• The aim of the present work therefore was to present efficacy and tolerability data of TNF-blocking agents on PsA in clinical practice, and to study potential predictors for drug survival (the length of time a patient continues to take a particular drug). (bmj.com)
  • The selective serotonin reuptake inhibitors fluoxetine, sertraline, fluvoxamine, and paroxetine have, in separate multicenter trials, demonstrated efficacy and tolerability in the treatment of OCD. (psychiatrist.com)
  • The suggestion that selective serotonin reuptake inhibitors possess efficacy similar to that of clomipramine, but have a superior side effect profile, may have important implications for patients with OCD who require long-term treatment. (psychiatrist.com)
  • This study should be the basis for further evaluations of long-term efficacy and safety of the use of cannabinoids in PD patients. (springer.com)
  • Although some reduction of erythema which was present in patients with papules and pustules of rosacea occurred in clinical studies, efficacy for treatment of erythema in rosacea in the absence of papules and pustules has not been evaluated. (nih.gov)
  • The trial design allows the first placebo-controlled data collection on the efficacy and safety of secukinumab in patients with GCA. (biomedcentral.com)
  • There are two more studies of phase 3 that have been conducted so that we now can say we have a wide range of robust data demonstrating the efficacy and safety and tolerability of this allergen specific immunotherapy. (touchimmunology.com)
  • The results which we show here are impressive also when compared with other developments that are currently undergoing and what we can show here from an efficacy point of view in the mid-scale phase 3 study, not one of these big mega studies with more than 1,000 patients. (touchimmunology.com)
  • Although no Food and Drug Administration (FDA) approved treatment has an indication for GD, a number of controlled trials have assessed the efficacy and tolerability of different pharmacotherapies. (springer.com)
  • however, current therapeutic options for migraine prophylaxis are associated with low efficacy and/or tolerability. (touchneurology.com)
  • Currently available preventive therapies are associated with low adherence rates due to lack of efficacy and/or poor tolerability. (touchneurology.com)
  • A phase II study and two phase III studies showed efficacy and safety in patients with episodic migraine, 5-7 and a randomised phase II trial showed efficacy and safety in patients with in chronic migraine ( Table 1 ). (touchneurology.com)
  • Some studies have advocated combining lamotrigine with valproate in refractory patients, to achieve maximum efficacy through a favourable pharmacodynamic interaction. (pocketdrugguide.com)
  • The primary outcomes were efficacy (change in depressive symptoms) and tolerability (discontinuations due to adverse events). (ox.ac.uk)
  • In terms of heterogeneity, the global I2 values were 38·63% for efficacy and 0% for tolerability. (ox.ac.uk)
  • Combined buprenorphine/naloxone, however, also demonstrates significant efficacy and favorable safety and tolerability in multiple populations, including youth and prescription opioid-dependent individuals, as does buprenorphine monotherapy in pregnant women. (lww.com)
  • To evaluate the safety and efficacy of abatacept plus methotrexate (MTX) over 5 years in patients with rheumatoid arthritis. (jrheum.org)
  • We describe safety analyses for all patients who received at least 1 dose of abatacept and efficacy analyses for the original ~10 mg/kg abatacept-treated group, over 5 years. (jrheum.org)
  • Abatacept maintained the efficacy observed at Year 1 over 5 years of treatment, and demonstrated consistent safety and tolerability. (jrheum.org)
  • This Phase IIb study demonstrated the safety and efficacy of abatacept plus methotrexate (MTX) over 1 year of double-blind (DB) treatment in patients with RA and an inadequate response to MTX 3 , 4 , and confirmed ~10 mg/kg to be the most effective dose. (jrheum.org)
  • Subsequent Phase III studies verified the efficacy and safety of abatacept both in patients with an inadequate response to MTX 5 and in patients with an inadequate response to anti-TNF agents 6 . (jrheum.org)
  • We describe the safety, tolerability, and efficacy of abatacept ~10 mg/kg over 5 years of treatment in the continuing open-label longterm extension (LTE) of a Phase IIb study. (jrheum.org)
  • We report on the safety and tolerability of all patients who received at least 1 dose of abatacept over 5 years, and the efficacy and health-related quality of life (HRQOL) of patients who had received ~10 mg/kg abatacept over 5 years in this continuing open-label extension of a Phase IIb study. (jrheum.org)
