• This study identifies a non-canonical EcR-corepressor complex with the potential for a direct regulation of ATP-dependent nucleosome remodelling by a nuclear hormone receptor. (sdbonline.org)
  • COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene. (wikipedia.org)
  • Recombinant full length protein corresponding to Human Retinoid X Receptor beta/RXRB. (abcam.com)
  • Further, emerging evidence suggests that nicotine can also regulate the expression of genes/proteins involved in various functions such as ERK1/2, CREB, and c-FOS [ 20 - 22 ], as well as the expression state of multiple biochemical pathways, for example, mitogen-activated protein kinase (MAPK), phosphatidylinositol phosphatase signaling, growth factor signaling, and ubiquitin-proteasome pathways [ 23 - 25 ]. (hindawi.com)
  • All members of transforming growth factor superfamily are synthesized as pre-pro-peptides that consist of a short N-terminal signalling peptide, a latency-associated protein (LAP) domain and the mature TGF domain [ 42 ]. (springer.com)
  • The human GR protein is produced from 9 exons of the GR gene and is composed of 3 major subdomains, each of which has specific structural and functional properties. (brainimmune.com)
  • NR0B1 protein was detected in cancerous tissues of more than 50% of human lung adenocarcinoma (ADCA) cases and tended to be expressed in low-differentiated cancerous tissues obtained from males. (oncotarget.com)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • This blog entry reviews a little background on vitamin D3, what is known about the vitamin D receptor (VDR) protein, the new research, and implications for health and longevity. (anti-agingfirewalls.com)
  • Several skeletal dysplasias in specific dog breeds have been associated with mutations in members of the collagen gene family or its binding proteins ( 8 - 10 ), fibrilin related protein ( 11 ), as well as an altered sulfate transporter protein ( 12 ). (frontiersin.org)
  • The immunogen of 22576-1-AP is androgen receptor Fusion Protein expressed in E. coli. (ptglab.com)
  • The DNA repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. (aacrjournals.org)
  • A cellular DNA-repair protein, namely O 6 -methylguanine-DNA methyltransferase (MGMT) protein, reverses alkylation at the O 6 position of guanine, thereby inhibiting the lethal cross-linking and bringing about resistance to alkylating agents ( 2, 3 ). (aacrjournals.org)
  • The nuclear receptor-related 1 protein is mostly expressed in the subplate in the dorsal cortex, but also in lower layer 6 in the lateral and perirhinal cortex, and can be detected from 12 PCW. (ox.ac.uk)
  • We sought genotype-phenotype correlations and undertook a comparative analysis with patients with PAH with BMPR2 (Bone Morphogenetic Protein Receptor type 2) causal variants (n = 162) or no identified variants in PAH-associated genes (n = 741) genotyped via the National Institute for Health Research BioResource-Rare Diseases. (stanford.edu)
  • Different mutations of EDA gene and EDAR gene could make different influence on the protein function and lead to the occurrence of HED. (bvsalud.org)
  • An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. (lookformedical.com)
  • Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)
  • Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
  • Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
  • The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
  • Loss of LXR-beta function is associated with an increase in the expression of UNCOUPLING PROTEIN 1 as well as OBESITY. (bvsalud.org)
  • In a cross-sectional study of 48 AD patients without diabetes, 20 cognitively normal diabetic patients, 16 patients with frontotemporal dementia, and 84 cognitively normal controls, researchers found that dysfunctionally phosphorylated insulin receptor substrate-1 (IRS-1), a neuronal protein, is detectable in blood using exosome-based technology and may be able to predict AD up to 10 years before the appearance of symptoms. (medscape.com)
  • We investigated publicly available transcriptomic gut profiles of young germ-free mouse hosts transplanted with old donor gut microbiota to identify immune-associated differentially expressed genes (DEGs). (biomedcentral.com)
  • A total of 112 differentially expressed genes (DEGs) were identified and used to construct a gut network of encoded proteins, in which DEGs were functionally annotated as being involved in an immune process based on gene ontology. (biomedcentral.com)
  • We additionally searched the National Library of Medicine (NLM) PubMed using the additional terms: (differentially expressed genes OR DEGs). (biomedcentral.com)
