• Age, and sex-adjusted plasma MDA levels had negative correlations with TAC (r = -0.30, p = 0.001) and total bilirubin (r = -0.30, p = 0.002) concentrations. (ajol.info)
  • Vitamin B12 deficiency, when coupled with high serum folate levels, has been found to increase overall homocysteine concentrations as well. (wikipedia.org)
  • Changes in plasma concentrations of total homocysteine (tHcy) reflect one aspect of the metabolic consequences of methyl group deficiency or nutrient supplementations. (nih.gov)
  • Low levels of these vitamins have been associated with high concentrations of homocysteine (Hcy) and can lead to health complications. (unboundmedicine.com)
  • Homocysteine, testosterone and allopregnanolone concentrations were measured in the fasting plasma from 16 women who underwent total thyroidectomy, and who were either hypothyroid or euthyroid. (degruyter.com)
  • With the normalization of thyroid hormone concentrations homocysteine levels decreased to normal levels. (degruyter.com)
  • Elevated plasma total homocysteine (tHcy) concentrations are associated with increased risk of vascular disease, and there is a strong inverse association between dietary and blood folate and blood tHcy concentrations. (unboundmedicine.com)
  • Vitamin B12, vitamin B6, and folate help convert homocysteine concentrations into other compounds (like cysteine and glutathione). (seekinghealth.com)
  • No strong associations were observed of these factors with Helicobacter pylori seropositivity, Chlamydia pneumoniae IgG titres, or plasma total homocysteine concentrations. (bmj.com)
  • Analyses of plasma folate, RBC folate, plasma homocysteine (HCY), and milk folate concentrations were performed. (avma.org)
  • Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. (thieme-connect.de)
  • MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males. (medscape.com)
  • We investigated whether baseline levels of plasma total homocysteine (tHcy), a marker of B vitamin status, modify the effects of ω3-FAs supplementation on cognitive performance in moderate AD. (fabresearch.org)
  • EDTA plasma samples were analyzed for total homocysteine (tHcy) with the Abbott IMx analyzer at the Laboratory of Clinical Chemistry of the VUMC. (lasa-vu.nl)
  • This study was aimed at investigating the effects of quercetin on mRNA expression and activity of critical enzymes in homocysteine metabolism in rats fed a methionine-enriched diet. (hindawi.com)
  • Because homocysteine metabolism is related to thyroid and steroid hormones, we studied these relationships in severe hypothyroidism and in euthyroid state. (degruyter.com)
  • These practices for prevention of spontaneous abortion are supported by some studies suggesting a connection between impaired homocysteine metabolism and recurrent miscarriages. (healthyplace.com)
  • Those vitamins are involved in the homocysteine metabolism. (lasa-vu.nl)
  • One hundred thirty-two adult heavy smokers completed a randomized, double blind, placebo-controlled clinical trial designed to investigate the effect of noni juice on serum cholesterol, triglyceride, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), high-sensitivity C-reactive protein (hs-CRP), and homocysteine. (hindawi.com)
  • The fact that cigarette smoke increases total cholesterol and triglycerides, as well as decreases high density lipoprotein cholesterol (HDL), has long been established. (hindawi.com)
  • This build up of homocysteine thiolactone causes low density lipoprotein to become aggregated, or sticky. (healthy.net)
  • We aimed to evaluate the effects of red grape juice (RGj) consumption on high density lipoprotein-cholesterol (HDL-C), apolipoprotein AI (apoAI), apolipoprotein B (apoB) and homocysteine (Hcy) levels in healthy human volunteers. (openbiochemistryjournal.com)
  • Associations between self-reported supplementation and duration of vegan diet with biomarkers of cobalamin (serum cobalamin, holotranscobalamin, homocysteine, folate) and iron status (serum ferritin, iron binding capacity, transferrin and saturation of transferrin) were assessed by cross-sectional analyses of medical data from a clinical nutrition center. (mdpi.com)
  • Folate, vitamin B 12 , homocysteine and methylenetetrahydrofolate reductase (MTHFR) are involved in one-carbon transfer (methylation) reactions necessary for the production of monoamine neurotransmitters, phospholipids and nucleotides. (cambridge.org)
  • Vascular risk factors , total HCY levels and methylenetetrahydrofolate reductase (MTHFR) gene mutations (C677T and A1298C) were examined. (bvsalud.org)
  • Key Benefits and Actions† Bioavailable, methylated folate and B12 in a well-absorbed lozenge Potent methylation, homocysteine, and MTHFR support. (seekinghealth.com)
  • Homocysteine can cyclize to give homocysteine thiolactone, a five-membered heterocycle. (wikipedia.org)
  • It has been proposed that both homocysteine and its thiolactone may have played a significant role in the appearance of life on the early Earth. (wikipedia.org)
  • The build up of homocysteine causes the formation of homocysteine thiolactone made from methionine in the liver by an enzyme that participates in protein formation and other processes. (healthy.net)
  • When LDL homocysteine thiolactone aggregates are released from the blood into the liver, they are taken up by the macrophages of the artery walls to form the foam cells that are seen in early arteriosclerotic plaques.These foam cells then degrade these aggregates and release fat and cholesterol into the developing plaques. (healthy.net)
  • The foam cells also release homocysteine thiolactone into surrounding cells of the artery walls, which affect the way that cells handle oxygen. (healthy.net)
  • A total of 732 Korean people aged 65 years or over were evaluated at baseline. (cambridge.org)
