• Balanced diets (as commercial dog food is considered) may be more protective against oxidative damage than homemade diets. (tubitak.gov.tr)
  • Antioxidants prevent or slow oxidative damage to molecules in the body's tissues. (sagescript.com)
  • GH and/or IGF-I did not change the basal level of oxidative damage to lipids. (nel.edu)
  • To counteract oxidative damage, spermatozoa and seminal plasma have several mechanisms to neutralize free radicals. (scialert.net)
  • Liver tissue showed an increase in oxidative damage, through lipid peroxidation and hydrogen peroxide production, in all metal exposures with Cr being the most dramatic and Ni showing damage at days 3 and 7. (cdc.gov)
  • To summarize, Cr-induced oxidative damage at day 1 was reduced or resolved at day 7, while Cd and Ni produced more oxidative damage at days 3 and 7 at the higher exposure levels. (cdc.gov)
  • Summing up, ROT can cause oxidative damage not only in the brain but also in other organs. (cranberryinstitute.org)
  • Conclusion V exposure in vitro resulted in oxidative damage with significant regional variations in brain tissue homogenates. (thieme-connect.com)
  • Conclusion: The current study suggests that oxidative damage is one of the major causes for the pathogenesis of OLP. (medicopublication.com)
  • Studies show that taurine supplementation increases total thiol content and decreases muscle soreness, lactate dehydrogenase level, creatine kinase activity, and oxidative damage (7). (ac.ir)
  • In order to prevent oxidative damage, the antioxidant system presents a group of cellular enzymes (SOD, catalase and glutathione system) responsible for the control of free radicals. (bvsalud.org)
  • Mn, serum Mn, urine Mn, Centromere-positive micronuclei in periphery blood lymphocytes, DNA protein-crosslinks in peripheral white blood cells, oxidative stress as urinary 8OHdG, and long-term oxidative damage measured as erythrocytic superoxide dismutase (SOD) activity (measure of systemic oxidative stress) and serum malondialdehyde (MDA) (product of lipid peroxidation and reflect tissue injuries). (who.int)
  • An antioxidant, quercetin scavenges free radicals and inhibits damage-perpetuating, post-injury lipid peroxidation . (healingtherapies.info)
  • Like quercetin, vitamin E is an antioxidant that protects neuronal membranes from lipid-peroxidation. (healingtherapies.info)
  • Dr. Royal Saunders and co-investigators (1987, Ohio) investigated the effects on lipid peroxidation of treating experimentally injured cats with a combination of vitamin E and another antioxidant, selenium. (healingtherapies.info)
  • C ompared to untreated controls, the spinal-cord tissue at the injury site of the antioxidant-treated cats had fewer molecules associated with lipid-peroxidation. (healingtherapies.info)
  • Vitamin E has been proven to have antioxidant and moisturizing properties in the skin and can protect against the damage of UVB radiation, with emphasis on the reduction of acute erythema and photoaging. (intechopen.com)
  • Determinations based on antioxidant enzyme activities showed significant alterations in glutathione, glutathione peroxidase, superoxide dismutase and catalase in tissues (liver and brain) and plasma of pesticide treated group while polyphenolic extracts from I. aquatica (IAE) attenuated their activities when given alongwith carbofuran. (niscair.res.in)
  • The present investigation should have included measurement of antioxidant enzymes in brain tissues as a further extension of this study. (thieme-connect.com)
  • In the present study, we evaluate antioxidant effects of Salvia officinalis L. hydroalcoholic extract and its therapeutic effect to counteract liver damage in male rats. (scirp.org)
  • These results support the hypothesis that the increased amount of copper/zinc superoxide dismutase is probably inadequate to exert an effective antioxidant protection but can result in a pro-inflammatory, pathogenic effect enhancing tissue damage. (indexindex.com)
  • Aim: The aim of this study was to compare the tissue levels of antioxidant Super oxide dismutase (SOD) and lipid peroxidation marker Malondialdehyde (MDA) in established cases of OLP and healthy individuals. (medicopublication.com)
  • This causes oxidative stress, a process that if not countered by the body's antioxidant defenses, will over time result in cell, tissue and DNA damage. (irondisorders.org)
  • Biomarkers of organ damage or dysfunction for the renal, hepatobiliary, and immune systems. (cdc.gov)
  • Subcommittee on Biomarkers of Organ Damage and Dysfunction. (cdc.gov)
  • Additional effects of lead exposure were evaluated by examining concentrations of biomarkers (oxidative stress, lipid peroxidation, and deoxyribonucleic acid damage) in liver tissues, δALAD inhibition, and renal and hepatic microscopic lesions in birds from lead-contaminated and reference sites. (usgs.gov)
