Tissues tumor suppressor proteins. Medical search. Frequent questions

BRCA1 and BRCA2 are tumor suppressor genes found in humans which encode proteins that function in DNA repair. (biochain.com)
Currently these samples all derive from breast cancer donors as the BRCA genes are strongly linked to oncogenesis in this tissue type. (biochain.com)
These genes encode for proteins called tumour suppressor proteins that check for errors and help repair DNA during growth and tissue repair as part of the normal cell division process. (againstbreastcancer.org.uk)
When a mutation is present in these genes, the tumour suppressing protein may not be made at all, or does not perform very well as part of the error checking and repair team. (againstbreastcancer.org.uk)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
Tumor suppressor genes code for proteins that inhibit cell division and growth, acting as a control mechanism to prevent excessive cell proliferation. (pharmiweb.com)
Tumor suppressor genes can promote cellular senescence, a state in which cells stop dividing, preventing the replication of damaged DNA. (pharmiweb.com)
The protein encoded by this gene is a member of the RP/EB family of genes. (nih.gov)
The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. (thermofisher.com)
These results suggest that, in some tumors, expression of NF1 may be downregulated by factors produced within the tumor and may represent a novel mechanism for inactivating these growth suppressing genes and allowing for increased cell proliferation in tumors. (wustl.edu)

p53 plays a role in regulation or progression through the cell cycle, apoptosis, and genomic stability by means of several mechanisms: It can activate DNA repair proteins when DNA has sustained damage. (wikipedia.org)
Tumor-derived exosomes are messengers that participate in tumor progression. (dovepress.com)
Our results suggest that tumor-derived exosomes may facilitate stromal fibroblasts an aggressive phenotype to equip the tumor progression. (dovepress.com)
2 , 3 Tumor cell-derived exosomes carry particular molecular components originated from donor cells to mediate tumorigenesis and drive tumor progression by regulating tumor microenvironment. (dovepress.com)
To test the idea that loss of Rab11 may promote cancer progression, archival human patient tissues were analyzed and 51 out of 70 colon cancer tissues had lower Rab11 protein staining. (sdbonline.org)
The authors observed that HLJ1 stopped proliferation of lung cancer cells, slowed the cell division cycle's progression, and inhibited the cells' ability to move and invade other tissues. (eurekalert.org)
These cells have emerged as an important contributor to tumor progression. (aacrjournals.org)
Reports on the accumulation of immune-suppressive myeloid cells associated with tumor progression were published sporadically beginning in the early 1970s ( 1 ). (aacrjournals.org)
These mediators and their receptors are enriched in colon cancer cells and colon cancer tissues, which demonstrate there, contribute to tumor development and progression. (lu.se)
Her focus of research is the role of estrogen and thyroid hormones in colon cancer progression and their effects on inflammatory components of the tumor microenvironment, in a big female cohort. (lu.se)

Menin acts as a tumor suppressor, which means it normally keeps cells from growing and dividing too rapidly or in an uncontrolled way . (medlineplus.gov)
Gaur et al suggest FLCN acts as a tumor suppressor by negatively regulating rRNA synthesis. (medscape.com)

