Toxicity damage lipid peroxidation. Medical search. Frequent questions

They confirmed that membrane lipid peroxidation (LPO) inhibition was confirmable by pre-treatment using the Tenofovir hydrate extracts. (gasyblog.com)
When CCl 4 gets into the liver, it acts as a xenobiotic and converted into free radicals CCl 3 and CCl 3 O 2 by the P-450 monooxygenase-dependent microsome system and causes liver damage through membrane lipid peroxidation [ 10 ]. (biomedcentral.com)

Reaction of chromium(VI) with glutathione or with hydrogen peroxide: identification of reactive intermediates and their role in chromium(VI)-induced DNA damage. (microbiologyresearch.org)
Lung injury induced by phosgene and mustard appears to be mediated by glutathione depletion, lipid peroxidation, free radical generation, and subsequent cellular toxicity. (bmj.com)
There is limited evidence to suggest that repletion of glutathione reduces and/or prevents lung damage by these agents. (bmj.com)
An early response to Mn toxicity in A. paniculata includes the upregulation of genes involved in glutathione metabolism. (rhhz.net)
Iron overload, glutathione (GSH) depletion and lipid peroxidation in the lung tissue of mice in the exposure group. (medworm.com)
Among antioxidant enzymes, catalase, superoxide dismutase, and glutathione peroxidase were decreased and lipid peroxidation was increased with regional alterations. (fluoridealert.org)
Lactate dehydrogenase (LDH) release, the reduced and oxidized glutathione ratio (GSH/GSSG), protein-SH groups, and lipid peroxidation levels were evaluated. (unipv.it)
The use of dexamethasone prevented cadmium damage, suggesting that the cytoprotective action of this hormone is related to its effect in preventing changes in thiols such as glutathione and protein-SH groups. (unipv.it)

Another recent study compared the antioxidant properties of compounds from the tryptophan metabolic pathway in the pineal gland against oxidative damage to the lipids and proteins of synaptosomes. (wikipedia.org)
Synaptosomes isolated from rat brains were used in an experiment assessing damage by measuring malondialdehyde, 4-hydroxyalkenal, and carbonyl content in the proteins. (wikipedia.org)
certain glycolytic enzymes and heat-shock proteins were specifically targeted by Cr-dependent oxidative damage. (microbiologyresearch.org)
This study establishes an oxidative mode of Cr toxicity in S. cerevisiae , which primarily involves oxidative damage to cellular proteins. (microbiologyresearch.org)
The ROS cause damage to nucleic acids, proteins and lipid membranes, and eventually cell death. (bmj.com)
it may result in oxidative stress, inflammation, and consequent damage to proteins, membranes and DNA. (svce.ac.in)
Reactive oxygen species produced by CYP 2 E 1 create oxidative stress, which leads to peroxidation of lipids, proteins, and DNA, resulting in cellular stress and injury. (scholarsresearchlibrary.com)
When the body is dreceives external stimuli, the accumulation of ROS causes damage to proteins, biofilms and DNA [6]. (biomedres.us)

Acute toxicity is related to occupational exposure and is quite uncommon. (medscape.com)
Oxidative damage in microbial cells occurs during exposure to the toxic metal chromium, but it is not certain whether such oxidation accounts for the toxicity of Cr. (microbiologyresearch.org)
The inference that protein oxidation is a primary mechanism of Cr toxicity was corroborated by an observed ∼20-fold increase in the cellular levels of protein carbonyls within 30 min of Cr exposure. (microbiologyresearch.org)
After 24 h of exposure to different doses (4-32 μg/mL) of BP-QDs, intracellular lipid peroxidation and iron overload occurred in Beas-2B cells. (medworm.com)
were used, suggest that when these free-radical scavengers are given intravenously within 12 to 16 hours after a high-dose acute CCl 4 exposure, they might prevent or decrease hepatic and renal damage [De Ferreyra et al. (cdc.gov)
DNA damage caused by exposure of pBR322 to Cr(VI)-UV is markedly inhibited by both extracts in varying degrees. (vit.ac.in)
Additional effects of lead exposure were evaluated by examining concentrations of biomarkers (oxidative stress, lipid peroxidation, and deoxyribonucleic acid damage) in liver tissues, δALAD inhibition, and renal and hepatic microscopic lesions in birds from lead-contaminated and reference sites. (usgs.gov)
This review focuses on the differential responses of cell types to ATZ toxicity, testicular effects of ATZ in both in vitro and in vivo models and chemopreventive strategies, so as to highlight the current state of the art on the toxicological outcomes of ATZ exposure in several experimental model systems. (frontiersin.org)
Carbon monoxide (CO) toxicity causes tissue hypoxia via multiple mechanisms and is most commonly due to exposure to house fires, wood-burning stoves, or motor vehicle exhaust fumes. (amboss.com)
CO toxicity should be suspected in any individual with a history of exposure and symptoms consistent with CO toxicity, and the diagnosis can be confirmed by an elevated COHb level on CO oximetry . (amboss.com)
In conclusion, the data obtained in our investigation confirm the protective effect of S. pachycarpa against acute exposure to CCl 4 -induced organ toxicity in rats. (biomedcentral.com)
GPL-TOX also includes Tiglylglycine, a marker for mitochondrial damage, which is often seen in chronic toxic chemical exposure. (biohelp.me)
This panel offers you comprehensive testing to assess exposure to common environmental toxins and the damage that can be caused by this exposure, all at a great value, and all from one urine sample. (biohelp.me)
The diagnosis of nitrogen dioxide (NO 2 ) toxicity largely depends on the history of exposure. (medscape.com)
These exposures, however, are with exposure, proceeding through operational and ana- expected to be acute in nature due to its intended use, which tomical changes, and resulting in toxicity. (cdc.gov)