  • Transcriptomes from the tissues of the brain-pituitary-gonad (BPG) axis of T10 samples revealed a differential gene expression profile compared to the other experimental groups, with clustering in a principal component analysis and in heat maps of all differentially expressed genes. (biomedcentral.com)
  • Furthermore, a functional analysis of differentially expressed genes revealed enriched gene ontology terms involved in the regulation of circadian rhythm, histone modification, meiotic nuclear division, and others. (biomedcentral.com)
  • This thermoception may have caused the observed effects through epigenetic mechanisms, since all analysed tissues further revealed differentially expressed genes involved in histone modification. (biomedcentral.com)
  • These diverse actions of glucocorticoids are mediated by the glucocorticoid receptor (GR), which belongs to the nuclear receptor superfamily and functions as a hormone-dependent transcription factor. (brainimmune.com)
  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancerindex.org)
  • Numerous studies aiming to identify the genetic variants or candidate genes have found a large number of promising genes and chromosomal regions involved in the etiology of nicotine addiction [ 13 ]. (hindawi.com)
  • Thus, the discovery of genomic regions and positional candidate genes (PCGs) for intestine length or weights and percentages of heart, liver, gizzard or lungs, is a first step for understanding their genetic architecture. (biomedcentral.com)
  • There are over 120 known genetic variants for neurological disorders in dogs alone ( 1 ), and with advances in molecular genetic technology and consistently decreasing costs, the list is continuing to expand at a rapid rate. (frontiersin.org)
  • The classic diagnostic approach emphasizes obtaining these assessments before conducting genetic analyses (often limited to individual candidate genes) and is expensive, laborious, and time-consuming. (biomedcentral.com)
  • Earlier studies using a candidate gene approach, family linkage studies and gene expression profiling uncovered a number of T2DM genes, but the genetic basis of common T2DM remained unknown. (scialert.net)
  • No prior knowledge of gene or gene effects is necessary, but the genetic locus must have sufficient impact on the disease susceptibility to be detectable. (scialert.net)
  • The genetic component of T2DM comes from ethnic group differences in prevalence rates. (scialert.net)
  • Mutations in some genes cause rare forms of T2DM, giving additional support for the genetic roles in the aetiology of the disease. (scialert.net)
  • Objective: To detect gene mutation in patients with hypohidrotic ectodermal dysplasia (HED) by using whole exome sequencing, to analyze the pathogenicity of the mutations, and to provide reference for the genetic diagnosis of HED patients. (bvsalud.org)
  • In this study, we systematically screened the coding exons of steroid hormone receptor coactivator and corepressor genes in a multiethnic panel of women with breast cancer in an attempt to identify and catalogue potentially functional coding polymorphisms that may serve as genetic markers of breast cancer risk. (biomedcentral.com)
  • The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity. (wikipedia.org)
  • Thus, organisms cannot survive in the absence of glucocorticoid action, as observed in the mouse model in which the glucocorticoid receptor (GR) gene is genetically deleted [3]. (brainimmune.com)
  • The glucocorticoid receptor (GR) is essential for the correct functioning of the HPA axis, thus alterations in the expression of the GR through altered methylation of the GR gene ( NR3C1 ) (and more specifically exon 1F) might contribute to the development of NSSI in individuals with a history of ACEs, as has been reported for different other mental disorders. (karger.com)
  • Subsequently, by using independent RNAi/ dominant negative forms, it was shown that Ecdysone Receptor (EcR) is essential for male fertility due to its requirement in the normal development of accessory glands in Drosophila: EcR depleted glands fail to make seminal proteins and have dying cells. (sdbonline.org)
  • Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. (thermofisher.com)
  • It binds and inactivates the 140 kDa subunit of RNA polymerase II, blocking all gene expression leading to proteins. (helmberg.at)
  • Cellular response to estrogens is mediated through estrogen receptors (ERα and ERβ), which upon binding to ligand and DNA hormone response elements, recruit coactivator and corepressor proteins that regulate the expression of steroid hormone target genes. (biomedcentral.com)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • Mutations in this gene are related to very different diseases. (stanford.edu)
