• alcohols
  • In humans and many other animals, they serve to break down alcohols that otherwise are toxic, and they also participate in generation of useful aldehyde, ketone, or alcohol groups during biosynthesis of various metabolites. (wikipedia.org)
  • other alcohols such as methanol and isopropyl alcohol are toxic. (wikipedia.org)
  • Other conditions that can produce similar symptoms include infections, exposure to other toxic alcohols, serotonin syndrome, and diabetic ketoacidosis. (wikipedia.org)
  • highly toxic
  • Between 1932 and 1968, Chisso's chemical factory in Minamata released large quantities of industrial wastewater that was contaminated with highly toxic methylmercury. (wikipedia.org)
  • intermediate
  • Utilized in the bacterial degradation of toxic aromatic compounds, the enzyme's crystal structure indicates that intermediates are shuttled directly between active sites through a hydrophobic intermediary channel, providing an unreactive environment in which to move the reactive acetaldehyde intermediate from the aldolase active site to the acetaldehyde dehydrogenase active site. (wikipedia.org)
  • In this pathway, the intermediate structures can be toxic, and health problems arise when those intermediates cannot be cleared. (wikipedia.org)
  • mechanisms
  • Widespread human and aquatic organism exposure to Phe has been reported, but the toxic effects of Phe and potential mechanisms are unclear. (readbyqxmd.com)
  • individuals
  • The metabolized acetaldehyde in the blood, which is six times higher than in individuals without the mutation, has shown to be a carcinogen in lab animals. (wikipedia.org)
  • concentrations
  • Though this feature is not adaptive from an energy point of view, by making alcohol in such high concentrations so that they would be toxic to other organisms, yeast cells could effectively eliminate their competition. (wikipedia.org)
  • Effect
  • There is some debate over whether the main cause is the direct toxic effect of alcohol itself or whether the disease is a result of alcoholism-related malnutrition. (wikipedia.org)