  • It is kept in equilibrium by the carnisinases which are enzymes specifically aimed at inactivating carnosine in the tissues or in the blood. (natmedtalk.com)
  • 16q24.3 (Morquio syndrome): The deficiency of enzymes in Morquio syndrome type A or type B leads to the accumulation of keratan sulfate and chondroitin-6-sulfate in the connective tissue, the skeletal system, and the teeth. (medscape.com)
  • Growth hormone (GH) and its tissue mediator, insulin-like growth factor-I (IGF-I), are involved in oxidative processes, lipid peroxidation (LPO) included. (nel.edu)
  • [ 11 ] This is the most toxic component due to high reduction-oxidation (redox) potential that generates oxygen-free radicals such as superoxide anion in the cells, which damages DNA, proteins, and membrane lipids in the cell. (medscape.com)
  • This includes damage to lipids that make up the cell membrane, proteins that form the structure of skin and carry out metabolic processes, and DNA that carries the genes of the cell. (sagescript.com)
  • it may result in oxidative stress, inflammation, and consequent damage to proteins, membranes and DNA. (svce.ac.in)
  • ROS can react with proteins, nucleic acids, and can cause lipids cell and tissue damage and can be measured using selective or general indicators. (creativebiomart.net)
  • Proteins, carbohydrates, and lipids (including phospholipids) are molecules that excessive ROS can modify. (ac.ir)
  • Pulmonary injury leading to early allograft dysfunction is caused by ischemia-reperfusion injury (IR) and originates from multiple pathogenic events, including endothelial damage, neutrophil extravasation into tissue, and peroxidation of cell membrane lipids, followed by pulmonary cell alterations and edema. (nih.gov)
  • According to the current view, damage-associated molecules released by infected or injured cells, or secreted by innate immune cells generate danger signals activating an immune response. (frontiersin.org)
  • When body iron stores increase above these relatively normal ratios, proportionally greater amounts of iron are stored in non-blood tissue in ferritin molecules or a complex called hemosiderin. (irondisorders.org)
  • The large proteoglycan molecules made up of protein cores, and GAG branches are secreted by cells and constitute a significant fraction of the extracellular matrix of connective tissue. (medscape.com)
  • The molecules most the study from the inpatient and outpatient exposed to damage by free radicals are the clinics of the National Liver Institute. (who.int)
  • Sperm cell membranes are high in polyunsaturated fatty acids and are sensitive to oxygen free radical induced damage mediated by lipid peroxidation. (scialert.net)
  • Basically, after the initial mechanical injury, a complicated physiological chain reaction ge nerates free-radicals, which steal electrons from the lipids in neighboring neuronal membranes, resulting in further cell death. (healingtherapies.info)
  • For example, it is 1) lipophilic (i.e., affinity for fat or lipid), allowing it to diffuse through cell membranes and scavenge free radicals within the cells, 2) anti-inflammatory, and 3) anti-edematous, i.e., inhibits damage-causing swelling. (healingtherapies.info)
  • Effects of growth hormone and insulin-like growth factor-I on the iron-induced lipid peroxidation in the rat liver and porcine thyroid homogenates. (nel.edu)
  • Aim This study aimed to evaluate the effects of vitamin C (VC) and deferoxamine (DF) against V-induced LPO in brain tissue homogenates in vitro. (thieme-connect.com)
  • 0.001) enhancement of LPO (average increase with 20μMV was by +105% and with 100μMV was by +130%), respectively, in brain tissue homogenates compared with water controls. (thieme-connect.com)
  • Coexposure of brain tissue homogenates to V + VC (20 and 100μM) further accelerated the LPO (+24% and +16%, respectively) compared with V alone. (thieme-connect.com)
  • Neoplastic and normal mammary tissue , 1 cm^3 each, was used for TBARS and \alpha-tocopherol measurements. (tubitak.gov.tr)
  • The increased lipid peroxidation due to oxidative stress induction (increased TBARS and decreased \alpha-tocopherol concentration) found in neoplastic compared to normal mammary tissue of dogs with mammary cancer was similar in both groups of dogs fed with a different kind of diet, commercial or homemade. (tubitak.gov.tr)
  • The lipid peroxidation (TBARS) and the enzymatic activity of catalase (CAT) were measured in the cardiac muscle. (bvsalud.org)
  • Rheumatoid arthritis is characterized by a chronic hypertrophic synovitis leading to destruction of connective tissue and functional damage of cartilage and bone structures. (indexindex.com)
  • The enzyme deficiencies lead to the accumulation of mucopolysaccharides in the lysosomes of the cells in the connective tissue and to an increase in their excretion in the urine. (medscape.com)
  • High concentrations of carnosine are present in long-lived cells (such as in neuronal tissues). (natmedtalk.com)