We were able to connect differences in temporal p53 expression with radiation response, and these insights allowed us to 'coax' radioresistant tumors into more radiosensitive ones," said co-corresponding author Ralph Weissleder, the Thrall Family Professor of Radiology and HMS professor of systems biology at Mass General. (sciencedaily.com)
TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome. (wikipedia.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
MiR-21 promoted invasion of fibroblasts by down-regulation of tissue inhibitor of metalloproteinase 3 (TIMP3) expression and increasing of matrix metalloprotein (MMP) expression in fibroblast cells via melanoma-derived exosomes in a time-dependent manner. (dovepress.com)
10 High expression of miR-21 in melanoma cells inhibits mRNA expression of crucial tumor suppressor proteins such as the tissue inhibitor of metalloproteinases 3 (TIMP3). (dovepress.com)
It has also been demonstrated that GKN1 expression induces apoptosis in gastric cancer cells thus suggesting a possible role of the protein as tumor suppressor. (unina.it)
The results showed that GKN1 downregulation in gastric cancer tissues is associated with high levels of H3K9triMe and with the recruitment of SUV39H1 on GKN1 promoter, suggesting the presence of an epigenetic transcriptional complex that negatively regulates GKN1 expression in gastric tumor. (unina.it)
Jeremy J.W. Chen, Ph.D., of National Chung-Hsing University, Pan-Chyr Yang, M.D., Ph.D., of National Taiwan University in Taiwan, and colleagues increased or blocked the expression of HLJ1 in lung carcinoma cells in the lab and examined the gene's expression in tumor and surrounding tissue cells of 71 patients with non-small-cell lung cancer. (eurekalert.org)
In addition, HLJ1 expression was lower in tumor tissue than normal tissue in 55 of the 71 patients studied, and patients with high HLJ1 expressing tumors had reduced cancer recurrence and lived longer than those with low expressing tumors. (eurekalert.org)
The authors conclude that HLJ1 expression is a novel tumor suppressor in non-small-cell lung cancer. (eurekalert.org)
While the function of ADAM8 in PDAC cells is already known, its role in tumor-associated cells remains elusive and no information is available on the expression profile of ADAM8 in cells of TME. (uni-marburg.de)
The expression levels revealed that PRMT1 promotes the tumor-suppressing effect of p14ARF, a tumor suppressor protein, and a correlation between patient survival and PRMT1 was observed suggesting that PRMT1 is a promising diagnostic marker. (uni-marburg.de)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
We found RCC tissues displayed significantly higher miR-34a expression level than their corresponding noncancerous tissues, particularly in chromophobic subtype. (hindawi.com)
The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
MIR-34A has its own transcript and is expressed at higher levels than MIR-34B/C in most tissues, and this expression could be dysregulated in multiple diseases, especially in cancers [ 11 ]. (hindawi.com)
These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)
We reviewed published microarray and RNA sequencing studies in which gene expression profiles were compared between human RB and normal retina tissues. (molvis.org)
Expression of DCT was absent or barely detected in retina tissues, various human ocular cells, and major organs. (molvis.org)
In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. (modellab.cn)
The ET-specific fusion protein EWS/FLI1 induces the expression of the histone methyltransferase EZH2 (enhancer of zeste, Drosophila, homolog 2). (tum.de)
Additionally, EZH2 occupies promoter regions of putative tumor suppressor as well as oncogenic miRNAs and influences Argonaute Protein 2 expression. (tum.de)
EZH2 bindet zudem an Promotorregionen putativer Tumor-supprimierender als auch onkogener microRNAs und beeinflusst die Expression des Argonaute Proteins 2. (tum.de)
[ 35 ] Expression of the Birt-Hogg-Dubé syndrome protein has been widespread in a variety of tissues, including the kidneys, lungs, and skin. (medscape.com)
Epstein-Barr virus latent membrane protein expression and cyclin DI cell cyase protein expression in malignant and normal oesophageal tissues to see whether any variation in their expression in these tissues could be of diagnostic or prognostic value. (bvsalud.org)
EBV-LMPI protein expression and cyclin DI expression were studied immunohisto chemically in these tissue sections. (bvsalud.org)
2 cases of EBV-LMPI protein expression did not express p53 protein and 7 cases did not express both p53 and EBV-LMPI proteins. (bvsalud.org)
EBV-LMPI expression in tumour cells of 10 of 26 cases of oesophageal carcinoma may also be of value in diagnosis and pathogenesis. (bvsalud.org)
Loss of NF1 expression has been reported in Schwann cell tumors (neurofibrosarcomas) from patients with NF1 and its loss is associated with increased proliferation of these cells. (wustl.edu)
Barely detectable expression of NF1 RNA was found in this tumor by in situ hybridization using an NF1-specific riboprobe as well as by Northern blot and reverse-transcribed (RT)-PCR analysis. (wustl.edu)
Expression arrays in menin-null MEFs revealed altered expression of several extracellular matrix proteins that are critical in organogenesis. (johnshopkins.edu)
The expression changes associated with the loss of the tumor suppressor menin provide insights into the defective organogenesis observed during early embryonic development in Men1-null mouse embryos. (johnshopkins.edu)
We assessed miR-637 expression in 98 and 16 gliomas and non-tumoral brain tissues, respectively, using in situ hybridization. (scirp.org)
It can directly bind to the 3'-untranslated region of the target mRNA through its seed sequence and inhibit the expression of the encoded protein at the post-transcriptional level [3]. (scirp.org)
The present study revealed that miR‑30a‑5p expression was downregulated in human CRC tissues and cells. (spandidos-publications.com)
Expression of cell cycle proteins in head and neck cancer correlates with tumour site rather than tobacco use. (bvsalud.org)