  • Whole exome sequencing and sanger sequencing were performed to detect gene mutations. (bvsalud.org)
  • Bioinformatics tools predicted that the mutations of EDA gene detected in this study were highly species conserved and disease-causing. (bvsalud.org)
  • Conclusions: Three reported mutations of EDA gene and a previously unreported mutation of EDAR gene were detected in four HED families. (bvsalud.org)
  • The other mutations are much less common, occurring in about 1% of cases. (msdmanuals.com)
  • Three transcript variants encoding different isoforms have been found for this gene. (cancerindex.org)
  • A total of 13,748 annotated sequence SNPs were in the 14 PCGs, including 156 SNPs in coding regions (124 synonymous, 26 non-synonymous, and 6 splice variants). (biomedcentral.com)
  • This study adds one novel NR5A1 variant to the pool of pathogenic variants and enriches the adolescents of information available about the mutation spectrum of this gene in Chinese population. (biomedcentral.com)
  • First, molecular events in T2DM pathogenesis have been examined directly by testing the role of sequence variants of specific candidate genes. (scialert.net)
  • The candidate gene approach focuses on the search for an association between T2DM and sequence variants in or near biologically defined candidate genes which have been chosen based on their known physiological function. (scialert.net)
  • Variants located in the T-BOX and nuclear localization domains were associated with earlier presentation (P = 0.005) and increased incidence of interstitial lung disease (P = 0.003). (stanford.edu)
  • We identified 45 coding variants with frequencies ≥ 1% in any one ethnic group (43 non-synonymous variants). (biomedcentral.com)
  • Cataloging and testing of coding variants in coactivator and corepressor genes should continue and may serve as a valuable resource for investigations of other hormone-related phenotypes, such as inter-individual response to hormonal therapies used for cancer treatment and prevention. (biomedcentral.com)
  • 12 , 13 ] Polymorphic variants in these mediators of hormonal responsiveness could affect the functional activity of estrogen receptors following stimulation by endogenous or exogenous (i.e. (biomedcentral.com)
  • Androgen receptor (AR) also konwn as Dihydrotestosterone receptor (DHTR), Nuclear receptor subfamily 3 group C member 4 (NR3C4).It is one of steriod hormoen receptors, which are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (ptglab.com)
  • 11 ] The relative recruitment of coactivators versus corepressors for a given ligand (e.g. estradiol vs tamoxifen) is tissue specific and may account for agonist vs. antagonist activity of the same ligand in different tissues. (biomedcentral.com)
  • Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody [NBP2-22523] - Analysis of 25 ug of mouse thyroid (lane 1), NIH-3T3 (lane 2) and A431 (lane 3) cell lysates onto an SDS polyacrylamide gel. (novusbio.com)
  • Given the established role of estrogens in breast cancer, we hypothesized that coding variation in steroid receptor coactivator and corepressor genes may alter inter-individual response to estrogen and serve as markers of breast cancer risk. (biomedcentral.com)
  • Peroxisome proliferator-activated receptor gamma 2 ( PPAR-γ2 ) is a transcription factor with a key role in adipocyte differentiation, lipid storage and glucose homeostasis. (biomedcentral.com)
  • Some genes are thought to be involved in the development of T2DM and obesity amongst which, the peroxisome proliferator activated receptor gamma (PPAR-γ) gene. (biomedcentral.com)
  • Finally, we used siRNAs against the major transcription factors (TFs) predicted for these regions [peroxisome proliferator-activated receptor γ (PPARγ), Krüppel-Like Factor 4 (KLF4), and vitamin D receptor (VDR)] to assess EDN1 expression in cell culture and validate the binding sites. (stanford.edu)
  • PA1-824 detects peroxisome proliferator activated receptor (PPAR) gamma 2 from human and mouse tissues. (thermofisher.com)
  • Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). (thermofisher.com)
  • Generally, subfamily UGT1A enzymes conjugate the 3-hydroxyls of estrogens, while the activity of subfamily UGT2B is directed towards 16- and 17-hydroxyls. (helsinki.fi)
  • The precise levels and timing of NR0B1 gene expression are critical for gonadal differentiation and sex determination during embryogenesis [ 1 ]. (oncotarget.com)