  • Here, we wanted to verify the extent of inflammation and oxidative stress in mice chronically-exposed to WPS and to evaluate, for the first time, its effect on alveolar injury and DNA damage and their association with impairment of lung function. (who.int)
  • Along with oxidative stress, WPS exposure significantly increased lung DNA damage index. (who.int)
  • Interestingly, we found dilated alveolar spaces and alveolar ducts with damaged interalveolar septae, and impairment of lung function following WPS exposure. (who.int)
  • CONCLUSION: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. (who.int)
  • These results show that human relaxin exerts a protective effect in IR-induced lung injury, likely due to ET reduction, endothelial protection, decreased leukocyte recruitment, and hindrance of free radical-mediated tissue injury, which renders relaxin a candidate drug for lung preservation. (nih.gov)
  • Liver tissue, kidney tissue, blood and lung lavage fluid were collected and analyzed. (cdc.gov)
  • 5. The inhaled material may alter the deposition of particles and may remain permanently within the lung tissues. (svce.ac.in)
  • [ 4 ] In patients who receive numerous transfusions-notably those with thalassemia major , sickle cell disease , myelodysplastic syndrome , aplastic anemia , hemolytic anemia , and refractory sideroblastic anemias , who may become transfusion dependent-the excess iron from the transfused erythrocytes gradually accumulates in various tissues, causing morbidity and mortality. (medscape.com)
  • It is a prominent product in thromboxane A2 synthesis wherein cyclooxygenase 1 or cycloxygenase 2 metabolizes arachidonic acid to prostaglandin H2 by platelets and a wide array of other cell types and tissues. (wikipedia.org)
  • Sparstolonin B was showed to alleviate joint swelling in RA rats, inhibited inflammatory cell infiltration and the release of ROS, reduced damage caused by oxidative stress, and suppressed the rate of apoptosis in synovial cells. (hindawi.com)
  • The immune system is constituted by a very complex network of cells, tissues, and organs that through soluble factors and direct cell-to-cell contacts interact among themselves and with cells belonging to other (organ) systems. (frontiersin.org)
  • Specifically, as a water-soluble free radical scavenger it prevents lipid peroxidation within the cell membrane (3). (natmedtalk.com)
  • But, in some conditions, these effects cannot be controlled and lead cell damages. (scirp.org)
  • 2. Cytotoxicity : A primary marker for the damaging effects of NPs has been cell viability as determined by state and exposed surface area of the cell membrane. (svce.ac.in)
  • Lipid peroxidation is a well-demonstrated mechanism of cellular which injury in both plants and animals. (creativebiomart.net)
  • In addition to micronucleus (MN) assay was performed in obtained blood tissues. (trjfas.org)
  • Limited endogenous mechanisms exist to reverse these damages. (scialert.net)
  • Studies have found that NAC prevents liver damage due to environmental toxins, anaesthesia and elevated cholesterol levels. (drmyattswellnessclub.com)
  • OP pesticides are known to cause inhibition of Acetylcholinesterase (AChE) activity in the target tissues ( Jayaratnam and Maroni, 1994 ) which accumulates acetylcholine and prevents the smooth transmission of nerve functions leading to convulsions and death. (scialert.net)
  • It seems that the main reason for effectiveness of royal jelly on the skeletal tissue of the body, bones, and teeth is related to its high calcium concentration, and due to that, RJP has been widely used in traditional oriental medicine (Guo et al. (researchgate.net)
  • 10) and skeletal (11, 12) tissues. (ac.ir)
  • Taking alpha-lipoic acid by mouth daily for up to 6 months does not improve liver function or reduce liver damage in people with alcohol-related liver disease. (medlineplus.gov)
  • Taking alpha-lipoic acid by mouth with or without standard hydration therapy during a coronary angiography doesn't seem to prevent kidney damage caused by contrast agents. (medlineplus.gov)
  • Taking alpha-lipoic acid by mouth daily for 24 months doesn't improve eye damage from diabetes. (medlineplus.gov)
  • If the organism is exposed to these factors during early life, when the maturing immune system is particularly susceptible, damages may be immediate, but can also emerge only late in life ( 4 ). (frontiersin.org)
  • In vitro study of the protective effect of manganese against vanadium-mediated nuclear and mitochondrial DNA damage. (thieme-connect.com)
  • NPs have been found to induce apoptosis in certain cells primarily due to the mitochondrial damage and oxidative stress brought on by the foreign NPs electrostatic reactions. (svce.ac.in)
  • In summary, findings in the present study confirmed that BP-QDs induce ferroptosis via increasing lipid peroxidation and iron accumulation in vitro and in vivo.PMID:3748. (medworm.com)
