. (cdc.gov)
  • Idiosyncratic drug reaction denotes a non-immunological hypersensitivity to a substance unrelated to drug toxicity. (helsinki.fi)
  • Did you consider thalidomide toxicity as a possible etiology? (emra.org)
  • Triweekly XELOX was not associated with an increased risk of severe toxicity during chemoradiotherapy, but it increased the risk of postoperative complications compared to capecitabine. (biomedcentral.com)
  • Severe toxicity in the combined therapy arm was significantly worse (P less than 0.001) than in either single modality arm. (emmes.com)
  • The combination of irinotecan (Camptosar), epirubicin, andcapecitabine (Xeloda) has shown an acceptable toxicity profile. (cancernetwork.com)
  • This toxicity profile is 'well acceptable' for the treatment, he said. (cancernetwork.com)
  • However, conventional radiotherapy is limited due to the presence of critical normal structures, such as small bowel, kidneys, and spinal cord, and further radiation can lead to unacceptable toxicity. (frontiersin.org)
  • This study aimed to analyze the efficacy and toxicity of stereotactic body radiotherapy (SBRT) for locoregional recurrent pancreatic cancer after radical resection. (frontiersin.org)
  • Analysis of all parameters of radiotherapy quality assurance data was not significantly associated with toxicity. (emmes.com)
  • Endotoxins may cause fever, leukopenia, and shock depending on the bacterial species and the health of the infected person. (helsinki.fi)
  • Dosage and duration of calcium folinate rescue primarily depend on the type and dosage of methotrexate therapy, the occurrence of toxicity symptoms, and the individual excretion capacity for methotrexate. (janusinfo.se)
  • Amphotericin B (AMB) is a polyene antibiotic with broad spectrum antifungal activity, but its clinical toxicities and poor solubility limit the wide application of AMB in clinical practice. (dovepress.com)
  • His CBC shows mild leukopenia and his CMP is positive for hypercalcemia - consistent with the diagnosis of multiple myeloma. (emra.org)
  • Conclusion The testes are the main target organs tested for 2BP toxicity. (sjweh.fi)
  • The AMB-PLGA-TPGS NP system significantly improves the AMB bioavailability by improving its antifungal activities and reducing its toxicity, and thus, these NPs may become a good drug carrier for antifungal treatment. (dovepress.com)
  • The acute toxicities and surgical complications were also compared. (biomedcentral.com)
  • Toxicity usually results from ingestion. (cdc.gov)
  • Overdose of the oral anticoagulant warfarin (Coumadin), or drug interactions with warfarin, can lead to toxicity. (medscape.com)
  • Recently, new drug-loaded nanoparticles (NPs) - diblock copolymer D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) (PLGA-TPGS) - have received special attention for their reduced toxicity, and increased effectiveness of drug has also been reported. (dovepress.com)
  • AMB-NPs were prepared with a modified nanoprecipitation method and then characterized in terms of physical characteristics, in vitro drug release, stability, drug-encapsulation efficiency, and toxicity. (dovepress.com)
  • The suspected etiologic mechanisms include ineffective hematopoiesis, reduction in blood cell life span, autoimmune process, toxicity of thyroid hormone.We report a ca. (endocrine-abstracts.org)
  • In terms of late toxicity, no treatment-related toxicity was found during follow-up. (frontiersin.org)
  • Furthermore, while acute toxicities of doxorubicin and amrubicin are comparable qualitatively, with amrubicin, cardiotoxicity or other delayed-type toxicities such as those observed with doxorubicin are rare. (cancernetwork.com)
  • Besides the reproductive organs and the hematopoietic system, no significant toxicity has been found. (sjweh.fi)