• Myelin alterations are accompanied by higher OPC density and proliferation during the first weeks of life, consistent with a transient alteration of mechanisms regulating OPC self-renewal and differentiation. (nature.com)
  • Meanwhile, optimizing the culture conditions for stem cell propagation is helpful in maintaining the pluripotency and differentiation potential of stem cells, which are critical for tissue engineering and regenerative medicine. (eurekaselect.com)
  • Thus, a liposarcoma appears to arise from a lipoblast but may actually develop through lipoblastic differentiation of a precursor multipotent mesenchymal cell. (medscape.com)
  • Cell viability and differentiation capacity toward the mesenchymal lineages were assessed, along with immunophenotype. (biomedcentral.com)
  • These phases include the inflammatory response, the activation, differentiation, and fusion of satellite cells, and the maturation and remodeling of newly formed myofibrils. (wikipedia.org)
  • These macrophages can also facilitate the proliferation and differentiation of satellite cells. (wikipedia.org)
  • Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway. (nih.gov)
  • It possesses a unique forkhead domain combined with a fragment of the target gene to initiate transcription [ 10 ] and regulates various biological processes such as tumor cell differentiation, cell proliferation, and migration [ 11 ]. (hindawi.com)
  • During tissue homeostasis and regeneration epithelial cells must balance proliferation, cell death and differentiation to maintain a functional organ. (ed.ac.uk)
  • Coexisting foamy and nonfoamy adenocarcinoma with glandular differentiation devoid of basal cell lining is helpful in clarifying their malignant nature. (medscape.com)
  • Various biological events associated with bone healing on implant surfaces can be investigated separately using appropriate cell cultures, such as cell adhesion, proliferation and differentiation, as well as the production and mineralization of extracellular matrix. (bvsalud.org)
  • Signaling through CysLT1R results in increased proliferation, survival and migration of intestinal epithelial cells, whereas signaling through CysLT2R leads to differentiation of colorectal cancer cells. (lu.se)
  • Connective tissue growth factor mediates TGF-β1-induced low-grade serous ovarian tumor cell apoptosis[J]. Oncotarget, 2017,8:85224-85233. (magtechjournal.com)
  • UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
  • miRNA-149 was underexpressed in gastric cancer tissues and cells, while overexpression of miRNA-149 promoted cell apoptosis, retarded cell cycle, and inhibited proliferation and migration in AGS and MKN28 cells. (hindawi.com)
  • While some assays utilize antibodies to study cell health, proliferation, cell cycle or apoptosis, other types of experiments can rely on non-antibody based methods of assessment, often called non-antibody chemical probes. (biolegend.com)
  • Cellular division for any cell type is dependent on the inherent function, location and the response of cells to repair, apoptosis, or death. (biolegend.com)
  • Our results indicated that AST inhibits cell proliferation through phase-specific cell cycle arrest and caspase-dependent apoptosis. (spandidos-publications.com)
  • Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
  • Molecular mechanisms and the influences of different regulation the expression of AKT1 on HCC cell growth, proliferation were determined by western blotting, MTT and colony formation assays, cell cycle and apoptosis were investigated by flow cytometry. (spandidos-publications.com)
  • The phosphoinositide 3-kinase (PI3K)/RAC seine/threonine-protein kinase (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is a promising therapeutic target owing to its frequent dysregulation in HCC and the critical functions it has in regulating cell survival, proliferation, apoptosis, migration and angiogenesis through phosphorylation of distinct protein substrates ( 6 , 7 ). (spandidos-publications.com)
  • However, the precise molecular mechanisms by which AKT1 promotes cell proliferation and regulates apoptosis ( 18 , 19 ) remain largely unclear. (spandidos-publications.com)
  • High expression of activated AKT can be detected in HCC, and AKT may promote cell proliferation and regulation of cells apoptosis in HCC ( 20 , 21 ). (spandidos-publications.com)