  • A study published in the August 2004 issue of The American Journal of Clinical Nutrition examined folate and homocysteine levels in a group of Finnish men and found that folate, but not homocysteine, had a significant inverse association with the risk of experiencing an acute coronary event (defined as a heart attack or prolonged episode of chest pain). (lifeextension.com)
  • Serum MDA and total homocysteine concentration were significantly higher, but TAC, total bilirubin and direct bilirubin levels were lower in CAD patients when compared to the controls. (ajol.info)
  • Total folate concentration in feed and forage was determined. (avma.org)
  • However, a large number of relative studies could prove the influence of folate on the homocysteine concentration of plasma which is considered a risk factor for cardiovascular diseases. (thieme-connect.de)
  • Because of this "self-looping" reaction, homocysteine-containing peptides tend to cleave themselves by reactions generating oxidative stress. (wikipedia.org)
  • More frequent total cholesterol HDL cholesterol, LDL cholesterol and triglyceride testing may be indicated for marked elevations or for changes to anti-lipid therapy due to inadequate initial patient response to dietary or pharmacologic therapy. (codemap.com)
  • We, therefore, aimed to undertake the present study to determine whether WMH or total SVD burden could be useful as a MRI marker for short-term outcome of minor cerebrovascular events. (researchsquare.com)
  • Abnormally high levels of homocysteine in the serum, above 15 μmol/L, are a medical condition called hyperhomocysteinemia. (wikipedia.org)
  • High levels of Homocysteine are associated with greater risk of heart disease, stroke, congestive heart disease, diabetic neuropathy, bone fracture, dementias, Alzheimer's disease, Preeclampsia and neural tube defect in pregnant females. (lotusdiagnostic.com)
  • Yes 82465 - When monitoring long-term anti-lipid dietary or pharmacologic therapy and when following patients with borderline high total or LDL cholesterol levels, it may be reasonable to perform the lipid panel annually. (codemap.com)
  • In contrast with other studies, homocysteine levels were not associated with acute coronary event risk in this study, although when smokers were separately analzyed, high homocysteine was associated with almost double the risk of an acute coronary event compared to the risk experienced by smokers with low homocysteine. (lifeextension.com)
  • A lipid panel (CPT code 80061) at a yearly interval will usually be adequate while measurement of the serum total cholesterol or a measured LDL should suffice for interim visits if the patient does not have hypertriglyceridemia. (codemap.com)
  • Recent studies in test tubes brings into question whether there is a connection between elevated homocysteine (and, therefore, folate deficiency) in the mother and Down's syndrome in the child. (healthyplace.com)
  • a serum homocysteine level higher than 15 micromol/L, for example, suggests vitamin B12 deficiency [ 11 ]. (nih.gov)
  • Medical experts don't recommend routine homocysteine testing to screen for heart disease risk in everyone. (medlineplus.gov)
  • And so far, studies have shown that lowering homocysteine levels doesn't reduce the risk of heart attack or stroke. (medlineplus.gov)
  • In an elderly population with cognitive impairment, we investigated the association between serum uric acid (sUA) and serum homocysteine (sHcy), known risk factors for cerebrovascular disease. (mdpi.com)
  • Total homocysteine (HCY) level might increase the risk of myocardial and cerebral infarction by damaging the vascular endothelium . (bvsalud.org)
  • For individuals with risk genetic predisposition , enhanced homocysteine -lowering strategies might be necessary to reduce the risk and progress of CSVD. (bvsalud.org)
  • Homocysteine levels and the risk of osteoporotic fracture. (lasa-vu.nl)
  • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. (thieme-connect.de)
  • Homocysteine and risk of ischemic heart disease and stroke. (thieme-connect.de)
  • Zhang F, Li X, Dong Q, Wang Y, Zhang H. Risk of Acute Cerebral Infarction and Plasma Asymmetrical Dimethylarginine and Homocysteine Levels: A Clinical Correlation Analysis of Chinese Population. (medscape.com)
  • There was a positive correlation between testosterone and homocysteine in the euthyroid state which suggests that not only estrogens but also androgen state should be considered in future studies on homocysteine. (degruyter.com)
  • Total HCY level was correlated with imaging burden of CSVD, especially with lacunes and brain volume loss. (bvsalud.org)
  • in plasma, it undergoes oxidization and transforms to disulfides homocystine and cysteine-homocysteine, the measured plasma level reflects these 3 components. (medscape.com)
  • Pirouzpanah S, Taleban FA, Mehdipour P, Atri M, Foroutan-Ghaznavi M. Plasma Total Homocysteine Level in Association With Folate, Pyridoxine, and Cobalamin Status Among Iranian Primary Breast Cancer Patients. (medscape.com)
  • Homocysteine play an important role in many metabolic pathways, mainly the methionine cycle to the folate cycle (see image below). (medscape.com)
  • simplified picture, showing Homocysteine involvement in different metabolic pathways as well as the role of vitamin B6, B12 and Folate as a co-factor in this pathways. (medscape.com)
  • Letter to the editor Re: "Confounding of the relation between homocysteine and peripheral arterial disease by lead, cadmium , and renal function. (cdc.gov)
  • Confounding of the relation between homocysteine and peripheral arterial disease by lead, cadmium , and renal function. (cdc.gov)
  • We aimed to explore the correlation between total HCY and CSVD imaging burden, based on Mendelian randomization methods . (bvsalud.org)