The traditional use of organic solvents in various branches of industry is being rethought as these compounds very often display high volatility, toxicity and lipophilicity (related to the ability to interact with biological membranes). (easychair.org)
Further study of reactive oxygen species was conducted using analysis of cellular H2O2 generation, lipid peroxidation of cellular membranes and DNA damage. (cdc.gov)
This is when the fatty membranes in our body are oxidized by free radical damage. (naturallyrecoveringautism.com)
MSM also has proven antioxidant benefits, which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes. (healthsurgeon.com)

This minireview summarises current research on iron toxicity, lipid peroxidation and ferroptosis in the pathomechanisms of ICH, the underlying molecular mechanisms of ferroptosis and the potential for combined therapeutic strategies. (bmj.com)
In summary, findings in the present study confirmed that BP-QDs induce ferroptosis via increasing lipid peroxidation and iron accumulation in vitro and in vivo.PMID:3748. (medworm.com)
Lipid peroxidation-dependent ferroptosis has become an emerging strategy for tumor therapy. (bvsalud.org)
Using cultured cell lines, Caenorhabditis elegans, and mice, we found that ferroptosis occurs in the context of iron-overload-mediated damage. (bvsalud.org)
Exogenous oleic acid protected against iron-overload-toxicity in cell culture and Caenorhabditis elegans by suppressing ferroptosis. (bvsalud.org)
These results highlight ferroptosis as a driver of iron-overload-mediated damage, which is inhibited by oleic acid. (bvsalud.org)
Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. (cdc.gov)

Can cranberry juice protect against rotenone-induced toxicity in rats? (cranberryinstitute.org)
Based on the data in this study, astaxanthin might play a protective role against cisplatin-induced gastrointestinal toxicity in rats. (springermedizin.at)
Plausible interactions between food contaminants and natural constituents in vivo and protective effect of polyphenols present in I . aquatica against carbofuran toxicity in Charles Foster rats were evaluated. (niscair.res.in)
The in vivo lipid peroxidation-mediated liver damage was induced by administration of CCl(4) to rats. (firebaseapp.com)
Previously studies [6] show that ingredients of have confirmed hepatoprotective activity against the carbon tetrachloride induced lipid peroxidation in the livers of rats, that was determined by elevated serum enzyme amounts. (gasyblog.com)
Acute toxicity was researched, and the full total outcomes demonstrated that extract was non toxic when put on SD rats. (gasyblog.com)

Although a number of studies have discussed the toxicity of GO sheets, the in vivo impact of their lateral dimensions is still not clear. (springer.com)
Elevated oxygen concentrations in vitro and in vivo reduce lipid peroxidation and hepatotoxicity. (cdc.gov)
The present study had evaluated the protective effect of hydroalcoholic (50-50: v/v) and aqueous extracts of L. kerstingii and M. oleifera against lipid peroxidation induced in vivo and in vitro by either cadmium or ethanol. (scialert.net)

Most metabolites of aflatoxin B 1 (AFB 1 ), especially exo-AFB 1 -8,9-epoxide (AFBO), can induce the production of reactive oxygen species (ROS) to vary degrees, causing oxidative stress and liver damage, and ultimately induce liver cancer in humans and animals. (hindawi.com)