  • Information extracted included study characteristics, participant characteristics, intervention details, settings, and outcome measures in terms of efficacy, acceptability, and tolerability.Main resultsWe included 24 studies in the review with a total of 4233 participants, of which 2124 were randomised to benzodiazepines and 1475 to placebo. (univr.it)
  • The efficacy of duloxetine (60 mg/day) has been compared to that of escitalopram (10 mg/day) and placebo in a randomised study of 684 patients (randomised in a 2:2:1 ratio). (pharmacologycorner.com)
  • This study aimed to assess the efficacy and safety of direct switch from once-daily tiotropium (TIO) 18 μg to indacaterol/glycopyrronium (IND/GLY) 110/50 μg once daily in COPD patients in Korea. (e-trd.org)
  • OBJECTIVES: To assess the comparative tolerability of selective serotonin reuptake inhibitors and tricyclic/heterocyclic antidepressant drugs. (ox.ac.uk)
  • The story of the atypical antipsychotics is a tale of the triumph of profit over patient benefit, of marketing over ethics. (cambridge.org)
  • Furthermore, the clinical antipsychotic trials of intervention effectiveness (CATIE) also found that in spite of patients' high tolerability to atypical antipsychotics, at present, there is a high dropout rate in the use of these drugs due to either inefficacy or intolerable side effects. (drugwatcher.org)
  • The mean increase in weight over a ten-week period for patients treated with standard doses of atypical antipsychotics was 4.45 kg with clozapine and 4.15 kg with olanzapine. (statpearls.com)
  • The positive effect of MTX was primarily linked to fewer dropouts because of adverse events. (bmj.com)
  • With significantly fewer dropouts due to adverse effects than clomipramine, paroxetine was also associated with superior tolerability. (psychiatrist.com)
  • We expect both treatment innovations to have fewer dropouts, to lead to faster symptom reduction and more favorable long term outcomes and consequently, lower treatment costs. (universiteitleiden.nl)
  • Believing that the atypicals were more efficacious, had fewer side-effects and may even be 'neuroprotective', decreasing the long-term deterioration and negative symptoms often associated with schizophrenia, the authors hypothesised 10 years ago that patients randomised to clozapine would have better long-term outcomes than those randomised to chlorpromazine. (cambridge.org)
  • The tolerability of scalp cooling has improved significantly thanks to newer devices. (think-pink.be)
  • Dropout analyses revealed significantly higher deterioration rates over time. (bvsalud.org)
  • Patients with open-angle glaucoma who have a worse mean deviation to their visual field, a greater vertical cup-to-disc ratio at baseline, or who are older are significantly more likely to experience a rapid decay of their visual field, according to a recent study of 767 eyes from 566 participants in the Advanced Glaucoma Intervention Study. (medscape.com)
  • A safety analysis revealed significantly more nausea, dry mouth, vomiting and yawning reported by patients on duloxetine treatment compared to those on escitalopram or placebo. (pharmacologycorner.com)
  • It has been seen that some classes of psychotropic medications have significantly improved patients' painful episodes, which have an important positive impact on quality of life. (bvsalud.org)
  • We hypothesize that nabilone will improve NMS in patients with PD and have a favorable safety profile. (springer.com)
  • The current findings provide initial support for the safety and tolerability of ketamine as an intervention for SI in patients who are at elevated risk for suicidal behavior. (nih.gov)
  • Telmisartan is approved for the treatment of hypertension, but has been studied at standard doses in both hypertensive and normotensive patients, and has an excellent safety profile in both populations. (yes4yes.com)
  • safety and tolerability of telmisartan in HIV-positive subjects. (yes4yes.com)
  • And on the other side, you know, every medal has two sides from the tolerability point of view, there were only a few drop-outs for tolerability or safety issues. (touchimmunology.com)
  • It will explore several secondary measures including change in health resource utilisation, effect on patient reported outcomes of migraine disability and the safety and tolerability of each medication. (bmj.com)
  • In July 2015, a long-term safety and tolerability study began enrolling 100 patients from previous Phase 1 and 2 trials who were willing to continue their randomized, blinded treatment for another year. (alzforum.org)
  • A direct switch from TIO to IND/GLY provided improvements in lung function and other patient-reported outcomes with an acceptable safety profile in patients with mild-to-moderate airflow limitation. (e-trd.org)
