Hypertension and hyperlipidemiaInsulin resistancePrimary hyperlipidemiaDyslipidemiaInteractionsHAARTObesityHyperglycemiaRhabdomyolysisPatientsAcuteImmunosuppressantMedicationsMetabolicSystemicHyperkalemiaSymptomsAntiretroviral drugsType 2 diabetAcquired immunodeCyclosporineMedicationStatinsModulatesLiverPregnancyLipidsInhibitorsTreatmentMetabolismImmunosuppressantsMultiple SclerosisDiseasesAbsorptionClinical trialsDoseDiscontinueMechanismsPrevalenceSecondaryOccursSubstancesResultsLowerMetabolitesChemotherapy
Hypertension and hyperlipidemia3
- Cardiovascular toxicities, such as hypertension and hyperlipidemia (lower incident). (alleviatenow.in)
- Patients with atrial fibrillation recovered from normal sinus rhythm that requires antihypertensive drugs are given patient consent after sufficient explanation of the treatment of hypertension and hyperlipidemia. (who.int)
- It is randomly assigned to the simulant targeted upstream therapy group and the general treatment group for active hypertension and hyperlipidemia. (who.int)
Insulin resistance1
- Apart from CVD, hyperlipidemia is also closely associated with diabetes, insulin resistance, and obesity [ 10 ]. (hindawi.com)
Primary hyperlipidemia3
- Pitavastatin is a HMG-CoA reductase inhibitor that is FDA approved for the treatment of primary hyperlipidemia and mixed dyslipidemia . (wikidoc.org)
- Pitavastatin is indicated as an adjunctive therapy to diet to reduce elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG), and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia. (wikidoc.org)
- Used as an adjunct to dietary therapy to treat primary hyperlipidemia (heterozygous familial and non-familial), mixed dyslipidemia and hypertriglyceridemia. (pediatriconcall.com)
Dyslipidemia1
- Statins, such as atorvastatin, rosuvastatin, simvastatin, and pitavastatin, also known as 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are one of the most frequently prescribed drugs to control hypercholesterolemia in recently growing patients with dyslipidemia and ischemic heart diseases. (e-enm.org)
Interactions19
- Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. (hindawi.com)
- Hyperlipidemic patients should be warned about the potential risks of herb-drug interactions, particularly those taking anticoagulants and antiplatelet drugs. (hindawi.com)
- Drug interactions are reported among 61 people who take Allegra and Olanzapine. (ehealthme.com)
- Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. (ijpsr.com)
- Experimental data in the field of herb drug interactions are limited, case reports scarce, and case series rare. (ijpsr.com)
- This lack of data is also true of drug drug interactions: published clinical studies are mainly case reports (controlled trials are scarce, since the random assignment of patients to trials that examine unintended effects is not ethical). (ijpsr.com)
- The true prevalence of drug interactions is substantial but unknown. (ijpsr.com)
- When there are any interactions between herbals and drugs occur that can be caused by either pharmaco-kinetic or pharmacodynamic mechanisms. (ijpsr.com)
- When an herbal changes the absorption, distribution, metabolism, protein binding, or excretion of a drug that results in altered levels of the drug or its metabolites that is called pharmacokinetic interactions. (ijpsr.com)
- Most of the current evidence of pharmacokinetic drug interactions involves metabolizing enzymes and drug transporters 1 . (ijpsr.com)
- Although drug interactions can involve enzymes such as glutathione S-transferases and uridine diphosphoglucuronyl transfereases (UGTs), most herbal drug interactions are related to oxidative metabolism by the cytochrome P-450 system (CYP) or by the effect of an herbal on the efflux drug transporter P-glycoprotein. (ijpsr.com)
- Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)
- In this article, we describe the mechanisms via which interactions between herbs and prescription drugs may occur, and highlight four popular herbs and a medicinal mushroom commonly used by cancer patients, along with reports of their interactions with standard drugs. (cancernetwork.com)
- We highlight four popular herbs and a medicinal mushroom commonly used by cancer patients-turmeric, green tea, ginger, ashwagandha, and reishi mushroom-along with reports of their interactions with standard drugs. (cancernetwork.com)
- We conclude by emphasizing the need to inform patients and physicians about herb-drug interactions and how to advise patients on appropriate use of herbal supplements to minimize the risk for interactions. (cancernetwork.com)
- 7] Poor manufacturing practices, lack of standardization, varied amounts of active ingredients, product contamination, and serious herb-drug interactions have been reported. (cancernetwork.com)
