• intermediate
  • Utilized in the bacterial degradation of toxic aromatic compounds, the enzyme's crystal structure indicates that intermediates are shuttled directly between active sites through a hydrophobic intermediary channel, providing an unreactive environment in which to move the reactive acetaldehyde intermediate from the aldolase active site to the acetaldehyde dehydrogenase active site. (wikipedia.org)
  • In this pathway, the intermediate structures can be toxic, and health problems arise when those intermediates cannot be cleared. (wikipedia.org)
  • compound
  • Producing a toxic compound, like ethanol, can slow the growth of bacteria, allowing the yeast to be more competitive. (wikipedia.org)
  • When consumed, the principal active agent, gyromitrin, is hydrolyzed into the toxic compound monomethylhydrazine (MMH). (wikipedia.org)
  • accumulation
  • These symptoms result from the accumulation of toxic levels of formate in the blood, and may progress to death by respiratory failure. (wikipedia.org)
  • liver
  • As discovered by site-directed mutagenesis, glutamate-268 is a key component of liver acetaldehyde dehydrogenase and is also critical to catalytic activity. (wikipedia.org)
  • This reaction is important in liver and kidney cells, where the peroxisomes detoxify various toxic substances that enter the blood. (wikipedia.org)
  • mechanisms
  • Widespread human and aquatic organism exposure to Phe has been reported, but the toxic effects of Phe and potential mechanisms are unclear. (readbyqxmd.com)
  • concentrations
  • Though this feature is not adaptive from an energy point of view, by making alcohol in such high concentrations so that they would be toxic to other organisms, yeast cells could effectively eliminate their competition. (wikipedia.org)
  • people
  • This has yet to be confirmed, although one paper by Yokoyama and colleagues, published in Alcohol Clinical and Experimental Research in 2005, did present evidence that hangovers tend to be more severe among people with less effective acetaldehyde metabolism. (news-medical.net)
  • Effect
  • There is some debate over whether the main cause is the direct toxic effect of alcohol itself or whether the disease is a result of alcoholism-related malnutrition. (wikipedia.org)
  • brain
  • It is known by a variety of common descriptive names such as "brain mushroom," "turban fungus," elephant ears, or "beefsteak mushroom/morel," although beefsteak mushroom can also refer to the much less toxic basidiomycete Fistulina hepatica. (wikipedia.org)
  • blood
  • The metabolized acetaldehyde in the blood, which is six times higher than in individuals without the mutation, has shown to be a carcinogen in lab animals. (wikipedia.org)