  • Tolerability refers to the degree to which overt adverse effects of a drug can be tolerated by a patient. (wikipedia.org)
  • Usually, it is measured by the rate of "dropouts", or patients that forfeit participation in a study due to extreme adverse effects. (wikipedia.org)
  • Three groups were compared in terms of colonization of stent and urine, stent related symptoms and febrile urinary tract infections (UTIs) during the period of indwelling stent and until 1 week after removal.RESULTS: In Group A, 9 (19.5%) patients had significant bacterial growth on the stents. (cranberryinstitute.org)
  • After 4 weeks, patients receiving the standardized cranberry supplementation reported to have a more effective reduction in UTI symptoms, as assessed on the visual analogue scale, compared with patients in the SM or nitrofurantoin groups. (cranberryinstitute.org)
  • Although open-label observations report a positive effect of cannabinoids on non-motor symptoms (NMS) in Parkinson's disease (PD) patients, these effects remain to be investigated in a controlled trial for a broader use in NMS in PD patients. (springer.com)
  • The difference is 35%, which is unusual for just five injections or treatment visits, but not only the symptoms and the medication need is reduced, but we also see a significant improvement in the quality of life of patients treated with this active component in comparison to placebo. (touchimmunology.com)
  • Reducing levodopa or dopamine agonist (DA) dosages may partially reduce GD symptoms among patients with co-occurring PD. (springer.com)
  • 2,3 Today, there is a rapid increase of TAI methods in highly symptomatic patient groups with anorectal symptoms. (wellspect.co.uk)
  • Because of the silent nature of glaucoma, patients will not usually present with any symptoms or visual complaints until late in the disease course, particularly with POAG. (medscape.com)
  • Rapid-cycling bipolar disorder patients have ≥4 episodes of major depression, mania, hypomania or mixed symptoms within a year. (mims.com)
  • Later on, it became clear that these symptoms do not indicate the effectiveness of a drug and these effects also lead to patients' non-compliance with medication. (drugwatcher.org)
  • Originally prescribed to treat schizophrenia and the manic symptoms of bipolar disorder, the drug was found to have obvious risks of male breast growth and an increased risk of death among elderly patients with dementia. (drugwatcher.org)
  • Many chronic obstructive pulmonary disease (COPD) patients receiving monotherapy continue to experience symptoms, exacerbations and poor quality of life. (e-trd.org)
  • Severe diseases, including those with severe symptoms, untreated inflammatory and infectious processes, due to which the patient cannot receive treatment in accordance with the study protocol. (who.int)
  • We contacted experts in the field for supplemental data.Selection criteriaAll double-blind (blinding of patients and personnel) controlled trials randomising adults with panic disorder with or without agoraphobia to benzodiazepine or placebo.Data collection and analysisTwo review authors independently checked the eligibility of studies and extracted data using a standardised form. (univr.it)
  • Strengths of this study include its controlled design, which will increase the quality of data on status migrainosus, the use of an active control, which will provide clinically meaningful outcomes and the incorporation of patient-centred and health-economic outcomes. (bmj.com)
  • If milestones in the R61 phase are achieved, up to 3 years of additional support (R33 phase) may be awarded to replicate the impact of the natural product on the biological signature(s) when used by humans and assess whether there is an association between the degree of the impact on the biological signature and functional or clinical outcomes in a patient population. (nih.gov)
  • We have previously shown that a single dose of ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, is associated with a rapid reduction in depressive symptom severity and SI in patients with treatment-resistant depression. (nih.gov)
  • The patient also has depressive episodes which may last for at least 2 weeks. (mims.com)
  • Duloxetine versus escitalopram and placebo in the treatment of patients with major depressive disorder: onset of antidepressant action, a non-inferiority study. (pharmacologycorner.com)
  • The aim of this project is to investigate the (cost)effectiveness of two innovative forms of trauma-focused therapy for patients with childhood abuse related PTSD. (universiteitleiden.nl)