  • The present study confirmed a potential function for AKT1 in promoting proliferation and inhibiting apoptosis of HCC. (spandidos-publications.com)
  • Subsequent mechanism investigations revealed that AKT1 served a notable function in cell proliferation and anti-apoptosis by directly regulating the expression of phosphatase and tensin homolog (PTEN) and Notch1. (spandidos-publications.com)
  • Momordicine I also induced apoptosis, intracellular reactive oxygen species (ROS) production, and senescence in glioma cells. (bvsalud.org)
  • Although most soft-tissue tumors of various histogenetic types are classified as either benign or malignant, many are of an intermediate nature, which typically implies aggressive local behavior with a low-to-moderate propensity for metastasis. (medscape.com)
  • Conclusions CTGF can promote proliferation, growth and metastasis of SKOV3, and that may contribute to the regulation of epithelium-mesenchymal transformation (EMT). (magtechjournal.com)
  • Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (cancerindex.org)
  • Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
  • However when these pathways are altered in cancer cells, this acts to enhance cell invasion the first step of metastasis. (mcgill.ca)
  • Ophiopogonin B inhibits proliferation and migration of human esophageal squamous cell carcinoma cell line EC9706 [J]. Basic & Clinical Medicine, 2022, 42(7): 1053-1059. (magtechjournal.com)
  • New devices have demonstrated significant results for the treatment of medical conditions, including mild-to-moderate acne vulgaris, wound healing, psoriasis, squamous cell carcinoma in situ (Bowen's disease), basal cell carcinoma, actinic keratosis, and cosmetic applications. (researchgate.net)
  • These lesions have been misdiagnosed as non-Hodgkin lymphoma and squamous cell carcinoma, and unnecessary radical treatment may result. (medscape.com)
  • This review summarizes recent breakthroughs in studies regarding proliferation of adult stem cells which complement and extend our knowledge to various aspects of cell biology and signal pathways. (eurekaselect.com)
  • In this review, we focus on signaling pathways regulating the proliferation of various stem cells isolated from adult tissues. (eurekaselect.com)
  • It is well-established that early embryonic signaling pathways are critical for growth and patterning of new tissue during regeneration. (frontiersin.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • We are particularly interested in the role of the Wnt pathway in these processes and are currently working on both canonical and non-canonical Wnt signalling to define how these pathways regulate tissue architecture, using the adult liver and cancers of the adult liver as a models for these studies. (ed.ac.uk)
  • Objective To investigate the effects of CTGF on proliferation and migration of SKOV3 and the underlying mechanism. (magtechjournal.com)
  • Connective tissue growth factor promotes the proliferation and migration of human ovarian cancer cell line SKOV3[J]. Basic & Clinical Medicine, 2021, 41(2): 193-196. (magtechjournal.com)
  • Lnc-SLC2A12-10:1 silencing inhibits the proliferation, migration and invasion of gastric cancer cell line AGS [J]. Basic & Clinical Medicine, 2022, 42(7): 1071-1076. (magtechjournal.com)
  • Down-regulation of lncRNA RHPN1-AS1 inhibits proliferation and migration of human bladder cancer cell line T24 [J]. Basic & Clinical Medicine, 2022, 42(6): 940-944. (magtechjournal.com)
  • miR-655-3p targeting KIF20A inhibits migration and invasion of lung adenocarcinoma cell line A549 [J]. Basic & Clinical Medicine, 2022, 42(4): 599-606. (magtechjournal.com)
  • The migration of these cells also increased as demonstrated by wound healing and transwell assays. (jcancer.org)
  • In contrast, silencing of UASR1 suppressed cell proliferation and migration. (jcancer.org)
  • We will establish the molecular basis through which the Crk adapter protein induces epithelial cell migration using a proteomic approach to identify Crk associated proteins and using cell biology and mouse models for cell invasion. (mcgill.ca)
  • Telmisartan markedly suppressed the proliferation, migration, and invasion of these three GBM cell lines. (bvsalud.org)
  • Hypoxia inducible factor-2α importance for migration, proliferation, and self-renewal of trunk neural crest cells. (lu.se)