  • By influencing gene expression in multiple tissues, calcitriol influences many physiological processes besides calcium/phosphate homeostasis including muscle and keratinocyte differentiation, insulin secretion, blood pressure regulation, and the immune response. (anti-agingfirewalls.com)
  • According to the bimodal switch model, steroid hormone receptors recruit corepressors in the absence of hormone and coactivators in its presence. (sdbonline.org)
  • First, an RNAi screen was carried out involving 19 hormone receptors, individually and specifically, in a male reproductive tissue (accessory gland) for their requirement in Drosophila male fertility. (sdbonline.org)
  • PPAR gamma 2, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex. (thermofisher.com)
  • However, we find no evidence that deregulated genes in Pten-deficient livers are direct transcriptional targets of E2F7/8, supporting that reduction in steatosis and progression towards liver cancer are likely consequences of inhibiting polyploidization. (bvsalud.org)
  • Glucocorticoids are steroid hormones secreted from the zona fasciculata of the adrenal cortex, and play numerous important roles in the maintenance of internal homeostasis by influencing activities of virtually all organs and tissues, such as the brain, liver, skeletal muscles and the immune-related organs and cells [1]. (brainimmune.com)
  • We studied the regulation of Shp by Vdr using reporter and mobility shift assays in transfected human embryonic kidney 293 cells, quantitative polymerase chain reaction with mouse tissues and mouse and human hepatocytes, and chromatin immunoprecipitation assays with mouse liver. (nih.gov)
  • In mice fed normal diets and given injections of 1,25(OH)2D3, liver and plasma concentrations of 1,25(OH)2D3 increased and decreased in unison. (nih.gov)
  • The methylation specific polymerase chain reaction in conjunction with sequencing verification was used to establish the methylation patterns of the 14 genes in the liver tissues of four healthy liver donors, as well as tumor and the paired non-cancerous tissues of 30 HCC patients. (wjgnet.com)
  • PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes involved in the beta-oxidation of fatty acids. (thermofisher.com)
  • In healthy liver tissue, extracellular matrix is very subtle to minimize diffusion distances. (helmberg.at)
  • A liver X receptor that is expressed primarily by cells in the liver and other metabolically-active tissues. (bvsalud.org)
  • A liver X receptor that is ubiquitously expressed. (bvsalud.org)
  • Serotonin 5-HT2 receptor agonists have shown efficacy in treating seizure disorders, such as epilepsy. (bioworld.com)
  • Subsequently, we cloned three NMDA receptor subunits CgNR1, CgNR2A and CgNR2B, with sequence analysis suggesting successful assembly of functional NMDA receptor complexes and binding to natural occurring agonists and the channel blocker MK-801. (exeter.ac.uk)
  • which results from mRNA alternative splicing of PPAR-γ is expressed predominantly in the adipose tissue. (biomedcentral.com)
  • The Ala isoform may lead to a less efficient stimulation of the PPAR-γ target genes and predisposes to lower levels of adipose tissue mass accumulation which in turn may be responsible for improved insulin sensitivity [ 7 ]. (biomedcentral.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • In my research, I mix cellular models, gene editing, and high throughput assays to find the determinants of penetrance in the development of PAH under these conditions. (stanford.edu)
  • In accordance with the publishing schedule , BioWorld Science was not published on Wednesday, Dec. 6, 2023, and will not be published on Friday, Dec. 8, 2023. (bioworld.com)
  • We screened the literature from inception until January 2022 by querying the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) using the search terms: (microbiome OR microbial OR microbiota OR microflora OR dysbiosis). (biomedcentral.com)
  • As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
  • This study examined the roles of hormone-dependent transcription factors (Nuclear Receptors), in accessory gland development, function and male fertility of a genetically tractable insect model, Drosophila melanogaster. (sdbonline.org)
  • Estrone is only a weak agonist of estrogen receptor but it serves as a precursor for biosynthesis of 17β-estradiol, 16α-hydroxyestrone and catechol estrogens. (helsinki.fi)
  • While 16α-hydroxyestrone has relatively weak affinity for estrogen receptor, it has prolonged effect due to covalent binding to the receptor. (helsinki.fi)
  • Plasma and tissue samples were collected and levels of Vdr, Shp, Cyp7a1, Cyp24a1, and rodent fibroblast growth factor (Fgf) 15 expression, as well as levels of cholesterol, were measured. (nih.gov)
