TopotecanTopoisomerase I InhibitorsTopoisomerase II InhibitorsDNA Topoisomerases, Type IDNA Topoisomerases, Type IITopoisomerase InhibitorsCamptothecinDNA Topoisomerase IVAmsacrineTeniposideAntineoplastic AgentsDNA, SuperhelicalEtoposideAntineoplastic Agents, PhytogenicDNA TopoisomerasesDNADNA CleavageAntigens, NeoplasmDNA, CatenatedRazoxaneNovobiocinEllipticinesDNA DamageDrug Administration ScheduleEnzyme InhibitorsOvarian NeoplasmsIntercalating AgentsInfusions, IntravenousCarcinoma, Small CellDNA-Binding ProteinsDrug Resistance, NeoplasmDNA GyraseDrug Screening Assays, AntitumorAntineoplastic Combined Chemotherapy ProtocolsMitoxantroneAcridinesTumor Cells, CulturedDose-Response Relationship, DrugPodophyllotoxinMolecular Sequence DataDoxorubicinBase SequenceNeutropeniaLung NeoplasmsNeoplasmsCisplatinCell Line, TumorRhabdomyosarcomaDrug ResistanceArea Under CurveNucleic Acid ConformationDNA, KinetoplastAminoacridinesThrombocytopeniaATP-Binding Cassette TransportersMutationDNA, NeoplasmThiobarbituratesCell CycleDNA BreaksAdministration, OralPaclitaxelQuinolonesPlasmidsRetinal NeoplasmsNeoplasm Recurrence, LocalAnti-Infective AgentsCatalysisMaximum Tolerated DoseFluoroquinolonesAminocoumarinsDrug SynergismAdministration, MetronomicSmall Cell Lung CarcinomaCell SurvivalSubstrate SpecificityEscherichia coliDNA Replication