We hypothesize that tumor-derived exosomes endow the fibroblasts in tumor microenvironment with invasive phenotype to the benefit of tumor metastasis. (dovepress.com)
ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9 by: Cook, Lena, et al. (uni-marburg.de)
The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist, including the surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, various signaling molecules, and extracellular matrix. (techscience.com)
The tumor microenvironment in the context of colon cancer and with a focus on the inflammatory mediators leukotriene D 4 (LTD 4 ) and prostaglandins (PGE 2 ) and their respective receptors. (lu.se)
Our aim is to generate solid support for novel and complementary treatments of colon cancer patients that focus on the inflammatory component of the tumor microenvironment. (lu.se)
We investigate how the lack of these receptors affects tumour growth and the surrounding tumour microenvironment in different colon cancer models. (lu.se)
Her focus is to target the tumor microenvironment for developing new and effective therapeutic strategies. (lu.se)

It is confirmed that large variety of miRNAs in exosomes play important roles in tumor metastasis and invasion. (dovepress.com)
Editorial: Albini A, Pfeffer U. A New Tumor Suppressor Gene: Invasion, Metastasis, and Angiogenesis as Potential Key Targets. (eurekalert.org)
Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)

Based on the findings, the inhibition of miR-543 was found to play a tumor suppressive role in PA through the down-regulation of Wnt/β-catenin pathway by negatively regulating Smad7. (cancerindex.org)
This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)

The protein is also a famous tumor suppressor -- around half of human cancers have p53 mutations that render it defective or suboptimal. (sciencedaily.com)
More than half of cancer cases worldwide are associated with genetic mutations in p53, the protein responsible for protecting DNA from changes that can lead to cancer. (medicalxpress.com)
BioChain has collected many tumor samples in both frozen and FFPE format with the aim of characterizing the DNA for BRCA mutations. (biochain.com)
However, we will continue to characterize additional tissue types where cancer development is linked to BRCA mutations. (biochain.com)
These data suggest that TP53 mutations may play a role in astrocytoma development and are predominantly associated with higher grade tumors. (nih.gov)
Many tumor suppressor proteins play a role in DNA repair, helping to correct genetic mutations and maintain the stability of the genome. (pharmiweb.com)
Children born with germline mutations tend to have bilateral tumors. (molvis.org)
Evolutionary, they share many similarities with tumors with BRAF V600E mutations, suggesting they are better classified along the conventional pathway rather than the Spitz pathway despite the frequent spitzoid morphology. (bvsalud.org)

Clear cell renal cell carcinoma is characterized by a loss of the tumor suppressor gene VHL that leads to a constitutive hypoxic response. (lu.se)

William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)
To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)

This gene provides instructions for producing a protein called menin. (medlineplus.gov)
The loss of functional menin allows cells to divide too frequently, leading to the formation of tumors characteristic of multiple endocrine neoplasia type 1. (medlineplus.gov)
Menin protein, produced by the MENIN gene, is a tumor suppressor. (medscape.com)

The phosphoinositide 3-kinase (PI3K)/RAC seine/threonine-protein kinase (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is a promising therapeutic target owing to its frequent dysregulation in HCC and the critical functions it has in regulating cell survival, proliferation, apoptosis, migration and angiogenesis through phosphorylation of distinct protein substrates ( 6 , 7 ). (spandidos-publications.com)

Exposure to radiation can wreak indiscriminate havoc on cells, tissues, and organs. (sciencedaily.com)
tumors can also develop in other organs and tissues. (medlineplus.gov)
Hyperparathyroidism is the most common feature, followed by tumors of the pituitary gland, additional endocrine glands, and other organs. (medlineplus.gov)
The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis. (rupress.org)
The tumor suppressor gene overgrown hematopoietic organs-31 (oho31) of Drosophila encodes a protein with extensive homology to the Importin protein of Xenopus (50% identity), the related yeast SRP1 protein, and the mammalian hSRP1 and RCH1 proteins. (rupress.org)
Ig-superfamily CADMs are involved in a wide range of biological processes and are critical for the development and functioning of various tissues and organs in the body. (pharmiweb.com)
Ig-superfamily CADMs are involved in mediating cell-to-cell adhesion, helping cells stick together and form tissues and organs. (pharmiweb.com)
Abstract Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information. (techscience.com)