  • In addition to its well-known effects on calcium/phosphate homeostasis, vitamin D, through its hormonal form, 1alpha,25-dihydroxyvitamin D(3) or calcitriol, is a cell differentiating factor and anti-proliferative agent with actions on a variety of tissues around the body (e.g., skin, muscle, immune system). (anti-agingfirewalls.com)
  • Further, clustering of these genes resulted in six clusters with themes in synaptic transmission, signal transduction, metabolic process, and apoptosis, which provided an intuitional view on the major molecular functions of the genes. (hindawi.com)
  • In summary, by analyzing the overall characteristics of the nicotine addiction related genes, this study provided valuable information for understanding the molecular mechanisms underlying nicotine addiction. (hindawi.com)
  • The subsequent targeting specific disease‐causing genes, comprising 360 endocrine disease-causing genes, was employed for molecular diagnosis. (biomedcentral.com)
  • [ 5 ] Although enormous progress has recently been made in defining and characterizing the molecular biology, immunology, and antiviral therapeutic targets for CMV, considerable work remains in devising strategies for prevention of CMV infection and in understanding the role of specific viral genes in pathogenesis. (medscape.com)
  • This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor.Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS). (ptglab.com)
  • Both glutathione S-transferase pi ( GSTpi ) (80%, 24/30 in tumor and 56.7%, 17/30 in the paired non-cancerous tissues) and cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) ( CFTR ) (77%, 23/30 in tumor and 50%, 15/30 in the paired non-cancerous tissues) genes were prevalently hypermethylated in HCC as well as their neighboring non-cancerous tissues. (wjgnet.com)
  • Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
  • Global transcriptomic analysis showed that inhibition of polyploidization in Pten-deficient livers resulted in reduced expression of genes involved in energy metabolism, including PPAR-gamma signalling. (bvsalud.org)
  • Notably, the separate overexpression of EcR-B1 or a transforming growth factor- β receptor Baboon , whose activation can upregulate the EcR-B1 expression, in MB neurons rescued the miR-34 -induced gamma axon pruning phenotype. (sdbonline.org)
  • However, exposure to MK-801 did not alter the expression of selected key enzymes, suggesting that NMDA receptors do not regulate the biosynthesis of catecholamines via gene expression. (exeter.ac.uk)
  • Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma. (wjgnet.com)
  • To establish the DNA methylation patterns of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma (HCC). (wjgnet.com)
  • these changes were not observed in Shp(-/-) mice given 1,25(OH)2D3 and fed Western diets. (nih.gov)
  • In addition, chromatin immunoprecipitation analysis of livers from mice showed that injection of 1,25(OH)2D3 increased recruitment of Vdr and rodent retinoid X receptor to the Shp promoter. (nih.gov)
  • And the post Hypervitaminosis D and premature aging indicates, among other topics, how mice with their VDR gene knocked out age prematurely. (anti-agingfirewalls.com)
  • The publication Premature aging in vitamin D receptor mutant mice (vitamin D receptor (VDR) knockout mice) states "Overall, VDR KO mice showed several aging related phenotypes, including poorer survival, early alopecia, thickened skin, enlarged sebaceous glands and development of epidermal cysts. (anti-agingfirewalls.com)
  • Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. (novusbio.com)
  • Previous microarray experiments in mice have shown several genes that are specifically expressed in the subplate layer of the rodent dorsal cortex. (ox.ac.uk)
  • Leukotriene B4 (LTB4) stimulates the release of cytokines and mediators that participate in tissue inflammation and acts as a chemoattractant for neutrophils, eosinophils and monocytes at the inflammation site. (bioworld.com)
  • RECENT FINDINGS: 1,25-Dihydroxyvitamin D stimulates the innate immune system, facilitating the clearance of infections such as tuberculosis. (anti-agingfirewalls.com)
  • The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. (ptglab.com)
  • The aim of this study was to investigate the association of Pro12Ala polymorphism in the PPAR-γ2 gene with susceptibility to obesity or T2DM in a Cameroonian population. (biomedcentral.com)
  • A portion of the 270 base pair bands of the PPAR-γ2 gene was successfully amplified. (biomedcentral.com)
  • PPAR-γ2 Pro12Ala gene polymorphism may not be associated with obesity and T2DM. (biomedcentral.com)
