Toxic rats to methoxychlor. Medical search. Frequent questions

2000. A metabolite of methoxychlor, 2,2-bis( p hydroxyphenyl)-1,1,1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme. (cdc.gov)
The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells. (cdc.gov)

This is because several of the contaminants in technical grade methoxychlor are directly estrogenic (Kupfer and Bulger 1987b), whereas pure methoxychlor is proestrogenic and requires metabolic activation before exhibiting estrogenic activity (Bulger et al. (cdc.gov)
Some of the estrogenic contaminants of technical grade methoxychlor are the same as those formed by metabolism in vivo (Bulger et al. (cdc.gov)

1980. Toxicity and bioaccumulation of endrin and methoxychlor in aquatic invertebrates and fish. (cdc.gov)

The primary purpose of this chapter is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of methoxychlor. (cdc.gov)

What [WSU researcher Michael] Skinner and his colleagues did is show that exposing a pregnant rat to high doses of a class of pesticides known as 'endocrine disruptors' causes an inherited reproductive disorder in male rats that is passed on without any genetic mutation…'It's not a change in the DNA sequence,' Skinner explained. (sightline.org)

1974. Pesticidal chemicals affecting some energy-linked functions of rat liver mitochondria in vitro . (cdc.gov)
How toxic are toxic chemicals in soil. (cdc.gov)
The effects of toxic chemicals can span generations. (sightline.org)
Exposure to insecticides -- particularly after frequent or intense applications of chemicals -- will be surely toxic to dogs. (petmoo.com)
Choose the least toxic or organic option Instead of toxic chemicals to control pests in your yard. (petmoo.com)
A detailed data profile and a legal file can be obtained from the International Register of Potentially Toxic Chemicals, Case postale 356, 1219 Ch telaine, Geneva, Switzerland (Telephone No. 9799111). (inchem.org)
Frederick vom Saal , a biologist at the University of Missouri, argues that endocrine disruptors defy the dose-response paradigms applied to toxic and carcinogenic chemicals: the response function is shaped like an upside-down U (Lutz 1996). (alexanderlaw.com)

Toxic residues can hang about on the treated surfaces (even when the pesticides have dried) so consider implementing necessary precautions to stop your pet from eating, licking, or chewing any plants or other items treated with pesticides. (petmoo.com)
The aim of this review was to present the main parameters used for the assessment of neurotoxicity during the initial period of life of rodents until puberty and to carry out a review of the most current literature on the toxic effects of pesticides, medications, licit and illicit drugs, toxins and environmental agents in rodent offspring. (bvsalud.org)

1974. Insecticides in the tissues of four generations of rats fed different dietary fats containing a mixture of chlorinated hydrocarbon insecticides. (cdc.gov)

1953). It is stored in the adipose tissue of rats, sheep, goats, and cows and accumulates in the milk. (inchem.org)

Toxicological Profile for Methoxychlor. (comprehensivephysiology.com)
Agency for Toxic Substances and Disease Registry, Toxicological profile for hexachlorocyclohexane. (jamanetwork.com)

2000. The effect of raloxifene on the uterine weight response in immature mice exposed to 17- estradiol, 1,1,1-trichloro-2,2- bis ( p -chlorophenyl)ethane, and methoxychlor. (cdc.gov)
1999. Methoxychlor given in the pre- implantation period blocks sexual arousal in male mice. (cdc.gov)
The WHO elaborated that their biggest concern was for occupational exposure, but that the evidence was "convincing" that glyphosate caused cancer in lab rats and mice. (truthout.org)

I missed this last week: Washington State University scientists have found that exposure to toxic substances can have effects that span generations . (sightline.org)
But the male offspring of the pair also had these problems, as did the next two generations of male rats. (sightline.org)

1964). In vitro metabolism by hepatic microsomal enzymes from rats treated 8 days previously with single i.p. doses of 10 or 100 mg/kg of chlordane in corn oil was increased for the 3 drugs reported (hexobarbital, aminopyrine and chlorpromazine). (inchem.org)

1963). Both technical chlordane and one of its pure isomers (gamma-chlordane) have been shown to have stimulating effects on rat liver microsomes for the metabolism of certain drugs (Burns et al. (inchem.org)

It is important to recognize that because of the biological activity of these contaminants, dose-response relationships obtained using technical grade methoxychlor may not be directly applicable to pure methoxychlor. (cdc.gov)

Since liver detoxification enzymes are not fully developed in fetal and neonatal period yet, it is thought that the toxic effects of BPA are even more serious during this crucial time [ 17 ]. (ac.ir)

So what this all means is that, in theory at least, if your great-grandparent was exposed to an environmental toxic, it's possible that you could be feeling the effects. (sightline.org)

Skinner's] lab was studying testes development in fetal rats, using a fungicide used in vineyards (vinclozin) and a common pesticide (methoxychlor) to disrupt the process. (sightline.org)
The results showed the different toxic agents capable of altering the development of rodent pups, causing reversible and, in some cases, irreversible damage in these animals. (bvsalud.org)