  • The general aim of the present project is to test the (cost)effectiveness and tolerability of two innovative forms of trauma-focused treatment in patients with chronic, childhood-related PTSD. (universiteitleiden.nl)
  • The short-term effectiveness of duloxetine is comparable to low-dose escitalopram but its tolerability is less. (pharmacologycorner.com)
  • There were considerably more dropouts due to nausea in the duloxetine group than in the escitalopram group. (pharmacologycorner.com)
  • The prevalence of chronic obstructive pulmonary disease (COPD) is considerably high, affecting 251 million patients globally. (e-trd.org)
  • Therefore, the current study investigated the role of treatment expectations for subjective symptom changes in CD patients who have undergone an integrative multimodal therapy program. (bvsalud.org)
  • Concomitant MTX and high CRP levels are associated with treatment continuation of anti-TNF therapy in patients with PsA regardless of joint distribution. (bmj.com)
  • Risk is increased for children under 16, and is also more common with concomitant valproate use, and in patients who have experienced rash on other anti-epileptic drugs. (pocketdrugguide.com)
  • Tolerability of a particular drug can be discussed in a general sense, or it can be a quantifiable measurement as part of a clinical study. (wikipedia.org)
  • For instance, cancer patients may tolerate significant pain or discomfort during a chemotherapeutic study with the hope of prolonging survival or finding a cure, whereas patients experiencing a benign condition, such as a headache, are less likely to. (wikipedia.org)
  • All but one study [79] did not exclude patients with severe OSA. (researchgate.net)
  • We evaluated their role in this setting.METHODS: We conducted a prospective randomized study to evaluate patients with indwelling DJ stents following urological procedures. (cranberryinstitute.org)
  • This is a randomized, parallel-group, double-blind, placebo-controlled, multi-center, phase II study in which patients, treating physicians, and the associated clinical staff as well as the sponsor clinical team are blinded. (biomedcentral.com)
  • Study design: Open-label, randomized clinical trial in 426 treatment naive patients. (jwatch.org)
  • This study aimed to investigate long-term treatment effects of two psychological treatments: cognitive behavioural therapy (CBT) as a broad-spectrum approach and exposure as a specific intervention for fear-avoidant pain patients. (bvsalud.org)
  • We have conducted this study in approximately 300 patients and can see significant effects when comparing the actively treated group with placebo group. (touchimmunology.com)
  • 8 Another study, that contained long-term-accumulated experience, found overall success of TAI therapy in 47% of patients with heterogenic background pathology, after an average follow-up period of 21 months. (wellspect.co.uk)
  • This study randomises forty patients (1:1) to receive either eptinezumab or an infusion of intravenous lignocaine for up to 5 days. (bmj.com)
  • All patients who received clozapine treatment with extended (12-weekly) monitoring in a large London National Health Service trust were included in a 1-year mirror-image study. (cambridge.org)
  • A recent very large, randomized open-label study indicated that lamotrigine might be the drug of choice in patients with partial epilepsy, as it was equally effective but better tolerated, but in a companion study it was substantially less effective than valproate in patients with generalized or unclassified epilepsy. (pocketdrugguide.com)
  • Phase 3 of the study is a prospective cohort study of approximately 2,400 adult patients 18 years and older who have been offered treatment for LTBI in the United States and Canada. (cdc.gov)
  • Taking an ecological approach, this study addresses a wide range of factors, including knowledge, attitudes, and beliefs, as well as toxicity, tolerability, social and economic factors, and issues associated with clinic structures and the health care delivery system. (cdc.gov)
  • All patients who completed the 1-year, DB period of this study (clinical trial registration number: NCT00254293) 3 , 4 were eligible to enter the open-label LTE period. (jrheum.org)
  • This was a randomized, open-label, parallel group, 12-week trial in mild-to-moderate COPD patients who received TIO 18 μg once daily for ≥12 weeks prior to study initiation. (e-trd.org)
  • Of the 442 patients screened, 379 were randomized and 347 completed the study. (e-trd.org)
  • Thus, the study can help professionals working in this area to take assertive behaviors regarding the treatment of fibromyalgia and expand scientific research on this topic, indirectly improving the clinical treatment of patients with this pathology. (bvsalud.org)