In the present study, the effects of dexamethasone on cadmium-induced toxicity were evaluated in isolated rat hepatocytes. (unipv.it)

In the aftermath of ICH, iron overload within the perihaematomal region can induce lethal reactive oxygen species (ROS) production and lipid peroxidation, which contribute to secondary brain injury. (bmj.com)
2 3 Primary brain damage develops in the first few hours after ICH as the formation and expansion of haematoma or oedema induce mass effects and elevations in intracranial pressure that lead to herniation and death. (bmj.com)
NPs have been found to induce apoptosis in certain cells primarily due to the mitochondrial damage and oxidative stress brought on by the foreign NPs electrostatic reactions. (svce.ac.in)
Cadmium a very toxic and ubiquitous metal and ethanol (95%) are known to induce lipid peroxidation (Traore et al . (scialert.net)
Taken together, our study demonstrated that GO-AgNPs potentially induce oxidative damage to DNA, which result in toxicity and cell apoptosis in caprine fetal fibroblast cell due to an increased generation of ROS. (researchsquare.com)

The cellular and molecular gastroenterology and hepatology addresses this automatically demonstrates acute toxicity of ethanol is caused by ethanol, rather than acetaldehyde, via novel non-oxidative metabolites of fatty acid ethyl esters. (scholarsresearchlibrary.com)
Although it is unclear what additional pathophysiological roles FAEEs play in acute and chronic ethanol toxicity in other organs, these findings warrant additional study in this area. (scholarsresearchlibrary.com)
Although there are limitations to this study, such as the use of rodents with different metabolic capacities than humans, it identifies novel targets that should be further explored using more translational approaches aimed at preventing acute alcohol toxicity or treating alcohol-associated liver disease. (scholarsresearchlibrary.com)

It is characterised by an accumulation of iron-induced lipid ROS, which leads to intracellular oxidative stress. (bmj.com)
In the aftermath of ICH, iron accumulation within the perihaematomal region contributes to the secondary brain damage. (bmj.com)
Iron overload, characterized by accumulation of iron in tissues, induces a multiorgan toxicity whose mechanisms are not fully understood. (bvsalud.org)
Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)

Zurück zum Zitat Shahid F, Farooqui Z, Khan F. Cisplatin-induced gastrointestinal toxicity: an update on possible mechanisms and on available gastroprotective strategies. (springermedizin.at)
The mechanisms underlying the response and recovery of A. paniculata to Mn toxicity were further investigated using transcriptome analysis. (rhhz.net)

Lead blocks the activity of 5-aminolevulinic acid dehydratase and leads to hemoglobin oxidation, which along with the lipid peroxidation can result in red cell hemolysis. (medscape.com)
To help identify the macromolecular target(s) of Cr-dependent oxidative damage, cells deficient for the reduction of phospholipid hydroperoxides ( gpx3 Δ and gpx1 Δ/ gpx2 Δ/ gpx3 Δ) and for the repair of DNA oxidation ( ogg1 Δ and rad30 Δ/ ogg1 Δ) were tested, but were found not to be Cr-sensitive. (microbiologyresearch.org)
DNA damage, and protein oxidation. (cdc.gov)
NO is also involved in cell kil ing but often used as a marker of oxidative Hanahan and Weinberg (2011), i n can also react with superoxide at DNA damage, although other bas- their landmark review "Hallmarks diffusion-limited rates to form per- es are also susceptible to oxidation. (who.int)

The induction of oxidative stress is shown by increased levels of lipid peroxidation, total peroxide, superoxide anion and lipoxygenase activity. (unboundmedicine.com)
Here, a Saccharomyces cerevisiae sod1 Δ mutant (defective for the Cu,Zn-superoxide dismutase) was found to be hypersensitive to Cr(VI) toxicity under aerobic conditions, but this phenotype was suppressed under anaerobic conditions. (microbiologyresearch.org)

Lovastatin exhibits toxicity in human fetal brain cells. (greenmedinfo.com)
Recent studies have indicated that exposures to methyl iodide (MeI) produce a number of effects in laboratory animals, including fetal toxicity, neurotoxicity, and degeneration of the nasal epithelium. (cdc.gov)
Recent studies have indicated that exposures to methyl based pharmacokinetic (PBPK) modeling, and evaluat- iodide (MeI) produce a number of effects in laboratory ani- ing the relevance of the observations in animals to human mals, including fetal toxicity, neurotoxicity, and degenera- health. (cdc.gov)