  • Human adipose tissue-derived stem cells (hASCs) are attractive cells for therapeutic applications and are currently being evaluated in multiple clinical trials. (biomedcentral.com)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • In vitro expansion of stem cells may benefit from high proliferation rates, which can produce a large amount of cells to regenerate tissue defects. (eurekaselect.com)
  • Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro. (nih.gov)
  • We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
  • In vitro and in vivo (animal and human) studies utilized a variety of LED wavelength, power intensity, and energy density parameters to begin to identify conditions for each biological tissue that are optimal for biostimulation. (researchgate.net)
  • Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)
  • In vitro studies using infra-/red light have not shown any useful impact on wound healing by activating cells located in deeper skin layers such as fibroblasts or stem cells [2] . (researchgate.net)
  • Stem cell senescence in the in vitro expansion stage is an essential concern in clinical procedures of cell therapy. (magiran.com)
  • In vitro models have been proposed in an attempt to better understand the early stages of osseointegration and how cells interact with surfaces modified by different methods. (bvsalud.org)
  • In vitro maintenance of multipotent neural crest stem cells as crestospheres. (lu.se)
  • Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma[J]. Oncol Rep,2019,42:2323-2332. (magtechjournal.com)
  • Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer[J]. Oncotarget,2015, 6:44551-44562. (magtechjournal.com)
  • 8] Chu CY, Chang CC, Prakash E, et al .Connective tissue growth factor(CTGF) and cancer progression[J]. J Biomed Sci,2008,15:675-685. (magtechjournal.com)
  • Connective tissue growth factor in tumor pathogenesis[J]. Fibrogenesis Tissue Repair,2012.doi:10.1186/1755-1536-5-S1-S8. (magtechjournal.com)
  • [6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
  • Additionally, moderate proliferation of the fibrous connective tissue and the myoepithelial cells near the proliferating acini was evident. (scielo.br)
  • This complete characterization of hASCs cultivated in pooled allogeneic human serum, a suitable xeno-free approach, shows that pooled allogeneic human serum provides a high proliferation rate, which can be attributed for the first time to C-MYC protein expression, and showed cell stability for safe clinical applications in compliance with good manufacturing practice. (biomedcentral.com)
  • This results in the formation of a relatively well-defined zone of compressed fibrous tissue that may contain scattered tumor cells. (medscape.com)
  • AKT is a key molecule in the PI3K/AKT/mTOR signaling pathway, which has been shown to serve notable functions in the regulation of cell viability and to be closely associated with a variety of disorders caused by dysfunctional cellular proliferation ( 8 , 9 ). (spandidos-publications.com)
  • Since hypoxia activates hypoxia-inducible factor (HIF-1)-dependent transcription in cancer cells that, in a paracrine fashion, drive tumor angiogenesis, we investigated the effects of UCN-01 on HIF-1-responsive promoter constructs. (karger.com)
  • ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. (jci.org)
  • In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
  • Methods SKOV3 cells were treated with recombinant human CTGF (rhCTGF).The proliferation of SKOV3 was detected by CCK-8 assay and colony formation assay. (magtechjournal.com)
  • Results After rhCTGF treatment, the proliferation rate of SKOV3 was increased, the colony formation and migzation were enhanced ( P <0.05).The expression of E-cadherin was decreased and the expression of vimentin was increased, which were related proteins of EMT( P <0.05). (magtechjournal.com)
  • SIRT5 promotes the proliferation of human breast cancer cells by regulating the succinylation of ALDH5A1 [J]. Basic & Clinical Medicine, 2022, 42(7): 1099-1107. (magtechjournal.com)
  • Here, we demonstrate that the dNTPase activity of SAMHD1 is regulated by acetylation, which promotes cell cycle progression in cancer cells. (oncotarget.com)
  • Collectively, these findings suggest that SAMHD1 acetylation enhances its dNTPase activity and promotes cancer cell proliferation. (oncotarget.com)