- Herb-drug interactions started appearing in the literature in the 1980s, when reports described the interactions of St. John's wort and grapefruit juice with several prescription drugs. (cancernetwork.com)
- Despite increasing concerns, the term "herb-drug interactions" was only introduced as a Medical Subject Headings (MeSH) term in 2004. (cancernetwork.com)
- Tablets is used due to the risk of adverse effects or loss of efficacy due to drug-drug interactions (see also sections 4.4. (who.int)
HAART1
- However, although the substantial benefits of HAART far outweigh its potential risks, it is known that prolonged treatment may result in a variety of disorders related to compliance and toxicity. (bvsalud.org)
Obesity8
- To calculate the market size, the report considers the revenue generated from the sales of off-label drugs, originally indicated for the treatment of diabetes, obesity, and associated conditions. (clickpress.com)
- Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
- Therefore, it is necessary to find more effective and safer anti-obesity drugs. (frontiersin.org)
- Although notoginsenosides are potential drugs for the treatment of obesity, their effects and mechanisms have not been analyzed in depth. (frontiersin.org)
- However, currently, there are very few drugs available for obesity treatment. (frontiersin.org)
- Therefore, the development of safe and effective new anti-obesity drugs has great clinical significance and economic value. (frontiersin.org)
- Anti-obesity drugs: The role of dieticians in monitoring side that AFM1 levels were detected in 100% of the samples, exceeding effects and toxicity the approved limit for milk, according to Codex Alimentarius and Norma Oficial Mexicana. (cdc.gov)
- The history of anti-obesity drugs clearly shows question is to what extent the OELs still perform their function, and the need of human (epidemiological and clinical) data applica- through which mechanisms. (cdc.gov)
Hyperglycemia2
- Hyperlactatemia was associated with lipoatrophy, hyperlipidemia, and hyperglycemia. (unige.ch)
- Three (17%) patients withdrew due to diarrhea, 2 with hyperglycemia at baseline developed diabetes mellitus, 7 (54%) required addition of or increase in lipid-lowering agents, but none had grade 3 or 4 hyperlipidemia. (researchgate.net)
Rhabdomyolysis1
- In combination with statin drugs, fibrates cause an increased risk of rhabdomyolysis, idiosyncratic destruction of muscle tissue, leading to kidney failure. (wikipedia.org)
Patients9
- Health-care providers and their patients may opt to consider using antiretroviral drugs after nonoccupational HIV exposures that carry a high risk for infection, but only after careful consideration of the potential risks and benefits and with a full awareness of the gaps in current knowledge. (cdc.gov)
- Health-care providers may want to provide their patients with a system for promptly initiating evaluation, counseling, and follow-up services after a reported sexual, injecting-drug-use, or other nonoccupational HIV exposure that might put a patient at high risk for acquiring infection. (cdc.gov)
- Most common adverse drug reactions (≥5%) from clinical trials in pediatric patients were anemia, vomiting, increased gamma-glutamyltransferase, and cholestasis. (drugs.com)
- For moderate to severe patients 12+ years not adequately controlled with other systemic drugs, including biologics. (rinvoqhcp.com)
- RINVOQ is indicated for the treatment of adults and pediatric patients 12 years of age and older with refractory, moderate to severe atopic dermatitis whose disease is not adequately controlled with other systemic drug products, including biologics, or when use of those therapies are inadvisable. (rinvoqhcp.com)
- This study was designed to administer 1, 2, or 4 mg pitavastatin to patients with hyperlipidemia at the age of 20 or older for at least 8 weeks. (e-enm.org)
- Only 1.74% (492/28,343) of pitavastatin-treated patients experienced adverse events, of which 0.43% (123/28,343) were adverse drug reactions. (e-enm.org)
- Less than 1% of patients experienced the grade 2 or more toxicity (Common Terminology Criteria for Adverse Events v4.03) in alanine aminotransferase, aspartate aminotransferase, serum creatinine, and serum creatine phosphokinase. (e-enm.org)
- In both groups, the patient s treatment is performed according to standard treatment procedures for patients with hypertension, hyperlipidemia, and atrial fibrillation, so there is no problem with 1:1 randomization. (who.int)
Acute3
- Drug toxicity includes acute kidney injury. (wikipedia.org)
- We suggest that these factors precipitate acute pancreatitis by causing either excessive release of acinar [Ca2+]i, or damage to the integrity of mechanisms that restore low resting levels of [Ca2+]i, and that the consequent calcium toxicity is the key trigger in the pathogenesis of acute pancreatitis. (nih.gov)
