• Low toxicity and reduced odor compared to other thiol compounds. (sigmaaldrich.com)
  • A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE. (rush.edu)
  • Mee lines (transverse white bands) on the fingernails are seen in acute and chronic arsenic toxicity. (medscape.com)
  • The most common ratings concern acute toxicity. (iloencyclopaedia.org)
  • Our findings shed further light on plants as a-yet-untapped resource of bioactive compounds and constructed the foundation for the development of new biological approaches to best manage Bayoud disease. (springeropen.com)
  • Plant-derived bioactive compounds might be a source of substances for the treatment of wounds stalled in a non-resolving stage of wound healing. (bvsalud.org)
  • Developmental Toxicity. (cdc.gov)
  • Sulfhydryl systems are a critical factor in the zebrafish developmental toxicity of the dithiocarbamate sodium metam (NaM). (oregonstate.edu)
  • In this study we investigated whether cell death plays a role in the manifestation of DTC-induced notochord distortions in the developing zebrafish and if thiol-containing compounds or antioxidants could modify this developmental toxicity. (oregonstate.edu)
  • However, cellular thiol status or critical sulfhydryl moieties are important considerations in the mechanisms of DTC developmental toxicity. (oregonstate.edu)
  • Sodium-2-mecarptoethane sulfonate (MESNA), a sulfhydryl-containing agent has long been used in detoxifying and ameliorating specifically the urotoxic effects of CP and other oxazaphosphorines. (researchwap.com)
  • Neoadjuvant Interdigitated Chemoradiotherapy Using Mesna, Doxorubicin, and Ifosfamide for Large, High-grade, Soft Tissue Sarcomas of the Extremity: Improved Efficacy and Reduced Toxicity. (rush.edu)
  • Weathering of rocks releases arsenic-containing dust and allows arsenic compounds to enter groundwater. (medscape.com)
  • OH The toxic actions of NO can be divided into two categories: direct toxic effects resulting from binding to Fe-containing proteins, and indirect effects mediated by O compounds formed when NO combines with O2 or with superoxide to form RNOS. (ecoshelta.com)
  • Heavy metals combine with sulfhydryl (SH) groups of proteins and inactivate them. (brainkart.com)
  • The inhibition of influx is due in large part to the binding of metal ions to sulphydryl groups on transport proteins (ATPases), while the stimulation of efflux appears to be governed by the displacement of calcium from the intercellular tight junctions of the epithelial cells. (astm.org)
  • The latter, combined with the possible direct displacement of the chlorine atoms by sulfhydryl groups of amino acids or proteins, accounts for the instability of cisplatin in biological matrices. (nih.gov)
  • Sulfhydryl reagents have been widely used as a pharmacological tool to explore the molecular functions of channel proteins. (mdmsignaling.com)
  • Mercury has 3 forms: (1) elemental mercury, (2) inorganic salts, and (3) organic compounds. (medscape.com)
  • Organic mercury compounds, specifically methylmercury, are concentrated in the food chain. (medscape.com)
  • Minamata disease is an example of organic toxicity. (medscape.com)
  • The term also refers to a method of treating wastes in which activated carbon is used to remove organic compounds from wastewater. (itrcweb.org)
  • The gills play a role in the excretion of some organic compounds (log P (astm.org)
  • Inorganic or organic compounds that contain arsenic. (bvsalud.org)
  • The reactive organosulfur compounds form disulfide bonds with free sulfhydryl groups of enzymes and compromise the integrity of the bacterial membrane. (frontiersin.org)
  • Dithiothreitol (DTT) is used in proteomics applications to maintain sulfhydryl (-SH) groups in the reduced state and for quantitative reduction of disulfide (-S-S-) groups. (sigmaaldrich.com)
  • The protein structure and purpose of thiol containing compounds, containing if the sulfhydryl number of cysteine Cyclopamine 4449-51-8 is oxidized cysteine residues which can form a disulfide bond, may be altered. (mdmsignaling.com)
  • Consequently, the present study was performed to investigate if the inhibitory effects of L type calcium channel caused by H2S was dependent on the disulfide bridge or sulfhydryl group. (mdmsignaling.com)
  • This list contains substances that have been identified at National Priorities List (NPL) sites and determined to pose a human health risk based on (1) known or suspected human toxicity, (2) frequency of occurrence at NPL sites or other facilities, and (3) the potential for human exposure to the substance. (cdc.gov)