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
  • In breast cancer tissues, UASR1 was upregulated. (jcancer.org)
  • Activation of the VEGFA/VEGFR2 signaling and expression of blood vascular endothelial cell (BEC) markers, such as NRP1 and EphrinB2, further differentiate these precursor cells into BECs, which then form the hierarchical network of blood vessels 4 . (nature.com)
  • Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)
  • We report that, in addition to direct inhibitory effects on endothelial cell growth, UCN-01 abrogates hypoxia-mediated transactivation of HIF-1-responsive promoters in a prostate cancer cell line. (karger.com)
  • We conclude that UCN-01, at clinically relevant concentrations, exerts an anti-neovascularization effect by blocking two important steps in vessel formation: (1) the response of cancer cells to hypoxia, and (2) endothelial cell proliferation. (karger.com)
  • We searched the databases such as EMBASE, PubMed, and Web of Science with the keywords "stem cell," "progenitor cell," "satellite," "senescence" and excluded the keywords "cancer," "tumor," "malignancy" and "carcinoma" until June 2020. (magiran.com)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • They also sequenced RNA from the uterine tissue and stained for phosphorylated proteins in the PI3K pathway-such as IGF1R, AKT, and S6-which indicates pathway activation. (eurekalert.org)
  • We will focus on signals required for anchorage independent growth, morphological cell transformation, epithelial mesenchymal transition, cell invasion and tumorigenesis. (mcgill.ca)
  • We will continue to identify key regulators of epithelial cell motility and invasion. (mcgill.ca)
  • The RAC serine/threonine-protein kinase (AKT) family of serine/threonine protein kinases, particularly the AKT1 isoform, has been identified abnormally expressed in hepatocellular carcinoma (HCC) cells, and is highly associated with cell behavior, including proliferation, survival, metabolism, and tumorigenesis. (spandidos-publications.com)
  • The use of hASCs for therapeutic applications has grown substantially in the last years, because the use of stem cells from adult tissues circumvent some ethical issues associated with the application of embryonic stem cells, and because of their accessibility via isolation from lipoaspirates, a disposable byproduct of cosmetic surgery. (biomedcentral.com)
  • Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. (jcancer.org)
  • Manifest illness stage (days to weeks postexposure)--The basal layer is repopulated through proliferation of surviving clonogenic cells. (cdc.gov)
  • Prior to the 1970s, surgery was the primary therapy for malignant soft tissue tumors, and most patients with high-grade tumors had a poor prognosis and a significant mortality. (medscape.com)
  • [ 2 , 3 ] See Soft-Tissue Sarcomas: What You Need to Know , a Critical Images slideshow, to help identify and treat some of these malignant tumors of mesenchymal origin. (medscape.com)
  • Furthermore, the cell expansion poses a risk of accumulating genetic abnormalities that could lead to malignant cell transformation. (biomedcentral.com)
  • In the last years, adoptive transfer of natural killer (NK) cells came into the focus of translational medicine, because of their high cytotoxic potential against transformed malignant cells. (frontiersin.org)
  • With their ability to detect and directly destroy virally infected or malignant cells, natural killer (NK) cells form an important part of the first line defense of the immune system. (frontiersin.org)
  • This study in Iraq used in situ hybridization to detect the frequency and genotyping of HPV in tissue specimens from 129 patients diagnosed with malignant breast cancer, 24 with benign breast tumours and 20 healthy controls. (who.int)
  • We model these processes on the timescale of cell proliferation, which typically is of the order of days. (ox.ac.uk)
  • In both processes, rapid proliferation gives rise to new tissue, cell fate has to be specified within that tissue, and distinct positional identities have to be established to generate a properly patterned structure. (frontiersin.org)
  • The scope of the special issue is to summarize and enlarge the knowledge in signalling processes and networks in diverse cells and tissues. (mdpi.com)