The major mechanism of lead toxicity is due to increased generation of reactive oxygen species (ROS) and interference with generation of antioxidants. (medscape.com)
The purpose of this study is to compare the ability of hexavalent and trivalent chromium to form reactive oxygen species which may be related to differences in their toxicity. (cdc.gov)
It can be engulfed by microglia and infiltrating macrophages in the perihematomal zone and metabolised into ferrous/ferric iron, which induces the formation of lethal reactive oxygen species (ROS) and lipid peroxidation. (bmj.com)
Some of the iron will then bind to other molecules not have transferrin's ability to protect its host from iron catalyzed lipid peroxidation and the formation of reactive oxygen species. (irondisorders.org)
Free radicals found in the body mainly include Reactive Oxygen Species (ROS), alipid free radicals and lipid peroxidation free radicals. (biomedres.us)

This study assessed reproductive outcomes for songbirds exposed to soil-borne lead in the district, examined the relation between lead concentrations in soils and in tissues of ground-feeding birds and prey species, and compared the results to literature-based toxicity thresholds for lead that are associated with negative effects in birds. (usgs.gov)

The increase in the DNA damage was noticed in all organs examined and in leukocytes. (cranberryinstitute.org)
Summing up, ROT can cause oxidative damage not only in the brain but also in other organs. (cranberryinstitute.org)
The liver is one of the only organs in the body that is able to replace damaged tissue with new cells rather than scar tissue. (jonbarron.org)
The aim of the present study was to investigate the protective effect of the Sophora pachycarpa (S. pachycarpa) seed extract against carbon tetrachloride-induced toxicity on body organs, blood, and biochemical factors. (biomedcentral.com)

In conclusion, cadmium toxicity was associated with an increase in intracellular oxidative stress responsible for accelerated cell death. (unipv.it)

Lipid peroxidation in the intestinal tissue was evaluated by measuring the level of malondialdehyde (MDA), which is the end product of lipid peroxidation. (springermedizin.at)
6 13 The blood accumulates and compresses the surrounding brain tissue, causing tissue damage, inflammation and neuronal death. (bmj.com)
This causes oxidative stress, a process that if not countered by the body's antioxidant defenses, will over time result in cell, tissue and DNA damage. (irondisorders.org)

The mechanism by which Zn promotes Cu toxicity in duckweed Spirodela polyrhiza L. was investigated in order to understand the possible interaction between these two metals. (unboundmedicine.com)

Phthalates have been implicated in reproductive damage, depressed leukocyte function, and cancer. (biohelp.me)

Similar results were found in the kidney even though lipid peroxidation is slightly increased by ethanol in this organ. (scialert.net)

Use of the chemotherapeutic agent Adriamycin is complicated by its potentially lethal cardiac toxicity. (mapi.com)

However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)
Studies have shown that GM can cause damage and apoptosis of rat tubule cells through oxidative stress [3-5]. (biomedres.us)

The aim of the present study was to demonstrate astaxanthin's attenuating effects against cisplatin (CIS)-induced gastrointestinal toxicity in a rat model. (springermedizin.at)

Chronic toxicity on the other hand is much more common. (medscape.com)

It is also known that the most effective way to prevent oxidative damages remains the use of antioxidant substances or nutrients which can be found in fruits and vegetables (Keen et al . (scialert.net)

The increase in oxidative stress leads to cell membrane damage due to lipid peroxidation. (medscape.com)
2. Cytotoxicity : A primary marker for the damaging effects of NPs has been cell viability as determined by state and exposed surface area of the cell membrane. (svce.ac.in)
This study contributes to the search for natural resources that might yield potent therapeutic drugs against Cr(VI)-induced oxidative cell damage. (vit.ac.in)

The purpose of this tale is to provide details about biomedical applications of nanoparticles (NPs) and their toxicology scrutiny to help readers quantify and qualify the toxicity of the drug products incorporating nanotechnology features. (svce.ac.in)

Aluminium toxicity causes an increase in lipid peroxidation, with most damage occurring in the brain. (wikipedia.org)
To date, there are few data indicating that toxicity of ROT is not limited to the brain but can also affect other tissues. (cranberryinstitute.org)
ROT enhanced lipid peroxidation solely in the brain. (cranberryinstitute.org)
14-16 Preclinical and clinical studies suggest that toxins released from an intracerebral haematoma may contribute to brain damage after ICH. (bmj.com)
IAE decreased enhanced lipid peroxidation levels in plasma and erythrocyte membrane and cholesterol levels in brain and plasma. (niscair.res.in)
The extent of mercury damage to the brain and heart depends on age, sex, and genetic factors. (naturallyrecoveringautism.com)
This curcumin and turmeric essential oil combo reversed cognitive damage caused by aluminum, a serious brain toxin. (terrytalksnutrition.com)