  • Hereditary hemochromatosis is a genetic disorder characterized by excessive iron (Fe) accumulation that results in tissue damage. (msdmanuals.com)
  • After 24 h of exposure to different doses (4-32 μg/mL) of BP-QDs, intracellular lipid peroxidation and iron overload occurred in Beas-2B cells. (medworm.com)
  • Exposure to soil-borne lead was correlated with elevated lead concentrations in tissues, inhibition of δ-aminolevulinic acid dehydratase (δALAD), and renal lesions in birds foraging on ground-dwelling invertebrates at contaminated sites (compared to reference sites) in the Southeast Missouri Lead Mining District. (usgs.gov)
  • Electron spin resonance results showed an increase in hydroxyl radical formation in liver and kidney tissue from Cr, day 1, as well as Cd & Ni on days 3 and 7, at the highest exposure levels. (cdc.gov)
  • Research has shown that 50% of patients who have had RA for more than ten years will incur damage to the extra-articular organs, such as the cardiovascular and nervous systems, the lungs, the kidneys, and the bones [ 4 ]. (hindawi.com)
  • The liver is one of the only organs in the body that is able to replace damaged tissue with new cells rather than scar tissue. (jonbarron.org)
  • The increase in the DNA damage was noticed in all organs examined and in leukocytes. (cranberryinstitute.org)
  • Nowadays, the immune system is thought to be activated by "danger signals" which are relevant not only to the induction of inflammation and immune responses but also to the activation of counter regulatory (anti-inflammatory/modulatory) mechanisms required to shutdown inflammation and allow tissue healing. (frontiersin.org)
  • Chronic alcohol use impairs not only gut and liver functions, but also multi-organ interactions, leading to persistent systemic inflammation and ultimately, to organ damage. (wjgnet.com)
  • Perturbing agents, such as toxic compounds ( 1 ), ionizing radiation ( 2 ), and some pathogens ( 3 ) can compromise the integrity of the immune system as they damage immune cells and/or irreversibly alter some immune functions. (frontiersin.org)
  • By comparing with previous studies, we speculate that primary cells generally are more sensitive to BP-QDs-induced damage than cancer cells. (medworm.com)
  • Post-injury hemorrhaging causes the hemoglobin within red blood cells to disintegrate, releasing oxidized iron, which triggers lipid peroxidation. (healingtherapies.info)
  • Quercetin binds to this iron, preventing it from reacting with the lipids on neighboring cells. (healingtherapies.info)
  • These cells are very active when we are young to protect us from environmental skin damage and reactions. (refinery29.com)
  • Compared to controls, more spinal-cord tissue was preserved in the quercetin-treated rats. (healingtherapies.info)
  • Tissue samples of small intestine extracted from rats were histopathologically and immunohistochemically analyzed. (springermedizin.at)
  • 3. Lipid solubility & molecular size are the most important factors. (svce.ac.in)
  • 4. Higher lipid solubility & small molecular size enhance NPs transformation towards body. (svce.ac.in)
  • So, it protects the tissues from these damaging 'second-wave' chemicals. (natmedtalk.com)
  • In this study, the action mechanism of colemanite (COL), a commercially important borate mineral, was aimed to investigate via evaluating parameters related to oxidative alterations on the brain, liver and blood tissues of zebrafish. (trjfas.org)
  • Examples of the possible consequences of free radical damage are provided with special emphasis on lipid peroxidation. (nih.gov)
  • Kidney tissue demonstrated immediate damage from Cr and then showed recovery, while Cd and Ni showed effects at day 7, at the highest concentration. (cdc.gov)
  • Histopathological examination showed an improvement in the histological structure of pancreas, liver and kidney tissues in the MSCs treated group compared with the degeneration observed in the diabetic untreated group which was in accordance with the biochemical finding. (alliedacademies.org)
  • This study assessed reproductive outcomes for songbirds exposed to soil-borne lead in the district, examined the relation between lead concentrations in soils and in tissues of ground-feeding birds and prey species, and compared the results to literature-based toxicity thresholds for lead that are associated with negative effects in birds. (usgs.gov)
  • These results indicate that the radical generation and the damage caused by them is not only a function of surface area but is also influenced by changing chemical and other characteristics due to particle size. (cdc.gov)
  • To date, there are few data indicating that toxicity of ROT is not limited to the brain but can also affect other tissues. (cranberryinstitute.org)
  • The testis was considered to be a thyroid hormone unresponsive tissue [ 3 ]. (hindawi.com)