  • In recent years, many interesting results and discoveries were achieved regarding the proliferative properties of stem cells. (eurekaselect.com)
  • Additionally, understanding the proliferation of stem cells may help us to uncover new mechanisms of drug resistance, since stem cells are believed to play an important role in drug resistance. (eurekaselect.com)
  • We also emphasize the significance of stem cells proliferation in cell research, as well as rapid propagation of adult stem cells for regenerative medicine. (eurekaselect.com)
  • GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
  • Stem cell senescence causes different complications. (magiran.com)
  • In addition to the aging phenomenon, stem cell senescence has been investigated in various concepts such as cancer, adverse drug effects, and as a limiting factor in cell therapy. (magiran.com)
  • This manuscript examines protective medicines and supplements which are capable of hindering stem cell senescence. (magiran.com)
  • Our investigation indicates that most of these studies examined endothelial progenitor cells, hematopoietic stem cells, mesenchymal stem cells, adipose-derived stem cells, and a few others were about less-discussed types of stem cells such as cardiac stem cells, myeloblasts, and induced pluripotent stem cells. (magiran.com)
  • Maintaining multipotent trunk neural crest stem cells as self-renewing crestospheres. (lu.se)
  • Enhanced expression of MycN/CIP2A drives neural crest toward a neural stem cell-like fate: Implications for priming of neuroblastoma. (lu.se)
  • The Concept of Cancer Stem Cells: Elaborating on ALDH1B1 as an Emerging Marker of Cancer Progression. (lu.se)
  • Soft-tissue tumors constitute a large and heterogeneous group of neoplasms. (medscape.com)
  • Current achievements in the field of soft-tissue tumors are the result of advances in molecular biology, oncogenetics, imaging techniques, immunochemistry, diagnosis by fine-needle aspiration (FNA), surgical reconstruction, radiation therapy, and tissue banking. (medscape.com)
  • Benign soft-tissue tumors are fairly common and are treated with surgery alone. (medscape.com)
  • Generally, soft-tissue tumors grow centripetally, though some benign tumors (eg, fibrous lesions) may grow longitudinally along tissue planes. (medscape.com)
  • Most soft-tissue tumors respect fascial boundaries, remaining confined to the compartment of origin until the later stages of development. (medscape.com)
  • A thin layer of tissue called the reactive zone surrounds the compression zone, especially in higher-grade tumors. (medscape.com)
  • Cancer treatments that increase risk for secondary tumors typically do so by creating and/or selecting for mutations that cause uncontrolled growth in other tissues. (eurekalert.org)
  • Human gastric cancer cell lines AGS and MKN28 were cultured and transfected with miR-149 overexpression plasmid and its control or FOXC1 siRNA and its control. (hindawi.com)
  • The human gastric epithelial permanent cell line (GES-1), human gastric cancer cell lines (AGS, BGC-823, MKN45, and SGC-7901), and HEK293 cells were provided by the Biomedical Experiment Center of Xi'an Jiaotong University. (hindawi.com)
  • SAM domain and HD domain containing protein 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that inhibits retroviruses by depleting intracellular deoxynucleotide triphosphates (dNTPs) in non-cycling myeloid cells. (oncotarget.com)
  • This zone may also consist of inflammatory cells and demonstrate neovascularity. (medscape.com)
  • In the liver, this regulation requires the constant integration of signals by epithelial cells from non-epithelial, niche cells, which includes inflammatory cells and fibroblasts. (ed.ac.uk)
  • These lesions are microscopically characterized by a diffuse, pseudoinvasive, mixed inflammatory reaction that includes large mononuclear cells, numerous eosinophils, and T cells. (medscape.com)
  • Normally, inflammation is the body's normal response to fight pathogens or to remove damaged cells from our tissues. (theepochtimes.com)
  • Once the immune cells have reached their goal, the infection is over, the wound is healed, and the inflammation subsides. (theepochtimes.com)
  • Exposure to radiation can damage the basal cell layer of the skin and result in inflammation, erythema, and dry or moist desquamation. (cdc.gov)
  • Focus on epithelial ovarian cancer[J]. Cancer Cell,2004,5:19-24. (magtechjournal.com)