  • These results suggest that, PPAR-γ2 is unlikely a major gene for obesity or T2DM in the study population. (biomedcentral.com)
  • Synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
  • PA1-824 immunogen is a synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
  • This sequence is not conserved in PPAR gamma-1. (thermofisher.com)
  • Because we showed that integration neither affects the levels of viral genes, nor those of virally disrupted human genes, a genome-wide screen was performed to identify human genes which expression is influenced by viral integration and have clinical relevance. (cancerindex.org)
  • TGF-β1 acts predominantly through phosphorylation of the C-terminal MH2 domains of SMAD2 and SMAD3 via activin receptor-like kinase 5 (ALK5), of which activity is located at the C-terminal part of TGFBR1. (springer.com)
  • Similar histone occupancies were confirmed in a comparison of cancerous tissues with strong, moderate and negative NR0B1 expression. (oncotarget.com)
  • Otherwise, Foxo1 drives the transcription of enzymes involved in gluconeogenesis (PEPCK, glucose-6-phosphatase). (helmberg.at)
  • Glucocorticoids, steroid hormones secreted from the adrenal cortex, play essential roles in the maintenance of internal homeostasis by influencing virtually all organs and tissues. (brainimmune.com)
  • Gene regulation by steroid hormones plays important roles in health and disease. (sdbonline.org)
  • We used logistic regression to estimate odds ratios for allelic effects in ethnic-pooled analyses as well as in subgroups defined by disease stage and steroid hormone receptor status. (biomedcentral.com)
  • Little is known about the effects of the vitamin D receptor (VDR) on hepatic activity of human cholesterol 7α-hydroxylase (CYP7A1) and cholesterol metabolism. (nih.gov)
  • Changes in hepatic Cyp7a1 messenger RNA (mRNA) correlated with those of Cyp24a1 (a Vdr target gene) and inversely with Shp mRNA, but not ileal Fgf15 mRNA. (nih.gov)
  • Polymorphisms in UGT genes have been linked to excretion of steroids and risk of some cancers. (helsinki.fi)
  • This mutation was first identified by Schuldiner's group in 1997 with different ethnic population showing various allelic frequencies that is probably modulated by environmental and other genetics factors. (biomedcentral.com)
  • The EDAR gene mutation founded in this research was reported in HED patients for the first time. (bvsalud.org)
  • Retinoic acid, although not at physiological concentrations, activate this receptor. (wikipedia.org)
  • Further, the GR gene expresses a splicing variant GRbeta, which does not bind glucocorticoids but functions as a dominant negative isoform for GRalpha. (brainimmune.com)
  • Two receptor subunits are known, receptor type I and type II subunits. (springer.com)
  • Thus, activated, type I subunits recruit and phosphorylate receptor SMADs (R-smad), which are the first intracellular mediators of TGF-β signalling. (springer.com)
  • NMDA receptor subunits are expressed in competent larvae, during metamorphosis and in spat, but this expression is neither self-regulated nor regulated by catecholamines. (exeter.ac.uk)
  • The blog post Klotho anti-aging gene in the news describes how " Klotho expression is also important for averting premature aging due to overexpression of Vitamin D," citing a number of papers relevant to that topic. (anti-agingfirewalls.com)
  • SUMMARY: The broad tissue distribution of the 25-hydroxyvitamin D 1alpha-hydroxylase enzyme and the vitamin D receptor establish a role for 1,25-dihydroxyvitamin D in the pathophysiology of various disease states and provide new therapeutic targets for vitamin D and its analogues. (anti-agingfirewalls.com)
  • Distribution of vitamin B12 in bivalve tissues: Investigations of larval and adult lifestages. (exeter.ac.uk)
  • Lifetime risk of T2DM development is 40% in offspring of one T2DM parent and increases up to 70% if both parents have T2DM ( Groop and Tuomi, 1997 ). (scialert.net)
  • Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)
  • The most frequent site of alkylation in DNA is the O 6 position of guanine, which forms cross-links between adjacent strands of DNA, leading to cell death. (aacrjournals.org)
  • In the human dorsal cortex, connective tissue growth factor-positive neurons can be seen in the ventricular zone at 15-22 postconceptional weeks (PCW) (most at 17 PCW) and are present in the subplate at 22 PCW. (ox.ac.uk)
  • Our results suggest that connective tissue growth factor- and nuclear receptor-related 1-positive cells are two distinct cell populations of the human subplate. (ox.ac.uk)