These data demonstrate that using multiple cores in a tissue microarray does not necessarily increase the ability to identify associations of biomarkers with tumor phenotype and prognosis but has always the disadvantage of additional work and tissue requirements. (nih.gov)
He investigated inflammatory biomarkers produced as a result of neutrophil activation, primarily using protein purification and mass spectrometry. (otago.ac.nz)
His current projects involve using mass spectrometry to characterise oxidative modifications to the neutrophil protein calprotectin that may be useful as biomarkers of inflammation, and to identify proteins that are being oxidatively-modified during the early stages of necroptosis. (otago.ac.nz)
We are therefore exploring whether transport proteins might represent a particularly attractive source for identification of novel biomarkers for kidney cancer. (lu.se)

The team found certain types of tumors in mice were more vulnerable to radiation after being given a drug that blocks p53 levels from declining and oscillating. (sciencedaily.com)
Many different types of tumors are associated with multiple endocrine neoplasia. (medlineplus.gov)

GBM can extensively infiltrate normal brain tissue, making surgical resection almost impossible, and postoperative recurrence is common [2]. (scirp.org)
They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. (lookformedical.com)

Hence TP53 is classified as a tumor suppressor gene. (wikipedia.org)
In addition to the full-length protein, the human TP53 gene encodes at least 15 protein isoforms. (wikipedia.org)
This region contains a candidate tumor suppressor gene, TP53, which has recently been implicated in the etiology of a broad array of human cancers. (nih.gov)
To study the possible role of TP53 in astrocytoma development, 24 randomly chosen human astrocytic tumors were examined for genomic TP53 sequence aberrations using primer-directed DNA amplification in conjunction with direct sequencing. (nih.gov)

The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. (cancerindex.org)
HLJ1 is a protein involved in a cell's defense mechanism against outside stress. (eurekalert.org)
We're therefore hopeful that this mechanism will be found in other tissues. (imperial.ac.uk)
It is possible that this mechanism evolved as a form of protection from extensive tissue damage caused by an uncontrolled immune response associated with unresolved inflammation. (aacrjournals.org)
We demonstrate that replicative senescence, a tumor suppressor mechanism and guardian of genome stability, sometimes requires genomic instability to initiate its own action," the authors said. (genengnews.com)

p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. (wikipedia.org)

Ample evidence supports a key role for MDSCs in immune suppression in cancer, as well as their prominent role in tumor angiogenesis, drug resistance, and promotion of tumor metastases. (aacrjournals.org)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. (modellab.cn)
Solid tumors are consistently less oxygenated than the normal tissues from which they arose. (lu.se)

8 , 9 The high-invasion and metastatic tendency of melanoma tumors complicates treatment of the malignancy. (dovepress.com)
The Ewing Family of Tumors (ET) is the second most common malignancy of bone and soft tissue in children and young adults. (tum.de)
That is, as the size of the gland decreases, the incidence of malignancy of a tumor in the gland increases in approximately these proportions. (medscape.com)

New research led by the University of Bristol has found the protein p53 plays a key role in epithelial migration and tissue repair. (medicalxpress.com)
Her research has focused on an N-terminally truncated protein isoform that is most highly expressed in epithelial tissue. (asbmb.org)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
A malignant epithelial tumor with a glandular organization. (lookformedical.com)

miRNAs regulate proteins expressions by arresting or degrading the mRNAs. (cancerindex.org)
moreover, normal cell regulation can be disrupted by tumor-suppressive or oncogenic miRNAs. (scirp.org)

We first isolated genomic DNA from the frozen tumor tissues and then processed them for subsequent NGS characterization using Paragon's BRCA1&2 panel. (biochain.com)

It is unclear why these tumors preferentially affect endocrine tissues. (medlineplus.gov)
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized primarily by endocrine tumors of the parathyroids, anterior pituitary, and enteropancreatic endocrine tissues. (johnshopkins.edu)

To probe the effects of p53 behavior, the team used an experimental anti-cancer drug to inhibit MDM2, a protein that degrades p53. (sciencedaily.com)
Therefore, YAP-mediated EMT is considered to be a critical therapeutic target to inhibit YAP-promoted tumor invasion, and YAP may be a promising target for the treatment of CRC. (spandidos-publications.com)
Another is SUSD4, which we recently showed to be bind and inhibit C1 and which we found on T cells infiltrating various solid tumors. (lu.se)