  • A novel role for microRNA-129-5p in inhibitimg ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ[J]. Oncotarget,2015,6:8676-8686. (magtechjournal.com)
  • K405R mutant expressing cancer cells have reduced G1/S transition and slower proliferation compared to wildtype. (oncotarget.com)
  • qRT-PCR was used to detect the expression of miRNA-149 and FOXC1 in gastric cancer tissues and cells. (hindawi.com)
  • In this study, we investigated the inhibitory effects of miR-149 on the biological functions of gastric cancer cells by targeting FOXC1. (hindawi.com)
  • Twenty pairs of gastric cancer and adjacent nontumor tissues, which were not subjected to radiotherapy or chemotherapy, were obtained from the First Affiliated Hospital of Xi'an Jiaotong University. (hindawi.com)
  • Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
  • We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
  • Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
  • In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
  • In the breast cancer group, cocktail HPV genotypes were detected in 60 (46.5%) archived tissue blocks. (who.int)
  • L'étude menée en Iraq a utilisé la méthode d'hybridation in situ pour déterminer la fréquence du papillomavirus humain et pour son génotypage dans les échantillons de tissus prélevés auprès de 129 patientes ayant reçu un diagnostic de cancer du sein malin, de 24 patientes porteuses d'une tumeur du sein bénigne et de 20 femmes témoins en bonne santé. (who.int)
  • Taken together, our data suggest that UASR1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. (jcancer.org)
  • Tight control of cell proliferation and morphogenesis is required to ensure normal tissue patterning and prevent cancer. (mcgill.ca)
  • A microarray approach will be used to identify genes associated with breast cancer progression and cell biology and animal models will be used to understand the function of such genes. (mcgill.ca)
  • Inflammaging is also related to cancer development-because in inflamed tissue we see increased cell proliferation," said Neri. (theepochtimes.com)
  • In cancer, these interactions become deregulated and epithelial cells can either be regulated independent of their microenvironment or the niche becomes permissive to tumour formation. (ed.ac.uk)
  • Our lab is interested in how the signals, which come from the regenerative microenvironment drive tissue repair following injury and how these signals are co-opted by the tumour to support cancer growth. (ed.ac.uk)
  • Cancer is an unregulated proliferation of cells. (msdmanuals.com)
  • Striated muscle tissue is a muscle tissue that features repeating functional units called sarcomeres. (wikipedia.org)
  • A main challenge of NK cell therapy is that it requires a high amount of functional NK cells. (frontiersin.org)
  • The functional and structural adhesion of bone tissue to the surface of load-bearing orthopedic implants seems to be a determinant factor for in vivo success 2 . (bvsalud.org)
  • Mastocytosis is a rare disorder characterized by functional secretion or abnormal proliferation of tissue mast cells. (medscape.com)
  • The MeOH extract of Ganoderma lucidum has an inhibitory action on histamine release from rat mast cells. (researchgate.net)
  • Ganoderic acids C and D were shown to inhibit histamine release from rat mast cells. (researchgate.net)
  • A study showed that ganoderic acids C and D isolated from G. lucidum inhibit the release of histamine from mast cells [81] . (researchgate.net)
  • Furthermore, mast cells and H1 receptors have not been the primary sites of antipruritic action of this extract. (researchgate.net)
  • NMH is a major metabolite of histamine, which is released from storage in mast cells and basophils when these cells degranulate in response to stimulation (both immunologic and nonimmunologic). (medscape.com)
  • Adult humans cannot regenerate cardiac muscle tissue after an injury, which can lead to scarring and thus heart failure. (wikipedia.org)
  • Other vertebrates can regenerate cardiac muscle tissue throughout their entire life span. (wikipedia.org)
  • Skeletal muscle is able to regenerate far better than cardiac muscle due to satellite cells, which are dormant in all healthy skeletal muscle tissue. (wikipedia.org)
  • For instance, H19 is the first lncRNA transcribed by RNA polymerase II and is expressed mainly in human embryonic cells. (jcancer.org)