  • This study is an update for medical professionals of different specialties, mainly rheumatologists and psychiatrists so that they can better guide patients' morbidity as they use these medications to manage the patient with fibromyalgia. (bvsalud.org)
  • Availability of written informed consent from the patient to participate in the study. (who.int)
  • The ability of the patient and the personnel caring for him to comply with the instructions of the research physician and comply with the study design. (who.int)
  • Serious adverse events occurring in the patient during the study. (who.int)
  • Tolerability, however, is often relative to the severity of the medical condition a drug is designed to treat. (wikipedia.org)
  • 2 Some patients treat their migraine attacks with drugs to relieve pain but, in some patients, the frequency, severity and impact on quality of life necessitates the use of preventive treatment to reduce the occurrence of acute attacks. (touchneurology.com)
  • The current state of pharmacology research for CUD highlights the need to consider particular characteristics of patients, such as gender, impulsivity, and severity of cannabis use, when selecting a medication in the off-label treatment of CUD or cannabis withdrawal. (nature.com)
  • Patients have episodes of hypomania alternating with mild depression that lasts for 2 years. (mims.com)
  • After eight weeks, the probability of responding to treatment (defined as a 50% improvement from baseline on the Hamilton Rating Scale for Depression) was not statistically different between patients given active drug or placebo. (pharmacologycorner.com)
  • A total of 38 patients will have 80% power to detect a probability of 0.231 that an observation in the treatment group is less than an observation in the placebo group using a Wilcoxon rank-sum test with a 0.050 two-sided significance level assuming a true difference of 2.5 points between nabilone and placebo in the primary outcome measure and a standard deviation of the change of 2.4 points. (springer.com)
  • Patients in both treatment arms receive a 26-week prednisolone taper regimen. (biomedcentral.com)
  • All our patients have to continue a life-long treatment. (jwatch.org)
  • BACKGROUND: There is a significant research gap with respect to the long-term sustainability of psychological treatment effects in chronic pain patients. (bvsalud.org)
  • The abstract ' Clinical Development of Mannan conjugated birch pollen allergoids for the treatment of birch pollen allergic patients - from first-inhuman to approval in 3 studies . (touchimmunology.com)
  • For GD patients not willing to consider drug treatment, n-acetyl cysteine or behavioral therapies may be effective. (springer.com)
  • For patients who fail to respond to simple analgesia, triptans and intravenous prochlorperazine or chlorpromazine, there are limited treatment options, and a paucity of high-quality evidence to guide clinical practice. (bmj.com)
  • Fluoxetine is probably the only antidepressant to consider when a pharmacological treatment is indicated, however patients should be carefully monitored for the risk of increased suicidality. (ox.ac.uk)
  • Our aim was to evaluate the achievement of low-density lipoprotein cholesterol (LDL-C) treatment goals in FH patients younger than 18 years enrolled in a large national registry. (revespcardiol.org)
  • When clozapine was discovered, it became evident that this drug can apparently improve delusions and hallucinations in treatment-resistant patients. (drugwatcher.org)
  • The evidence strongly supports the use of agonist therapies to reduce opioid use and to retain patients in treatment, with methadone maintenance remaining the gold standard of care. (lww.com)
  • They are becoming the treatment of choice for patients during their first psychotic break and indicated through their lifetime. (statpearls.com)
  • Treatment with second-generation antipsychotics can contribute to weight gain and, subsequently, metabolic syndrome with high blood sugar, hypertension, abnormal cholesterol, and triglyceride concentrations, posing a patient at risk for stroke, myocardial disease, and diabetes mellitus. (statpearls.com)
  • Refusal of the patient from the proposed treatment method. (who.int)
  • METHODS: Patients with chronic low back pain were randomized to CBT or exposure in vivo. (bvsalud.org)
  • However, if these methods are used, it should be in a collaborative manner to avoid promoting an adversarial relationship between the provider and patient. (guidelines.org.au)
  • In some treatments, scalp cooling can prevent complete hair loss in more than 70 % of patients. (think-pink.be)
  • Finally, it is important for patients to know that scalp cooling cannot prevent all hair loss or thinning, even in treatments with good success rates. (think-pink.be)