  • Concurrent exposure to divalent cations may enhance or reduce the toxicity of certain metals through competition for receptor-mediated transport or targets. (cdc.gov)
  • It can be present in the environment in several different forms, and overview of the different forms of mercury, their uses, routes of exposure and their toxicity. (yourvdesk.com)
  • Toxicity rating is an arbitrary grading of doses or exposure levels causing toxic effects. (iloencyclopaedia.org)
  • Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. (researchwap.com)
  • The result of the present study revealed that aqueous leaf extract of V. amygdalina has the potential to prevent urotoxicity and myelosuppression induced by CP and thus can be used as therapeutic adjuvant in the management of CP and other oxazaphosphorine toxicities. (researchwap.com)
  • Other major dose-related toxicities are myelosuppression, nausea, and vomiting. (nih.gov)
  • Genetic factors may influence the availability of sulfhydryl-containing compounds such as glutathione and metallothionein, which modify the distribution and toxicity of certain metals. (cdc.gov)
  • Chlorine compounds are rapidly inactivated by light and some metals so fresh solutions should always be used. (brainkart.com)
  • Due to its unique chemical structure, the chlorine atoms of cisplatin are more subject to chemical displacement reactions by nucleophiles, such as water or sulfhydryl groups, than to enzyme-catalyzed metabolism. (nih.gov)
  • N2O3, which can be derived either from NO2 or nitrite, is the agent of nitrosative stress, and nitrosylates sulfhydryl and similarily reactive groups in the cell. (ecoshelta.com)
  • Mercury in any form is poisonous, with mercury toxicity most commonly affecting the neurologic, gastrointestinal (GI) and renal organ systems. (medscape.com)
  • Peroxynitrite products also nitrate aromatic rings, forming compounds such as nitrotyrosine or nitroguanosine. (ecoshelta.com)
  • Acyclic or cyclic, saturated or unsaturated, carbon compounds (excluding aromatic compounds). (itrcweb.org)
  • A hydrocarbon compound in which the carbon atoms are in a straight-chain, branched, or cyclic arrangement and are saturated or unsaturated. (itrcweb.org)
  • Renal and liver function tests should be ordered to rule out insidious damage from arsenic toxicity. (medscape.com)
  • Cumulative renal toxicity associated with cisplatin is severe. (nih.gov)
  • Toxicity is the intrinsic capacity of a chemical agent to affect an organism adversely. (iloencyclopaedia.org)
  • Our results show that OA-encapsulateds compound exhibit several advantages when compared to non-encapsulated OA in terms of chemical stability, migration enhancement, and preservation of cell viability. (bvsalud.org)
  • 2. Denoting a compound of iodine in its pentavalent state. (theodora.com)
  • 3. Any compound containing an iodine atom linked to a carbon. (theodora.com)
  • Iodine compound are broad spectrum and considered effective for a variety of bacteria, mycobacteria, fungi and viruses. (brainkart.com)
  • Other skin manifestations of chronic arsenic toxicity include hyperpigmented and hypopigmented macules on the torso and limbs. (medscape.com)
  • Diffuse hyperpigmented patches in the intertriginous, genital, and acral areas may be an early sign of chronic arsenic toxicity. (medscape.com)
  • they are the building blocks for all body tissue, and many have one or more sulfhydryl groups. (yourvdesk.com)
  • Here we describe the results of a programme that aimed to rapidly discover lead compounds for clinical use, by combining structure-assisted drug design, virtual drug screening and high-throughput screening. (nature.com)
  • There is growing evidence that nutritional supplements-vitamins, minerals, amino acids, fatty acid nutrients, herbal and botanical products, and various other natural compounds like coenzyme Q10 and alpha lipoic acid-have specific health benefits, in addition to those provided by the right diet, daily exercise, reducing stress, and getting a good night's sleep. (tahomaclinicblog.com)
  • However, the regimen containing irinotecan resulted in a lower rate of hematologic toxicity and cumulative dose of cyclophosphamide. (medscape.com)
  • Dithiocarbamates (DTCs) are sulfhydryls (thiol)-containing compounds, often associated with metals, and have both antioxidant and pro-oxidant abilities depending on the compound, experimental system and condition. (oregonstate.edu)