If this damage cannot be repaired, particularly to DNA, cells will self-destruct to protect the surrounding tissue and organism as a whole. (sciencedaily.com)
Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body. (medlineplus.gov)
This gene provides instructions for producing a protein that is involved in signaling within cells. (medlineplus.gov)
So tumor cells-derived exosomes. (dovepress.com)
The RAC serine/threonine-protein kinase (AKT) family of serine/threonine protein kinases, particularly the AKT1 isoform, has been identified abnormally expressed in hepatocellular carcinoma (HCC) cells, and is highly associated with cell behavior, including proliferation, survival, metabolism, and tumorigenesis. (spandidos-publications.com)
MiR-363-3p levels in GC tissues and cells were tested by qRT-PCR. (medscimonit.com)
MiR-363-3p showed low levels in GC tissues and cells. (medscimonit.com)
ADAM8 was found to be significantly expressed in macrophages (6 %), natural killer cells (40 %), and neutrophils (63 %), which, among other stromal cells, have the highest percentage of stromal cells expressing ADAM8 in PDAC tissue. (uni-marburg.de)
From these data, it can be concluded that ADAM8 is not only present in PDAC cells but also in tumor-associated stromal macrophages, NK cells, and neutrophils in the TME and that ADAM8-expressing stromal cells may be a promising parameter that can serve for the early diagnosis of PDAC. (uni-marburg.de)
To investigate the role of PRMT-1 and 4 on TME in PDAC, immunohistochemical staining was performed with the same stromal cells on human PDAC tissue as previously used to build a network of correlation. (uni-marburg.de)
Both proteins control whether or not cancer cells spread to other parts of the body, but the exact mechanisms have remained unclear. (imperial.ac.uk)
Under the right conditions, such as certain gene activation or lowered immune system, cancer cells can migrate or ' metastasise ' and invade other tissues, which spreads the cancer. (imperial.ac.uk)
Dr Hernández and colleagues from the University of Tampere , Finland, studied talin's response to movement in fibroblasts - cells that help to heal wounds and repair damaged tissues. (imperial.ac.uk)
Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. (pharmiweb.com)
Tumor suppressors are involved in regulating the cell cycle, ensuring that cells only divide when necessary and that the process is tightly controlled. (pharmiweb.com)
The molecules are found on the cell surface, where they facilitate adhesion to neighboring cells or the extracellular matrix, creating stable cell structures and supporting tissue organization. (pharmiweb.com)
They facilitate adhesion between leukocytes and endothelial cells, enabling leukocyte extravasation into tissues during inflammation. (pharmiweb.com)
However, in cancer, myeloid cells are largely converted to serve a new master-tumor cells. (aacrjournals.org)
This process is epitomized by myeloid-derived suppressor cells (MDSC). (aacrjournals.org)
Mononuclear myeloid cells include terminally differentiated macrophages and dendritic cells (DC), as well as monocytes, which under inflammatory conditions differentiate in tissues to macrophages and DCs. (aacrjournals.org)
The observations of the accumulation in spleens and tumors of large numbers of these cells with potent immune-suppressive activity were readily reproducible in most murine tumor models. (aacrjournals.org)
Aged, nondividing cells however continue to play an array of biological roles and their accumulation in tissues over time compromises tissue functions, linking cellular aging to organismal aging and cancer. (genengnews.com)
The neurofibromatosis type 1 (NF1) gene encodes a tumor suppressor protein, neurofibromin, which is expressed at high levels in Schwann cells and other adult tissues. (wustl.edu)
RPL4 is overexpressed in NSCLC tissues and cells. (techscience.com)
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. (lookformedical.com)
A cell line derived from cultured tumor cells. (lookformedical.com)
She is investigating two different ligands and their receptive G-protein coupled receptors WNT5A/Frizzle and cysteinyl leukotriene C4/CysLTR2 signaling pathways which both upregulates 15-PGDH and induce re-differentiation of colon cancer cells. (lu.se)
Initial exponential tumor growth is followed by a plateau phase when cell death nearly equals the rate of formation of daughter cells. (msdmanuals.com)
Small tumors have a greater percentage of actively dividing cells than do large tumors. (msdmanuals.com)
This in turn attracts inflammatory cells that may be associated with malignant transformation but also with tumor regression. (lu.se)
function of several poorly characterized proteins expressed in tumor cells and which are structurally related to known complement inhibitors but also suggested to act as tumor suppressors. (lu.se)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma todetermine (1) the prevalence of p53 protein immunoreactivity, (2) number of p53 positive cells, and (3) the area of localization of p53 protein immunoreactivity. (bvsalud.org)

It is expressed in different isoforms in various tissues and interacts with TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. (bvsalud.org)

Based on the role of miRNA in tumor development, it can be classified as tumor-suppressive miRNA (TS-miRNA) or oncogenic miRNA [6]. (scirp.org)