  • 1 Encouraged by the positive results, TAI was used with adult patients with defecation disorders in whom conservative treatments had failed. (wellspect.co.uk)
  • The validity of the included studies is questionable due to possible unmasking of allocated treatments, high dropout rates, and probable publication bias. (univr.it)
  • Both treatments were well tolerated by patients. (e-trd.org)
  • However, doctors during this time only had few choices of medication for patients. (drugwatcher.org)
  • However, the average number of patients who reported at least a 30 percent reduction in pain was greater with cannabinoids than with placebo. (nih.gov)
  • The primary endpoint was the proportion of patients achieving a reduction of at least 50% from baseline in monthly migraine days (MMDs) during weeks 9-12. (touchneurology.com)
  • Melatonin was superior to amitriptyline in the percentage of patients with a greater than 50% reduction in migraine frequency. (bmj.com)
  • half of the patients show 50% reduction in attack frequency. (bmj.com)
  • 9 LIBERTY recruited patients who had failed 2-4 previous migraine therapies and were therefore considered difficult to treat. (touchneurology.com)
  • These represent the majority of migraine patients seen by neurologists in clinical practice, but who are often excluded from clinical studies. (touchneurology.com)
  • 2 Although migraine prophylaxis guidelines from North American, South American and European societies are available, only 3-5% of patients receive adequate preventive therapy. (bmj.com)
  • 4 , 5 About half of the patients with migraine stop seeking care for their headaches, partly because of their side effect profile. (bmj.com)
  • 7 Newer effective and tolerable options for migraine prophylaxis are necessary to reduce this gap and improve patients' quality of life. (bmj.com)
  • Non-attendance and high dropout rates in this particular patient group seem common. (universiteitleiden.nl)
  • Patient education on orthostatic hypertension and advice on factors that influence blood pressure (for example, high environmental temperatures, sudden changes in posture, alcohol, and large, carbohydrate‑rich meals). (nice.org.uk)
  • In refractory patients, doses may be as high as 500-1000 mg/day. (pocketdrugguide.com)
  • Metabolic disturbances and changes in subcutaneous (SAT) and visceral (VAT) fat (lipodystrophy) contribute to this risk, and are common in HIV-positive patients. (yes4yes.com)
  • We also examined response rate, all-cause dropouts and suicidality. (ox.ac.uk)
  • The intervention was well tolerated and no dropouts occurred during the primary 7-day assessment period. (nih.gov)
  • The probability of meeting these criteria was 42.6% in patients given duloxetine, 35.2% in patients given escitalopram and 21.5% in patients given placebo. (pharmacologycorner.com)
  • Nausea was the most common adverse event occurring in 23.8% of patients taking duloxetine, 12% of patients taking escitalopram and 8.8% of patients taking placebo. (pharmacologycorner.com)
  • Fatal cases of liver failure have been reported with duloxetine so it is contraindicated for patients with hepatic impairment and should not be given to patients who are drinking substantial amounts of alcohol. (pharmacologycorner.com)
  • Patient participation in another clinical trial. (who.int)
  • If any visual field or optic nerve changes consistent with early glaucoma are present, then diagnose the patient as having such. (medscape.com)
  • The primary endpoint is the proportion of patients in sustained remission until week 28 in the secukinumab group compared to the proportion of patients in the placebo group. (biomedcentral.com)
  • Patients were randomly assigned to a night with a positional device (PD) and a night on CPAP (10 +/- 3 cm H2O). (researchgate.net)
  • Fifty patients are randomly assigned in a 1:1 ratio to receive either 300 mg secukinumab or placebo subcutaneously at baseline, weeks 1, 2 and 3, and every 4 weeks from week 4. (biomedcentral.com)
  • A total of 246 patients were randomly assigned (1:1) to erenumab (140 mg, administered by subcutaneous injection) or placebo. (touchneurology.com)
  • In contrast, lithium or other mood stabilizers may be most effective for GD for patients presenting with a co-occurring bipolar spectrum disorder (BSD). (springer.com)
  • In addition to antidepressants, it was seen that antipsychotics and anticonvulsants could also be used by patients to improve quality of life when used alone or in combination with serotonin or norepinephrine reuptake inhibitors. (bvsalud.org)
  • The use of tumour necrosis factor (TNF) blocking agents in psoriatic arthritis (PsA) is increasing, and the SSATG register has followed patients with PsA for more than 5 years. (bmj.com)