  • Exp Cell Res, 2022 Feb 1. (nih.gov)
  • There are two types of striated muscle: Cardiac muscle (heart muscle) Skeletal muscle (muscle attached to the skeleton) Striated muscle tissue contains T-tubules which enables the release of calcium ions from the sarcoplasmic reticulum. (wikipedia.org)
  • Unlike skeletal muscle, cardiac muscle cells are unicellular. (wikipedia.org)
  • Unlike skeletal and cardiac muscle tissue, smooth muscle tissue is not striated since there are no sarcomeres present. (wikipedia.org)
  • Both smooth muscle cells and cardiac muscle cells have a single nucleus, and skeletal muscle cells have many nuclei. (wikipedia.org)
  • In tumor tissues, lncRNAs are markedly deregulated and pervasively involved in development and progression of cancers [ 6 - 8 ]. (jcancer.org)
  • The blood and lymphatic vascular systems are essential for the efficient transport of oxygen, nutrients, signaling molecules, and leukocytes to and from peripheral tissues, the removal of waste products, and the preservation of fluid homeostasis. (nature.com)
  • Hypophosphatasia (HPP) is an inborn error of metabolism caused by loss-of-function mutations in the biomineralization-associated alkaline phosphatase gene, encoding tissue-nonspecific alkaline phosphatase (TNSALP). (karger.com)
  • The model for how secondary cancers occur after chemotherapy, for example, is that cells acquire driver mutations that lead to clonal outgrowth," said presenter Kirsten Kübler, MD, PhD , an associate scientist at the Broad Institute of MIT and Harvard, research staff at Massachusetts General Hospital, and an instructor at Harvard Medical School, who recently joined the faculty of the Berlin Institute of Health at Charité in Berlin. (eurekalert.org)
  • To investigate the mechanisms of decreased PI3K pathway mutations in TA-UCs, the researchers examined uterine tissue from tamoxifen-treated mice. (eurekalert.org)
  • Microarray data analysis revealed that telmisartan regulates DNA replication, mismatch repair, and the cell cycle pathway in GBM cells. (bvsalud.org)
  • These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
  • Further studies showed that UASR1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth. (jcancer.org)
  • Future advances in molecular oncology may further improve diagnostic, prognostic, and treatment protocols for patients with soft-tissue sarcomas . (medscape.com)
  • Although SAMHD1 is expressed ubiquitously throughout the human body, the molecular mechanisms regulating its enzymatic activity and function in non-immune cells are relatively unexplored. (oncotarget.com)
  • However, histomorphologic, immunohistochemical, and experimental data suggest that most, if not all, sarcomas arise from primitive, multipotential mesenchymal cells, which in the course of neoplastic transformation differentiate along one or more lines. (medscape.com)
  • To evaluate the proliferative capacity of mesenchymal cells derived from human periodontal ligament on polished and plasma-treated titanium surfaces. (bvsalud.org)
  • Mesenchymal cells were isolated from periodontal ligament of impacted third molars (n=2) and cultured on titanium disks (polished and nitrided) and on a plastic surface as a positive control of cell proliferation. (bvsalud.org)
  • We concluded that plasma nitriding produced surfaces that permitted the proliferation of human periodontal ligament mesenchymal cells. (bvsalud.org)
  • In this respect, this study evaluated the proliferation of mesenchymal cells derived from the periodontal ligament of human third molars on polished and plasma-nitrided titanium surfaces. (bvsalud.org)
  • Periodontal ligament mesenchymal cells were obtained from two healthy human teeth (impacted third molars). (bvsalud.org)
  • We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
  • Patient-derived breast tissue was processed for its component adipocytes, organoids, and stromal vascular fraction. (nesps.org)
  • However, direct injection of IL-2 has been shown to be accompanied by severe side effects, such as vascular leak syndrome, activation-induced cell death, and strong induction of regulatory CD4 pos T cells, which did not occur after IL-15 administration ( 15 , 16 ). (frontiersin.org)
  • Macrophages induce phagocytosis of the cell debris. (wikipedia.org)