Associations between tumor hypoxia and aggressively malignant phenotypes are observed across a range of cancers. (lu.se)

Kadakia, previously chair of the department of biochemistry and molecular biology, studies the tumor suppressor protein p63. (asbmb.org)

When unchecked, fibroblasts can produce scar tissue in the liver, which leads to cirrhosis and HCC. (imperial.ac.uk)

It can arrest growth by holding the cell cycle at the G1/S regulation point on DNA damage recognition-if it holds the cell here for long enough, the DNA repair proteins will have time to fix the damage and the cell will be allowed to continue the cell cycle. (wikipedia.org)
Additionally, DBC1 knockdown eliminated the up-regulation of MMP7, EMT-related proteins, and cell cycle-related proteins as well as the enhanced proliferation and invasiveness induced by ZNF326. (cancerindex.org)
Mechanisms and Regulation of Tissue Growth and. (hhmi.org)
[ 42 ] Another study by Nahorski et al demonstrated tumor suppression by the interaction of p0071 (plakophilin-4, a potential novel folliculin-interacting protein) and the regulation of RhoA. (medscape.com)

Loss of Pcs impairs Rab11 localization on the trans-side of Golgi units and induces the cytoplasmic accumulation of post-Golgi vesicles bearing rhabdomere proteins, as observed in Rab11-deficiency. (sdbonline.org)

The Smad7 protein is negative regulator of the TGF-β signaling pathway, which is upregulated in patients with breast cancer. (cancerindex.org)
Yes-associated protein (YAP), which is a crucial downstream effector of the Hippo signaling pathway, has also been demonstrated to be involved in the EMT process ( 11 , 12 ). (spandidos-publications.com)

Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. (cancerindex.org)
M2 protein interacts with MAVS. (cdc.gov)

In vulnerable tissues, p53 levels go up and remain high, leading to cell death. (sciencedaily.com)
So, the team explored whether manipulating p53 dynamics could increase tumor vulnerability, focusing on human colon cancer cell lines with unmutated, functional p53. (sciencedaily.com)
A mutant p53 will no longer bind DNA in an effective way, and, as a consequence, the p21 protein will not be available to act as the "stop signal" for cell division. (wikipedia.org)
The p21 protein binds directly to cyclin-CDK complexes that drive forward the cell cycle and inhibits their kinase activity, thereby causing cell cycle arrest to allow repair to take place. (wikipedia.org)
This unchecked cell division can lead to the formation of tumors in endocrine glands and other tissues. (medlineplus.gov)
During the interphase of early embryonic cell cycles, the OHO31 protein is present in the cytoplasm and massively accumulates in the nucleus at the onset of mitosis in late interphase and prophase. (rupress.org)
Moreover, the cell cycle-dependent accumulation of OHO31 in the nucleus indicates that this protein may be required for critical nuclear reactions occurring at the onset of mitosis. (rupress.org)
Role of tumor-derived exosomal miR-21 in cell invasion was determined by qPCR. (dovepress.com)
GKN1 is down-regulated in gastric tumor tissues and derived cell lines so it has recently emerged as a potential biomarker for gastric cancer. (unina.it)
A New Tumor Suppressor DnaJ-Like Heat Shock Protein, HLJ1, and Survival of Patients With Non-Small-Cell Lung Carcinoma. (eurekalert.org)
Firstly, to describe the stromal cell types expressing ADAM8 in PDAC, immunohistochemical staining was performed on human PDAC tissue and the results were evaluated. (uni-marburg.de)
The talin protein attaches to the cell membrane and creates a bridge between the outside and inside of the cell. (imperial.ac.uk)
Cell adhesion molecules are a diverse group of proteins that play a crucial role in mediating cell-to-cell interactions and cell-to-extracellular matrix interactions. (pharmiweb.com)
This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. (modellab.cn)
Adhesion G-protein-coupled receptors (aGPCRs) are characterized by the presence of auto-proteolysing extracellular regions that are involved in cell-cell and cell-extracellular matrix interactions1. (stanford.edu)
Abstract Non-small cell lung cancer (NSCLC) is a malignant tumor with high incidence worldwide. (techscience.com)
Her research involves methods as tissue microarray (TMA) of colon cancer patients for immunohistochemistry (IHC) and Western blot, qPCR, transfection, luciferase assay, immunofluorescens on colon cancer cell lines. (lu.se)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
Two contiguous sections from 30 tissue specimens (10 each from oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma) were subjected to hematoxylin and eosin (H/E) staining for histopathological diagnosis and immunohistochemical (IHC) staining for demonstration of p53. (bvsalud.org)
Higher p53 positive cell counts were demonstrated in oral squamous cell carcinoma compared to hyperplastic and dysplastic tissues. (bvsalud.org)