  • Already most of our patients are on ART for more than 7-10 years. (jwatch.org)
  • Many of these patients' viral control remains under control (undetectable level) for not less than 7- 10 years. (jwatch.org)
  • Perform screening at least every 3-5 years in asymptomatic patients aged 40 years or younger and more often if the person is African American or older than 40 years. (medscape.com)
  • Little is known about the characteristics of persons with familial hypercholesterolemia (FH) younger than 18 years, the lipid-lowering therapy used in these patients, and the lipid goals reached in real life. (revespcardiol.org)
  • We analyzed patients younger than 18 years enrolled in a large ongoing registry of molecularly-defined patients with FH in Spain. (revespcardiol.org)
  • Incidence rates of adverse events (AE) and serious AE were 489.7 and 20.0/100 patient-years in Year 1 versus 374.9 and 18.9/100 patient-years in the cumulative period, respectively. (jrheum.org)
  • The age of patients is from 18 to 75 years. (who.int)
  • The exception is for patients who were treated for basal cell or squamous cell skin cancer, cervical cancer in situ, or other tumors more than 5 years ago and are expected to be completely cured. (who.int)
  • We conducted a randomized, controlled trial of ketamine in patients with mood and anxiety spectrum disorders who presented with clinically significant SI (n = 24). (nih.gov)
  • It is important to quantify the drop-out rates of different antidepressant drugs in order to have a better understanding of the relative tolerability of these drugs. (ox.ac.uk)
  • the product has a good tolerability profile. (cranberryinstitute.org)
  • The poor tolerability profile of the old tricyclics was explained by differences in drop-outs for side-effects, but not for inefficacy. (ox.ac.uk)
  • Patients included are naïve to biological therapy and have newly diagnosed or relapsing GCA. (biomedcentral.com)
  • Typical doses for patients with newly diagnosed epilepsy are 100-200 mg/day. (pocketdrugguide.com)
  • If the patient is receiving valproate at the time of initiation, starting doses and doses during titration should be cut in half, whereas if they are receiving enzyme-inducing anti-epileptic drugs such as phenytoin, carbamazepine or phenobarbital, doses can be doubled. (pocketdrugguide.com)
  • A multidisciplinary group of experts, including pulmonary, surgical, dentistry and ear-nose-throat specialists, methodologists and patient representatives considered the most relevant clinical questions (for both clinicians and patients) relating to the management of OSA. (researchgate.net)
  • Every patient within the agreed target group is offered scalp cooling. (think-pink.be)
  • Patients (n = 261) with active PsA, starting anti-TNF therapy for the first time in southern Sweden, were included. (bmj.com)
  • We hypothesized that positional therapy would be equivalent to continuous positive airway pressure (CPAP) at normalizing the apnea-hypopnea index (AHI) in patients with positional obstructive sleep apnea (OSA). (researchgate.net)
  • Positional therapy is equivalent to CPAP at normalizing the AHI in patients with positional OSA, with similar effects on sleep quality and nocturnal oxygenation. (researchgate.net)
  • Background: HIV-positive patients are at increased risk of cardiovascular disease (CVD), a finding linked to both HIV infection and anti-retroviral therapy (ART). (yes4yes.com)
  • Today, compliance is the major issue with TAI therapy, and may be improved through greater knowledge of which patient is best suited for TAI. (wellspect.co.uk)
  • Therapy choice should be individually determined, depending on patient tolerability and needs. (wellspect.co.uk)
  • Out of 17 studies and 1229 patients, TAI therapy was considered successful in 53% of all cases. (wellspect.co.uk)
  • Side effects, out-of-pocket costs, convenience, and patient preferences also need to be considered. (guidelines.org.au)
  • Emphasize the following points during the examination to distinguish POAG from either secondary causes of glaucoma or from OHT in patients with only elevated IOP and no damage. (medscape.com)
  • Telmisartan has been shown to decrease VAT, total cholesterol, and LDL levels, and improve fasting glucose, HDL, and markers of vascular inflammation in HIV-negative patients. (yes4yes.com)
  • Three-times-a-day dosing may improve tolerability. (pocketdrugguide.com)
  • Earlier cooling systems had worse results and were more difficult for patients to tolerate. (think-pink.be)
  • Yet, felbamate may still be an important drug in the armamentarium for refractory patients, because it may control seizures when other drugs fail, and tends to be alerting rather than sedating. (pocketdrugguide.com)