- Recommended drugs for acute attacks were oral non-steroidal anti-inflammatory drugs (NSAIDs), oral colchicine (ES = 0.87 (95% confidence interval, 0.25 to 1.50)), or joint aspiration and injection of corticosteroid. (bmj.com)
Immunosuppressant1
- Immunosuppressant are drugs that inhibit cellular or humoral or both types of immune responses. (alleviatenow.in)
Medications2
- Synergistic therapeutic effects may complicate the dosing of long-term medications eg: Herbs traditionally used to decrease glucose concentrations in diabetes-I could theoretically precipitate hypoglycemia if taken in combination with conventional drugs. (ijpsr.com)
- Herbs, however, contain biologically active compounds and can potentially interact with prescription medications, including chemotherapy drugs. (cancernetwork.com)
Metabolic2
- Since thiazide adverse effects may predominate (hyponatremia, metabolic alkalosis), due to variations in bioavailability, individual dose adjustment of the two drugs may be better. (pharmacology2000.com)
- We support the concept that elevated glucose and fatty acids synergize in causing toxicity in islets and other organs, a process that may be instrumental in the pleiotropic defects associated with the metabolic syndrome and type 1 and type 2 diabetes. (diabetesjournals.org)
Systemic2
- Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity. (medicscientist.com)
- Liver disease has adverse effect on pharmacokinetic profile, and causes increased systemic exposure of the drug. (pediatriconcall.com)
Hyperkalemia1
- Hyperkalemia more likely when potassium-sparing diuretics are used as the only diuretic drug or in the presence of renal insufficiency. (pharmacology2000.com)
Symptoms2
- Could drugs other then ARVs cause these symptoms? (immunopaedia.org.za)
- Monitor for symptoms of muscle toxicity during concomitant therapy. (pediatriconcall.com)
Antiretroviral drugs4
- More than 25 antiretroviral drugs from six therapeutic classes are now available for the management of HIV infection (box 1). (natap.org)
- Some health-care providers have proposed offering antiretroviral drugs to persons with unanticipated sexual or injecting-drug-use HIV exposure to prevent transmission. (cdc.gov)
- The Public Health Service (PHS) has recommended using antiretroviral drugs to reduce the acquisition of HIV infection among persons exposed in the workplace (e.g., accidental needlesticks received by health-care workers) (1,2). (cdc.gov)
- Although health-care providers and others have proposed offering antiretroviral drugs to persons with unanticipated sexual or injecting-drug-use HIV exposures (3,4), no data exist regarding the effectiveness of such therapy for these types of exposures. (cdc.gov)
Type 2 diabet1
- The patient's medical history is significant for type 2 diabetes, hyperlipidemia, and hypertension . (medscape.com)
Acquired immunode1
- Other common, non-alcohol related causes include acquired immunodeficiency syndrome, drug toxicity, and pregnancy. (health-care-clinic.org)
Cyclosporine1
- Other toxicities are same as cyclosporine except Hirsutism. (alleviatenow.in)
Medication3
- Our patient was assessed with a Grade 4 severity of toxicity and all medication was stopped. (immunopaedia.org.za)
- Any pharmacological modification caused by herbal substances to another prescription medication (diagnostic, therapeutic or other action of a drug) in or on the body. (ijpsr.com)
- Our Intralipid 20% (20% I.V. Fat Emulsion) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
Statins2
- Clinical trials have shown that the combination of statins and fibrates results in a significantly greater reduction in LDL-C and triglyceride levels and greater increases in high-density lipoprotein cholesterol (HDL-C) compared with monotherapy with either drug. (wikipedia.org)
- Beställ Online Zocor Belgium main advantage of the latest generation of statins is that low and medium doses of drugs are. (boltc.com)
Modulates2
- 2001. -Tocopherol modulates liver toxicity of the pyrethroid cypermethrin. (cdc.gov)
- The drug also modulates nitric oxide synthase (NOS) expression and reduces ischemic-reperfusion injuries in rat hearts (PMID: 15914111). (pediatriconcall.com)
Liver1
- Treatment may be restarted when blood levels return to acceptable values seen in chart above, drug-induced liver diagnosis is excluded or infection is controlled. (rinvoqhcp.com)
Pregnancy1
- If the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus and the lack of known clinical benefit with continued use during pregnancy. (wikidoc.org)
Lipids2
- Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
- USPI recommendation for lipids: at 12 weeks and thereafter according to hyperlipidemia guidelines. (rinvoqhcp.com)
Inhibitors2