The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. (wikipedia.org)
Proteins that are frequently altered in tumors play a prominent role in cancer research. (medicalxpress.com)
The protein RFX7, a largely unknown transcription factor, has recently been linked to lymph node cancer. (medicalxpress.com)
Researchers at Karolinska Institutet in Sweden have published new findings in the journal Cancer Discovery showing how pharmacological activation of the protein p53 boosts the immune response against tumours. (medicalxpress.com)
The latest animation technology has revealed the molecular detail of how our bodies are protected from cancer by a key 'tumour suppressor' protein called p53. (medicalxpress.com)
To estimate the potential benefit of multiple cores, we analyzed Ki67 and p53 in triplet cores taken from three different areas of 3,261 prostate cancer tissue blocks. (nih.gov)
The newly discovered 'switch' controls the activity of two proteins - 'deleted in liver cancer-1' ( DLC1 ), a tumour suppressor, and talin. (imperial.ac.uk)
Our findings have implications for tissue engineering, cancer research, and drug testing using organ-on-chip technology. (imperial.ac.uk)
These forces change the shape of talin, which deactivates DLC1 so that it cannot perform its tumour suppressing fuction, leading to cancer. (imperial.ac.uk)
A tumor suppressor gene, also known as anti-onco gene, is an essential component of the body's defense against cancer. (pharmiweb.com)
Tumors or cancer of the MOUTH. (lookformedical.com)
Tumors or cancer of the SKIN . (lookformedical.com)
Tumors or cancer of the LUNG. (lookformedical.com)
Tumors or cancer of the LIVER. (lookformedical.com)
Tumors or cancer of the UTERINE CERVIX. (lookformedical.com)
MicroRNA‑30a‑5p (miR‑30a‑5p), which functions as a tumor suppressor, has been reported to be downregulated in colorectal cancer (CRC) tissues and to be associated with cancer invasion. (spandidos-publications.com)
Colorectal cancer (CRC) is a common gastrointestinal tumor in China ( 1 ). (spandidos-publications.com)
Lubnas research is mainly focused on the tumor suppressor protein 15-hydroxyprostaglandin dehydrogenase which is known to be down-regulated in colon cancer. (lu.se)
We study how these proteins are related to tumor development in breast, prostate and melanoma cancer models. (lu.se)
Through their efforts, we are gaining a better understanding of cancer formation and developing diagnostic tools for early detection, while also exploring ways to prevent tumor growth and much more. (lu.se)

Also unknown is why telomeric uncapping which is considered a DNA double stranded break does not stably activate the "guardian of the genome," a tumor suppressor protein called p53. (genengnews.com)

World Health Organization (WHO) grade IV glioma, which includes glioblastoma multiform (GBM), is a highly invasive and fatal malignant tumor [1]. (scirp.org)

These data highlight the importance of membrane protein recycling during development. (sdbonline.org)
Cryogenic electron microscopy (cryo-EM) has widened the field of structure-based drug discovery by allowing for routine determination of membrane protein structures previously intractable. (stanford.edu)

If the tumors become cancerous, the condition can be life-threatening. (medlineplus.gov)

Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. (otago.ac.nz)
High-resolution structures of GPR56 and LPHN3 in their active, G-protein-coupled states, reveal that after dissociation of the extracellular region, the decrypted TA peptides engage the seven-transmembrane domain core with a notable conservation of interactions that also involve extracellular loop 2. (stanford.edu)

Astrocytomas, including the most malignant form, glioblastoma multiforme, are the most frequent and deadly primary tumors of the human nervous system. (nih.gov)
To these aim, chromatin immunoprecipitation (ChIP) assays for the repressive trimethylation of histone 3 at lysine 9 (H3K9triMe) and its specific histone-lysine Nmethyltransferase (SUV39H1) were performed on biopsies of normal and tumor human gastric tissues. (unina.it)
Role of tau N-terminal motif in the secretion of human tau by End Binding proteins. (nih.gov)
A suggested positive control is human stomach tissue lysate. (thermofisher.com)
The majority of human tumors are low immunogenic and complement may be involved in their recognition via direct "danger signal" elicited activation. (lu.se)

One of these is CSMD1, a large transmembrane protein deleted in number of tumors but also acting as classical complement inhibitor targeting complement convertases. (lu.se)