  • Her studies with laboratory animals showed that sulfhydryl compounds may protect against toxicity from x-irradiation and alkylating agents by a distribution pattern which causes more of a protective compound to accumulate in the sensitive tissues than in the tumor. (wikipedia.org)
  • The best understood mechanisms of toxicity to the gills are those due to metallic cations. (astm.org)
  • Traditional medicines are becoming popular, due to high toxicity and adverse effects of orthodox medicaments. (pharmatutor.org)
  • Emphasis is placed on mechanisms of toxicity at environmentally relevant pollutant levels. (astm.org)
  • Toxicity classification concerns the grouping of chemicals into general categories according to their most important toxic effect. (iloencyclopaedia.org)
  • Blood arsenic level, spot, or 24-hour urine arsenic level adjusted with creatinine are commonly used for detecting arsenic toxicity. (medscape.com)
  • In the DPPHâ ¢ and ABTSâ ¢+ assay, pure compounds were characterized by higher antioxidant activity than the complexes. (bvsalud.org)
  • In the FRAP study, all hesperetin and HHSB complexes and HTSC-HP-ß-CD (mech) were characterized by higher values of antioxidant activity than pure compounds. (bvsalud.org)
  • The principal phytochemicals that exhibit antibacterial activity are oil-soluble organosulfur compounds that include allicin, ajoenes, and allyl sulfides. (frontiersin.org)
  • The organosulfur compounds of garlic exhibit a range of antibacterial properties such as bactericidal, antibiofilm, antitoxin, and anti-quorum sensing activity against a wide range of bacteria including multi-drug resistant (MDR) strains. (frontiersin.org)
  • Clinical Methods for Mitigating Toxicity. (cdc.gov)
  • Through a combination of structure-based virtual and high-throughput screening, we assayed more than 10,000 compounds-including approved drugs, drug candidates in clinical trials and other pharmacologically active compounds-as inhibitors of M pro . (nature.com)
  • To facilitate the rapid discovery of antiviral compounds with clinical potential, we developed a strategy that combines structure-assisted drug design, virtual drug screening and high-throughput screening to repurpose existing drugs to target SARS-CoV-2 M pro . (nature.com)
  • The inclusion systems were prepared using mechanical and co-evaporation methods using a molar ratio compound: HP-ß-CD = 1:1. (bvsalud.org)
  • Multiple antibacterial effects of organosulfur compounds provide an excellent framework to develop them into novel antibiotics. (frontiersin.org)
  • Retinoid use requires close monitoring by experienced clinicians collaborating on integrative strategy, particularly given significant risk of toxicity. (interactionsguide.com)
  • DU's toxicity is generally considered to be the greater of the two potential health threats. (health.mil)
  • Hazard is the potential for the toxicity to be realized in a specific setting or situation. (iloencyclopaedia.org)
  • Mercury toxicity has a wide range of symptoms, which reflect mercurys widespread effects in the body. (yourvdesk.com)
  • Two major health concerns are related to the use of DU in military applications: heavy-metal toxicity effects and radiation effects. (health.mil)
  • Arsenical compounds are used in industrial, agricultural, and medicinal substances. (medscape.com)
  • One of these compounds (ebselen) also exhibited promising antiviral activity in cell-based assays. (nature.com)
  • The encapsulation of insoluble compounds can help improve their solubility and activity. (bvsalud.org)
  • It is these very high levels of NO that are associated with generation of H2N N RNOS and NO toxicity. (ecoshelta.com)
  • The amount heme compounds are present in excess capacity. (ecoshelta.com)
  • RNOS TOXICITY with T residues, leading to the creation of a daughter molecule with an A-T base pair in When present in very high concentrations (e. (ecoshelta.com)
  • We identified a mechanism-based inhibitor (N3) by computer-aided drug design, and then determined the crystal structure of M pro of SARS-CoV-2 in complex with this compound. (nature.com)
  • The review provides a focused and comprehensive portrait of the status of garlic and its compounds as antibacterial agents. (frontiersin.org)
  • CHAPTER 24 / OXYGEN TOXICITY AND FREE RADICAL INJURY 447 oxidizing agent that is stable and directly toxic. (ecoshelta.com)
  • The truth that L type calcium channels are put through direct change by sulfhydryl reagents is demonstrated. (mdmsignaling.com)
  • Cyclodextrins are natural macromolecules that show a unique tridimensional structure that can encapsulate a wide variety of hydrophobic compounds. (bvsalud.org)