  • This study utilizes a high-fidelity ex vivo biomimetic, three-dimensional model to study the effects of implant shells on patient-derived BIA-ALCL cells within the breast microenvironment. (nesps.org)
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • Recent studies have revealed the importance of long noncoding RNAs (lncRNAs) as tissue-specific regulators of gene expression. (nature.com)
  • Study IV showed that tamoxifen inhibited the proliferation, disrupted the cell cycle progression, and inhibited the ECM adhesion capacity of healthy breast epithelial cells. (lu.se)
  • Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)
  • Myelinating OLs originate from parenchymal precursors expressing the neuron-glia antigen 2 (NG2) chondroitin sulphate proteoglycan and the platelet derived growth factor receptor alpha (PDGFRα), commonly referred to as oligodendrocyte progenitor cells (OPCs) 4 . (nature.com)
  • The peripheral portion of the tumor compresses surrounding, normal soft tissue because of centripetal expansile growth. (medscape.com)
  • Mathematical model of growth factor driven haptotaxis and proliferation in a tissue engineering scaffold. (ox.ac.uk)
  • in Biomaterials 27(10):2213-2221, 2006, 32(11):2775-2785, 2011) we investigate the effect of growth factor driven haptotaxis and proliferation in a perfusion tissue engineering bioreactor, in which nutrient-rich culture medium is perfused through a 2D porous scaffold impregnated with growth factor and seeded with cells. (ox.ac.uk)
  • The ultimate goal of such modeling is to ascertain initial conditions (growth factor distribution, initial cell seeding, etc.) that will lead to a final desired outcome. (ox.ac.uk)
  • We also discuss the more elusive potential mechanisms that link wounding to tissue growth and patterning. (frontiersin.org)
  • Light-emitting diodes (LED), originally developed for NASA plant growth experiments in space show promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. (researchgate.net)
  • Our work in the past few years has uncovered an important regulator of invasive cell growth, the Met receptor tyrosine kinase. (mcgill.ca)
  • BMPs are also growth factors that drive development in the embryo and play a key role in the functioning of cells. (medicalnewstoday.com)
  • Cell proliferation was analyzed and growth curves were constructed for the different groups by determining the number of cells adhered to the different surfaces at 24, 48 and 72 h after plating. (bvsalud.org)
  • [ 7 ] Knowledge of preceding treatment and the finding of other therapy-related changes, such as glandular atrophy, as well as basal cell hyperplasia, should alert to this differential. (medscape.com)
  • In this document, the absorbed dose refers to that dose received by at least 10 cm2 of the basal cell layer of the skin. (cdc.gov)
  • Tamoxifen blocks estrogen receptor activity in the breast, but it can activate the estrogen receptor in other tissues, such as the uterus. (eurekalert.org)
  • They found that tamoxifen increased the expression of Ki67, a marker of cell proliferation. (eurekalert.org)
  • Cell cultures have been extensively used in implantology to evaluate the effect of the substrate on the behavior of osteoblasts during osseointegration. (bvsalud.org)
  • Only 3 benign breast tumour tissues (12.5%) and none of the healthy breast tissue specimens were HPV-DNA-positive. (who.int)
  • Other patterns include arrangement of the histiocytes in cords or single cells that percolate between benign prostatic glands. (medscape.com)
  • Large quantities of histamine can also be produced by dendritic cells and T cells, though these cells do not store histamine. (medscape.com)
  • Extracellular-Matrix-Reinforced Bioinks for 3D Bioprinting Human Tissue. (lu.se)
  • Our results unveil a novel player in the complex regulation of OPC biology, on the one hand showing that JNK1 ablation cell-autonomously determines alterations of OPC proliferation and branching architecture and, on the other hand, suggesting that JNK1 signaling in OLs participates in myelination in vivo. (nature.com)
  • 3. Department of Medical Microbiology, Immunology & Cell Biology, Southern Illinois University School of Medicine. (jcancer.org)
  • The researchers were jointly led by Maksim Plikus, an assistant professor of developmental and cell biology, and Qing Nie, a professor of mathematics, both of UCI. (medicalnewstoday.com)