A new study now finds that cellular survival after radiation exposure depends on behavior of the tumor-suppressor protein p53 over time. (sciencedaily.com)
After radiation exposure, all four tissues expressed elevated p53 along with other markers of DNA and cellular damage as expected. (sciencedaily.com)
Tumor-Suppressor Networks: Cellular Mechanisms. (hhmi.org)
They are involved in various cellular processes, including tissue development, immune responses, and maintenance of tissue integrity. (pharmiweb.com)
They play a vital role in tissue development, maintaining tissue integrity, and organizing complex cellular structures. (pharmiweb.com)
Our current understanding of cellular aging rests upon the uncapping of the repetitive, non-protein-coding extremities of our linear chromosomes called telomeres. (genengnews.com)

Retinoblastoma (RB) is a malignant childhood intraocular tumor. (molvis.org)

The formalin-fixed, paraffin-embedded (FFPE) tissue sections with a 5-μm thickness were cut for subsequent miR-637 in situ hybridization (ISH). (scirp.org)

The experimental evidence is being accumulated to show opposing roles of complement in tumor control. (lu.se)

The p21 gene contains several p53 response elements that mediate direct binding of the p53 protein, resulting in transcriptional activation of the gene encoding the p21 protein. (wikipedia.org)

There was significant miR-637 downregulation in glioma tissues (P (scirp.org)

MATERIALS AND METHODS: We conducted a retrospective search through our molecular archives to identify sequenced melanocytic tumors with MAP2K1 in-frame deletions. (bvsalud.org)

Pituitary tumors (eg, as prolactinoma) can affect children as young as 5 years. (medscape.com)

Thereafter, the OHO31 protein is predominantly expressed, albeit at reduced levels, in proliferating tissues. (rupress.org)

Despite representing one of the largest classes of therapeutic targets, most inactive-state G protein-coupled receptors (GPCRs) have remained inaccessible for cryo-EM because their small size and membrane-embedded nature impedes projection alignment for high-resolution map reconstructions. (stanford.edu)
Our research focuses on proteins involved in inflammation, specifically the involvement of cysteinyl leukotriene receptors. (lu.se)

7 It has been shown that miR-21 is a promoter of oncogenes and is highly expressed in several malignant tumors. (dovepress.com)

The slowing in growth rate may be related to exhaustion of the supply of nutrients and oxygen for the rapidly expanding tumor. (msdmanuals.com)
Local growth is facilitated by enzymes (eg, proteases) that destroy adjacent tissues. (msdmanuals.com)

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. (cancerindex.org)
A nuclear protein and tumor suppressor that contains a C-terminal PHD ZINC FINGER. (bvsalud.org)

Affected individuals carry a germ-line loss-of-function mutation of the MEN1 gene, and tumors arise after loss of the second allele. (johnshopkins.edu)

A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. (thermofisher.com)

Other associated tumors include lipomas, angiofibromas, and those located in the adrenal gland cortex (rarely, in the adrenal medulla). (medscape.com)

DISCUSSION AND CONCLUSION: Melanocytic tumors with MAP2K1 in-frame deletion could represent another spectrum of melanocytic tumors with close genotypic-phenotypic correlation. (bvsalud.org)

Anatomy17

Organisms6

Diseases55

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes60

Disciplines and Occupations1

Information Science4

Health Care2

Genes10

Progression10

Acts as a tumor suppressor2

Expression36

Microenvironment7

Metastasis5

Inhibition2

Mutations8

Loss of the tumor1

Hippel-Lindau2

Menin3

Apoptosis1

Organs8

Biomarkers4

Types of tumors2

Recurrence2

TP534

Mechanism5

Often mutated1

Metastases2

Normal tissues2

Malignancy3

Epithelial4

MiRNAs2

Genomic1

Endocrine tissues2

Inhibit3

Cells35

Negatively1

Oncogenic1

Cancers1

Molecular biology1

Fibroblasts1

Regulation4

Induces1

Signaling pathway2

Interacts2

Cell21

Cancer20

Genome1

Malignant tumor1

Membrane protein2

Cancerous1

Peptides2

Human5

Inhibitor1

Cellular6

Retinoblastoma1

Situ hybridization1

Roles1

Transcriptional activation1

Glioma1

Materials and Met1

Pituitary1

Predominantly1

Receptors2

Oncogenes1

Growth2

Nuclear protein2

Men11

Encodes a protein1

Adrenal gland1

Correlation1