Oleic acid changed the cellular lipid composition, characterized by decreased levels of polyunsaturated fatty acyl phospholipids and decreased levels of ether-linked phospholipids. (bvsalud.org)
This monounsaturated fatty acid represents a potential therapeutic approach to mitigating organ damage in iron overload individuals. (bvsalud.org)
Among these signaling lipids, a particular group of oxygenated polyunsaturated fatty acids (PUFA), so called lipid mediators, has been thoroughly investigated over several decades. (cdc.gov)

1 µm) in terms of mesothelial damage and peritoneal inflammation, after intraperitoneal (i.p.) injection in mice. (springer.com)
Overall, these findings are essential for a better understanding of the parameters governing GO toxicity and inflammation, and the rational design of safe GO-based formulations for various applications, including biomedicine. (springer.com)

Carbon Tetrachloride Toxicity: How Should Patients Exposed to Carbon Tetrachloride Be Treated and Managed? (cdc.gov)

A recent study compared the effectiveness of melatonin and other similar compounds on the lipopolysaccharide induced lipid peroxidation. (wikipedia.org)

Zinc Reduces Copper Toxicity Induced Oxidative Stress By Promoting Antioxidant Defense in Freshly Grown Aquatic Duckweed Spirodela Polyrhiza L." Journal of Hazardous Materials, vol. 175, no. 1-3, 2010, pp. 1081-4. (unboundmedicine.com)

citation needed] Lipopolysaccharide is produced by Gram-negative bacteria and stimulates the production of free radicals which in turn cause lipid peroxidation. (wikipedia.org)
The results showed support for pinoline's ability to reduce damage from lipid peroxidation[citation needed]. (wikipedia.org)

Thus, this study demonstrates that zinc reversed the effect of copper, combating against Cu induced oxidative damage and improvement of duckweed's growth and toxicity under natural condition. (unboundmedicine.com)
It states that reviewed data indicates dietary modification or supplementation with antioxidants such as vitamin C, vitamin E, coenzyme Q10, selenium, carnitine and zinc can improve markers of male fertility and reduce markers of seminal oxidative damage. (nutraingredients-usa.com)

Our investigation looked into the involvement of free radicals in smoke toxicity and the relationship between particle size and radical generation. (cdc.gov)
Free radicals are responsible for lipid peroxidation and have received much attention recently in connection with a variety of pathologies such as cancer (Zhu et al . (scialert.net)

MSM is considered one of the safest substances in biology, similar in toxicity to water. (healthsurgeon.com)

The parameters measured proved to be good markers for the rapid and preliminary diagnosis of fungicide toxicity. (ua.pt)

Although drinking patterns can influence the progression of alcohol-related liver disease, the combinations of environment, genetics, and other comorbidities can also contribute to end-organ damage. (scholarsresearchlibrary.com)
Therapy that target oxidative metabolism of alcohol have poor efficacy and adherence, underscoring gaps in understanding of the complex biology underlying alcohol toxicity and the growing need for alternate therapies for persons with alcohol-induced end-organ damage. (scholarsresearchlibrary.com)
Additionally, Harish against CCL4-induced liver organ damage. (gasyblog.com)

This is a potentially toxic form of iron that can damage most all body systems. (irondisorders.org)
Iron toxicity results when circulating iron exceeds the capacity of transferrin available to bind it. (irondisorders.org)
Eugenol completely inhibited both iron and Fenton reagent-mediated lipid peroxidation. (firebaseapp.com)

1. The penetration of nanoparticles through skin occurs via lipids and dissolved material. (svce.ac.in)

The symptoms of mercury toxicity mimic many of the symptoms of autism. (naturallyrecoveringautism.com)

Prevention of Cr(VI)-induced cellular damage has been sought in this study in aqueous and methanolic extracts ofLawsonia inermis Linn. (vit.ac.in)

Anatomy21

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Chemicals and Drugs153

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes31

Disciplines and Occupations1

Technology, Industry, Agriculture5

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Membrane lipid peroxidation2

Glutathione8

Proteins8

Exposure15

Membranes4

Ferroptosis7

Rats6

Vivo3

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Induce5

Acute3

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