- If allopurinol toxicity occurs, options include other xanthine oxidase inhibitors, allopurinol desensitisation, or a uricosuric. (bmj.com)
- Nonsteroidal anti-inflammatory drugs (NSAIDs), both non-selective and selective cyclooxygenase-2 (COX-2) inhibitors, are very widely prescribed, but they may cause increased blood pressure (BP) and adverse cardiovascular (CV) events. (cardiologyonline.com)
Treatment6
- Thus, prevention and treatment of hyperlipidemia are effective approaches to reduce the incident rate of chronic diseases. (hindawi.com)
- There is a growing interest in TCM treatment of hyperlipidemia. (hindawi.com)
- In the last few decades, hundreds of Chinese herbal medicines in the form of compounds, extracts, single herbs, or formulae have been reported to be effective for the prevention and treatment of hyperlipidemia [ 16 ], especially those high-fat diet (HFD) induced cases. (hindawi.com)
- Medical treatment after sexual, injecting-drug-use, or other nonoccupational HIV exposure * is likely to be a relatively ineffective method for preventing HIV infection compared with preventing exposure in the first place. (cdc.gov)
- Drug : According to the current atrial fibrillation guidelines, the target number of single-center, prospective study-blind randomization targets was calculated at a ratio of 1:1 between the simultaneous targeted upstream therapy group and the general treatment group. (who.int)
- However, co-infections may influence disease severity, treatment outcomes, and development of drug resistance. (cdc.gov)
Metabolism2
- It was defined as "the effect of herbs, other plants, or plant extracts on the activity, metabolism, or toxicity of drugs. (cancernetwork.com)
- Ritonavir is a potent inhibitor of CYP3A4- and CYP2D6- mediated drug metabolism. (who.int)
Immunosuppressants1
- These children often need to extend the time of taking hormonal drugs or add other immunosuppressants, which can have significant toxicity. (dntb.gov.ua)
Multiple Sclerosis1
- There are also some conditions which may cause muscle weakness and paralysis such as Botulism, Myasthenia gravis, Guillian-Barre syndrome, Eaton Lambert syndrome, Electrolyte disturbance, Organophosphate toxicity, Multiple sclerosis exacerbation, Amyotrophic lateral sclerosis, Inflammatory myopathy. (wikidoc.org)
Diseases1
- These drugs have met a high degree of success in organ transplant and autoimmune diseases. (alleviatenow.in)
Absorption1
- Absorption is decreased if the drug is taken with high-fat or high-carbohydrate meals. (alleviatenow.in)
Clinical trials1
- Most common adverse drug reactions (≥5%) from clinical trials in adults were nausea, vomiting, and pyrexia. (drugs.com)
Dose1
- Many people overcome these by taking their daily dose of the drug just before going to bed. (infectiontalk.net)
Discontinue1
- Immediately discontinue all ARV drugs and manage the medical event (i.e. symptomatic and supportive therapy) and reintroduce ARV's using a modified regimen (i.e. substituting another ARV drug for the offending drug) when the patient's condition is stable. (immunopaedia.org.za)
Mechanisms1
- Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. (hindawi.com)
Prevalence2
- Since the prevalence of hypercholesterolemia has risen consistently increased, many guidelines recommended statin as the first drug to prevent CVD according to the CVD risk and low density lipoprotein cholesterol (LDL-C) level [ 2 ]. (e-enm.org)
- The prevalence of acquired drug resistance to individual drugs was comparatively lower in Sri Lanka compared to other countries except ethambutol resistance. (who.int)
Secondary1
- Injecting-drug-use exposure through shared injection equipment can put a patient at risk for acquiring other viral infections (e.g., hepatitis B and hepatitis C). All persons evaluated for possible nonoccupational HIV exposure should be counseled to initiate, resume, or improve risk-reduction behaviors to avoid future exposure and to prevent possible secondary transmission until their current HIV infection status is determined. (cdc.gov)
Occurs1
- If high concentrations of [Ca2+]i persist, toxicity results, intracellular signalling is disrupted, and cell damage occurs. (nih.gov)
Substances1
- What Drugs, Substances, or Supplements Interact with Intralipid 20? (rxlist.com)
Results1
- While randomized controlled trials provide useful information about drug safety and efficacy, they do not always reflect the observed results in the real world. (e-enm.org)
Lower1
- The later three components aid the effects and facilitate the delivery of monarch (the principal component) or lower the toxicity of other components. (hindawi.com)
Metabolites1
- Drugs and metabolites are primarily eliminated in the feces. (alleviatenow.in)
Chemotherapy1
- These drugs have been used to prevent rejection of transplants and these are used as chemotherapy for cancers. (aao.org)