8. Oral p-tert-octylphenol exposures induce minimal toxic or estrogenic effects in adult female Sprague-Dawley rats. (nih.gov)

2 groups of 50 male Osborne-Mendel rats were administered in the diet 360 -500 and 720 -1000 ppm methoxychlor for 78 weeks. (inchem.org)
Inflammatory, degenerative and proliferative lesions as seen in the control and treated animals were similar in number and kind to spontaneous lesions occurring in aged Osborne-Mendel rats. (inchem.org)

When administered orally to immature rats, the parabens were inactive. (researchgate.net)

1970). TOXICOLOGICAL STUDIES Special study on teratogenicity Groups of pregnant rats received oral closes of methoxychlor at dose levels of 0, 34.6, 138, 242 and 346 mg/kg from gestation day 6 through 15. (inchem.org)

Because of inadequate reporting, conclusions cannot be drawn from the results of a fourth experiment in which some liver tumours were observed in rats fed up to 2000 ppm in the diet (equivalent to about 100 mg/kg bw/day). (inchem.org)

Baligar, P. N. and Kaliwal, B.B. (2001) Induction of gonadal toxicity to female rats after chronic exposure to mancozeb. (ac.ir)
In this study, the effects of prenatal exposure to deltamethrin on learning and memory abilities, N -methyl- D -aspartate receptor (NMDAR) subunits, brain derived neurotrophic factor (BDNF), Tyrosine kinase B (TrkB) receptor, and phosphorylated cAMP response element binding protein (pCREB) in the hippocampus of offspring rats were investigated. (frontiersin.org)

Response of adult murine uterine epithelium to 50% methoxychlor. (cdc.gov)

Groups each of six female SD rats, as F0-generation, were administered with deltamethrin (0, 0.54, 1.35, and 2.7, 9 mg/kg), or memantine (10 mg/kg), or co-administered with deltamethrin (9 mg/kg) and memantine (10 mg/kg) daily by gavage during pregnancy. (frontiersin.org)

Agency for Toxic Substances and Disease Registry 1999. (nih.gov)
Part of this effect may result from synthetic toxic substances acting on the endocrine system (endocrine disruptors), many of which are routinely used in work processes. (scielo.br)
Catalytic Conversion of Hazardous and Toxic Chemicals: Catalytic Hydrodechlorination of Polychlorinated Pesticides and Related Substances. (epa.gov)

Additional studies on biochemistry, long term studies in animal species other than the rat and reproduction studies were required. (inchem.org)

Ataya, K. and Tadros, M. Mohammad, S. (1988) Cyclophosphamide inhibits antral follicular development in the rat ovary. (ac.ir)

2 groups of 50 female rats received 750, and 1500 ppm for 78 weeks. (inchem.org)

14. Treatment with bisphenol A and methoxychlor results in the growth of human breast cancer cells and alteration of the expression of cell cycle-related genes, cyclin D1 and p21, via an estrogen receptor-dependent signaling pathway. (nih.gov)
The results showed the different toxic agents capable of altering the development of rodent pups, causing reversible and, in some cases, irreversible damage in these animals. (bvsalud.org)

Thus, there was an increased incidence of hemangiosarcomas at all sites in male rats receiving methoxychlor (9 low dose and 2 high dose) as compared to a single control male and a single control female with these tumours. (inchem.org)

In a receptor-binding assay, butylparaben was able to compete with 3H-estradiol for binding to the rat estrogen receptor with an affinity approximately 5 orders of magnitude lower than that of diethylstilboestrol, and between 1 and 2 orders of magnitude less than nonylphenol. (researchgate.net)

Rats exposed for 4 weeks to 0.1, 0.5, or 1.0mg displayed no significant differences in uterine epithelial cell height when compared to sesame-oil controls. (cdc.gov)

For this reason, the chemical purity of the methoxychlor used in key quantitative studies is provided. (cdc.gov)

Hypertrophied uterine lining cells were noted in the rats exposed to the higher levels of 2.5 and 5.0mg. (cdc.gov)

20 rats of each sex served as controls. (inchem.org)

Effect of Diphenylhydantoin on Storage of DDT in the Rat. (epa.gov)
Asmathbanu, I. and Kaliwal, B.B. (1997) Temporal effect of methyl parathion on ovarian compensatory hypertrophy, follicular dynamics and estrous cycle in hemicastrated albino rats. (ac.ir)

Anatomy1

Organisms1

Chemicals and Drugs13

Phenomena and Processes2

Metabolite2

Estrogenic2

Toxicity1

Toxicology1

Reproductive1

Chemicals7

Pesticides2

Tissues1

Milk1

Toxicological2

Mice3

Generations2

Vitro1

Metabolism1

Dose-response1

Liver1

Effects1

Development2

Sprague Dawley1

Osborne-Mendel2

Orally1

19701

20001

Exposure2

Adult1

Gavage1

Substances3

Species1

19881

Groups1

Results2

High1

Approximately1

Weeks1

Chemical1

Cells1

Controls1

Effect2